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Grey and white matter changes at different stages of Alzheimer’s disease
Open accessAbstract
This study investigates abnormalities of grey (GM) and white matter (WM) in Alzheimer's disease (AD), by modeling the AD pathological process as a continuous course between normal aging and fully developed dementia, with amnesic mild cognitive impairment (aMCI) as an intermediate stage. All subjects (9 AD, 16 aMCI patients, and 13 healthy controls) underwent a full neuropsychological assessment and an MRI examination at 3 Tesla, including a volumetric scan and diffusion tensor (DT)-MRI. The volumes were processed to perform a voxel-based morphometric analysis of GM and WM volume, while DT-MRI data were analyzed using tract based spatial statistics, to estimate changes in fractional anisotropy and mean diffusivity data. GM and WM volume and mean diffusivity and fractional anisotropy were compared across the three groups, and their correlation with cognitive functions was investigated. While AD presented a pattern of widespread GM atrophy, tissue loss was more subtle in patients with aMCI. WM atrophy was mainly located in the temporal lobe, but evidence of WM microscopic damage, assessed by DT-MRI, was also observable in the thalamic radiations and in the corpus callosum. Memory and executive functions correlated with either GM volume or fractional anisotropy in fronto-temporal areas. In conclusion, this study shows a comprehensive assessment of the brain tissue damage across AD evolution, providing insights on different pathophysiological mechanisms (GM atrophy, Wallerian dege…
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“Previous neuroimaging studies comparing GM changes between AD patients and healthy individuals have identified significant morphological atrophy in the hippocampus, entorhinal cortex, amygdala, putamen, and thalamus (de Jong et al., 2008; Serra et al., 2010; Matsuda, 2013).”
From Multimodal MRI combined with RNA sequencing reveals pathological signatures in the 9-month-old 3×Tg-AD mouse brain (2026) · cites this paper as Serra et al., 2010
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Metadata
- Authors
- Serra, L., Cercignani, M., Lenzi, D., Perri, R., Fadda, L., Caltagirone, C., Macaluso, E., & Bozzali, M.
- Affiliations
- Fondazione Santa Lucia (IT)
- University of Rome Tor Vergata (IT)
- Corresponding author
- Bozzali, Marco
- ORCID
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2010-01-06
- Volume
- 19
- Issue
- 1
- Pages
- 147-159
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1568194840
- Cited by
- 149
- References
- 53
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 11 · 2022: 4 · 2021: 12 · 2020: 10 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 10 · 2015: 12 · 2014: 8 · 2013: 13 · 2012: 20
- FWCI
- 11.56
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- cc-by
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- Alzheimer's disease, gray matter atrophy
- MeSH terms
- Aged, Alzheimer Disease, Cerebral Cortex, Female, Humans, Male, Middle Aged, Nerve Fibers, Myelinated, Disease Progression
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