The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index.
Brain aluminum, magnesium and phosphorus contents of control and Alzheimer-diseased patients
Abstract
A study was undertaken to determine Al, Mg and P concentrations in 5 different brain regions of 3 control and 3 Alzheimer-diseased patients. One of the aims of this work was to evaluate the performance of applied analytical techniques. The digested samples were analyzed by inductively coupled plasma atomic emission spectrometry for Al, Mg and P. The dried samples were measured by instrumental neutron activation analysis for Al and Mg. The determination of human brain Al levels is complicated by the interfering reaction of P. We have previously worked out an analytical method which can eliminate this interference. The accuracy of the measured data was investigated by the analysis of biological standard reference materials. Our second goal was to study the possible elemental concentration changes in Alzheimer-diseased patients. Significantly higher Al and lower Mg and P values were found in some AD brain regions compared to the controls.
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“Of note, the presence of magnesium ions in vivo may have protective effects in AD; studies have shown that AD is associated with deficiencies in magnesium (Mg2+) in serum or brain [549, 550].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [549]
Citations
Cites
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Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
Krewski, D., Yokel, R. A., Nieboer, E., Borchelt, D., Cohen, J., Harry, J., Kacew, S., Lindsay, J., Mahfouz, A. M., & Rondeau, V. (2007) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701597766 · Cited by 998
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994
Aluminium and lead: molecular mechanisms of brain toxicity
Verstraeten, S. V., Aimo, L., & Oteiza, P. I. (2008) · Archives of Toxicology · doi:10.1007/s00204-008-0345-3 · Cited by 601
Aluminum and Alzheimer's Disease: After a Century of Controversy, Is there a Plausible Link?
Tomljenovic, L. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101494 · Cited by 371
Magnesium in Aging, Health and Diseases
Barbagallo, M., Veronese, N., & Dominguez, L. J. (2021) · Nutrients · doi:10.3390/nu13020463 · Cited by 394
Metadata
- Authors
- Andrási, E., Páli, N., Molnár, Z., & Kösel, S.
- Affiliations
- Eötvös Loránd University (HU)
- Budapest University of Technology and Economics (HU)
- Institut für Neuropathologie (DE)
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2005-08-23
- Volume
- 7
- Issue
- 4
- Pages
- 273-284
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1626736233
- Cited by
- 139
- References
- 44
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 12 · 2020: 7 · 2019: 4 · 2018: 7 · 2017: 7 · 2016: 12 · 2015: 10 · 2014: 12 · 2013: 12 · 2012: 6
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institut national de la recherche scientifique
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Keywords
- Alzheimer's disease
- MeSH terms
- Aged, Aged, 80 and over, Aluminum, Brain Chemistry, Frontal Lobe, Globus Pallidus, Hippocampus, Humans, Magnesium, Phosphorus, Neurofibrillary Tangles
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