Fractional anisotropy changes in Alzheimer’s disease depend on the underlying fiber tract architecture: a multiparametric DTI study using joint independent component analysis
Open accessAbstract
Diffusion tensor imaging (DTI) allows the simultaneous measurement of several diffusion indices that provide complementary information on the substrate of white matter alterations in neurodegenerative diseases. These indices include fractional anisotropy (FA) as measure of fiber tract integrity, and the mode of anisotropy (Mode) reflecting differences in the shape of the diffusion tensor. We used a multivariate approach based on joint independent component analysis of FA and Mode in a large sample of 138 subjects with Alzheimer's disease (AD) dementia, 37 subjects with cerebrospinal fluid biomarker positive mild cognitive impairment (MCI-AD), and 153 healthy elderly controls from the European DTI Study on Dementia to comprehensively study alterations of microstructural white matter integrity in AD dementia and predementia AD. We found a parallel decrease of FA and Mode in intracortically projecting fiber tracts, and a parallel increase of FA and Mode in the corticospinal tract in AD patients compared to controls. Subjects with MCI-AD showed a similar, but spatially more restricted pattern of diffusion changes. Our findings suggest an early axonal degeneration in intracortical projecting fiber tracts in dementia and predementia stages of AD. An increase of Mode, parallel to an increase of FA, in the corticospinal tract suggests a more linear shape of diffusion due to loss of crossing fibers along relatively preserved cortico-petal and cortico-fugal fiber tracts in AD. Supporting this interpretation, we found three populations of fiber tracts, namely cortico-petal and cortico-fugal, commissural, and intrahemispherically projecting fiber tracts, in the peak area of parallel FA and Mode increase.
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DTI alterations observed in the corticospinal tract in the current study cannot be unambiguously attributed to that tract and may be due to alterations in crossing fibres such as the superior longitudinal fasciculus or corpus callosum.
“DTI alterations such as those observed in the corticospinal tract in the current study should be interpreted with caution, as the current TBSS approach cannot be unambiguously attributed to that tract, but potentially are because of alterations in crossing fibres such as the superior longitudinal fasciculus or corpus callosum (Douaud et al., 2011; Teipel et al., 2014; Mito et al., 2018).”
From White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease (2018) · cites this paper as Teipel et al., 2014
Voxel-based analysis utilising DTI models does not adequately estimate orientationally-sensitive diffusivity measures such as axial and radial diffusivity (AD and RD).
“Therefore, apart from the limited area of white matter occupied by coherent fiber tracts, voxel-based analysis utilising DTI models does not adequately estimate orientationally-sensitive diffusivity measures, such as axial and radial diffusivity (AD and RD) [12, 13].”
From Differentiating axonal loss and demyelination in chronic MS lesions: A novel approach using single streamline diffusivity analysis (2021) · cites this paper as [12]
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Distinct Types of White Matter Changes Are Observed after Anterior Temporal Lobectomy in Epilepsy
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Analysis of longitudinal diffusion-weighted images in healthy and pathological aging: An ADNI study
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Investigating Tissue-Specific Abnormalities in Alzheimer’s Disease with Multi-Shell Diffusion MRI
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Correction for Eddy Current-Induced Echo-Shifting Effect in Partial-Fourier Diffusion Tensor Imaging
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Fractals in the Neurosciences: A Translational Geographical Approach
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- Authors
- Teipel, S. J., the EDSD study group, Grothe, M. J., Filippi, M., Fellgiebel, A., Dyrba, M., Frisoni, G. B., Meindl, T., Bokde, A. L. W., Hampel, H., Klöppel, S., & Hauenstein, K.
- Affiliations
- German Center for Neurodegenerative Diseases (DE)
- University of Rostock (DE)
- Vita-Salute San Raffaele University (IT)
- University of Geneva (CH)
- Trinity College Dublin (IE)
- Goethe University Frankfurt (DE)
- University Medical Center Freiburg (DE)
- ORCID
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2014-06-04
- Volume
- 41
- Issue
- 1
- Pages
- 69-83
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1527867630
- Cited by
- 82
- References
- 50
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 10 · 2018: 10 · 2017: 8 · 2016: 6 · 2015: 8 · 2014: 6
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- DZNE Pub (submittedVersion)
- Funders
- Japan International Cooperation Agency
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, fractional anisotropy
- MeSH terms
- Aged, Alzheimer Disease, Axons, Brain, Europe, Female, Humans, Image Processing, Computer-Assisted, Male, Nerve Degeneration, Nerve Fibers, Myelinated, Pyramidal Tracts, Anisotropy, Disease Progression, Diffusion Magnetic Resonance Imaging, Early Diagnosis, Diffusion Tensor Imaging, Cognitive Dysfunction, White Matter
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