Gray and white matter changes in Alzheimer's disease: a diffusion tensor imaging study
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Purpose: To investigate microstructural changes in cortical and white matter pathways in patients with Alzheimer's disease using diffusion tensor imaging (DTI). Materials and Methods: Measures of mean diffusivity (MD) and fractional anisotropy (FA) were compared in the brains of 13 Alzheimer's disease (AD) patients and a group of 13 aged‐matched control participants employing an optimized DTI technique involving a fully automated, voxel‐based morphometric (VBM) analysis. Results: After rigorous control for anatomical variation and confounding partial volume effects, we found significantly elevated MD measures within the hippocampus, amygdala, and medial temporal, parietal, and frontal lobe gray matter regions in the AD participants. The largest number of pixels with increased MD was localized bilaterally, within the posterior cingulate gyrus. The FA was significantly reduced within the thalamus, parietal white matter, and posterior limbs of the internal capsule, indicating significant involvement of corticothalamic and thalamocortical radiations. Conclusion: This study demonstrates that rigorous VBM analysis of DTI data can be used to investigate microstructural changes in cortical, subcortical, and white matter regions in AD. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc.
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Rose et al. (2008) proposed excluding all voxels exceeding a certain threshold of mean diffusivity of 1300 × 10−6 mm2/s.
“First, Rose et al. (2008) proposed to exclude all voxels exceeding a certain threshold of MD (1300 × 10− 6 mm2/s).”
From Mean diffusivity in cortical gray matter in Alzheimer's disease: The importance of partial volume correction (2018) · cites this paper as Rose et al. (2008)
Data Processing and Analysis states that pixels with MD greater than 1300 × 10−6 mm²/s were removed, supporting the threshold and exclusion method. The exclusion applied to the gray-matter mask, however, not to all voxels generally; the white-matter mask was thresholded using FA instead. (LLM, conf=0.85)
Experimental — accuracy not yet measuredLeft and right hippocampi and the posterior cingulate cortex were chosen as regions of interest following the literature on peak differences in regional mean diffusivity and volumes in Alzheimer's disease.
“Left and right hippocampi as well as the posterior cingulate cortex (PCC) were chosen as regions of interest following the literature on peak differences in regional MD and volumes in AD (Cherubini et al., 2010, Eustache et al., 2016, Rose et al., 2008).”
From Mean diffusivity in cortical gray matter in Alzheimer's disease: The importance of partial volume correction (2018) · cites this paper as Rose et al., 2008
The Results and Discussion (page not provided) report elevated mean diffusivity in the posterior cingulate in AD, with the largest number of affected voxels there. The paper also discusses elevated hippocampal diffusivity, including reports involving both hippocampi, but it does not report regional volume differences in these regions; it only notes earlier findings of reduced gray-matter density. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe MD measurements in grey matter regions are in good agreement with previous studies that have detected elevated values in the brains of AD patients and in mouse models exhibiting amyloid pathology at late stages of progression.
“The MD measurements in grey matter regions are in good agreement with previous studies that have detected elevated values in the brains of AD patients (Fellgiebel et al., 2004, Kantarci et al., 2001, Rose et al., 2008) and in mouse models exhibiting amyloid pathology at late stages of progression (Sun et al., 2005).”
From In vivo imaging of tau pathology using multi-parametric quantitative MRI (2015) · cites this paper as Rose et al., 2008
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- Authors
- Rose, S. E., Janke PhD, A. L., & Chalk, J. B.
- Affiliations
- The University of Queensland (AU)
- Corresponding author
- Rose, Stephen E.
- ORCID
- Rose, Stephen E.
- Venue
- Journal of Magnetic Resonance Imaging
- Publisher
- Wiley
- Published
- 2007-11-29
- Volume
- 27
- Issue
- 1
- Pages
- 20-26
- ISSN
- 1053-1807 (ISSN-L)
- 1522-2586
- OpenAlex
- W2019624613
- Cited by
- 178
- References
- 4
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 10 · 2021: 10 · 2020: 5 · 2019: 9 · 2018: 4 · 2017: 11 · 2016: 9 · 2015: 13 · 2014: 8 · 2013: 9 · 2012: 13
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Magnetic Resonance Imaging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, white matter microstructure, gray matter changes, mean diffusivity, fractional anisotropy, posterior cingulate cortex, hippocampus, amygdala, thalamus, internal capsule, corticothalamic pathway, thalamocortical circuits, voxel-based morphometry
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Female, Humans, Image Processing, Computer-Assisted, Male, Neuropsychological Tests, Case-Control Studies, Anisotropy, Diffusion Magnetic Resonance Imaging
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