Cited by 295Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchPrion Diseases and Protein Misfolding

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Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of Aβ42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease

House, Emily, Collingwood, Joanna, Khan, Ayesha, Korchazkina, Olga, Berthon, Guy, Exley, Christopher·2004·Journal of Alzheimer's Disease

DOI 10.3233/jad-2004-6310

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Abstract

Metals are found associated with beta-pleated sheets of Abeta42 in vivo and may be involved in their formation. Metal chelation has been proposed as a therapy for Alzheimer's disease on the basis that it may safely dissolve precipitated Abeta peptides. We have followed fibrillisation of Abeta42 in the presence of an additional metal ion (Al(III), Fe(III), Zn(II), Cu(II)) over a period of 32 weeks and we have investigated the dissolution of these aged peptide aggregates in the presence of both desferrioxamine (DFO) and ethylenediaminetetraacetic acid (EDTA). Abeta42 either alone or in the presence of Al(III) or Fe(III) formed beta-pleated sheets of plaque-like amyloids which were dissolved upon incubation with either chelator. Zn(II) inhibited whilst Cu(II) prevented the formation of beta-pleated sheets of Abeta42and neither of these influences were affected by incubation of the aged peptide aggregates with either DFO or EDTA. Freshly prepared solutions of Abeta42 either alone or in the presence of added Al(III) or Fe(III) did not form beta-pleated amyloid in the presence of DFO when incubated for up to 8 weeks. EDTA did not prevent beta-pleated amyloid formation in the same treatments and promoted beta-pleated amyloid formation in the presence of either Zn(II) or Cu(II). The presence of significant concentrations of Al(III) and Fe(III) as contaminants of 'Abeta42 only' preparations suggested that both of these metals were involved in either triggering the formation or stabili…

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Authors: House, E., Collingwood, J., Khan, A., Korchazkina, O., Berthon, G., & Exley, C.
Affiliations: Keele University (GB)
Centre for Science and Technology in Medicine, Keele University, Staffordshire, UK
Université Toulouse III - Paul Sabatier (FR)
Corresponding author: Exley, Christopher
ORCID: Collingwood, Joanna
Khan, Ayesha
Exley, Christopher
Venue: Journal of Alzheimer's Disease
Publisher: SAGE Publications
Published: 2004-06-03
Volume: 6
Issue: 3
Pages: 291-301
ISSN: 1387-2877 (ISSN-L)
1875-8908
DOI: 10.3233/jad-2004-6310
OpenAlex: W1480108665
Cited by: 294
References: 0
Citations by year: 2026: 3 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 8 · 2021: 17 · 2020: 15 · 2019: 20 · 2018: 16 · 2017: 16 · 2016: 9 · 2015: 16 · 2014: 8 · 2013: 15 · 2012: 27
FWCI: 6.88
Type: journal article
Language: en
Open access: closed
Locations: Journal of Alzheimer s Disease (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (R01 AG02030-01 A1)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
Keywords: amyloid-beta 42, metal ions
MeSH terms: Aluminum, Alzheimer Disease, Brain, Chromatography, High Pressure Liquid, Copper, Edetic Acid, Humans, Iron, Peptide Fragments, Zinc, Chelation Therapy, Amyloid beta-Peptides, In Vitro Techniques

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Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of Aβ42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease

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