Non-bulky Lesions in Human DNA: The Ways of Formation, Repair, and Replication
Open accessAbstract
DNA damage is a major cause of replication interruption, mutations, and cell death. DNA damage is removed by several types of repair processes. The involvement of specialized DNA polymerases in replication provides an important mechanism that helps tolerate persistent DNA damage. Specialized DNA polymerases incorporate nucleotides opposite lesions with high efficiency but demonstrate low accuracy of DNA synthesis. In this review, we summarize the types and mechanisms of formation and repair of non-bulky DNA lesions, and we provide an overview of the role of specialized DNA polymerases in translesion DNA synthesis.
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Long-patch BER involves the resynthesis of a longer fragment of DNA, up to 13 nucleotides.
“long-patch BER involves the resynthesis of longer (up to 13 nucleotides) fragment of DNA molecule.”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [114]
In long-patch BER, DNA ligase I ligates the break.
“Finally, DNA ligase I ligates the break in long-patch BER [25,113,114].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [114]
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- Authors
- Ignatov, А. V., Bondarenko, K. A., & Makarova, A. V.
- Affiliations
- Russian Academy of Sciences (RU)
- ORCID
- Bondarenko, K. A.
- Venue
- Acta Naturae
- Publisher
- Acta Naturae Ltd
- Published
- 2017-09-15
- Volume
- 9
- Issue
- 3
- Pages
- 12-26
- ISSN
- 2075-8243 (ISSN-L)
- 2075-8251
- PMC
- PMC5662270
- OpenAlex
- W2775355486
- Cited by
- 31
- References
- 242
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 1 · 2020: 10 · 2019: 3 · 2018: 2 · 2017: 1
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Acta Naturae (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- DNA damage, DNA repair, translesion synthesis, DNA replication, replication errors
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