The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Adiposity, Type 2 Diabetes, and Alzheimer's Disease
Open accessAbstract
This manuscript provides a comprehensive review of the epidemiologic evidence linking the continuum of adiposity and type 2 diabetes (T2D) with Alzheimer's disease (AD). The mechanisms relating adiposity and T2D to AD may include hyperinsulinemia, advanced products of glycosylation, cerebrovascular disease, and products of adipose tissue metabolism. Elevated adiposity in middle age is related to a higher risk of AD but the data on this association in old age is conflicting. Several studies have shown that hyperinsulinemia, a consequence of higher adiposity and insulin resistance, is also related to a higher risk of AD. Hyperinsulinemia is a risk factor for T2D, and numerous studies have shown a relation of T2D with higher AD risk. The implication of these associations is that a large proportion of the world population may be at increased risk of AD given the trends for increasing prevalence of overweight, obesity, hyperinsulinemia, and T2D. However these associations may present a unique opportunity for prevention and treatment of AD. Several studies in the prevention and treatment of T2D are currently conducting, or have planned, cognition ancillary studies. In addition, clinical trials using insulin sensitizers in the treatment or prevention of AD are under way.
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Mechanisms underlying inflammation in neurodegeneration
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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
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Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States
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The relationship between obesity and cognitive health and decline
Dye, L., Boyle, N. B., Champ, C., & Lawton, C. (2017) · Proceedings of the Nutrition Society · doi:10.1017/s0029665117002014 · Cited by 469
Estrogens, Neuroinflammation, and Neurodegeneration
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Metadata
- Authors
- Luchsinger, J. A., & Gustafson, D. R.
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2009-04-17
- Volume
- 16
- Issue
- 4
- Pages
- 693-704
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1581074060
- Cited by
- 211
- References
- 42
- FWCI
- 13.66
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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