Curcumin ameliorates impaired insulin/IGF signalling and memory deficit in a streptozotocin-treated rat model
Open accessAbstract
Increased serum insulin levels and reduced peripheral insulin activities seen in insulin resistance syndrome are associated with age-dependent cognitive impairment and Sporadic Alzheimer's Disease (SAD), suggesting a disturbance in the insulin signalling system in the brain and possibly being one of the causes of dementia. Therefore, the streptozotocin (STZ)-induced animal may be an appropriate model for the investigation of SAD and related dementia. This study was designed to investigate the beneficial effect of Curcumin (CUR), a neuroprotective agent, on intracerebroventricular (ICV) STZ-induced cognitive impairment in rats. For this purpose, adult male Wistar rats were bilaterally ICV injected with STZ (3 mg/kg). An artificial cerebrospinal fluid (aCSF) was given to the control group (SHAM) instead of STZ on days 1 and 3. Learning and memory performance were assessed using the "passive avoidance task" and the "Morris water maze test". After confirmation of acquisition impairment with these tests, the STZ group was divided into two subgroups: STZ + vehicle (Vh) and STZ + CUR. The rats in the SHAM and STZ + Vh groups were administered intraperitoneally with 0.5 ml Vh and the rats in the STZ + CUR group were treated intraperitoneally with CUR (300 mg kg(-1) day(-1) in Vh) for 10 days starting from the 25th day after STZ injection. The Morris water maze test was reapplied on the 35th day after STZ injection and all of the rats were sacrificed on day 36 for quantitation of IGF-1 and for histopathological evaluation. Rats in the STZ + CUR group were found to have a higher performance in cognitive tests than rats in the STZ + Vh group (P < 0.01). In parallel with the cognitive tests, IGF-1 levels were decreased in all of the STZ-injected groups (1.78 +/- 0.34) compared to the SHAM group (3.46 +/- 0.41). In contrast, CUR treatment significantly increased IGF-1 levels (P < 0.001). The degree of neuronal loss decreased after CUR treatment compared to the SHAM group (P < 0.02). These results clearly indicate that CUR treatment is effective in reducing the cognitive impairment caused by STZ in rats, and may be a potential therapeutic agent for altering neurodegeneration in SAD.
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Curcumin significantly improved cognitive function by improving the IGF-1 level in the intracerebroventricular-streptozotocin model of sporadic Alzheimer's disease.
“Curcumin significantly improved cognitive function by improving the IGF-1 level in the intracerebroventricular (ICV)-streptozotocin (STZ) model of sporadic AD [116].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [116]
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- Authors
- Isik, A. T., Celik, T., Ulusoy, G., Ongoru, O., Elibol, B., Doruk, H., Bozoglu, E., Kayir, H., Mas, M. R., & Akman, S.
- Affiliations
- Middle East Technical University (TR)
- Gülhane Askerî Tıp Akademisi (TR)
- ORCID
- Elibol, Birsen
- Venue
- AGE
- Published
- 2008-10-08
- Volume
- 31
- Issue
- 1
- Pages
- 39-49
- ISSN
- 0161-9152 (ISSN-L)
- 1574-4647
- PMC
- PMC2645992
- OpenAlex
- W2094474853
- Cited by
- 76
- References
- 41
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 7 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 8 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 9
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AGE (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- OpenMETU (Middle East Technical University) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- curcumin, streptozotocin, insulin resistance, insulin/IGF-1 signalling, sporadic Alzheimer's disease, cognitive impairment, memory impairment, insulin-like growth factor I, neuroprotection, neuronal loss, intracerebroventricular administration, passive avoidance, Morris water maze, dementia, neurodegeneration, neuroinflammation
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