Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat

Agrawal, Rahul; Mishra, Bhanvi; Tyagi, Ethika; Nath, Chandishwar; Shukla, Rakesh

doi:10.1016/j.phrs.2009.12.008

Cited by 133Curcumin's Biomedical ApplicationsAlzheimer's disease research and treatmentsMedicinal Plants and Neuroprotection

Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat

Agrawal, Rahul, Mishra, Bhanvi, Tyagi, Ethika, Nath, Chandishwar, Shukla, Rakesh·2010·Pharmacological Research

DOI 10.1016/j.phrs.2009.12.008

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Abstract

Curcumin, the principal curcuminoid of turmeric, exhibits beneficial role in several neurodegenerative disorders such as dementia of Alzheimer type. Recent evidences suggest the involvement of brain insulin receptors (IRs) in the pathophysiology of dementia disorders. Therefore, the present study was undertaken to investigate the effect of curcumin on memory functions, brain IRs, acetylcholinesterase (AChE) activity and oxidative stress in intracerebroventricular (ICV) administered streptozotocin (STZ) induced dementia in rats. Rats were injected with STZ (3 mg/kg, ICV) bilaterally twice, on day 1 and 3 and curcumin (200 mg/kg, po) was administered in pre- and post-treatment schedules. STZ (ICV) treated group had shown memory deficit as indicated by no significant decrease in latency time in Morris water maze test and significant decrease in IR protein level in both hippocampus and cerebral cortex. Pre- and post-treatment of curcumin in STZ (ICV) treated rats significantly restored the memory deficit and IR protein level in both the regions. Furthermore, STZ (ICV) resulted into enhanced AChE activity in hippocampus and cerebral cortex which was normalized by curcumin pre- and post-treatment. An increase in MDA level and decrease in GSH level were obtained in both hippocampus and cerebral cortex in STZ treated group, indicating state of oxidative stress, which was also attenuated by pre- and post-treatment of curcumin. The results suggest that besides the anticholinesterase and antioxidant activity, effect on brain IR may also be an important factor for protective effect of curcumin against STZ induced dementia model.

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Curcumin improves memory and cognitive deficits in rats.
“Furthermore, curcumin has been found to improve memory and cognitive deficits in rats [57].”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [57]
Curcumin treatment restored learning and memory functions in the streptozotocin model of Alzheimer's disease by reducing oxidative stress, enhancing ChAT activity and restoring insulin receptor protein.
“Another experimental study showed that curcumin treatment restored learning and memory functions in the STZ model of AD by reducing the oxidative stress, enhancing ChAT activity and restoring insulin receptor protein [117,118].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [117]

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Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer’s type (SDAT)
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Authors: Agrawal, R., Mishra, B., Tyagi, E., Nath, C., & Shukla, R.
Affiliations: Central Drug Research Institute (IN)
Corresponding author: Shukla, Rakesh
ORCID: Shukla, Rakesh
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2010-03
Volume: 61
Issue: 3
Pages: 247-252
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2009.12.008
OpenAlex: W2065632662
Cited by: 133
References: 38
Citations by year: 2026: 5 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 15 · 2020: 11 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 9 · 2014: 11 · 2013: 10 · 2012: 11
FWCI: 3.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords: curcumin, Alzheimer's disease model, memory impairment, acetylcholinesterase activity, oxidative stress, lipid peroxidation, glutathione, hippocampus, cerebral cortex, neuroprotection
MeSH terms: Animals, Brain, Curcumin, Dementia, Disease Models, Animal, Male, Memory, Memory Disorders, Receptor, Insulin, Streptozocin, Rats, Sprague-Dawley, Rats

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Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat

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