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Recent Advances in Biosensor Technology for Potential Applications – An Overview
Open accessAbstract
Imperative utilization of biosensors has acquired paramount importance in the field of drug discovery, biomedicine, food safety standards, defense, security, and environmental monitoring. This has led to the invention of precise and powerful analytical tools using biological sensing element as biosensor. Glucometers utilizing the strategy of electrochemical detection of oxygen or hydrogen peroxide using immobilized glucose oxidase electrode seeded the discovery of biosensors. Recent advances in biological techniques and instrumentation involving fluorescence tag to nanomaterials have increased the sensitive limit of biosensors. Use of aptamers or nucleotides, affibodies, peptide arrays, and molecule imprinted polymers provide tools to develop innovative biosensors over classical methods. Integrated approaches provided a better perspective for developing specific and sensitive biosensors with high regenerative potentials. Various biosensors ranging from nanomaterials, polymers to microbes have wider potential applications. It is quite important to integrate multifaceted approaches to design biosensors that have the potential for diverse usage. In light of this, this review provides an overview of different types of biosensors being used ranging from electrochemical, fluorescence tagged, nanomaterials, silica or quartz, and microbes for various biomedical and environmental applications with future outlook of biosensor technology.
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“Wearable and mobile sensor technologies can be useful tools in precision nutrition research and practice”
From Wearable Technology to Quantify the Nutritional Intake of Adults: Validation Study (2020) · cites this paper as [14]
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- Turner, 2013, Biosensors: sense and sensibility, Chem. Soc. Rev., 42, 3184, 10.1039/c3cs35528d · DOI
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BackgroundPortable Single Thermocouple Biosensor Based on Dual Suspension Microfluidic Structure
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“In terms of the development aspect related to biotechnology, currently, there is a dynamic development of biomedical sensors/ biosensors – devices containing a sensing system based on biologically active particles (Vigneshvar et al., 2016).”
In Vivo Biosensors for Directed Protein Evolution
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Antibody Immobilization in ZnO-Thin film transistors for low-cost biosensors applications
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“Biosensors field is one of the fields that requires more improvements and currently an enormous amount of work is undertaken [4], [5].”
BackgroundConvenience biosensing approach of lactic acid in stratum corneum for skin care assessment
Mizukoshi, K., Arakawa, T., & Mitsubayashi, K. (2020) · Skin research and technology · doi:10.1111/srt.12834 · Cited by 1
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BackgroundA Study on Real Time Transmission Technique of Multiple Sensor Data
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“Among the BAW sensors, Quartz Crystal Microbalance (QCM), made of a quartz resonator, shows the most competitive [19, 20].”
BackgroundCognitive Cloud-Based Telemedicine System
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“Biosensor is an analytical device which involves biological sensing element with wide range of application in drug discovery, food safety and environment monitoring [11,12].”
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Liu, C., Bianchi, L., & Saccomandi, P. (2026) · IEEE Sensors Reviews · doi:10.1109/sr.2026.3715381
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Basso, C. R., Crulhas, B. P., Castro, G., & Pedrosa, V. A. (2021) · doi:10.1016/b978-0-12-821100-7.00021-2 · Cited by 1
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Macro-, Micro- and Nanosensors Based on Biological/Chemical Materials
Kashin, V., Kolesov, V., Kuznetsova, I., Soldatov, E., Plekhanova, Y., Tarasov, S., Kitova, A. E., Signore, M., Ingle, A., Rai, M., et al. (2021) · doi:10.1007/978-3-030-55490-3_1 · Cited by 1
Aydın, E. B., Aydın, M., & Sezgintürk, M. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818592-6.00006-2 · Cited by 4
Recent advances in bioanalytical techniques using enzymatic assay
Deshpande, K., & Mishra, G. (2019) · Advances in Biological Science Research · doi:10.1016/b978-0-12-817497-5.00008-2 · Cited by 1
Current Developments and Potential Applications of Biosensor Technology
Mani, I., & Vasdev, K. (2018) · doi:10.4172/2155-6210.1000253 · Cited by 1
“Biosensors have great significance in the several areas like security, environmental monitoring, biomedicine, defense, drug discovery and food safety standards [9].”
BackgroundDetection of Surrogate Cells Presenting Vaccinia Virus Protein by DNA Aptamers
Choi, J.-H., Park, S.-Y., Hong, J.-M., Kim, S., & Kim, Y.-G. (2017) · doi:10.1002/bkcs.11038 · Cited by 1
Yeast-Based Systems for Environmental Control
Gayda, G., Gonchar, M., & Sibirny, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-58829-2_13 · Cited by 1
Anbuselvan, N., Lee, L., & Chan, K. (2026) · Journal of Computational Electronics · doi:10.1007/s10825-026-02649-7
“These attributes enable the development of highly reliable and sensitive biosensors capable of detecting a wide range of biomolecules, from metal ions to complex proteins, with excellent chemical stability and high temperature tolerance [13].”
Derivatives of dPMTO, dMTMO, and dTPT3 as efficient genetic alphabets for artificial DNA
Jena, N., Daheriya, R., & Singh, A. (2026) · Journal of Molecular Modeling · doi:10.1007/s00894-026-06966-3
“Artificial bases can also be used to make biosensors [14], antiviral drugs [15], drug delivery systems [16], DNA aptamers [17], and in other bionanotechnological applications [18].”
Badi'ah, H. I., Wulansari, S., & Hasanah, U. (2026) · Science and Technology Indonesia · doi:10.26554/sti.2026.11.4.1344-1359
“…4 concentration plays a pivotal role in governing both the nucleation kinetics and the subsequent growth dynamics of AuNPs, thereby exerting a direct influence on particle size, morphology, colloidal stability, and the position and intensity of the SPR absorption band (Vigneshvar et al., 2016).”
Rahman, M. A. (2026) · Physica Status Solidi (a) · doi:10.1002/pssa.70512
“Modern biotechnology has evolved into a multidisciplinary framework that integrates fields such as genetic modification [1, 2], molecular-level life sciences [3], biochemical processes [4], cellular science [5], developmental biology [6], immune sys-tem research [7], and BS technologies [8, 9].”
Dabagh, S., Kopyl, S., Marrella, A., Giannoni, P., & Kholkin, A. (2026) · Nano Energy · doi:10.1016/j.nanoen.2026.112437
Biosensors as Powerful Tools for Campylobacter Spp. Detection
Khan, J. A., Husain, F., Ahmad, I., Neyaz, L., Elbanna, K., & Abulreesh, H. (2026) · Advances in microbiology · doi:10.2478/am-2026-0011
“However, biosensor development faces limitations, including reliance on synthetic cell-surface receptors and biological agents (enzymes, antibodies, and nucleic acids) (Ahmed et al. 2014; Vigneshvar et al. 2016; Zeng et al. 2016).”
Miari, D. E., Al-Masri, R. A., Aşır, S., & Qamar, S. U. R. (2026) · Topics in Catalysis · doi:10.1007/s11244-026-02338-6
A diversified consortium of engineered biosensors enables multi-target quantification
Chiang, A. J., Csicsery, N., O’Laughlin, R., Baumgart, L. A., Stasiowski, E., Nguyen, P., Doughty, A. C. V., Ashraf, M., Mink, R., Olson, E. C., et al. (2026) · Cell Systems · doi:10.1016/j.cels.2026.101702 · Cited by 1
Canavalia ensiformis urease immobilization for urea biosensing: Rapid urea detection dipstick
Hussain, U., Mahmood, M., Yaqoob, A., Gull, I., Faryad, M., & Saleem, M. (2026) · Biocatalysis and Biotransformation · doi:10.1080/10242422.2026.2700390
Physical Models of Membrane Behavior Based on the Hodgkin–Huxley Formalism
Romano, P. (2026) · Biophysica · doi:10.3390/biophysica6040062
“Subsequent experimental advances, including the development of the Patch Clamp technique [6] and more recently microelectronic biosensors [7], have significantly improved the measurement and monitoring of cellular electrical activity, providing increasingly detailed data for membrane modeling.”
German, N., Ramanavičienė, A., & Ramanavičius, A. (2026) · Langmuir · doi:10.1021/acs.langmuir.6c02417 · Cited by 1
Kudryashova, N., Dobrokhotov, I., Ershova, E., & Moskalev, A. (2026) · Biochemistry (Moscow) · doi:10.1134/s0006297926601127
“Molecular recognition underlies modern biosensor technologies, diagnostic platforms, and analytical methods [1, 2].”
Zadeh-Hadad, S., Bakhshi, B., Tohodi-Moghadam, T., & Shams, S. (2026) · European Journal of Medical Research · doi:10.1186/s40001-026-04530-6
“A sensor is a device capable of generating a signal to determine or measure a physical property to which the material responds [19, 20].”
Khaire, P. B., Barai, V., Nandgude, S., Atre, A., & Patwardhan, M. S. (2026) · Environmental Monitoring & Assessment · doi:10.1007/s10661-026-15426-7
“The new technologies enable accurate SSC assessment under diverse environmental conditions (Shin et al., 2021; Vigneshvar et al., 2016).”
Zhang, Z.-Y., Wang, Z.-R., Zhang, L.-Y., & Gai, C. (2026) · IEEE International Conference on Nano/Micro Engineered and Molecular Systems · doi:10.1109/nems69704.2026.11633765
“In recent years, the application of biosensing technology in disease detection has continuously expanded[1-3].”
Spectrometers with prism-type excitation of surface plasmon resonance: ways to increase efficiency
Kostyukevych, S., Kostyukevych, K., Khrystosenko, R., Gorbov, I., & Kryuchyn, A. (2026) · BiOS · doi:10.1117/12.3100738
“Over the past decades, there has been a growing interest in miniature, highly sensitive, low-cost optical sensors for direct, cost-effective analysis of a wide range of low-and high-molecular-weight compounds and their commercial application in such industries as biotechnology and medicine [1].”
Song, X., Zeng, M., Yang, T., & Han, M. R. (2026) · Pharmacology Research & Perspectives · doi:10.1002/prp2.70218
Expansion of CKD diagnostics through biosensor technology: An early detection approach.
Sahu, G. P., Nandi, A., Saha, A., Chakraborty, S., Ganti, S. S., & Sharma, K. (2026) · Clinica chimica acta; international journal of clinical chemistry · doi:10.1016/j.cca.2026.120833
Review of Bayesian Approaches for Structural Integrity Assessment and Damage Identification
Bhadauria, P. K. S., Ranit, A. B., Chaudhary, P. S., Dongre, K. A., Harle, S. M., & Bhagat, A. P. (2025) · Operations Research Forum · doi:10.1007/s43069-025-00587-x
Li, Z., Zhou, G., Li, H., Mi, J., Shi, J., & Shen, J. (2025) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbbio.2025.3627203 · Cited by 1
“Biosensors represent another emerging area that aims to use biological sensing elements capable of specific reactions to measure the desired data [128].”
Partitioning Indicator Displacement Assay
Tocci, V., Shiel, E. A., Zhou, H., Liu, S., Bell, T. N., & Lenhert, S. (2025) · ACS Omega · doi:10.1021/acsomega.5c00413 · Cited by 1
Gated Nanosensor for Sulphate-Reducing Bacteria Detection
López‐Palacios, A., Morellá-Aucejo, Á., Moreno, Y., Ponz-Carcelén, R., Pedro-Monzonís, M., Marcos, M., Bernardos, A., Sancenón, F., Aznar, E., Martínez-Máñez, R., et al. (2025) · Nanomaterials · doi:10.3390/nano15100774
“As an alternative to more classical systems, nanotechnology is a valuable avenue for biosensor development [22].”
Babykala, R., Bhuvaneswari, M., Malarvizhi, R., & Sivan, A. K. (2025) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2025.141949
Research Progress and Application of Multifunctional Piezoelectric Hydrogels
Guo, J., Zhang, Q., Gai, D., Yang, L.-C., Liang, W.-F., & Zhang, C. (2024) · Cyber .. · doi:10.1109/cyber63482.2024.10748657
“The application of piezoelectric hydrogels in biomedicine covers many frontier fields from biosensors and drug delivery systems to tissue engineering and regenerative medicine [33-35].”
Parkavi (2024) · Shanlax International Journal of Arts, Science and Humanities · doi:10.34293/sijash.v12i1.8022
Metadata
- Authors
- Vigneshvar, S., Sudhakumari, C. C., Senthilkumaran, B., & Prakash, H.
- Affiliations
- Vellore Institute of Technology University (IN)
- University of Hyderabad (IN)
- Corresponding author
- Senthilkumaran, Balasubramanian
- Prakash, Hridayesh
- Venue
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Published
- 2016-02-16
- Volume
- 4
- Pages
- 11-11
- ISSN
- 2296-4185 (ISSN-L)
- PMC
- PMC4754454
- OpenAlex
- W2284805588
- Cited by
- 674
- References
- 62
- Citations by year
- 2026: 43 · 2025: 82 · 2024: 101 · 2023: 77 · 2022: 93 · 2021: 74 · 2020: 73 · 2019: 50 · 2018: 42 · 2017: 30 · 2016: 9
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Greater South Information System
- Funders
- Department of Science and Technology, Ministry of Science and Technology
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Keywords
- biosensors, electrochemical biosensor, fluorescent biosensor, nanomaterials, quartz crystal microbalance, aptamers, affibody, peptide arrays, molecularly imprinted polymers, drug discovery, food safety, environmental monitoring, biosensor development
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