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Recent Advances in Biosensor Technology for Potential Applications – An Overview
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Imperative utilization of biosensors has acquired paramount importance in the field of drug discovery, biomedicine, food safety standards, defense, security, and environmental monitoring. This has led to the invention of precise and powerful analytical tools using biological sensing element as biosensor. Glucometers utilizing the strategy of electrochemical detection of oxygen or hydrogen peroxide using immobilized glucose oxidase electrode seeded the discovery of biosensors. Recent advances in biological techniques and instrumentation involving fluorescence tag to nanomaterials have increased the sensitive limit of biosensors. Use of aptamers or nucleotides, affibodies, peptide arrays, and molecule imprinted polymers provide tools to develop innovative biosensors over classical methods. Integrated approaches provided a better perspective for developing specific and sensitive biosensors with high regenerative potentials. Various biosensors ranging from nanomaterials, polymers to microbes have wider potential applications. It is quite important to integrate multifaceted approaches to design biosensors that have the potential for diverse usage. In light of this, this review provides an overview of different types of biosensors being used ranging from electrochemical, fluorescence tagged, nanomaterials, silica or quartz, and microbes for various biomedical and environmental applications with future outlook of biosensor technology.
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“Wearable and mobile sensor technologies can be useful tools in precision nutrition research and practice”
From Wearable Technology to Quantify the Nutritional Intake of Adults: Validation Study (2020) · cites this paper as [14]
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“The using of 3D micro-environment could help to encapsulation of whole cell especially transparent materials in the optical methods which will improve biosensor fields [Vigneshvar et al., 2016].”
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Locatelli, M., Kabir, A., Perrucci, M., Ulusoy, H. İ., Ulusoy, S., Manousi, N., Samanidou, V., Ali, I., Kaya, S. I., Mansour, F. R., et al. (2024) · Microchemical Journal · doi:10.1016/j.microc.2024.111903 · Cited by 60
Nanosensors: Recent perspectives on attainments and future promise of downstream applications
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Carneiro, L. P. T., Ferreira, N. S., Tavares, A. P. M., Pinto, A., Mendes, A., & Sales, M. (2020) · Biosensors & bioelectronics · doi:10.1016/j.bios.2020.112877 · Cited by 56
Couplants in Acoustic Biosensing Systems
Manwar, R., Saint-Martin, L., & Avanaki, K. (2022) · Chemosensors · doi:10.3390/chemosensors10050181 · Cited by 55
“Biosensors are analytical devices consisting of sensing elements that are used to detect the presence or concentration of a biological analyte, such as a molecule, a subcellular structure, or a microorganism [1,2].”
BackgroundSiderophore-based biosensors and nanosensors; new approach on the development of diagnostic systems
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The Current Trends of Biosensors in Tissue Engineering
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Acoustic Biosensors and Microfluidic Devices in the Decennium: Principles and Applications
Nair, M. P., Teo, A. J. T., & Li, K. H. H. (2021) · Micromachines · doi:10.3390/mi13010024 · Cited by 51
“Biosensors, as the name implies, are devices that detect biomolecular recognition events through the use of a transducer, converting the physiochemical reaction phenomenon into a measurable electrical output [8,14].”
BackgroundCeO2 nanoparticles based extended gate field effect transistor for enzyme free detection of glucose
Shanmugam, P., Kuppuswamy, G. P., Pushparaj, K., Arumugam, B., Sundaramurthy, A., & Sivalingam, Y. (2021) · Journal of Materials Science Materials in Electronics · doi:10.1007/s10854-021-07441-w · Cited by 46
Recent advances in AC electrokinetic sample enrichment techniques for biosensor development
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A Review on Perception of Binding Kinetics in Affinity Biosensors: Challenges and Opportunities
McCann, B., Tipper, B. D., Shahbeigi, S., Soleimani, M., Jabbari, M., & Esfahani, M. N. (2025) · ACS Omega · doi:10.1021/acsomega.4c10040 · Cited by 56
Nanomaterial Based Biosensors for Detection of Viruses Including SARS-CoV-2: A Review
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“Biosensors are conjugated with aptamers, peptide arrays, polymers, and other attachments to recognize, read and produce a detectable output signal to identify the virus, ideally with naked eyes [49].”
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“For the fabrication of these biosensors, the process of surface preparation is critical for stability, sensitivity, and safety in the application of clinical diagnostics [14].”
MethodThe Use of Electrochemical Biosensors in Food Analysis
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Advanced diagnostic approaches developed for the global menace of rice diseases: a review
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“The advancement of biosensors has benefited drug discovery, diagnosis, biomedicine, food safety and processing, security, defence, and environmental monitoring (Vigneshvar et al. 2016).”
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“Given the increasing detection requirements of diverse small molecules, the development of novel and universal biosensing approach for a new type of recognition elements will boost the construction of diverse biosensors (1, 4).”
Prospects of ionic liquids application in electronic and bioelectronic nose instruments
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Carbon nanomaterials and its applications in pharmaceuticals: A brief review
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“These biosensors have a high throughput of analysis by minimizing reagent consumption, owing to being automated and enhances the flow of a fluid with a small volume of samples to be manipulated with precision [43].”
BackgroundMethodInfluentialMolecularly Imprinted Polymer/Metal Organic Framework Based Chemical Sensors
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“The field of chemosensors and biosensors has experienced a constant expansion, with an increasing number of papers published in the last years regarding their development and applications [1].”
BackgroundEngineering Micro–Nanomaterials for Biomedical Translation
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Chemical and Bio Sensing Using Graphene-Enhanced Raman Spectroscopy
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Recent trends in core/shell nanoparticles: their enzyme-based electrochemical biosensor applications
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“In its broadest sense, the term “Biosensor” describes a promising and innovative analytical system that includes a wide range of biological sensing elements such as drug analysis, bio-detection, bioengineering, environmental monitoring, military, and security [5].”
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Qu, L., Xiu, X., Sun, G., Zhang, C., Yang, H., Liu, Y., Li, J., Du, G., Lv, X., & Liu, L. (2022) · Biotechnology and Bioengineering · doi:10.1002/bit.28055 · Cited by 43
“Currently, many emerging metabolic engineering strategies can be used to balance cell growth and product accumulation effectively (Li et al., 2020; Perez et al., 2016; Vigneshvar et al., 2016).”
Background
Metadata
- Authors
- Vigneshvar, S., Sudhakumari, C. C., Senthilkumaran, B., & Prakash, H.
- Affiliations
- Vellore Institute of Technology University (IN)
- University of Hyderabad (IN)
- Corresponding author
- Senthilkumaran, Balasubramanian
- Prakash, Hridayesh
- Venue
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Published
- 2016-02-16
- Volume
- 4
- Pages
- 11-11
- ISSN
- 2296-4185 (ISSN-L)
- PMC
- PMC4754454
- OpenAlex
- W2284805588
- Cited by
- 674
- References
- 62
- Citations by year
- 2026: 43 · 2025: 82 · 2024: 101 · 2023: 77 · 2022: 93 · 2021: 74 · 2020: 73 · 2019: 50 · 2018: 42 · 2017: 30 · 2016: 9
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Greater South Information System
- Funders
- Department of Science and Technology, Ministry of Science and Technology
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Keywords
- biosensors, electrochemical biosensor, fluorescent biosensor, nanomaterials, quartz crystal microbalance, aptamers, affibody, peptide arrays, molecularly imprinted polymers, drug discovery, food safety, environmental monitoring, biosensor development
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