Current trends in candidemia and species distribution among adults: Candida glabrata surpasses C. albicans in diabetic patients and abdominal sources
Abstract
Candidemia rate and species distribution vary according to the type of patients, country of origin and antifungal prophylaxis use. To present current candidemia epidemiological trends. A retrospective examination of candidemia in adults (≥18 years-old) hospitalised from 2007 to 2015. Cases were identified through the microbiology laboratory. Candida species were distinguished based on colony morphology and VITEK-2 YBC cards, (bioMerieux, Durham, NC, USA). Patient characteristics, species distribution, source and outcome were assessed. We encountered 275 patients (294 episodes) with candidemia. The rate of candidemia dropped in 2010 (P = 0.003) without further decline. Nearly all cases (97.5%) were healthcare-associated. C. albicans (n = 118) and C. glabrata (n = 77) proportions varied without a discernable trend. C. glabrata was more common in diabetics [52.9% vs. 32.0% (non-diabetics); P = 0.004] and abdominal sources [53.3% vs. 35.5% (other sources); P = 0.03], especially gastric/duodenal foci [88.9% vs. 44.1% (other abdominal foci); P = 0.02]. All-cause 30-day mortality rate was 43.3% without changes over time or differences between C. albicans and C. glabrata. In conclusion, the candidemia rate remains stable after a decline in 2010. C. albicans remains the most common species but C. glabrata predominates in diabetics and abdominal sources. These findings suggest possible species-related differences in colonisation dynamics or pathogenicity.
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C. glabrata bloodstream infections are commonly found in elderly individuals, diabetic patients and solid organ transplant recipients.
“C. glabrata bloodstream infections are commonly found in elderly individuals, diabetic patients and solid organ transplant recipients [6,8,9].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [9]
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- Authors
- Khatib, R., Johnson, L. B., Fakih, M. G., Riederer, K., & Briski, L.
- Affiliations
- St. John Medical Center (US)
- Corresponding author
- Khatib, Riad
- ORCID
- Fakih, Mohamad G.
- Venue
- Mycoses
- Publisher
- Wiley
- Published
- 2016-07-12
- Volume
- 59
- Issue
- 12
- Pages
- 781-786
- ISSN
- 0027-5557 (ISSN-L)
- 0933-7407
- 1439-0507
- OpenAlex
- W2462867566
- Cited by
- 48
- References
- 29
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 1
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mycoses (publishedVersion)
- PubMed (publishedVersion)
- Funders
- St. John Hospital Medical Staff Fund
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- candidemia, Candida glabrata, Candida albicans, species distribution, diabetes mellitus, 30-day mortality, antifungal prophylaxis, epidemiological trends
- MeSH terms
- Abdomen, Adult, Aged, Aged, 80 and over, Candida albicans, Female, Humans, Male, Middle Aged, Retrospective Studies, Candida glabrata, Diabetes Complications, Candidemia
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