Cited by 171Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI

Rubia, Katya, Lee, Francis, Cleare, Anthony J., Tunstall, Nigel, Fu, Cynthia H. Y., Brammer, Michael, McGuire, Phillip·2005·Psychopharmacology

Abstract

Rationale and objective In animal and human studies, the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) has been implicated in mediating impulsiveness and aggression. To test the hypothesis that 5-HT modulates neuro-cognitive brain activation during inhibitory control, we examined the effect of acute tryptophan depletion (ATD), a dietary challenge, which has been shown to decrease 5-HT synthesis in the brain, on functional brain activation during a go/no-go task.Methods Nine healthy, right-handed volunteers performed a rapid, event-related go/no-go task in two functional magnetic resonance imaging (fMRI) scanning sessions, 5 h after either a tryptophan-free or a balanced amino acid drink in a double-blind, sham depletion-controlled, counterbalanced, crossover design. The task required subjects to selectively execute or inhibit a motor response. Tryptophan depletion significantly lowered total plasma tryptophan concentration by 80%, but did not significantly alter inhibitory performance or mood ratings.Results ATD significantly reduced right orbito-inferior prefrontal activation during the no-go condition, and increased activation in superior and medial temporal cortices.Conclusions These findings provide neuro-functional evidence of a serotonergic modulation of right inferior prefrontal during inhibitory motor control. The increased engagement of temporal brain regions may reflect compensatory mechanisms.

Integrity signals

Registry

Crossref · 10.1007/s00213-004-2116-z

Cites

113 of 113 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 114 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Rubia, K., Lee, F., Cleare, A. J., Tunstall, N., Fu, C. H. Y., Brammer, M., & McGuire, P.
Affiliations
King's College London (GB)
Corresponding author
Rubia, Katya
Venue
Psychopharmacology
Published
2005-01-26
Volume
179
Issue
4
Pages
791-803
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
OpenAlex
W2137257511
Cited by
171
References
114
Citations by year
2024: 1 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 6 · 2016: 2 · 2015: 13 · 2014: 15 · 2013: 10 · 2012: 12
FWCI
8.57
Type
journal article
Language
en
Open access
closed
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
tryptophan depletion, serotonin, inhibitory control, response inhibition, go/no-go task, orbitofrontal cortex, temporal cortex, impulsivity, aggression, serotonergic modulation, compensatory brain activation
MeSH terms
Adult, Affect, Aggression, Amino Acids, Choice Behavior, Double-Blind Method, Female, Humans, Image Processing, Computer-Assisted, Impulsive Behavior, Functional Laterality, Magnetic Resonance Imaging, Male, Psychomotor Performance, Reaction Time, Tryptophan, Prefrontal Cortex, Cross-Over Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review