Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

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Items 801–900 of 1,001

1. Association of cigarette smoking with cognitive impairment in male patients with chronic schizophrenia
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4. Subcommissural Organ-Spondin-Derived Peptide Restores Memory in a Mouse Model of Alzheimer’s Disease
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5. Antiaging activity of polyphenol rich Calophyllum inophyllum L. fruit extract in Saccharomyces cerevisiae BY611 yeast cells
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6. Comprehensive investigations for a potential natural prophylaxis—A cellular and murine model for apple cider vinegar against hydrogen peroxide and scopolamine induced oxidative stress
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7. A combinatorial approach to screen structurally diverse acetylcholinesterase inhibitory plant secondary metabolites targeting Alzheimer’s disease
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8. Simultaneous Determination of Seven Lipophilic and Hydrophilic Components in Salvia miltiorrhiza Bunge by LC-MS/MS Method and Its Application to a Transport Study in a Blood-Brain-Barrier Cell Model
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9. [18F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer’s disease pathology in APP/PS1 mice
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10. The Rat Brain Transcriptome: From Infancy to Aging and Sporadic Alzheimer’s Disease-like Pathology
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11. A Novel Polysaccharide DSPP-1 from Durian Seed: Structure Characterization and Its Protective Effects Against Alzheimer’s Disease in a Transgenic Caenorhabditis elegans Model
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12. Evidence That Increasing Serum 25(OH)D Concentrations to 30 ng/mL in the Kingdom of Saudi Arabia and the United Arab Emirates Could Greatly Improve Health Outcomes
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13. Role of TPEN in Amyloid-β25–35-Induced Neuronal Damage Correlating with Recovery of Intracellular Zn2+ and Intracellular Ca2+ Overloading
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14. Exploring the significance of lipids in Alzheimer's disease and the potential of extracellular vesicles
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15. The structurally diverse phytocannabinoids cannabichromene, cannabigerol and cannabinol significantly inhibit amyloid β‐evoked neurotoxicity and changes in cell morphology in PC12 cells
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16. Extract of Cynomorium songaricum ameliorates mitochondrial ultrastructure impairments and dysfunction in two different in vitro models of Alzheimer’s disease
    Dan Cheng, Lei Su, Xu Wang, Xinjie Li, Lingling Li, Mengyuan Hu, Yi Lu · 2021 · BMC Complementary Medicine and Therapies
17. SQSTM1/p62 Post-Translational Modifications and Reverse Processes Modulate Disease Pathogenesis via KEAP1-NRF2 Signaling and Selective Autophagy
    Dong‐Rong Zhu, Yue Li, Lirong Zhao, Duxiang Pei, Yutong Guo, Liren Liu · 2025 · Antioxidants and Redox Signaling
18. Nacre extract from pearl oyster attenuates amyloid beta-induced memory impairment
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19. Single-neuron whole genome sequencing identifies increased somatic mutation burden in Alzheimer's disease related genes
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20. An Investigation into the Effects of Water- and Fat-Soluble Vitamins in Alzheimer's and Parkinson's Diseases
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21. A Standardized Extract of Microalgae Phaeodactylum tricornutum (Mi136) Inhibit D-Gal Induced Cognitive Dysfunction in Mice
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22. Brain Mitochondria as a Therapeutic Target for Carnosic Acid
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23. Another Use for a Proven Drug: Experimental Evidence for the Potential of Artemisinin and Its Derivatives to Treat Alzheimer’s Disease
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24. A novel neuroprotective peptide YVYAETY identified and screened from Flammulina velutipes protein hydrolysates attenuates scopolamine-induced cognitive impairment in mice
    Yutong Dong, Qiuhui Hu, Liyan Zhao, Gaoxing Ma, Ning Ma, Junmiao Zhang, Yang Ji, Li Liu · 2024 · Food & Function
25. Mitochondrial alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks
    Fanny Eysert, Paula Fernanda Kinoshita, Julien Lagarde, Sandra Lacas‐Gervais, Laura Xicota, Guillaume Dorothée, Michel Bottlaender, Frédéric Checler, Marie‐Claude Potier, Marie Sarazin et al. · 2024 · Acta Neuropathologica Communications
26. Exposure to coal dust exacerbates cognitive impairment by activating the IL6/ERK1/2/SP1 signaling pathway
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27. A comprehensive update on cannabidiol, its formulations and drug delivery systems
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28. Electroacupuncture activates AMPKα1 to improve learning and memory in the APP/PS1 mouse model of early Alzheimer’s disease by regulating hippocampal mitochondrial dynamics
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29. Exploring Cimetidine as a Potential Therapeutic Attenuator against Amyloid Formation in Parkinson’s Disease: Spectroscopic and Microscopic Insights into Alpha-Synuclein and Human Insulin
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30. Associations of Spatial Disparities of Alzheimer’s Disease Mortality Rates with Soil Selenium and Sulfur Concentrations and Four Common Risk Factors in the United States
    Hongbing Sun · 2017 · Journal of Alzheimer s Disease
31. A multistationary loop model of ALS unveils critical molecular interactions involving mitochondria and glucose metabolism
    Bruno Burlando, Marco Milanese, Giulia Giordano, Tiziana Bonifacino, Silvia Ravera, Franco Blanchini, Giambattista Bonanno · 2020 · PLoS ONE
32. The Role of Equilibrium between Free Radicals and Antioxidants in Depression and Bipolar Disorder
    Anastasia Kotzaeroglou, Ioannis Tsamesidis · 2022 · Medicines
33. Traversing through the cell signaling pathways of neuroprotection by betanin: therapeutic relevance to Alzheimer’s Disease and Parkinson’s Disease
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34. Exploring the potential of mindfulness-based therapy in the prevention and treatment of neurodegenerative diseases based on molecular mechanism studies
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35. Serum ischaemia‐modified albumin might be a potential biomarker for oxidative stress in amnestic mild cognitive impairment
    Lei Du, Jianhua Ma, Dan He, Xiaoning Zhang · 2018 · Psychogeriatrics
36. Timing Matters: Circadian Effects on Energy Homeostasis and Alzheimer’s Disease
    Aline Loehfelm, Alisa Boucsein, Dominik Pretz, Alexander Tups · 2018 · Trends in Endocrinology and Metabolism
37. Inhibitory effects of curcumin on H2O2-induced cell damage and APP expression and processing in SH-SY5Y cells transfected with APP gene with Swedish mutation
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38. Luteolin Protects Pheochromocytoma (PC‐12) Cells against Aβ25-35‐Induced Cell Apoptosis through the ER/ERK/MAPK Signalling Pathway
    Han-Rui Wang, Siying Pei, Dongxu Fan, Yan‐Hui Liu, Xiaofeng Pan, Fan‐Xu Song, Shuhua Deng, Hongbin Qiu, Ning Zhang · 2020 · Evidence-based Complementary and Alternative Medicine
39. Isoliquiritigenin attenuated cognitive impairment, cerebral tau phosphorylation and oxidative stress in a streptozotocin-induced mouse model of Alzheimer's disease
    Zhi Tang, Ting Sha, Yuanshang Wang, Yan Chun Xiao, Yuanting Ding, Ruiqing Ni, Xiaolan Qi · 2025 · Life Sciences
40. Impairment of Tricarboxylic Acid Cycle (TCA) Cycle in Alzheimer's Disease: Mechanisms, Implications, and Potential Therapies
    Gudimetla Susmitha Mohan, Rahul Kumar · 2025 · Aging and Disease
41. Tortoise Plastron and Deer Antler Gelatin Prevents Against Neuronal Mitochondrial Dysfunction In Vitro: Implication for a Potential Therapy of Alzheimer’s Disease
    Dan Cheng, Xinjing Yang, Lu Zhang, Zongshi Qin, Wenqi Li, Hai-Chun Xu, Zhang‐Jin Zhang · 2021 · Frontiers in Pharmacology
42. Novel Lawsone–Quinoxaline Hybrids as New Dual Binding Site Acetylcholinesterase Inhibitors
    Paptawan Suwanhom, Teerapat Nualnoi, Pasarat Khongkow, Varomyalin Tipmanee, Luelak Lomlim · 2023 · ACS Omega
43. Network pharmacology and in vivo studies reveal the neuroprotective effects of paeoniflorin on Alzheimer's disease
    Mengyuan Zhang, Haoran Zheng, Jiale He, Mei Zhang · 2023 · Heliyon
44. Oligosaccharides from black ginseng innovatively prepared by low‐temperature steam‐heating process ameliorate cognitive impairment in Alzheimer's disease mice via the Keap‐1/Nrf2 pathway
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45. Oral Administration of Euonymus alatus Leaf Extract Ameliorates Alzheimer’s Disease Phenotypes in 5xFAD Transgenic Mice
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46. Multitarget action of Benzothiazole-piperazine small hybrid molecule against Alzheimer's disease: In silico, In vitro, and In vivo investigation
    Chandra Bhushan Mishra, Shruti Shalini, Siddharth Gusain, Pawan Kumar, Shikha Kumari, Yong-Sung Choi, Jyoti Kumari, Balakrishna Moku, Anita Kumari Yadav, Amresh Prakash et al. · 2024 · Biomedicine & Pharmacotherapy
47. Dendrimers—Novel Therapeutic Approaches for Alzheimer’s Disease
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48. Safflower yellow alleviates cognitive impairment in mice by modulating cholinergic system function, oxidative stress, and CREB/BDNF/TrkB signaling pathway
    Yanqiang Qi, Yanyou Wang, Mingyue Ni, Yingxi He, Le Li, Yanli Hu · 2024 · Journal of Ethnopharmacology
49. Mitochondria-targeting by small molecules against Alzheimer's disease: A mechanistic perspective
    Chinmay Pal · 2024 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
50. Advancements in nose-to-brain drug targeting for Alzheimer’s disease: a review of nanocarriers and clinical insights
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51. Human serum albumin-3-amino-1-propanesulfonic acid conjugate inhibits amyloid-β aggregation and mitigates cognitive decline in Alzheimer's disease
    Divya Shastri, Chaitany Jayprakash Raorane, Vinit Raj, Sang-Kil Lee · 2025 · Journal of Controlled Release
52. Oxidative Stress in Elderly with Different Cognitive Status: My Mind Project
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53. High KEAP1, NRF2 and low HO-1 Serum Levels in Children with Autism
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54. Sigma ligands as potent inhibitors of Aβ and AβOs in neurons and promising therapeutic agents of Alzheimer's disease
    Wenhui Ma, Ai-Fang Chen, Xiaoyang Xie, Yun‐Sheng Huang · 2020 · Neuropharmacology
55. A review of antioxidant and anti-acetylcholinesterase activities of Centella asiatica (L.) Urb. for the treatment of Alzheimer’s disease
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56. Cholinergic drugs bind at the minor groove and reverse induced oxidative stress of calf thymus DNA: a new perspective towards an unexplored therapeutic efficacy
    Prayasee Baruah, Pynskhemborlang T. Phanrang, Ibemhanbi Konthoujam, Kripamoy Aguan, Sivaprasad Mitra · 2021 · New Journal of Chemistry
57. Effect of APOE ε4 allele on levels of apolipoproteins E, J, and D, and redox signature in circulating extracellular vesicles from cognitively impaired with no dementia participants converted to Alzheimer's disease
    Mohamed Raâfet Ben Khedher, Mohamed Haddad, Danielle Laurin, Charles Ramassamy · 2021 · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
58. Phytochemical investigations, antioxidant, cytotoxic, antidiabetic and antibiofilm activities of Kalanchoe laxiflora flowers
    Ezzat E.A. Osman, Asmaa Shams El Dein Mohamed, Ahmed Elkhateeb, Gobouri Adil, Marwa M. Abdel‐Aziz, El-Sayed Saleh Abdel-Hameed · 2021 · European Journal of Integrative Medicine
59. Protective effects of Vinca herbaceous extract against scopolamine-induced behavioral disturbances and brain oxidative stress in rats
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60. Deletion of Wnt10a Is Implicated in Hippocampal Neurodegeneration in Mice
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61. Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction
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62. Targeting Novel microRNAs in Developing Novel Alzheimer's Disease Treatments
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63. MicroRNA-668-3p regulates oxidative stress and cell damage induced by Aβ1-42 by targeting the OXR1/p53-p21 axis
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64. Structurally Altered, Not Wild-Type, Pentameric C-Reactive Protein Inhibits Formation of Amyloid-β Fibrils
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65. Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer's disease
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66. Muscular Swedish mutant APP-to-Brain axis in the development of Alzheimer’s disease
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67. Unexpected Classes of Aquaporin Channels Detected by Transcriptomic Analysis in Human Brain Are Associated with Both Patient Age and Alzheimer’s Disease Status
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68. Rewiring of neuronal networks during synaptic silencing
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69. A Synthetic Pro-Drug Peptide Reverses Amyloid-β-Induced Toxicity in the Rat Model of Alzheimer’s Disease
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70. Cerebrospinal fluid oxidative stress markers in Alzheimer's disease
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71. The potential role of nanoyttria in alleviating oxidative stress biomarkers: Implications for Alzheimer's disease therapy
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72. Upregulation of Prickle2 Ameliorates Alzheimer’s Disease-Like Pathology in a Transgenic Mouse Model of Alzheimer’s Disease
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73. Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression
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74. Early detection of redox imbalance in the APPswe/PS1dE9 mouse model of Alzheimer’s disease by in vivo electron paramagnetic resonance imaging
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75. Sulforaphane inhibits the production of Aβ partially through the activation of Nrf2-regulated oxidative stress
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76. Astrocyte Circadian Timekeeping in Brain Health and Neurodegeneration
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77. Rutin ameliorates scopolamine-induced learning and memory impairments through enhancement of antioxidant defense system and cholinergic signaling
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78. Beyond the classical amyloid hypothesis in Alzheimer's disease: Molecular insights into current concepts of pathogenesis, therapeutic targets, and study models
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79. Systemic Metabolism and Mitochondria in the Mechanism of Alzheimer’s Disease: Finding Potential Therapeutic Targets
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80. Deciphering the links between psychological stress, depression, and neurocognitive decline in patients with Down syndrome
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81. Action of the Purinergic and Cholinergic Anti-inflammatory Pathways on Oxidative Stress in Patients with Alzheimer’s Disease in the Context of the COVID-19 Pandemic
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82. Hippocampal metabolic subregions and networks: Behavioral, molecular, and pathological aging profiles
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83. Protocol Report on the Transcranial Photobiomodulation for Alzheimer’s Disease (TRAP-AD) Study
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84. Identification of Uncaria rhynchophylla in the Potential Treatment of Alzheimer’s Disease by Integrating Virtual Screening and In Vitro Validation
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85. Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF retrograde transport and neurodegeneration via p75NTR
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86. Amyloid‑β guided responsive theranostic fluorescent probe for imaging of endogenous hydrogen peroxide in Alzheimer disease
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87. Analytical Methods and Effects of Bioactive Peptides Derived from Animal Products: A Mini-Review
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88. Effects of Cycloastragenol on Alzheimer's Disease in Rats by Reducing Oxidative Stress, Inflammation, and Apoptosis
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89. The relation of synaptic biomarkers with Aβ, tau, glial activation, and neurodegeneration in Alzheimer’s disease
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90. The neuroprotective role of celastrol on hippocampus in diabetic rats by inflammation restraint, insulin signaling adjustment, Aβ reduction and synaptic plasticity alternation
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91. Neuroprotective Effect of Codonopsis pilosula Polysaccharide on Aβ25-35-Induced Damage in PC12 Cells via the p38MAPK Signaling Pathways
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92. Role of organometallic complexes in targeted therapies of different diseases: Infectious diseases, Cancer and Neurodegenerative Diseases
    N. V, T. Anand, Chandra Kant Singh, K. K. Sodhi · 2024 · Journal of Organometallic Chemistry
93. Mitochondria-targeting Cu2-xSe-TPP with dual enzyme activity alleviates Alzheimer's disease by modulating oxidative stress
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94. Defining Alzheimer’s Disease through Proteomic CSF Profiling
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95. An endophenotype network strategy uncovers YangXue QingNao Wan suppresses Aβ deposition, improves mitochondrial dysfunction and glucose metabolism
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96. Mitochondrial Network Branching Enables Rapid Protein Spread with Slower Mitochondrial Dynamics
    Prabha Chuphal, Jordan D. Lanctôt, Sean P. Cornelius, Aidan I. Brown · 2024 · PRX Life
97. Cellular Uptake of Tau Aggregates Triggers Disulfide Bond Formation in Four-Repeat Tau Monomers
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98. Sodium Thiosulfate: An Innovative Multi-Target Repurposed Treatment Strategy for Late-Onset Alzheimer’s Disease
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99. Nanotechnology in Parkinson’s Disease: overcoming drug delivery challenges and enhancing therapeutic outcomes
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100. Xanthine Oxidoreductase: A Double-Edged Sword in Neurological Diseases
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