Diffusion tensor imaging and tract-based spatial statistics in Alzheimer's disease and mild cognitive impairment
Abstract
We aimed to explore the changes in fractional anisotropy (FA) in subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD) by analyzing diffusion tensor imaging (DTI) data using the Tract-Based Spatial Statistics (TBSS). DTI data were collected from 17 AD patients, 27 MCI subjects and 19 healthy controls. Voxel-based analysis with TBSS was used to compare FA among the three groups. Additionally, guided by TBSS findings, a region of interest (ROI)-based analysis along the TBSS skeleton was performed on group-level and the accuracy of the method was assessed by the back-projection of ROIs to the native space FA. Neurofiber tracts with decreased FA included: the parahippocampal white matter, cingulum, uncinate fasciculus, inferior and superior longitudinal fasciculus, corpus callosum, fornix, tracts in brain stem, and cerebellar tracts. Quantitative ROI-analysis further demonstrated the significant decrease on FA values in AD patients relative to controls whereas FA values of MCI patients were found in between the controls and AD patients. We conclude that TBSS is a promising method in examining the degeneration of neurofiber tracts in MCI and AD patients.
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The Benjamini-Hochberg procedure was applied to control the false discovery rate at 0.1.
“To control false discovery rate, Benjamini-Hochberg procedure was applied with a false discovery rate of 0.1 35, 36”
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- Authors
- Liu, Y., Spulber, G., Lehtimäki, K. K., Könönen, M., Hallikainen, I., Gröhn, H., Kivipelto, M., Hallikainen, M., Vanninen, R., & Soininen, H.
- Affiliations
- University of Eastern Finland (FI)
- Kuopio University Hospital (FI)
- Corresponding author
- Soininen, Hilkka
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 32
- Issue
- 9
- Pages
- 1558-1571
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2035351162
- Cited by
- 236
- References
- 4
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 7 · 2023: 8 · 2022: 2 · 2021: 13 · 2020: 13 · 2019: 18 · 2018: 11 · 2017: 9 · 2016: 16 · 2015: 24 · 2014: 20 · 2013: 28 · 2012: 22
- FWCI
- 12.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, mild cognitive impairment, fractional anisotropy, white matter degeneration, diffusion tensor imaging, tract-based spatial statistics, white matter tracts, cingulum, uncinate fasciculus, longitudinal fasciculus, corpus callosum, fornix
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Male, Severity of Illness Index, Diffusion Tensor Imaging, Cognitive Dysfunction
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