Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855

Oxyl radicals, redox-sensitive signalling cascades and antioxidants

Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

Ray, P. D., Huang, B.-W., & Tsuji, Y. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.008 · Cited by 4,373

Oxidative mechanisms in the toxicity of metal ions

Stohs, S. J., & Bagchi, D. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00159-h · Cited by 4,219

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126

LTP and LTD

Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968

Clinical and biomarker changes in dominantly inherited Alzheimer's disease

Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814

Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway

Kensler, T. W., Wakabayashi, N., & Biswal, S. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141046 · Cited by 3,630

The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease

Naik, R. A., Mir, M. N., Malik, I. A., Bhardwaj, R., Alshabrmi, F. M., Mahmoud, M. A., Alhomrani, M., Alamri, A. S., Alsanie, W. F., Hjazi, A. M., et al. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl25551 · Cited by 29

Pathogenic synergy: dysfunctional mitochondria and neuroinflammation in neurodegenerative diseases associated with aging

Mani, S., Wasnik, S., Shandilya, C., Srivastava, V., Khan, S., & Singh, K. K. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1615764 · Cited by 33

Energy, Entropy and Quantum Tunneling of Protons and Electrons in Brain Mitochondria: Relation to Mitochondrial Impairment in Aging-Related Human Brain Diseases and Therapeutic Measures

Bennett, J. P., & Onyango, I. G. (2021) · Biomedicines · doi:10.3390/biomedicines9020225 · Cited by 32

A network pharmacology-based study on key pharmacological pathways and targets of Qi Fu Yin acting on Alzheimer's disease

Xiao, Q., Ye, T., Wang, X., Han, L., Wang, T.-X., Qi, D., Cheng, X., & Wang, S. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111336 · Cited by 28

A Review of Pharmacology, Toxicity and Pharmacokinetics of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside

Wang, C., Dai, S., Gong, L., Fu, K., Ma, C., Liu, Y., Zhou, H., & Li, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.791214 · Cited by 28

Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling

Hu, W., Wang, Z., Zhang, H., Mahaman, Y. A. R., Huang, F., Meng, D., Zhou, Y., Wang, S., Jiang, N., Xiong, J., et al. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01204-z · Cited by 28

The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity

Ring, J., Tadić, J., Ristic, S., Poglitsch, M., Bergmann, M., Radic, N., Mossmann, D., Liang, Y., Maglione, M., Jerkovic, A., et al. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202113952 · Cited by 27

Vascular and Nonvascular Mechanisms of Cognitive Impairment and Dementia

Kara, B., Gordon, M. N., Gifani, M., Dorrance, A. M., & Counts, S. (2022) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2022.07.006 · Cited by 29

Females exhibit higher GluA2 levels and outperform males in active place avoidance despite increased amyloid plaques in TgF344-Alzheimer's rats

Chaudry, O., Ndukwe, K., Xie, L., Figueiredo-Pereira, M., Serrano, P., & Rockwell, P. (2022) · Scientific Reports · doi:10.1038/s41598-022-23801-w · Cited by 28

Enhancing the stability, BBB permeability and neuroprotective activity of verbascoside in vitro using lipid nanocapsules in combination with menthol

Wu, L., Huang, W., Peng, K., Wang, Y., Chen, Q., & Lu, B. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.135682 · Cited by 28

An updated patent review of Nrf2 activators (2020-present)

Zhao, Z., Dong, R., Cui, K., You, Q., & Jiang, Z. (2023) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2023.2178299 · Cited by 28

Platycodin D stimulates AMPK activity to inhibit the neurodegeneration caused by reactive oxygen species-induced inflammation and apoptosis

Zhang, J.-T., Xie, L.-Y., Shen, Q. “., Liu, W., Li, M., Hu, R., Hu, J., Wang, Z., Chen, C., & Li, W. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116294 · Cited by 29

Mitochondrial mechanisms in Alzheimer’s disease: Quest for therapeutics

Kalani, K., Chaturvedi, P., Chaturvedi, P., Verma, V. K., Lal, N., Awasthi, S. K., & Kalani, A. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103547 · Cited by 28

Therapeutic Candidates for Alzheimer’s Disease: Saponins

Zhang, R., Zeng, M., Zhang, X., Zheng, Y., Lv, N., Wang, L., Gan, J., Li, Y., Jiang, X., & Yang, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310505 · Cited by 32

A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer’s disease

Boeddrich, A., Haenig, C., Neuendorf, N., Blanc, E., Ivanov, A., Kirchner, M., Schleumann, P., Bayraktaroğlu, I., Richter, M., Molenda, C., et al. (2023) · Genome Medicine · doi:10.1186/s13073-023-01206-2 · Cited by 30

Mitochondrial dysfunction and Alzheimer's disease: prospects for therapeutic intervention

Lim, J. W., Lee, J., & Pae, A. N. (2020) · BMB Reports · doi:10.5483/bmbrep.2020.53.1.279 · Cited by 28

Mapping Post-Translational Modifications in Brain Regions in Alzheimer's Disease Using Proteomics Data Mining

Deolankar, S. C., Patil, A. H., Balaya, R. D. A., Subba, P., Mahadevan, A., & Prasad, T. S. K. (2021) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2021.0054 · Cited by 27

Advancing Alzheimer’s Therapeutics: Exploring the Impact of Physical Exercise in Animal Models and Patients

Andrade-Guerrero, J., Rodríguez-Arellano, P., Barron-Leon, N., Orta‐Salazar, E., Ledesma-Alonso, C., Díaz-Cintra, S. Y., & Soto-Rojas, L. O. (2023) · Cells · doi:10.3390/cells12212531 · Cited by 28

Metformin Use and Risk of Delirium in Older Adults With Type 2 Diabetes

Sun, M., Wang, X., Lu, Z., Yang, Y., Lv, S., Miao, M., Chen, W., Wu, S., & Zhang, J. (2024) · Diabetes Care · doi:10.2337/dc24-1414 · Cited by 27

Alzheimer’s Disease Etiology Hypotheses and Therapeutic Strategies: A Perspective

Scarano, N., Musumeci, F., Casini, B., Brullo, C., D’Ursi, P., Fossa, P., Schenone, S., & Cichero, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146980 · Cited by 32

Multitarget-Directed Ligands for Alzheimer’s Disease: Recent Novel MTDLs and Mechanistic Insights

Almaghrabi, M. (2025) · Pharmaceuticals · doi:10.3390/ph18111685 · Cited by 33

Usnic acid enantiomers restore cognitive deficits and neurochemical alterations induced by Aβ1–42 in mice

Cazarin, C. A., Dalmagro, A. P., Gonçalves, A. E., Boeing, T., da Silva, L. M., Corrêa, R., Klein‐Júnior, L. C., Pinto, B. C., Lorenzett, T. S., Sobrinho, T. U. D. C., et al. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112945 · Cited by 28

Roflumilast, a cAMP-Specific Phosphodiesterase-4 Inhibitor, Reduces Oxidative Stress and Improves Synapse Functions in Human Cortical Neurons Exposed to the Excitotoxin Quinolinic Acid

Bhat, A., Tan, V. X., Heng, B., Lovejoy, D. B., Sakharkar, M. K., Essa, M. M., Chidambaram, S. B., & Guillemin, G. J. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00636 · Cited by 27

Regulatory effects of ghrelin on endoplasmic reticulum stress, oxidative stress, and autophagy: Therapeutic potential

Wang, H., Dou, S., Zhu, J., Shao, Z., Wang, C., & Cheng, B. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102112 · Cited by 27

A di-Copper Peptidyl Complex Mimics the Activity of Catalase, a Key Antioxidant Metalloenzyme

Coulibaly, K., Thauvin, M., Melenbacher, A., testard, C., Trigoni, E., Vincent, A., Stillman, M. J., Vriz, S., Policar, C., & Delsuc, N. (2021) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.0c03718 · Cited by 28

Sleep–Wake Disorders in Alzheimer’s Disease: A Review

Sun, Y.-Y., Wang, Z., Zhou, H.-Y., & Huang, H. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00097 · Cited by 27

N-Acetylcysteine Amide against Aβ-Induced Alzheimer’s-like Pathology in Rats

Alkandari, A. F., Madhyastha, S., & Rao, M. S. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612733 · Cited by 27

Mitochondrial methionine sulfoxide reductase B2 links oxidative stress to Alzheimer's disease-like pathology

Xiang, X., Li, S., Deng, X., Tang, Y., Min, Z., Luo, B., Wen, Q., Li, K., Chen, J., Ma, Y., et al. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.05.006 · Cited by 26

Vascular Cognitive Impairment: Information from Animal Models on the Pathogenic Mechanisms of Cognitive Deficits

Hort, J., Vališ, M., Kuča, K., & Angelucci, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102405 · Cited by 27

Acetylation of Aβ42 at Lysine 16 Disrupts Amyloid Formation

Adhikari, R., Yang, M., Saikia, N., Dutta, C., Alharbi, W. F. A., Shan, Z. J., Pandey, R., & Tiwari, A. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00069 · Cited by 29

Apolipoprotein E ε4 modulates astrocyte neuronal support functions in the presence of amyloid‐β

Fleeman, R. M., Kuhn, M. K., Chan, D. C., & Proctor, E. A. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15781 · Cited by 20

Spotlight on Coenzyme Q10 in scopolamine-induced Alzheimer’s disease: oxidative stress/PI3K/AKT/GSK 3ß/CREB/BDNF/TrKB

Abuelezz, S. A., & Hendawy, N. (2023) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgad048 · Cited by 26

Underlying mechanisms behind the neuroprotective effect of vanillic acid against diabetes‐associated cognitive decline: An in vivo study in a rat model

Ghaderi, S., Gholipour, P., Komaki‬, A., Shahidi, ‬., Seif, F., Bahrami‐Tapehebur, M., Salehi, I., Zarei, M., Sarihi, A., & Rashno, M. (2024) · Phytotherapy Research · doi:10.1002/ptr.8111 · Cited by 26

Astrocyte-to-neuron H2O2 signalling supports long-term memory formation in Drosophila and is impaired in an Alzheimer’s disease model

Rabah, Y., Berwick, J.-P., Sagar, N., Pasquer, L., Plaçais, P.-Y., & Préat, T. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01189-3 · Cited by 26

Herpesviral infections and antimicrobial protection for Alzheimer's disease: Implications for prevention and treatment

Qin, Q., & Li, Y. (2019) · Journal of Medical Virology · doi:10.1002/jmv.25481 · Cited by 26

Anti‐Alzheimer's multitarget‐directed ligands with serotonin 5‐HT6 antagonist, butyrylcholinesterase inhibitory, and antioxidant activity

Marcinkowska, M., Bucki, A., Panek, D., Siwek, A., Fajkis-Zajączkowska, N., Bednarski, M., Zygmunt, M., Godyń, J., Valdivieso, Á. D. R., Kotańska, M., et al. (2019) · Archiv der Pharmazie · doi:10.1002/ardp.201900041 · Cited by 26

Impact of cooking on the antioxidant activity of spice turmeric

Sun, J.-L., Ji, H., & Shen, L. (2019) · Food & Nutrition Research · doi:10.29219/fnr.v63.3451 · Cited by 26

Effects of Eugenol on Alzheimer’s Disease-like Manifestations in Insulin- and Aβ-Induced Rat Models

Taheri, P., Yaghmaei, P., Tehrani, H. S., & Ebrahim‐Habibi, A. (2019) · Neurophysiology · doi:10.1007/s11062-019-09801-z · Cited by 26

Navigating Alzheimer’s Disease via Chronic Stress: The Role of Glucocorticoids

Sharma, V., & Singh, T. G. (2019) · Current Drug Targets · doi:10.2174/1389450120666191017114735 · Cited by 26

Effects of intra-dentate gyrus microinjection of myokine irisin on long-term potentiation in male rats

Mohammadi, S., Oryan, S., Komaki‬, A., Eidi, A., & Zarei, M. (2019) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20190184 · Cited by 27

HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2

Yang, X., Ji, J., Liu, C., Zhou, M., Li, H., Ye, S., & Hu, Q. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106383 · Cited by 26

Association Between Gout and Dementia in the Elderly: A Nationwide Population-Based Cohort Study

Min, K. H., Kang, S. O., Oh, S. J., Han, J. M., & Lee, K. E. (2021) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2021.01.016 · Cited by 25

Multi-target inhibition ability of neohesperidin dictates its neuroprotective activity: Implication in Alzheimer's disease therapeutics

Chakraborty, S., Rakshit, J., Bandyopadhyay, J., & Basu, S. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.02.073 · Cited by 26

The Potential Roles of Redox Enzymes in Alzheimer’s Disease: Focus on Thioredoxin

Jia, J., Zeng, X., Xu, G., & Wang, Z. (2021) · ASN NEURO · doi:10.1177/1759091421994351 · Cited by 26

Design, Synthesis, and Evaluation of Chalcone Derivatives as Multifunctional Agents against Alzheimer's Disease

Wang, X., Zhou, L., Tan, R., Liang, G., Fang, S., Li, W., Xie, M., Wen, Y., Wu, J., & Chen, Y. (2021) · Chemistry & Biodiversity · doi:10.1002/cbdv.202100341 · Cited by 27

Protective Effect of Chitosan Oligosaccharide against Hydrogen Peroxide-Mediated Oxidative Damage and Cell Apoptosis via Activating Nrf2/ARE Signaling Pathway

Zhang, X., Liang, S., Gao, X., Huang, H., Lao, F., & Dai, X. (2021) · Neurotoxicity Research · doi:10.1007/s12640-021-00419-w · Cited by 26

Effects of in vitro simulated digestion on the antioxidant activity of different Camellia sinensis (L.) Kuntze leaves extracts

Governa, P., Manetti, F., Miraldi, E., & Biagi, M. (2021) · European Food Research and Technology · doi:10.1007/s00217-021-03864-1 · Cited by 29

Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases

Ji, W., Li, Y., Peng, H., Zhao, R., & Zhang, X. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114029 · Cited by 27

Amelioration of oxidative stress, cholinergic dysfunction, and neuroinflammation in scopolamine-induced amnesic rats fed with pomegranate seed

Akbarian, M., Mirzavi, F., Amirahmadi, S., Hosseini, M., Alipour, M., Feizi, H., & Rajabian, A. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-00971-7 · Cited by 27

Therapeutic potential of puerarin against cerebral diseases: From bench to bedside

Liu, T., Su, K., Cai, W., Ao, H., & Li, M. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175695 · Cited by 26

Selective PPAR-Delta/PPAR-Gamma Activation Improves Cognition in a Model of Alzheimer’s Disease

Steinke, I., Govindarajulu, M., Pinky, P. D., Bloemer, J., Yoo, S., Ward, T., Schaedig, T., Young, T., Wibowo, F. S., Suppiramaniam, V. D., et al. (2023) · Cells · doi:10.3390/cells12081116 · Cited by 26

Development of a novel immune infiltration-related diagnostic model for Alzheimer’s disease using bioinformatic strategies

Zhuang, X., Zhang, G., Bao, M., Jiang, G., Wang, H., Li, S., Wang, Z., & Sun, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1147501 · Cited by 26

Protective effect of a hydromethanolic extract from Fraxinus excelsior L. bark against a rat model of aluminum chloride-induced Alzheimer's disease: Relevance to its anti-inflammatory and antioxidant effects

Iranpanah, A., Fakhri, S., Bahrami, G., Majnooni, M. B., Gravandi, M. M., Taghavi, S., Badrbani, M. A., Amirian, R., & Farzaei, M. H. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117708 · Cited by 26

Design, synthesis, and biological evaluation of histone deacetylase inhibitors possessing glutathione peroxidase-like and antioxidant activities against Alzheimer’s disease

Hu, J., An, B., Pan, T., Li, Z., Huang, L., & Li, X. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.10.022 · Cited by 26

Modified Ce/Zr-MOF Nanoparticles Loaded with Curcumin for Alzheimer’s Disease via Multifunctional Modulation

Yang, Y., Wang, Y., Jiang, X., Mi, J., Ge, D., Tong, Y., & Zhu, Y. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s479242 · Cited by 25

Fasudil reduces β -amyloid levels and neuronal apoptosis in APP/PS1 transgenic mice via inhibition of the Nogo-A/NgR/RhoA signaling axis

Guo, M., Zhang, H., Zhang, P.-J., Liu, X., Song, L.-J., Wei, W., Wang, Y.-Y., Mu, B., Chai, Z., Yu, J., et al. (2020) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2020.04.243 · Cited by 25

CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β‑amyloid metabolism‑associated enzymes

Jiang, H., Niu, F., Zheng, Y., & Xu, Y. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.11919 · Cited by 25

Neuroprotective Effect and Antioxidant Potency of Fermented Cultured Wild Ginseng Root Extracts of Panax ginseng C.A. Meyer in Mice

Kim, C. J., Ryu, H. Y., Lee, S., Han-Joo, L., Chun, Y. S., Kim, J., Yu, C.-Y., Ghimire, B. K., & Lee, J. G. (2021) · Molecules · doi:10.3390/molecules26103001 · Cited by 26

Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer’s disease agents

Mzezewa, S. C., Omoruyi, S. I., Zondagh, L. S., Malan, S. F., Ekpo, O. E., & Joubert, J. (2021) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2021.1913137 · Cited by 26

Free and nanoencapsulated curcumin prevents scopolamine-induced cognitive impairment in adult zebrafish

Coradini, K., de Andrade, D. F., Altenhofen, S., Reolon, G. K., Nery, L. R., Silva, N. E., Vianna, M. R. M. R., Bonan, C. D., & Beck, R. C. R. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102781 · Cited by 25

Multi-Target Effects of Novel Synthetic Coumarin Derivatives Protecting Aβ-GFP SH-SY5Y Cells against Aβ Toxicity

Huang, C.-C., Chang, K., Chiu, Y., Chen, Y., Lung, T.-H., Hsieh‐Li, H. M., Su, M., Sun, Y., Chen, C., Lin, W., et al. (2021) · Cells · doi:10.3390/cells10113095 · Cited by 25

Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?

Kim, C.-K., Sachdev, P. S., & Braidy, N. (2022) · Aging and Disease · doi:10.14336/ad.2021.0705 · Cited by 27

Esculentoside A alleviates cognitive deficits and amyloid pathology through peroxisome proliferator-activated receptor γ-dependent mechanism in an Alzheimer's disease model

He, Z., Li, X., Wang, Z., Tu, S., Feng, J., Du, X., Ni, J., Li, N., & Liu, Q. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.153956 · Cited by 25

Levels of Soluble Interleukin 6 Receptor and Asp358Ala Are Associated With Cognitive Performance and Alzheimer Disease Biomarkers

Quillen, D., Hughes, T. M., Craft, S., Howard, T. D., Register, T. C., Suerken, C. K., Hawkins, G. A., & Milligan, C. (2023) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000200095 · Cited by 24

Complexity of Sex Differences and Their Impact on Alzheimer’s Disease

Kadlecová, M., Freude, K., & Haukedal, H. (2023) · Biomedicines · doi:10.3390/biomedicines11051261 · Cited by 27

Nanotherapy for Alzheimer's disease and vascular dementia: Targeting senile endothelium

D'Arrigo, J. S. (2017) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2017.12.002 · Cited by 27

Physical and cognitive training are able to prevent recognition memory deficits related to amyloid beta neurotoxicity

Daré, L. R., Garcia, A., Alves, N., Dias, D. V., Souza, M. A., & Mello‐Carpes, P. B. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.03.007 · Cited by 26

Exploring the Role of GLP-1 Receptor Agonists in Alzheimer’s Disease: A Review of Preclinical and Clinical Evidence

Teixeira, L. C. R., Luizon, M. R., & Gomes, K. B. (2025) · Receptors · doi:10.3390/receptors4010002 · Cited by 28

Modulation of sodium-coupled choline transporter CHT function in health and disease

Ojiakor, O. A., & Rylett, R. J. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104810 · Cited by 24

Multifunctional compounds for the treatment of Alzheimer’s disease

Storr, T. (2020) · Canadian Journal of Chemistry · doi:10.1139/cjc-2020-0279 · Cited by 25

Critical thinking on amyloid-beta-targeted therapy: challenges and perspectives

Sun, B., Chen, Y., Fan, D., Zhu, C., Zeng, F., & Wang, Y. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1810-y · Cited by 27

Lacidipine Prevents Scopolamine-Induced Memory Impairment by Reducing Brain Oxido-nitrosative Stress in Mice

Khurana, K., Kumar, M., & Bansal, N. (2021) · Neurotoxicity Research · doi:10.1007/s12640-021-00346-w · Cited by 24

Beneficial consequences of probiotic on mitochondrial hippocampus in Alzheimer’s disease

Beltagy, D. M., Nawar, N. F., Mohamed, T. M., Tousson, E., & El-Keey, M. M. (2021) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2020-0156 · Cited by 24

Carvacrol as a Potential Neuroprotective Agent for Neurological Diseases: A Systematic Review Article

Zamanian, M. Y., Kujawska, M., Nikbakhtzadeh, M., Hassanshahi, A., Ramezanpour, S., Kamiab, Z., & Bazmandegan, G. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210506185042 · Cited by 24

The Improvement of Sepsis-Associated Encephalopathy by P2X7R Inhibitor through Inhibiting the Omi/HtrA2 Apoptotic Signaling Pathway

Wang, K., Sun, M., Juan, Z., Zhang, J., Sun, Y., Wang, G., Wang, C., Li, Y., Kong, W., Fan, L., et al. (2022) · Behavioural Neurology · doi:10.1155/2022/3777351 · Cited by 24

Alzheimer’s disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR‐edited human neuronal cells

You, Y., Hersh, S. W., Aslebagh, R., Shaffer, S. A., Ikezu, S., Mez, J. B., Lunetta, K. L., Logue, M. W., Farrer, L. A., & Ikezu, T. (2022) · Aging Cell · doi:10.1111/acel.13617 · Cited by 24

The Role of Human Herpesvirus 6 Infection in Alzheimer’s Disease Pathogenicity—A Theoretical Mosaic

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