The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Streptozotocin-induced sporadic Alzheimer’s disease: Selection of appropriate dose
Abstract
The long term effect of single (day 1) and twice (day 1 and 3) injections of intracerebroventricular (ICV) streptozotocin (STZ) at the doses of 1 and 3 mg/kg on the cognitive functions of male Wistar rats was evaluated. Elevated plus maze, passive avoidance, and Morris water maze tests were used to assess the cognitive functions. A significant cognitive deficit was found at the 2nd week onwards, which persisted up to the 14th week with single and twice ICV-STZ (3 mg/kg) injections, whereas no cognitive impairment was found in ICV-STZ (1 mg/kg) treated groups after 8-10 weeks.
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“Mehla and colleagues showed anti-AD effects of C. ternatea in ICV-STZ induced AD-like conditions in rats [145].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [145]
In the citing paper
“Pretreatment with hydro-alcoholic extract at the doses of 100, 300 and 500 mg/kg, p.o ameliorated the ICV-STZ induced cognitive impairment by decreasing the oxidative stress and rho kinase (ROCK II) expression in the rat brain [15,145].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [145]
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Metadata
- Authors
- Mehla, J., Pahuja, M., & Gupta, Y. K.
- Affiliations
- All India Institute of Medical Sciences (IN)
- Corresponding author
- Gupta, Yogendra Kumar
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2012-12-03
- Volume
- 33
- Issue
- 1
- Pages
- 17-21
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1670803694
- Cited by
- 113
- References
- 25
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 6 · 2023: 10 · 2022: 12 · 2021: 14 · 2020: 12 · 2019: 6 · 2018: 14 · 2017: 11 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- streptozotocin, Alzheimer's disease model
- MeSH terms
- Alzheimer Disease, Animals, Avoidance Learning, Disease Models, Animal, Injections, Intraventricular, Male, Streptozocin, Rats, Wistar, Maze Learning, Rats
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