National Trends in the Distribution of Candida Species Causing Candidemia in Japan from 2003 to 2014: A Report by the Epidemiological Investigation Committee for Human Mycoses in Japan
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The Epidemiological Investigation Committee for Human Mycoses in Japan performed a retrospective epidemiological survey of candidemia and causative Candida species. Data from 2003 to 2014 were collected from 10 Japanese university hospitals. A total of 328,318 blood cultures were included. The prevalence of fungi in all cultures and in positive cultures were 0.58±0.09% and 4.46±0.66%, respectively. Among the results that were positive for Candida species (N=1,921), Candida albicans was the most common species (39.5%) and was followed by Candida parapsilosis (23.3%), Candida glabrata (13.2%), Candida tropicalis (7.1%), Candida krusei (3.2%), and others (13.7%). During the last 6 years, the frequency of C. albicans has significantly decreased in Japan, while that of C. glabrata has increased. Additional surveys are needed to continuously monitor the trends in the distribution of candidemia.
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The difference in incidence between this study and Kakeya et al. is possibly because this study used the number of patients who underwent blood culture tests as the denominator, while Kakeya et al. used the number of blood cultures.
“The difference is possibly because this study used the number of patients who underwent blood culture tests, while Kakeya et al. used the number of blood cultures as the denominator to calculate the incidence rate.”
The overall incidence of candidemia over the 10 years was 0.83%, which was higher than the 0.58 ± 0.09% reported by Kakeya et al.
“The overall incidence of candidemia over the 10 years was 0.83%, which was higher than that (0.58 ± 0.09%) reported by Kakeya, et al.”
Kakeya et al. analyzed 1921 Candida isolates from 10 hospitals between 2003 and 2014 and reported an increase in non-albicans candidemia.
“In Japan, Kakeya, et al. analyzed 1921 Candida isolates from 10 hospitals between 2003 and 2014 and reported an increase in the proportion of non-albicans candidemia.11”
Overall, these studies suggest that non-albicans candidemia in Japan potentially increased between 2003 and 2009.
“Overall, these studies suggest that non-albicans candidemia in Japan has potentially increased between 2003 and 2009.”
Another Japanese study reported chronological surveillance data from 10 hospitals between 2003 and 2014, but did not take antifungal susceptibility into consideration.
“Another study reported chronological surveillance data from 10 participating hospitals between 2003 and 2014.11 However, this report did not take antifungal susceptibility into consideration.”
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Cites
Attributable Mortality of Nosocomial Candidemia, Revisited
Gudlaugsson, O., Gillespie, S., Lee, K., Berg, J. V., Hu, J., Messer, S., Herwaldt, L., Pfaller, M., & Diekema, D. (2003) · Clinical Infectious Diseases · doi:10.1086/378745 · Cited by 1,140 · see citing works
Global trends in the distribution of Candida species causing candidemia
Guinea, J. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12539 · Cited by 680 · see citing works
Lortholary, O., Desnos-Ollivier, M., Sitbon, K., Fontanet, A., Bretagne, S., & Dromer, F. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01128-10 · Cited by 362 · see citing works
Pfaller, M. A., Diekema, D. J., Jones, R. N., Messer, S. A., & Hollis, R. J. (2002) · Journal of Clinical Microbiology · doi:10.1128/jcm.40.3.852-856.2002 · Cited by 331 · see citing works
Pfaller, M. A., Diekema, D. J., Rinaldi, M. G., Barnes, R., Hu, B., Veselov, A. V., Tiraboschi, N., Nagy, E., & Gibbs, D. L. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.12.5848-5859.2005 · Cited by 228 · see citing works
Lacroix, C., Gicquel, A., Sendid, B., Meyer, J., Accoceberry, I., François, N., Morio, F., Désoubeaux, G., Chandenier, J., Kauffmann‐Lacroix, C., et al. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12210 · Cited by 131 · see citing works
Takakura, S. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh053 · Cited by 117 · see citing works
Candidemia is Costly--Plain and Simple
Fridkin, S. K. (2005) · Clinical Infectious Diseases · doi:10.1086/496935 · Cited by 68 · see citing works
Khatib, R., Johnson, L. B., Fakih, M. G., Riederer, K., & Briski, L. (2016) · Mycoses · doi:10.1111/myc.12531 · Cited by 48 · see citing works
Distribution of Candida species isolated from blood cultures in hospitals in Osaka, Japan
Morii, D., Seki, M., Binongo, J., Ban, R., Kobayashi, A., Sata, M., Hashimoto, S., Shimizu, J., Morita, S., & Tomono, K. (2014) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2014.05.009 · Cited by 30 · see citing works
Self-citationShigemura, K., Osawa, K., Jikimoto, T., Yoshida, H., Hayama, B., Ohji, G., Iwata, K., Fujisawa, M., & Arakawa, S. (2014) · The Journal of Antibiotics · doi:10.1038/ja.2013.141 · Cited by 26 · see citing works
Terminal-stage prognostic analysis in candidemia
Takuma, T., Shoji, H., & Niki, Y. (2015) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2015.01.007 · Cited by 5 · see citing works
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Candida parapsilosis: from genes to the bedside
Tóth, R., Nosek, J., Mora-Montes, H. M., Gabaldon, T., Bliss, J. M., Nosanchuk, J. D., Turner, S. A., Butler, G., Vágvölgyi, C., & Gácser, A. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00111-18 · Cited by 327 · see citing works
Kajihara, T., Yahara, K., Nagi, M., Kitamura, N., Hirabayashi, A., Hosaka, Y., Abe, M., Miyazaki, Y., & Sugai, M. (2022) · Medical Mycology · doi:10.1093/mmy/myac071 · Cited by 29 · see citing works
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- Authors
- Kakeya, H., Yamada, K., Kaneko, Y., Yanagihara, K., Tateda, K., Maesaki, S., Takesue, Y., Tomono, K., Kadota, J.-I., Kaku, M., Miyazaki, Y., Kamei, K., Shibuya, K., Niki, Y., Yoshida, M., & Sei, Y.
- Affiliations
- Osaka City University (JP)
- Nagasaki University (JP)
- Toho University Omori Medical Center (JP)
- Saitama Medical University (JP)
- Hyogo Medical University (JP)
- The University of Osaka (JP)
- Oita University (JP)
- Tohoku University (JP)
- National Institute of Infectious Diseases (JP)
- Chiba University (JP)
- Toho University (JP)
- SHOWA Medical University (JP)
- Teikyo University Hospital (JP)
- ORCID
- Venue
- Medical Mycology Journal
- Published
- 2018
- Volume
- 59
- Issue
- 1
- Pages
- E19-E22
- ISSN
- 2185-6486 (ISSN-L)
- 2186-165X
- OpenAlex
- W2790089290
- Cited by
- 36
- References
- 12
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 7 · 2018: 2
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Medical Mycology Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chiba University
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- candidemia, Candida species distribution, Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, Candida krusei, fungemia, temporal trends, blood culture surveillance
- MeSH terms
- Candida, Candida albicans, Hospitals, University, Humans, Japan, Retrospective Studies, Time Factors, Prevalence, Candida glabrata, Candidemia
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