Cited by 31DNA Repair MechanismsDNA and Nucleic Acid ChemistryGenetic factors in colorectal cancer

Non-bulky Lesions in Human DNA: The Ways of Formation, Repair, and Replication

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Ignatov, А. V., Bondarenko, K. A., Makarova, A. V.·2017·Acta Naturae

Abstract

DNA damage is a major cause of replication interruption, mutations, and cell death. DNA damage is removed by several types of repair processes. The involvement of specialized DNA polymerases in replication provides an important mechanism that helps tolerate persistent DNA damage. Specialized DNA polymerases incorporate nucleotides opposite lesions with high efficiency but demonstrate low accuracy of DNA synthesis. In this review, we summarize the types and mechanisms of formation and repair of non-bulky DNA lesions, and we provide an overview of the role of specialized DNA polymerases in translesion DNA synthesis.

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Authors
Ignatov, А. V., Bondarenko, K. A., & Makarova, A. V.
Affiliations
Russian Academy of Sciences (RU)
Venue
Acta Naturae
Published
2017-09-15
Volume
9
Issue
3
Pages
12-26
ISSN
  • 2075-8243 (ISSN-L)
  • 2075-8251
OpenAlex
W2775355486
Cited by
31
References
242
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 1 · 2020: 10 · 2019: 3 · 2018: 2 · 2017: 1
FWCI
1.79
Type
journal article
Language
en
Open access
Locations
  • Acta Naturae (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords
DNA damage, DNA repair, translesion synthesis, DNA replication, replication errors

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