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Cited by 140Dementia and Cognitive Impairment ResearchAdvanced Neuroimaging Techniques and ApplicationsCancer-related cognitive impairment studies

Diagnostic utility of hippocampal size and mean diffusivity in amnestic MCI.

Müller, Matthias J., Greverus, Dirk, Weibrich, Carsten, Dellani, Paulo Roberto, Scheurich, Armin, Stoeter, Peter, Fellgiebel, Andreas·2007·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2006.01.009
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Abstract

Hippocampus atrophy is a frequent finding in mild cognitive impairment (MCI), whereas diffusion-tensor-imaging (DTI) has demonstrated its value to detect subtle brain tissue changes in several neuropsychiatric diseases including MCI. To compare the diagnostic accuracy of both methods, high resolution MRI scans for hippocampus volumetry, and co-registered DTI-scans for ROI-based mean diffusivity (MD) and fractional anisotropy (FA) were carried out in 18 patients with amnestic MCI (7 females, age 67.3+/-8.7 years, MMSE 25.2+/-2.2) and 18 controls (age 66.9+/-9.0 years, MMSE 28.7+/-1.0). Diagnostic properties of normalized hippocampus volume (HV) and DTI measures with regard to MCI status were estimated by receiver operating characteristics (ROC) analyses and logistic regression. Parameters of the left hippocampus showed superior predictive power when compared to the right. At a specificity set to 80%, left HV had low sensitivity (50%); left hippocampal MD values revealed superior sensitivity (89%), similar to left hippocampal FA (78%). The results demonstrate higher sensitivity of DTI-derived left hippocampal parameters than volume measures in detecting subtle hippocampal abnormalities related to MCI.

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Crossref · 10.1016/j.neurobiolaging.2006.01.009

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  • Reduced FA and increased MD in the hippocampus were reported in many human studies, probably attributed to increased extracellular space volume and neurodegeneration.

    “Reduced FA and increased MD in hippocampus were reported in many of these human studies, probably attributed to increased extracellular space volume and neurodegeneration (Muller et al., 2007; Cherubini et al., 2010; Hong et al., 2013; Nowrangi et al., 2013).”

    From Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging (2022) · cites this paper as Muller et al., 2007

  • In some studies, hippocampal diffusivity demonstrated higher diagnostic and prognostic accuracy than hippocampal volume.

    “In some studies, hippocampal diffusivity even demonstrated a higher diagnostic and prognostic accuracy than hippocampal volume (Fellgiebel et al., 2006, Kantarci et al., 2005, Müller et al., 2007).”

    From Mean diffusivity in cortical gray matter in Alzheimer's disease: The importance of partial volume correction (2018) · cites this paper as Müller et al., 2007

  • The MCI subjects of the sample were not uniquely amnestic MCI, making the sample more heterogeneous than MCI subgroups in other studies.

    “As a limitation, the MCI subjects of our sample were not uniquely amnestic MCI. Thus, our sample is more heterogeneous than the MCI subgroups in other studies”

    From Mean diffusivity in cortical gray matter in Alzheimer's disease: The importance of partial volume correction (2018) · cites this paper as Müller et al., 2007

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Authors
Müller, M. J., Greverus, D., Weibrich, C., Dellani, P. R., Scheurich, A., Stoeter, P., & Fellgiebel, A.
Affiliations
Johannes Gutenberg University Mainz (DE)
Corresponding author
Müller, Matthias J.
ORCID
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2007-03
Volume
28
Issue
3
Pages
398-403
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/j.neurobiolaging.2006.01.009
OpenAlex
W2061771692
Cited by
140
References
28
Citations by year
2026: 2 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 1 · 2020: 8 · 2019: 3 · 2018: 5 · 2017: 8 · 2016: 7 · 2015: 14 · 2014: 7 · 2013: 12 · 2012: 14
FWCI
4.88
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
Keywords
amnestic mild cognitive impairment, hippocampal atrophy, hippocampal volume, mean diffusivity, fractional anisotropy, diffusion tensor imaging, hippocampal volumetry, diagnostic accuracy, left hippocampus, hippocampal asymmetry
MeSH terms
Aged, Amnesia, Analysis of Variance, Cognition Disorders, Female, Hippocampus, Humans, Functional Laterality, Male, Middle Aged, ROC Curve, Reproducibility of Results, Logistic Models, Case-Control Studies, Diffusion Magnetic Resonance Imaging

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