The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index.
Brain aluminum, magnesium and phosphorus contents of control and Alzheimer-diseased patients
Abstract
A study was undertaken to determine Al, Mg and P concentrations in 5 different brain regions of 3 control and 3 Alzheimer-diseased patients. One of the aims of this work was to evaluate the performance of applied analytical techniques. The digested samples were analyzed by inductively coupled plasma atomic emission spectrometry for Al, Mg and P. The dried samples were measured by instrumental neutron activation analysis for Al and Mg. The determination of human brain Al levels is complicated by the interfering reaction of P. We have previously worked out an analytical method which can eliminate this interference. The accuracy of the measured data was investigated by the analysis of biological standard reference materials. Our second goal was to study the possible elemental concentration changes in Alzheimer-diseased patients. Significantly higher Al and lower Mg and P values were found in some AD brain regions compared to the controls.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Of note, the presence of magnesium ions in vivo may have protective effects in AD; studies have shown that AD is associated with deficiencies in magnesium (Mg2+) in serum or brain [549, 550].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [549]
Citations
Cites
Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117
Diagnosis of Alzheimer's Disease
Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499
Observations on the brains of demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90063-8 · Cited by 2,084
The Dialysis Encephalopathy Syndrome
Alfrey, A. C., LeGendre, G. R., & Kaehny, W. D. (1976) · New England Journal of Medicine · doi:10.1056/nejm197601222940402 · Cited by 1,628
Uber eine eigenartige Erkrankung der Hirnrinde
Alzheimer, A. (1907) · Medical Entomology and Zoology · Cited by 1,503
Perl, D. P., & Brody, A. R. (1980) · Science · doi:10.1126/science.7367858 · Cited by 985
EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION
KLATZO, I., Wı́sniewski, H. M., & STREICHER, E. (1965) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196504000-00002 · Cited by 609
Geographical relation between Alzheimer's disease and aluminum in drinking water.
Martyn, C. N., Barker, D. J. P., Osmond, C., Harris, E. C., Edwardson, J. A., & Lacey, R. F. (1989) · PubMed · Cited by 587
Neurofibrillary tangles of paired helical filaments
Wı́sniewski, H. M., Narang, H. K., & Terry, R. D. (1976) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(76)90059-9 · Cited by 372
Regional brain trace-element studies in Alzheimer's disease.
Thompson, C. M., Markesbery, W. R., Ehmann, W. D., Mao, Y. X., & Vance, D. E. (1988) · PubMed · Cited by 230
Brain trace element concentrations in aging
Markesbery, W. R., Ehmann, W. D., Alauddin, M., & Hossain, T. I. M. (1984) · Neurobiology of Aging · doi:10.1016/0197-4580(84)90081-2 · Cited by 225
BRAIN-ALUMINIUM CONCENTRATION IN DIALYSIS ENCEPHALOPATHY
MCDERMOTT, J. R., Smith, A. I., Ward, M. K., Parkinson, I. S., & Kerr, D. N. S. (1978) · The Lancet · doi:10.1016/s0140-6736(78)90681-5 · Cited by 223
Gajdusek, D. C., & Salazar, A. Μ. (1982) · Neurology · doi:10.1212/wnl.32.2.107 · Cited by 193
Brain trace elements in Alzheimer's disease.
Ehmann, W. D., Markesbery, W. R., Alauddin, M., Hossain, T. I., & Brubaker, E. H. (1986) · PubMed · Cited by 192
Trace element imbalances in isolated subcellular fractions of Alzheimer's disease brains
Wenstrup, D. E., Ehman, W. D., & Markesbery, W. R. (1990) · Brain Research · doi:10.1016/0006-8993(90)91804-p · Cited by 189
TRACE ELEMENT CONCENTRATION IN HUMAN BRAIN
HÖCK, A., Demmel, U., Schicha, H., Kasperek, K., & Feinendegen, L. E. (1975) · Brain · doi:10.1093/brain/98.1.49 · Cited by 177
Instrumental neutron activation analysis of brain aluminum in Alzheimer disease and aging
Markesbery, W. R., Ehmann, W. D., Hossain, T. I. M., Alauddin, M., & Goodin, D. T. (1981) · Annals of Neurology · doi:10.1002/ana.410100604 · Cited by 173
Neutron activation analysis techniques for identifying elemental status in Alzheimer's disease
Ward, N., & Mason, J. A. (1987) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/bf02050527 · Cited by 124
Dedman, D., Treffry, A., Candy, J., Taylor, G. A., Morris, C. M., Bloxham, C. A., Perry, R. H., Edwardson, J. A., & Harrison, P. M. (1992) · Biochemical Journal · doi:10.1042/bj2870509 · Cited by 121
Line coincidence tables for inductively coupled plasma atomic emission spectrometry
Boumans, P. W. J. M. (1980) · Medical Entomology and Zoology · Cited by 114
A method based on ICP-MS for the analysis of Alzheimer's amyloid plaques.
Beauchemin, D., & Kisilevsky, R. (1998) · Analytical Chemistry · doi:10.1021/ac970783f · Cited by 79
Mechanism of Alzheimer's disease: Arguments for a neurotransmitter-aluminium complex implication
Deloncle, R., & Guillard, O. (1990) · Neurochemical Research · doi:10.1007/bf01208586 · Cited by 77
Magnesium status and ageing: an update.
Durlach, J., Bac, P., Durlach, V., Rayssiguier, Y., Bara, M., & Guiet-Bara, A. (1998) · PubMed · Cited by 72
Chafi, A. H., Hauw, J., Rancurel, G., Berry, J., & Galle, C. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90158-p · Cited by 65
Muñoz, D. G., Pendlebury, W. W., Kessler, J. B., & Perl, D. P. (1986) · Acta Neuropathologica · doi:10.1007/bf00686078 · Cited by 59
Aluminium Speciation in Biology
Martin, R. B. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514306.ch2 · Cited by 54
Brain Iron and Zinc Contents of German Patients with Alzheimer Disease
Andrási, E., Farkas, E. B., Gawlik, D., Rösick, U., & Brätter, P. (2000) · Journal of Alzheimer s Disease · doi:10.3233/jad-2000-2103 · Cited by 47
Self-citationSanz‐Medel, A., Roza, R. R., Alonso, R. G., Vallina, A. N., & Cannata-Andía, J. B. (1987) · Journal of Analytical Atomic Spectrometry · doi:10.1039/ja9870200177 · Cited by 46
Ferritin: The role of aluminum in ferritin function
Fleming, J. T., & Joshi, J. G. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90066-s · Cited by 40
Stedman, J. D., & Spyrou, N. M. (1997) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/bf02034435 · Cited by 33
YASUI, M., Kiichiro, O. T. A., & Yoshida, M. (1997) · PubMed · Cited by 24
Simultaneous determination of aluminium and phosphorus by neutron activation analysis
Gatschke, W., & Gawlik, D. (1980) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/bf02516952 · Cited by 22
Cedergren, A., & Frech, W. (1987) · Pure and Applied Chemistry · doi:10.1351/pac198759020221 · Cited by 22
Determination of aluminium in human brain tissue by electrothermal atomic absorption spectrometry
Xu, N., Majidi, V., Ehmann, W. D., & Markesbery, W. R. (1992) · Journal of Analytical Atomic Spectrometry · doi:10.1039/ja9920700749 · Cited by 19
Determination of Mo and Mn in human brain samples by different techniques
Császma, I., Andrási, E., Lásztity, A., Bertalan, É., & Gawlik, D. (2003) · Journal of Analytical Atomic Spectrometry · doi:10.1039/b301732j · Cited by 19
Self-citationAlterations in neuronal cytoskeleton in Alzheimer disease
(1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90087-g · Cited by 16
Andrási, E., Orosz, L., Bezúr, L., Ernyei, L., & Molnar, Z. (1995) · Microchemical Journal · doi:10.1006/mchj.1995.1013 · Cited by 15
Self-citationDetermination of Selenium and Tin in Human Brain by Graphite Furnace Atomic Absorption Spectrometry
Szoboszlai, N., Andrási, E., Ajtony, Z., & Császma, I. (2001) · Microchimica Acta · doi:10.1007/s006040170032 · Cited by 10
Self-citationMitani, K. (1992) · PubMed · Cited by 9
Henning, H. (1989) · Journal of Molecular Medicine · doi:10.1007/bf01745293 · Cited by 8
Proposed mechanism for alteration of albumin structure and function in Alzheimer's disease
Glick, J. L. (1991) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(05)80346-7 · Cited by 7
Determination of aluminium and some main and trace elements in needles of austrian pine trees
Hedrich, E., & Grass, F. (1988) · The Science of The Total Environment · doi:10.1016/0048-9697(88)90272-0 · Cited by 5
The deficit of thought in senile dementia Alzheimer's type.
Emery, O. B. (1988) · PubMed · Cited by 5
Cited by
Sorted by citations
Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
Krewski, D., Yokel, R. A., Nieboer, E., Borchelt, D., Cohen, J., Harry, J., Kacew, S., Lindsay, J., Mahfouz, A. M., & Rondeau, V. (2007) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701597766 · Cited by 998
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994
Aluminium and lead: molecular mechanisms of brain toxicity
Verstraeten, S. V., Aimo, L., & Oteiza, P. I. (2008) · Archives of Toxicology · doi:10.1007/s00204-008-0345-3 · Cited by 601
Aluminum and Alzheimer's Disease: After a Century of Controversy, Is there a Plausible Link?
Tomljenovic, L. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101494 · Cited by 371
Magnesium in Aging, Health and Diseases
Barbagallo, M., Veronese, N., & Dominguez, L. J. (2021) · Nutrients · doi:10.3390/nu13020463 · Cited by 394
Metadata
- Authors
- Andrási, E., Páli, N., Molnár, Z., & Kösel, S.
- Affiliations
- Eötvös Loránd University (HU)
- Budapest University of Technology and Economics (HU)
- Institut für Neuropathologie (DE)
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2005-08-23
- Volume
- 7
- Issue
- 4
- Pages
- 273-284
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1626736233
- Cited by
- 139
- References
- 44
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 12 · 2020: 7 · 2019: 4 · 2018: 7 · 2017: 7 · 2016: 12 · 2015: 10 · 2014: 12 · 2013: 12 · 2012: 6
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institut national de la recherche scientifique
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Keywords
- Alzheimer's disease
- MeSH terms
- Aged, Aged, 80 and over, Aluminum, Brain Chemistry, Frontal Lobe, Globus Pallidus, Hippocampus, Humans, Magnesium, Phosphorus, Neurofibrillary Tangles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review