Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents

The Human Intestinal Microbiome in Health and Disease

Lynch, S. V., & Pedersen, O. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1600266 · Cited by 3,637 · see citing works

Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease

Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622 · see citing works

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.188 · Cited by 3,076 · see citing works

2019 Alzheimer’s disease facts and figures.

Alzheimer's Association (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.01.010 · Cited by 2,461 · see citing works

Altered fecal microbiota composition in patients with major depressive disorder

Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275 · see citing works

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

Cheignon, C., Tomas, M., Bonnefont-Rousselot, D., Faller, P., Hureau, C., & Collin, F. (2018) · Redox Biology · doi:10.1016/j.redox.2017.10.014 · Cited by 2,185 · see citing works

Microglia in Alzheimer’s disease

Hansen, D. V., Hanson, J. E., & Sheng, M. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201709069 · Cited by 1,935 · cited 1× · see citing works

Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., et al. (2013) · Science · doi:10.1126/science.1227166 · Cited by 1,777 · see citing works

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

Tönnies, E., & Trushina, E. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161088 · Cited by 1,750 · see citing works

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

Kops, G. J. P. L., Dansen, T. B., Polderman, P. E., Saarloos, I., Wirtz, K. W. A., Coffer, P. J., Huang, T.-T., Bos, J. L., Medema, R. H., & Burgering, B. M. T. (2002) · Nature · doi:10.1038/nature01036 · Cited by 1,580 · see citing works

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

Cattaneo, A., Cattane, N., Galluzzi, S., Provasi, S., Lopizzo, N., Festari, C., Ferrari, C., Guerra, U. P., Paghera, B., Muscio, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.019 · Cited by 1,382 · see citing works

Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease

Wang, X., Wang, W., Li, L., Perry, G., Lee, H.-G., & Zhu, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.015 · Cited by 1,357 · see citing works

The role of oxidative stress in neurodegenerative diseases

Kim, G. H., Kim, J. E., Rhie, S. J., & Yoon, S. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.325 · Cited by 1,355 · see citing works

Gamma frequency entrainment attenuates amyloid load and modifies microglia

Iaccarino, H. F., Singer, A. C., Martorell, A. J., Rudenko, A., Gao, F., Gillingham, T. Z., Mathys, H., Seo, J., Kritskiy, O., Abdurrob, F., et al. (2016) · Nature · doi:10.1038/nature20587 · Cited by 1,328 · see citing works

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

Montagne, A., Nation, D. A., Sagare, A. P., Barisano, G., Sweeney, M. D., Chakhoyan, A., Pachicano, M., Joe, E., Nelson, A. R., D’Orazio, L. M., et al. (2020) · Nature · doi:10.1038/s41586-020-2247-3 · Cited by 1,281 · see citing works

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

Initiative, A. D. N., Shi, Y., Yamada, K., Liddelow, S. A., Smith, S. T., Zhao, L., Luo, W., Tsai, R. M., Spina, S., Grinberg, L. T., et al. (2017) · Nature · doi:10.1038/nature24016 · Cited by 1,220 · see citing works

Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

Someya, S., Yu, W., Hallows, W. C., Xu, J., Vann, J. M., Leeuwenburgh, C., Tanokura, M., Denu, J. M., & Prolla, T. A. (2010) · Cell · doi:10.1016/j.cell.2010.10.002 · Cited by 1,150 · see citing works

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

Wang, X., Sun, G., Feng, T., Zhang, J., Huang, X., Wang, T., Xie, Z., Chu, X., Yang, J., Wang, H., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0216-x · Cited by 1,144 · see citing works

Antioxidant responses and cellular adjustments to oxidative stress

Espinosa-Diez, C., Miguel, V., Mennerich, D., Kietzmann, T., Sánchez-Pérez, P., Cadenas, S., & Lamas, S. (2015) · Redox Biology · doi:10.1016/j.redox.2015.07.008 · Cited by 1,046 · see citing works

Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease

Mecocci, P., MacGarvey, U., & Beal, M. F. (1994) · Annals of Neurology · doi:10.1002/ana.410360510 · Cited by 1,037 · see citing works

Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress

Butterfield, D. A., & Lauderback, C. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00794-3 · Cited by 999 · see citing works

Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii , a commensal bacterium deficient in Crohn’s disease

Quévrain, E., Maubert, M.-A., Michon, C., Chain, F., Marquant, R., Tailhades, J., Miquel, S., Carlier, L., Bermúdez‐Humarán, L. G., Pigneur, B., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307649 · Cited by 861 · see citing works

Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders

Mahley, R. W. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1427-y · Cited by 837 · see citing works

Insights into the Role of Erysipelotrichaceae in the Human Host

Kaakoush, N. O. (2015) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2015.00084 · Cited by 817 · see citing works

Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration

Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Physiology · doi:10.1113/jp273106 · Cited by 813 · see citing works

The blood–brain barrier in health and disease: Important unanswered questions

Profaci, C. P., Munji, R. N., Pulido, R. S., & Daneman, R. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190062 · Cited by 781 · see citing works

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

Kong, X., Wang, R., Xue, Y., Liu, X., Zhang, H., Chen, Y., Fang, F., & Chang, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011707 · Cited by 718 · see citing works

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

Moussa, C., Hebron, M. L., Huang, X., Ahn, J., Rissman, R. A., Aisen, P. S. S., & Turner, R. S. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0779-0 · Cited by 712 · see citing works

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial

Dysken, M. W., Sano, M., Asthana, S., Vertrees, J. E., Pallaki, M., Llorente, M., Love, S., Schellenberg, G. D., McCarten, J. R., Malphurs, J., et al. (2014) · JAMA · doi:10.1001/jama.2013.282834 · Cited by 628 · see citing works

Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model

Kim, M.-S., Kim, Y., Choi, H., Kim, W., Park, S., Lee, D., Kim, D. K., Kim, H. J., Choi, H., Hyun, D.-W., et al. (2020) · Gut · doi:10.1136/gutjnl-2018-317431 · Cited by 614 · see citing works

The role of thiols in antioxidant systems

Ulrich, K., & Jakob, U. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.05.035 · Cited by 561 · see citing works

Intestinal Microbiota, Microbial Translocation, and Systemic Inflammation in Chronic HIV Infection

Dinh, D. M., Volpe, G. E., Duffalo, C., Bhalchandra, S., Tai, A., Kane, A. V., WANKE, C. A., & Ward, H. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu409 · Cited by 531 · see citing works

ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion

Huang, Y.-W. A., Zhou, B., Wernig, M., & Südhof, T. C. (2017) · Cell · doi:10.1016/j.cell.2016.12.044 · Cited by 528 · see citing works

Gram-negative bacterial molecules associate with Alzheimer disease pathology

Zhan, X., Stamova, B., Jin, L.-W., DeCarli, C., Phinney, B., & Sharp, F. R. (2016) · Neurology · doi:10.1212/wnl.0000000000003391 · Cited by 521 · see citing works

Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target

Zhang, J., Xiang, H., Liu, J., Chen, Y., He, R.-R., & Liu, B. (2020) · Theranostics · doi:10.7150/thno.45922 · Cited by 503 · see citing works

Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw023 · Cited by 496 · see citing works

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

Palacios, O. M., Carmona, J. J., Michan, S., Chen, K. Y., Manabe, Y., III, J. L. W., Goodyear, L. J., & Tong, Q. (2009) · Aging · doi:10.18632/aging.100075 · Cited by 487 · see citing works

Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota

Li, B., He, Y., Ma, J., Huang, P., Du, J., Cao, L. H., Wang, Y., Xiao, Q., Tang, H., & Chen, S. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.07.002 · Cited by 480 · see citing works

Increased Nuclear DNA Oxidation in the Brain in Alzheimer's Disease

Gabbita, S. P., Lovell, M. A., & Markesbery, W. R. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71052034.x · Cited by 479 · see citing works

Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

Reiman, E. M., Arboleda-Velasquez, J. F., Quiroz, Y. T., Huentelman, M. J., Beach, T. G., Caselli, R. J., Chen, Y., Su, Y., Myers, A. J., Hardy, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14279-8 · Cited by 473 · see citing works

The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease

Vogt, N. M., Romano, K. A., Darst, B. F., Engelman, C. D., Johnson, S. C., Carlsson, C. M., Asthana, S., Blennow, K., Zetterberg, H., Bendlin, B. B., et al. (2018) · Alzheimer's Research & Therapy · doi:10.1186/s13195-018-0451-2 · Cited by 471 · see citing works

Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease

Calvo-Rodríguez, M., Hou, S. S., Snyder, A. C., Kharitonova, E. K., Russ, A., Das, S., Fan, Z., Muzikansky, A., Garcı́a-Alloza, M., Serrano‐Pozo, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16074-2 · Cited by 432 · see citing works

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

vom Berg, J., Prokop, S., Miller, K. R., Obst, J., Kälin, R. E., Lopategui-Cabezas, I., Wegner, A., Mair, F., Schipke, C. G., Peters, O., et al. (2012) · Nature Medicine · doi:10.1038/nm.2965 · Cited by 416 · see citing works

Microbial imbalance in inflammatory bowel disease patients at different taxonomic levels

Alam, M. T., Amos, G. C. A., Murphy, A. R. J., Murch, S., Wellington, E. M. H., & Arasaradnam, R. P. (2020) · Gut Pathogens · doi:10.1186/s13099-019-0341-6 · Cited by 380 · see citing works

Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus

Zhao, Y., Jaber, V., & Lukiw, W. J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00318 · Cited by 379 · see citing works

Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer's disease-type beta-amyloid neuropathological mechanisms

Ho, L., Ono, K., Tsuji, M., Mazzola, P., Singh, R., & Pasinetti, G. M. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1400909 · Cited by 376 · see citing works

Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System

Ren, X., Zou, L., Zhang, X., Branco, V., Wang, J., Carvalho, C. M. L., Holmgren, A., & Lu, J. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6925 · Cited by 365 · see citing works

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer’s disease

Manczak, M., & Reddy, P. H. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds360 · Cited by 348 · see citing works

Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias

Beecham, G. W., Hamilton, K., Naj, A. C., Martin, E. R., Huentelman, M., Myers, A. J., Corneveaux, J. J., Hardy, J., Vonsattel, J.-P., Younkin, S. G., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004606 · Cited by 343 · see citing works

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

Jadiya, P., Kolmetzky, D. W., Tomar, D., Di Meco, A., Lombardi, A. A., Lambert, J. P., Luongo, T. S., Ludtmann, M. H., Praticò, D., & Elrod, J. W. (2019) · Nature Communications · doi:10.1038/s41467-019-11813-6 · Cited by 323 · see citing works

Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease

Moscoso, A., Grothe, M. J., Ashton, N. J., Karikari, T. K., Lantero‐Rodriguez, J., Snellman, A., Suárez‐Calvet, M., Blennow, K., Zetterberg, H., Schöll, M., et al. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2020.4986 · Cited by 310 · see citing works

Amyloid‐Beta Interaction with Mitochondria

Pagani, L., & Eckert, A. (2011) · International Journal of Alzheimer’s Disease · doi:10.4061/2011/925050 · Cited by 309 · see citing works

De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease

Wong, H. K., Veremeyko, T., Patel, N., Lemere, C. A., Walsh, D. M., Esau, C., Vanderburg, C. R., & Krichevsky, A. M. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt164 · Cited by 293 · see citing works

A Randomized Placebo-Controlled Pilot Trial of Omega-3 Fatty Acids and Alpha Lipoic Acid in Alzheimer's Disease

Shinto, L., Quinn, J., Montine, T., Dodge, H. H., Woodward, W., Baldauf-Wagner, S., Waichunas, D., Bumgarner, L., Bourdette, D., Silbert, L., et al. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-130722 · Cited by 288 · see citing works

Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

Brunt, V. E., Gioscia‐Ryan, R. A., Casso, A. G., VanDongen, N. S., Ziemba, B. P., Sapinsley, Z. J., Richey, J. J., Zigler, M. C., Neilson, A. P., Davy, K. P., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14759 · Cited by 285 · see citing works

Functional role of mitochondrial reactive oxygen species in physiology

Angelova, P. R., & Abramov, A. Y. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.06.005 · Cited by 271 · see citing works

Interaction of Mitochondria with the Endoplasmic Reticulum and Plasma Membrane in Calcium Homeostasis, Lipid Trafficking and Mitochondrial Structure

Szymański, J., Janikiewicz, J., Michalska, B., Patalas‐Krawczyk, P., Perrone, M., Ziółkowski, W., Duszyński, J., Pinton, P., Dobrzyń, A., & Wieckowski, M. R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071576 · Cited by 269 · see citing works

Gut microbiota changes in the extreme decades of human life: a focus on centenarians

Santoro, A., Ostan, R., Candela, M., Biagi, E., Brigidi, P., Capri, M., & Franceschi, C. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2674-y · Cited by 250 · see citing works

Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in <i>ApoE4</i> Carriers

Tao, Q., Ang, T. F. A., DeCarli, C., Auerbach, S. H., Devine, S., Stein, T. D., Zhang, X., Massaro, J., Au, R., & Qiu, W. Q. (2018) · JAMA Network Open · doi:10.1001/jamanetworkopen.2018.3597 · Cited by 239 · see citing works

<i>APOE</i> genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology

Tran, T. T. T., Corsini, S., Kellingray, L., Hegarty, C., Le Gall, G., Narbad, A., Müller, M., Tejera, N., O'Toole, P. W., Minihane, A.-M., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900071r · Cited by 233 · see citing works

Apolipoprotein C-II: new findings related to genetics, biochemistry, and role in triglyceride metabolism

Wolska, A., Dunbar, R. L., Freeman, L. A., Ueda, M., Amar, M. J., Sviridov, D. O., & Remaley, A. T. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.10.025 · Cited by 231 · see citing works

Role of thiols in oxidative stress

Baba, S. P., & Bhatnagar, A. (2018) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2018.03.005 · Cited by 230 · see citing works

Elevated Circulating Trimethylamine N-Oxide Levels Contribute to Endothelial Dysfunction in Aged Rats through Vascular Inflammation and Oxidative Stress

Li, T., Chen, Y., Gua, C., & Li, X. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00350 · Cited by 216 · see citing works

Diet-induced alterations of host cholesterol metabolism are likely to affect the gut microbiota composition in hamsters

Martínez, I., Perdicaro, D. J., Brown, A. W., Hammons, S., Carden, T. J., Carr, T. P., Eskridge, K. M., & Walter, J. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.03046-12 · Cited by 215 · see citing works

SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease

Lee, J., Kim, Y., Liu, T., Hwang, Y. J., Hyeon, S. J., Im, H., Lee, K., Alvarez, V. E., McKee, A. C., Um, S., et al. (2018) · Aging Cell · doi:10.1111/acel.12679 · Cited by 213 · see citing works

Regulation of Mitochondrial Transport and Inter-Microtubule Spacing by Tau Phosphorylation at the Sites Hyperphosphorylated in Alzheimer's Disease

Shahpasand, K., Uemura, I., Saito, T., Asano, T., Hata, K., Shibata, K., Toyoshima, Y., Hasegawa, M., & Hisanaga, S.-I. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5927-11.2012 · Cited by 206 · see citing works

Tau phosphorylation affects its axonal transport and degradation

Rodríguez-Martín, T., Cuchillo‐Ibáñez, I., Noble, W. J., Nyenya, F., Anderton, B. H., & Hanger, D. P. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.015 · Cited by 200 · see citing works

The role of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis

Yetkin-Arik, B., Vogels, I. M. C., Nowak-Sliwinska, P. M., Weiss, A., Houtkooper, R. H., Noorden, C. J. F. V., Klaassen, I., & Schlingemann, R. O. (2019) · Scientific Reports · doi:10.1038/s41598-019-48676-2 · Cited by 186 · see citing works

Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer’s disease: a 6-month, randomized, placebo-controlled, multicenter trial

Laudon, M., Wade, A. G., Farmer, M. V., Harari, G., Fund, N., Nir, T., Frydman‐Marom, A., & Zisapel, N. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s65625 · Cited by 174 · see citing works

Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of Alzheimer’s Disease

ZAKARIA, R., WAN YAACOB, W. M. H., OTHMAN, Z., LONG, I., AHMAD, A. H., & AL-RAHBI, B. (2017) · Physiological Research · doi:10.33549/physiolres.933480 · Cited by 167 · see citing works

Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins

Li, X., Hu, Y., Wang, Z.-H., Luo, Y., Zhang, Y., Liu, X., Feng, Q., Wang, Q., Ye, K., Liu, G., et al. (2016) · Scientific Reports · doi:10.1038/srep24756 · Cited by 164 · see citing works

A reciprocal relationship between reactive oxygen species and mitochondrial dynamics in neurodegeneration

Hung, C. H.-L., Cheng, S. S., Cheung, Y.-T., Wuwongse, S., Zhang, N. Q., Ho, J. Y. S., Lee, S. M., & Chang, R. C. (2017) · Redox Biology · doi:10.1016/j.redox.2017.08.010 · Cited by 144 · see citing works

Effects of oral butyrate supplementation on inflammatory potential of circulating peripheral blood mononuclear cells in healthy and obese males

Cleophas, M. C. P., Ratter, J. M., Bekkering, S., Quintin, J., Schraa, K., Stroes, E. S. G., Netea, M. G., & Joosten, L. A. B. (2019) · Scientific Reports · doi:10.1038/s41598-018-37246-7 · Cited by 134 · see citing works

Neuroinflammation and the Gut Microbiota: Possible Alternative Therapeutic Targets to Counteract Alzheimer’s Disease?

Cerovic, M., Forloni, G., & Balducci, C. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00284 · Cited by 126 · see citing works

Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease

Chen, S.-Y., Gao, Y., Sun, J., Meng, X., Yang, D., Fan, L., Li, X., & Wang, P. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00497 · Cited by 126 · see citing works

Oxidatively modified nucleic acids in preclinical Alzheimer's disease (PCAD) brain

Lovell, M. A., Soman, S., & Bradley, M. A. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.08.003 · Cited by 124 · see citing works

Effect of ApoE isoforms on mitochondria in Alzheimer disease

Yin, J., Reiman, E. M., Beach, T. G., Serrano, G. E., Sabbagh, M. N., Nielsen, M., Caselli, R. J., & Shi, J. (2020) · Neurology · doi:10.1212/wnl.0000000000009582 · Cited by 116 · see citing works

<i>APOE2</i> eases cognitive decline during Aging: Clinical and preclinical evaluations

Shinohara, M., Kanekiyo, T., Yang, L., Linthicum, D., Shinohara, M., Fu, Y., Price, L., Frisch‐Daiello, J. L., Han, X., Fryer, J. D., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24628 · Cited by 111 · see citing works

Blood‐based metabolic signatures in Alzheimer's disease

de Leeuw, F. A., Peeters, C. F. W., Kester, M. I., Harms, A. C., Struys, E. A., Hankemeier, T., van Vlijmen, H. W. T., van der Lee, S. J., van Duijn, C. M., Scheltens, P., et al. (2017) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2017.07.006 · Cited by 106 · see citing works

Redox proteomics and amyloid β-peptide: Insights into Alzheimer disease

Butterfield, D. A., & Boyd‐Kimball, D. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14589 · Cited by 105 · see citing works

Diabetes as a risk factor for Alzheimer’s disease in the Middle East and its shared pathological mediators

Jayaraj, R. L., Azimullah, S., & Beiram, R. (2019) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2019.12.028 · Cited by 105 · see citing works

Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer’s Disease Prevention and Early Intervention

Keeney, J. T.-R., Ibrahimi, S., & Zhao, L. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-150348 · Cited by 102 · see citing works

Oxidative Stress and Gut-Derived Lipopolysaccharides in Neurodegenerative Disease: Role of NOX2

Loffredo, L., Ettorre, E., Zicari, A. M., Inghilleri, M., Nocella, C., Perri, L., Spalice, A., Fossati, C., De Lucia, M. C., Pigozzi, F., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8630275 · Cited by 100 · see citing works

Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients

Di Domenico, F., Pupo, G., Giraldo, E., Badìa, M.-C., Monllor, P., Lloret, A., Eugenia Schininà, M., Giorgi, A., Cini, C., Tramutola, A., et al. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.12.004 · Cited by 97 · see citing works

Trimethylamine-N-oxide as One Hypothetical Link for the Relationship between Intestinal Microbiota and Cancer - Where We Are and Where Shall We Go?

Chan, C. W. H., Law, B. M. H., Waye, M. M. Y., Chan, J. Y., So, W. K. W., & Chow, K. M. (2019) · Journal of Cancer · doi:10.7150/jca.31737 · Cited by 96 · see citing works

PGC‐1α overexpression by in vivo transfection attenuates mitochondrial deterioration of skeletal muscle caused by immobilization

Kang, C., Goodman, C. A., Hornberger, T. A., & Ji, L. L. (2015) · The FASEB Journal · doi:10.1096/fj.14-266619 · Cited by 92 · see citing works

Apolipoproteins E and CIII interact to regulate HDL metabolism and coronary heart disease risk

Morton, A. M., Koch, M., Mendivil, C. O., Furtado, J. D., Tjønneland, A., Overvad, K., Wang, L., Jensen, M. K., & Sacks, F. M. (2018) · JCI Insight · doi:10.1172/jci.insight.98045 · Cited by 91 · see citing works

Axonal Transport Defects in Alzheimer’s Disease

Wang, Z., Tan, L., & Yu, J. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8810-x · Cited by 86 · see citing works

Vascular Oxidative Stress and Mitochondrial Failure in the Pathobiology of Alzheimer’s Disease: A New Approach to Therapy

Sochocka, M., Koutsouraki, E., Gąsiorowski, K., & Leszek, J. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113129990072 · Cited by 85 · see citing works

Sirtuin 1 and Alzheimer's disease: An up-to-date review

Rizzi, L., & Roriz‐Cruz, M. (2018) · Neuropeptides · doi:10.1016/j.npep.2018.07.001 · Cited by 83 · see citing works

Actigraphy‐estimated sleep and 24‐hour activity rhythms and the risk of dementia

Lysen, T. S., Luik, A. I., Ikram, M. K., Tiemeier, H. W., & Ikram, M. K. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12122 · Cited by 83 · see citing works

Understanding the Role of ApoE Fragments in Alzheimer’s Disease

Muñoz, S. S., Garner, B., & Ooi, L. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2629-1 · Cited by 81 · see citing works

Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP)

Reitz, C., Tosto, G., Vardarajan, B. N., Rogaeva, E. A., Ghani, M., Rogers, R. S., Conrad, C., Haines, J. L., Pericak‐Vance, M. A., Fallin, M. D., et al. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.13 · Cited by 80 · see citing works

Dexmedetomidine Provides Protection Against Hippocampal Neuron Apoptosis and Cognitive Impairment in Mice with Alzheimer’s Disease by Mediating the miR-129/YAP1/JAG1 Axis

Sun, W., Zhao, J., & Li, C. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02069-z · Cited by 71 · see citing works

Blood–brain barrier dysfunction in immuno-mediated neurological diseases

Shimizu, F., Nishihara, H., & Kanda, T. (2018) · Immunological Medicine · doi:10.1080/25785826.2018.1531190 · Cited by 69 · see citing works

The Role of Hydrogen Peroxide and Other Reactive Oxygen Species in Wound Healing

Kanta, J. (2011) · Acta Medica (Hradec Kralove Czech Republic) · doi:10.14712/18059694.2016.28 · Cited by 68 · see citing works

An APOE Haplotype Associated with Decreased ε4 Expression Increases the Risk of Late Onset Alzheimer's Disease

Lescai, F., Chiamenti, A. M., Codemo, A., Pirazzini, C., D'Agostino, G., Ruaro, C., Ghidoni, R., Benussi, L., Galimberti, D., Esposito, F., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101764 · Cited by 68 · see citing works

Human copper chaperone for superoxide dismutase 1 mediates its own oxidation-dependent import into mitochondria

Suzuki, Y., Ali, M., Fischer, M., & Riemer, J. (2013) · Nature Communications · doi:10.1038/ncomms3430 · Cited by 68 · see citing works

Oxidative stress affects processing of amyloid precursor protein in vascular endothelial cells

Muche, A., Arendt, T., & Schliebs, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178127 · Cited by 68 · see citing works

A polymorphism in SOD2 is associated with development of Alzheimer’s disease

Wiener, H. W., Perry, R. T., Chen, Z., Harrell, L. E., & Go, R. C. P. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00308.x · Cited by 66 · see citing works

miR-16-5p is upregulated by amyloid β deposition in Alzheimer's disease models and induces neuronal cell apoptosis through direct targeting and suppression of BCL-2

Kim, Y. J., Kim, S. H., Park, Y., Park, J., Lee, J. H., Kim, B. C., & Song, W. K. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110954 · Cited by 65 · see citing works

A novel oxidative stress marker in patients with Alzheimer’s disease: dynamic thiol–disulphide homeostasis

Gümüşyayla, Ş., Vural, G., Bektaş, H., Denız, O., Neşeli̇oğlu, S., & Erel, Ö. (2016) · Acta Neuropsychiatrica · doi:10.1017/neu.2016.13 · Cited by 64 · see citing works

FOXO protects against age‐progressive axonal degeneration

Hwang, I., Oh, H., Santo, E. E., Kim, D., Chen, J. W., Bronson, R. T., Locasale, J. W., Na, Y., Lee, J., Reed, S., et al. (2017) · Aging Cell · doi:10.1111/acel.12701 · Cited by 64 · see citing works

Murine Gut Microbiome Association With APOE Alleles

Parikh, I. J., Estus, J. L., Zajac, D. J., Malik, M., Weng, J. M., Tai, L. M., Chlipala, G. E., LaDu, M. J., Green, S. J., & Estus, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00200 · Cited by 63 · see citing works

Detergent‐Insoluble EAAC1/EAAT3 Aberrantly Accumulates in Hippocampal Neurons of Alzheimer's Disease Patients

Duerson, K. C., Woltjer, R. L., Mookherjee, P., Leverenz, J. B., Montine, T. J., Bird, T. D., Pow, D. V., Rauen, T., & Cook, D. G. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00186.x · Cited by 60 · see citing works

Oncogenic and oncosuppressive signal transduction at mitochondria-associated endoplasmic reticulum membranes

Marchi, S., Giorgi, C., Prill, M., Duszyński, J., Wieckowski, M. R., & Pinton, P. (2014) · Molecular & Cellular Oncology · doi:10.4161/23723548.2014.956469 · Cited by 60 · see citing works

Alzheimer’s Disease – The Past, the Present and the Future

Botchway, B. O. A. (2017) · Science Journal of Clinical Medicine · doi:10.11648/j.sjcm.20170601.11 · Cited by 60 · see citing works

Oxidative Stress as a Biomarker for Alzheimer’S Disease

Collin, F., Cheignon, C., & Hureau, C. (2018) · Biomarkers in Medicine · doi:10.2217/bmm-2017-0456 · Cited by 58 · see citing works

Oxidative stress and APO E polymorphisms in Alzheimer's disease and in mild cognitive impairment

Chico, L., Simoncini, C., Gerfo, A. L., Rocchi, A., Petrozzi, L., Carlesi, C., Volpi, L., Tognoni, G., Siciliano, G., & Bonuccelli, U. (2013) · Free Radical Research · doi:10.3109/10715762.2013.804622 · Cited by 51 · see citing works

Hawthorn fruit extract reduced trimethylamine-N-oxide (TMAO)-exacerbated atherogenesis in mice via anti-inflammation and anti-oxidation

He, Z., Kwek, E., Hao, W., Zhu, H., Liu, J., Ma, K. Y., & Chen, Z. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-020-00535-y · Cited by 51 · see citing works

SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology

Malik, A., Szydłowska, K., Nizińska, K., Asaro, A., van Vliet, E., Popp, O., Dittmar, G., Fritsche-Guenther, R., Kirwan, J., Nykjaer, A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.027 · Cited by 46 · see citing works

A Genetic Variant of the Sortilin 1 Gene is Associated with Reduced Risk of Alzheimer’s Disease

Andersson, C.-H., Hansson, O., Minthon, L., Andreasen, N., Blennow, K., Zetterberg, H., Skoog, I. G., Wallin, A., Nilsson, S., & Kettunen, P. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160319 · Cited by 45 · see citing works

Aerobic Training Increases Expression Levels of SIRT3 and PGC-1α in Skeletal Muscle of Overweight Adolescents Without Change in Caloric Intake

Vargas‐Ortiz, K., Pérez‐Vázquez, V., Díaz-Cisneros, F. J., Figueroa, A., Jiménez-Flores, L. M., Rodriguez-DelaRosa, G., & Macías, M. H. (2015) · Pediatric Exercise Science · doi:10.1123/pes.2014-0112 · Cited by 39 · see citing works

ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer’s disease mouse model

Chan, E. S., Shetty, M. S., Sajikumar, S., Chen, C., Soong, T. W., & Wong, B.-S. (2016) · Scientific Reports · doi:10.1038/srep26119 · Cited by 39 · see citing works

Interleukin‐12/23 deficiency differentially affects pathology in male and female Alzheimer's disease‐like mice

Eede, P., Obst, J., Benke, E., Yvon‐Durocher, G., Richard, B. C., Gimber, N., Schmoranzer, J., Böddrich, A., Wanker, E. E., Prokop, S., et al. (2020) · EMBO Reports · doi:10.15252/embr.201948530 · Cited by 39 · see citing works

Nutrition: Review on the Possible Treatment for Alzheimer’s Disease

Botchway, B. O. A., Moore, M. K., Akinleye, F. O., Iyer, I. C., & Fang, M. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170874 · Cited by 37 · see citing works

Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling

Asaro, A., Carlo‐Spiewok, A., Malik, A. R., Rothe, M., Schipke, C. G., Peters, O., Heeren, J., & Willnow, T. E. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12121 · Cited by 37 · see citing works

Plasma Thiols Levels in Alzheimer's Disease Mice under Diet-Induced Hyperhomocysteinemia: Effect of S-Adenosylmethionine and Superoxide-Dismutase Supplementation

Persichilli, S., Gervasoni, J., Napoli, A. D., Fuso, A., Nicolia, V., Giardina, B., Scarpa, S., Desiderio, C., & Cavallaro, R. A. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142391 · Cited by 36 · see citing works

rs2070424 of the SOD1 gene is associated with risk of Alzheimer's disease

Spisak, K., Klimkowicz‐Mrowiec, A., Pera, J., Dziedzic, T., Golenia, A., & Słowik, A. (2014) · Neurologia i Neurochirurgia Polska · doi:10.1016/j.pjnns.2014.09.002 · Cited by 35 · see citing works

Correction: Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer’s Disease and Related Dementias

Staff, T. P. G. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004867 · Cited by 32 · see citing works

Type 2 Diabetes Interacts With Alzheimer Disease Risk Factors to Predict Functional Decline

Thomas, K. R., Bangen, K. J., Weigand, A. J., Edmonds, E. C., Sundermann, E. E., Wong, C. G., Eppig, J. S., Werhane, M. L., Delano‐Wood, L., & Bondi, M. W. (2019) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000332 · Cited by 29 · see citing works

TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer’s disease in Han Chinese

Lu, R.-C., Wang, H., Tan, M., Yu, J., & Tan, L. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-013-1106-x · Cited by 28 · see citing works

SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in a Northern Han Chinese population

Wang, H.-F., Yu, J., Zhang, W., Wang, W., Liu, Q., Ma, X., Ding, H., & Tan, L. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.067 · Cited by 28 · see citing works

Increased Trimethylamine N-Oxide Is Not Associated with Oxidative Stress Markers in Healthy Aged Women

Olek, R. A., Samulak, J. J., Sawicka, A. K., Hartmane, D., Grı̄nberga, S., Pugovičs, O., & Łysiak−Szydłowska, W. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/6247169 · Cited by 27 · see citing works

APOE ε4 is associated with younger age at ischemic stroke onset but not with stroke outcome

Lagging, C., Lorentzen, E., Stanne, T. M., Pedersén, A., Söderholm, M., Cole, J. W., Jood, K., Lemmens, R., Phuah, C., Rost, N. S., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000008459 · Cited by 27 · see citing works

Sleep and diurnal rest-activity rhythm disturbances in a mouse model of Alzheimer’s disease

Filon, M. J., Wallace, E. P., Wright, S., Douglas, D. J., Steinberg, L. I., Verkuilen, C. L., Westmark, P. R., Maganti, R. K., & Westmark, C. J. (2020) · SLEEP · doi:10.1093/sleep/zsaa087 · Cited by 23 · see citing works

Apolipoprotein E ε4 Allele was Associated With Nonlesional Mesial Temporal Lobe Epilepsy in Han Chinese Population

Li, Z., Ding, C., Gong, X., Wang, X., & Cui, T. (2016) · Medicine · doi:10.1097/md.0000000000002894 · Cited by 22 · see citing works

Hidden Twins: SorCS Neuroreceptors Form Stable Dimers

Januliene, D., Manavalan, A., Ovesen, P. L., Pedersen, K.-M., Thirup, S., Nykjær, A., & Moeller, A. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.08.006 · Cited by 22 · see citing works

Elevated expression of ageing and immunity genes in queens of the black garden ant

Lucas, E. R., & Keller, L. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.03.020 · Cited by 20 · see citing works

Functional and therapeutic potential of mitochondrial SIRT3 deacetylase in disease conditions

Kanwal, A. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1546119 · Cited by 19 · see citing works

Positive association of a Sirt1 variant and parameters of oxidative stress on Alzheimer’s disease

Camporez, D., Belcavello, L., Almeida, J. F. F., Sena, G. G. S., Pimassoni, L. H. S., Morelato, R. L., Batitucci, M. D. C. P., & Paula, F. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04704-y · Cited by 19 · see citing works

Association of the C47T Polymorphism in SOD2 with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease in Carriers of the APOEε4 Allele

Gamarra, D., Elcoroaristizabal, X., Martínez, M. F., & de Pancorbo, M. M. (2015) · Disease Markers · doi:10.1155/2015/746329 · Cited by 18 · see citing works

Mitochondrial catalase induces cells transformation through nucleolin-dependent Cox-2 mRNA stabilization

Liao, X., Huang, C., Zhang, D., Wang, J., Li, J., Jin, H., & Huang, C. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.10.387 · Cited by 16 · see citing works

Apolipoprotein E polymorphisms are associated with ischemic stroke susceptibility in a Northwest China Han population

Zhao, L.-L., Su, G., Chen, L., Yan, Q., Wang, X., Yuan, W., Wang, L., & Zhang, Z. (2017) · Bioscience Reports · doi:10.1042/bsr20171088 · Cited by 15 · see citing works

SORL1 Gene is Associated with the Conversion from Mild Cognitive Impairment to Alzheimer’s Disease

Piscopo, P., Tosto, G., Belli, C., Talarico, G., Galimberti, D., Gasparini, M., Canevelli, M., Poleggi, A., Crestini, A., Albani, D., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141551 · Cited by 14 · see citing works

Mitochondrial superoxide dismutase deficiency accelerates chronological aging in the fission yeast Schizosaccharomyces pombe

Ogata, T., Senoo, T., Kawano, S., & Ikeda, S. (2015) · Cell Biology International · doi:10.1002/cbin.10556 · Cited by 13 · see citing works

Increased Levels of Protein-methionine Sulfoxide in Plasma Correlate with a Shift from a Mild Cognitive Impairment to an Alzheimer's Disease Stage.

Deng, Y., Marsh, B. M., & Moskovitz, J. (2019) · PubMed · Cited by 5 · see citing works

The roles of microglia and astrocytes in myelin phagocytosis in the central nervous system

Xu, T., Liu, C., Deng, S., Gan, L., Zhang, Z., Yang, G., Tian, H., & Tang, Y. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221137762 · Cited by 106 · see citing works

The Potential Role of Polyphenols in Oxidative Stress and Inflammation Induced by Gut Microbiota in Alzheimer’s Disease

Shabbir, U., Tyagi, A., Elahi, F., Aloo, S. O., & Oh, D. (2021) · Antioxidants · doi:10.3390/antiox10091370 · Cited by 70 · see citing works

Neuroprotective Effects of Olive Oil: A Comprehensive Review of Antioxidant Properties

Gonçalves, M., Vale, N., & Silva, P. (2024) · Antioxidants · doi:10.3390/antiox13070762 · Cited by 55 · see citing works

Alzheimer's disease: The role of proteins in formation, mechanisms, and new therapeutic approaches

Gholami, A. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137532 · Cited by 51 · see citing works

Reverse engineering the Gut-Brain Axis and microbiome-metabolomics for symbiotic/pathogenic balance in neurodegenerative diseases

Munir, M. U., Ali, S. A., Chung, K. H. K., Käkinen, A., Javed, I., & Davis, T. P. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2422468 · Cited by 44 · see citing works

Gut Microbiota and Immune System Dynamics in Parkinson’s and Alzheimer’s Diseases

Kuštrimović, N. Z., Balkhi, S., Bilato, G., & Mortara, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212164 · Cited by 38 · see citing works

A Systematic Review of Body Fluids Biomarkers Associated With Early Neurological Deterioration Following Acute Ischemic Stroke

Ji, X., Tian, L., Yao, S., Han, F., Niu, S., & Qu, C. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.918473 · Cited by 35 · see citing works

Correlation between Alzheimer’s Disease and Gastrointestinal Tract Disorders

Kuźniar, J., Kozubek, P., Czaja, M., & Leszek, J. (2024) · Nutrients · doi:10.3390/nu16142366 · Cited by 24 · see citing works

Biometals in Alzheimer disease: emerging therapeutic and diagnostic potential of molybdenum and iodine

Botchway, B. O. A., Liu, X., Zhou, Y., & Fang, M. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04220-5 · Cited by 23 · see citing works

Pathways linking microbiota-gut-brain axis with neuroinflammatory mechanisms in Alzheimer’s pathophysiology

Hochuli, N., Kadyan, S., Park, G., Patoine, C., & Nagpal, R. (2023) · Microbiome Research Reports · doi:10.20517/mrr.2023.39 · Cited by 24 · see citing works

Apolipoprotein E is required for brain iron homeostasis in mice

Ma, J., Guo, Q., Shen, M., Li, W., Zhong, Q.-X., & Qian, Z. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102779 · Cited by 22 · see citing works

QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis

Liu, H., Huang, Z., Deng, B., Chang, Z., Yang, X., Guo, X., Yuan, F., Yang, Q., Wang, L., Zou, H., et al. (2023) · Aging and disease · doi:10.14336/ad.2022.0514 · Cited by 20 · see citing works

Extracellular Vesicles, Cell-Penetrating Peptides and miRNAs as Future Novel Therapeutic Interventions for Parkinson’s and Alzheimer’s Disease

Keighron, C. N., Avazzadeh, S., Goljanek‐Whysall, K., McDonagh, B., Howard, L., Ritter, T., & Quinlan, L. R. (2023) · Biomedicines · doi:10.3390/biomedicines11030728 · Cited by 21 · see citing works

Lipids, Gut Microbiota, and the Complex Relationship with Alzheimer’s Disease: A Narrative Review

Simão, D. O., Vieira, V. S., Tosatti, J. A. G., & Gomes, K. B. (2023) · Nutrients · doi:10.3390/nu15214661 · Cited by 17 · see citing works

NHANES 2011–2014 Reveals Decreased Cognitive Performance in U.S. Older Adults with Metabolic Syndrome Combinations

Díaz-Camargo, E. A., Hernández-Lalinde, J., Sánchez-Rubio, M., Chaparro-Suárez, Y. K., Álvarez-Caicedo, L. V., Fierro-Zarate, A., Donado, M. L. G., García-Pacheco, H., Rojas, J., & Bermúdez, V. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20075257 · Cited by 12 · see citing works

Lycium barbarum L.: a potential botanical drug for preventing and treating retinal cell apoptosis

Xiong, M., Peng, J., Zhou, S., Gao, Q., Lu, J., Chen, O., Song, H., & Peng, Q. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1571554 · Cited by 10 · see citing works

Nutrient-Response Pathways in Healthspan and Lifespan Regulation

Dabrowska, A. F., Kumar, J., & Rallis, C. (2022) · Cells · doi:10.3390/cells11091568 · Cited by 8 · see citing works

Deteriorated thiol-disulphide and oxidized-reduced glutathione status in blood in Alzheimer’s disease

Türel, C. A., & Alışık, M. (2024) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2024.110817 · Cited by 7 · see citing works

APOE4 triggers dysregulated synaptic vesicle release by disrupting SNARE complex assembly

Chen, F., Chen, Y., Feng, S., Chen, H., Deng, L., Ma, F., Ke, Q., Liang, Q., Ji, C. F., Peng, X., et al. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05787-6 · Cited by 7 · see citing works

Mitochondria and Neurodegenerative Diseases: A New Hotspot

Li, A., Cao, S., Jin, K., & Su, H. (2022) · Aging and Disease · doi:10.14336/ad.2022.1213 · Cited by 5 · see citing works

From brain waves to heartbeats: Exploring the combined role of electroencephalography and heart-rate variability in Alzheimer's disease diagnosis and management

Botchway, B. O. A., Kousiappa, I., Koupparis, A. M., Papacostas, S., Georgiades, S., Bashiardes, S., Hadjisavvas, A., Loucaides, G., Adamou, A., Christou, Y. P., et al. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261428636 · Cited by 5 · see citing works

Metabolites and MRI-derived markers of dementia risk in a Puerto Rican cohort

Gordon, S., Lee, J., Scott, T. M., Bhupathiraju, S. N., Ordovás, J. M., Kelly, R. S., Bhadelia, R. A., Koo, B., Bigornia, S., Tucker, K. L., et al. (2025) · Metabolomics · doi:10.1007/s11306-025-02240-4 · Cited by 4 · see citing works

Aducanumab binds high molecular weight soluble Aβ oligomers and restores intracellular calcium levels

Yu, L., Wang, X., Doan, T. H., Fan, Y., Bussière, T., Bacskai, B. J., & Kastanenka, K. V. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01812-9 · Cited by 3 · see citing works

Exploring the connections between Microbiome and Dementia: systematic review

Leite, A. M. T., & González‐Argote, J. (2023) · Salud Ciencia y Tecnología - Serie de Conferencias · doi:10.56294/sctconf2023336 · Cited by 3 · see citing works

Interweaving microglial senescence and gut microbiome dynamics in Alzheimer's disease – Mechanisms and therapeutic frontiers

Waghmare, A., Rahangdale, S. R., Khare, K., Taksande, B. G., Umekar, M. J., & Mangrulkar, S. V. (2026) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2026.104075 · Cited by 1 · see citing works

Lactobacillus mucosae Reduces Neuronal Oxidative Stress in Alzheimer’s Disease via the Regulation of CB2 Signaling

Kong, Y., Lv, X., Yang, Y., Li, Q., Dai, C., Lin, X., Liu, J., & Li, J. (2026) · Journal of Integrative Neuroscience · doi:10.31083/jin48598 · Cited by 1 · see citing works

A comprehensive study of oxidative stress‐related effects on the prognosis and drug therapy of cervical cancer

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(2023) · doi:10.46994/ets_36

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Marcharla, E., Surya Narayanan, S., Sundaram, T., Ganesan, R., & Ganesan, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29932-2.00005-0

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Chauhan, V. P. S., & Chauhan, A. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.004 · Cited by 341 · see citing works

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Das, T. K., & Ganesh, B. P. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2206504 · Cited by 101 · see citing works

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Circulating Oxidative Damage and Antioxidant Defense System Biomarkers in Early Stage Alzheimer’s Disease

Ramı́rez-Expósito, M. J., & Martı́nez-Martos, J. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407824-6.00042-2