mTOR Regulation of Glycolytic Metabolism in T Cells

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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

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Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

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mTOR differentially regulates effector and regulatory T cell lineage commitment

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Protein O-GlcNAcylation: emerging mechanisms and functions

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The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

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The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

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Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

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De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

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Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

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Fuel feeds function: energy metabolism and the T-cell response

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Regulation of Immune Responses by mTOR

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Unraveling the Complex Interplay Between T Cell Metabolism and Function

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Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

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mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

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Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

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Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

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Activation of mTORC2 by Association with the Ribosome

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Normalization of CD4 + T cell metabolism reverses lupus

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PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

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Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

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The dawn of the age of amino acid sensors for the mTORC1 pathway

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Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

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Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

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Fatty acid metabolism in the regulation of T cell function

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Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

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mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation

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Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants

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The dichotomous nature of T helper 17 cells

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T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming

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Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma

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Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8⁺ T cells

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Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation

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Glucose Availability Regulates IFN-γ Production and p70S6 Kinase Activation in CD8+ Effector T Cells

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Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

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mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

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Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases

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The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

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A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation

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The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

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Mitochondrial Priming by CD28

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Different Dynamics of CD4+ and CD8+ T Cell Responses During and After Acute Lymphocytic Choriomeningitis Virus Infection

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Monocarboxylate transporter MCT1 is a target for immunosuppression

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The cytotoxic T cell proteome and its shaping by the kinase mTOR

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Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation

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Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation

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A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells

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mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis

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NFATc1 controls the cytotoxicity of CD8+ T cells

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Calcium–NFAT transcriptional signalling in T cell activation and T cell exhaustion

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IL-7 Is Essential for Homeostatic Control of T Cell Metabolism In Vivo

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Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4+ CD4−CD8− Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus

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mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells

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Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner

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Inflammatory IL-15 is required for optimal memory T cell responses

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RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation

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T Cell Dysfunction and Exhaustion in Cancer

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Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8 + T cells

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Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor Microenvironment

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Why All the Fuss about Oxidative Phosphorylation (OXPHOS)?

Xu, Y., Xue, D., Bankhead, A., & Neamati, N. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01013 · Cited by 161 · see citing works

The immunobiology of mTOR in autoimmunity

Suto, T., & Karonitsch, T. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102373 · Cited by 149 · see citing works

Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations

Mandarano, A. H., Maya, J., Giloteaux, L., Peterson, D. L., Maynard, M., Gottschalk, C. G., & Hanson, M. R. (2019) · Journal of Clinical Investigation · doi:10.1172/jci132185 · Cited by 143 · see citing works

The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials

Mata, R., Yao, Y., Cao, W., Ding, J., Zhou, T., Zhai, Z., & Gao, C.-Y. (2021) · Research · doi:10.34133/2021/4189516 · Cited by 112 · see citing works

The Tumor Microenvironment Factors That Promote Resistance to Immune Checkpoint Blockade Therapy

Russell, B. L., Sooklal, S. A., Malindisa, S. T., Daka, L. J., & Ntwasa, M. M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.641428 · Cited by 84 · see citing works

Fibroblast Memory in Development, Homeostasis and Disease

Kirk, T., Ahmed, A., & Rognoni, E. (2021) · Cells · doi:10.3390/cells10112840 · Cited by 78 · see citing works

Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell memory in mice

Kalia, V., Yuzefpolskiy, Y., Vegaraju, A., Xiao, H., Baumann, F. M., Jatav, S., Church, C. D., Prlic, M., Jha, A., Nghiem, P., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aba6006 · Cited by 69 · see citing works

Colony-Stimulating Factor 1 Receptor (CSF1R) Activates AKT/mTOR Signaling and Promotes T-Cell Lymphoma Viability

Murga‐Zamalloa, C., Rolland, D. C. M., Polk, A., Wolfe, A., Dewar, H., Chowdhury, P., Önder, Ö., Dewar, R., Brown, N. A., Bailey, N. G., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-1486 · Cited by 65 · see citing works

Targeting Immune Cell Metabolism in the Treatment of Inflammatory Bowel Disease

Zaiatz-Bittencourt, V., Jones, F., Doherty, G. A., & Ryan, E. J. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab024 · Cited by 63 · see citing works

Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation

Hope, H. C., Brownlie, R. J., Fife, C. M., Steele, L. P., Lorger, M., & Salmond, R. J. (2021) · JCI Insight · doi:10.1172/jci.insight.137761 · Cited by 61 · see citing works

Novel strategies to manage CAR-T cell toxicity

Mulvey, A., Trueb, L., Coukos, G., & Arber, C. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01100-5 · Cited by 64 · see citing works

Fueling CARs: metabolic strategies to enhance CAR T-cell therapy

der Vreken, A. V., Vanderkerken, K., Bruyne, E. D., Veirman, K. D., Breckpot, K., & Menu, E. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00535-1 · Cited by 60 · see citing works

Obesity and CD8 T cell metabolism: Implications for anti‐tumor immunity and cancer immunotherapy outcomes

Turbitt, W. J., Rosean, C. B., Weber, K. S., & Norian, L. A. (2020) · Immunological Reviews · doi:10.1111/imr.12849 · Cited by 60 · see citing works

Metabolic regulation of T cells in the tumor microenvironment by nutrient availability and diet

Zhao, S., Peralta, R. M., Avina-Ochoa, N., Delgoffe, G. M., & Kaech, S. M. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101485 · Cited by 57 · see citing works

OXPHOS inhibitors, metabolism and targeted therapies in cancer

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Baicalein and Baicalin Promote Melanoma Apoptosis and Senescence via Metabolic Inhibition

Huang, L., Peng, B., Nayak, Y. R., Wang, C., Si, F., Liu, X., Dou, J., Xu, H., & Peng, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00836 · Cited by 51 · see citing works

The balance between protective and pathogenic immune responses to pneumonia in the neonatal lung is enforced by gut microbiota

Stevens, J., Steinmeyer, S. H., Bonfield, M., Peterson, L. S., Wang, T. C., Gray, J. K., Lewkowich, I. P., Xu, Y. J., Du, Y., Guo, M., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abl3981 · Cited by 50 · see citing works

The Role of Transcription Factor PPAR-γ in the Pathogenesis of Psoriasis, Skin Cells, and Immune Cells

Sobolev, V. V., Tchepourina, E., Korsunskaya, I. M., Geppe, N. A., Chebysheva, S. N., Soboleva, A. G., & Mezentsev, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179708 · Cited by 50 · see citing works

Oncogenic pathways activated by pro-inflammatory cytokines promote mutant p53 stability: clue for novel anticancer therapies

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The Post-amyloid Era in Alzheimer's Disease: Trust Your Gut Feeling

Osorio, C. P., Kanukuntla, T., Diaz, E. L., Jafri, N., Cummings, M., & Sfera, A. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00143 · Cited by 49 · see citing works

The Role of Non-essential Amino Acids in T Cell Function and Anti-tumour Immunity

Hope, H. C., & Salmond, R. J. (2021) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-021-00633-6 · Cited by 52 · see citing works

mTOR Dysregulation by Vaccinia Virus F17 Controls Multiple Processes with Varying Roles in Infection

Meade, N., King, M. W., Munger, J. C., & Walsh, D. (2019) · Journal of Virology · doi:10.1128/jvi.00784-19 · Cited by 50 · see citing works

Targeting metabolism to reverse T‐cell exhaustion in chronic viral infections

Sears, J. D., Waldron, K. J., Wei, J. N., & Chang, C. (2020) · Immunology · doi:10.1111/imm.13238 · Cited by 49 · see citing works

The role of mitochondria in the resistance of melanoma to PD-1 inhibitors

Du, F., Yang, L.-H., Liu, J., Wang, J., Fan, L., Duangmano, S., Liu, H., Liu, M., Wang, J., Zhong, X., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04200-9 · Cited by 48 · see citing works

Immune metabolism regulation of the germinal center response

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Deletion of PTPN22 improves effector and memory CD8+ T cell responses to tumors

Brownlie, R. J., Wright, D. J., Zamoyska, R., & Salmond, R. J. (2019) · JCI Insight · doi:10.1172/jci.insight.127847 · Cited by 45 · see citing works

Enforcing GLUT3 expression in CD8+ T cells improves fitness and tumor control by promoting glucose uptake and energy storage

Cribioli, E., Attianese, G. M. P. G., Ginefra, P., Signorino-Gelo, A., de Silly, R. V., Vannini, N., Hess, C., Irving, M. B., & Coukos, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.976628 · Cited by 44 · see citing works

Enhanced immune memory through a constant photothermal-metabolism regulation for cancer prevention and treatment

Luo, L., Li, X., Zhang, J., Zhu, C., Jiang, M., Luo, Z., Qin, B., Wang, Y., Chen, B., Du, Y., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120678 · Cited by 44 · see citing works

A metabolic switch to memory CAR T cells: Implications for cancer treatment

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Metabolic Traits in Cutaneous Melanoma

Neagu, M. T. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00851 · Cited by 41 · see citing works

Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control

Perdomo-Celis, F., Passaes, C., Monceaux, V., Volant, S., Boufassa, F., de Truchis, P., Marcou, M., Bourdic, K., Weiss, L., Jung, C., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci157549 · Cited by 40 · see citing works

mTOR Signaling Regulates Metabolic Function in Oligodendrocyte Precursor Cells and Promotes Efficient Brain Remyelination in the Cuprizone Model

Jeffries, M. A., McLane, L. E., Khandker, L., Mather, M. L., Evangelou, A. V., Kantak, D., Bourne, J. N., Macklin, W. B., & Wood, T. L. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1377-20.2021 · Cited by 41 · see citing works

The low-density lipoprotein receptor–mTORC1 axis coordinates CD8+ T cell activation

Bonacina, F., Moregola, A., Svecla, M., Coe, D., Uboldi, P., Fraire, S., Beretta, S., Beretta, G., Pellegatta, F., Catapano, A. L., et al. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202202011 · Cited by 40 · see citing works

CD4+ T cell metabolism, gut microbiota, and autoimmune diseases: implication in precision medicine of autoimmune diseases

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Recent advances of mitochondrial complex I inhibitors for cancer therapy: Current status and future perspectives

Zhou, Y., Zou, J., Xu, J. B., Zhou, Y., Cen, X., & Zhao, Y. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115219 · Cited by 40 · see citing works

Iron controls T helper cell pathogenicity by promoting glucose metabolism in autoimmune myopathy

Lai, Y., Zhao, S., Chen, B., Huang, Y., Guo, C., Li, M., Ye, B., Wang, S., Zhang, H., & Yang, N. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.999 · Cited by 36 · see citing works

Hypoxia-Driven HIF-1α Activation Reprograms Pre-Activated NK Cells towards Highly Potent Effector Phenotypes via ERK/STAT3 Pathways

Lim, S. A., Moon, Y., Shin, M. H., Kim, T.-J., Chae, S., Yee, C., Hwang, D., Park, H., & Lee, K. (2021) · Cancers · doi:10.3390/cancers13081904 · Cited by 39 · see citing works

Immune–Metabolic Interactions and T Cell Tolerance in Pregnancy

Moldenhauer, L. M., Hull, M. L., Foyle, K. L., McCormack, C. D., & Robertson, S. A. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2200362 · Cited by 37 · see citing works

Role of FABP5 in T Cell Lipid Metabolism and Function in the Tumor Microenvironment

Jin, R., Hao, J., Yu, J., Wang, P., Sauter, E. R., & Li, B. (2023) · Cancers · doi:10.3390/cancers15030657 · Cited by 37 · see citing works

Targeting the tumor microenvironment and T cell metabolism for effective cancer immunotherapy

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Precise targeting of lipid metabolism in the era of immuno-oncology and the latest advances in nano-based drug delivery systems for cancer therapy

Zhang, H., Li, Y., Huang, J., Shen, L., & Yang, X. W. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.07.021 · Cited by 36 · see citing works

Strategies to Overcome Failures in T-Cell Immunotherapies by Targeting PI3K-δ and –γ

Chandrasekaran, S., Funk, C. R., Kleber, T. J., Paulos, C. M., Shanmugam, M., & Waller, E. K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.718621 · Cited by 36 · see citing works

Azithromycin promotes relapse by disrupting immune and metabolic networks after allogeneic stem cell transplantation

Vallet, N., Grand, S. L., Bondeelle, L., Hoareau‐Coudert, B., Corneau, A., Bouteiller, D., Tournier, S., Lew‐Derivry, L., Bohineust, A., Tourret, M., et al. (2022) · Blood · doi:10.1182/blood.2022016926 · Cited by 36 · see citing works

Metabolic signatures of immune cells in chronic kidney disease

Li, J., Yang, Y., Wang, Y., Li, Q., & He, F. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.35 · Cited by 35 · see citing works

Metabolism and Autoimmune Responses: The microRNA Connection

Colamatteo, A., Micillo, T., Bruzzaniti, S., Fusco, C., Garavelli, S., Rosa, V. D., Galgani, M., Spagnuolo, M. I., Rella, F. D., Puca, A. A., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01969 · Cited by 36 · see citing works

Actin-related protein 2/3 complex subunit 1B promotes ovarian cancer progression by regulating the AKT/PI3K/mTOR signaling pathway

Ke, M., Zhu, H., Lin, Y. W., Zhang, Y., Tang, T., Xie, Y., Chen, Z., Wang, X., & Shen, Y. L. (2024) · Journal of Translational Internal Medicine · doi:10.2478/jtim-2024-0025 · Cited by 34 · see citing works

Metabolic profiles of regulatory T cells in the tumour microenvironment

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Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions

Soriano‐Baguet, L., Grusdat, M., Kurniawan, H., Benzarti, M., Binsfeld, C., Ewen, A., Longworth, J., Bonetti, L., Guerra, L., Franchina, D. G., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112153 · Cited by 33 · see citing works

IL‐33 activates mTORC1 and modulates glycolytic metabolism in CD8+ T cells

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Fungal Colonization and Infections—Interactions with Other Human Diseases

Mahalingam, S. S., Jayaraman, S., & Pandiyan, P. (2022) · Pathogens · doi:10.3390/pathogens11020212 · Cited by 33 · see citing works

Tissue-Resident Macrophage Membrane-Coated Nanomedicine for Targeted Tumor Therapy

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The Role of Autophagy in the Function of CD4+ T Cells and the Development of Chronic Inflammatory Diseases

Jeong, J., Choi, Y. J., & Lee, H. K. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.860146 · Cited by 33 · see citing works

mTOR as a Potential Target for the Treatment of Microbial Infections, Inflammatory Bowel Diseases, and Colorectal Cancer

Afzal, O., Altamimi, A. S. A., Mubeen, B., Alzarea, S. I., Almalki, W. H., Al-Qahtani, S. D., Atiya, E. M., Al-Abbasi, F. A., Ali, F., Ullah, I., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012470 · Cited by 30 · see citing works

Regulatory T Cell Metabolism in Atherosclerosis

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NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function

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mTOR Signaling in the Regulation of CD4+ T Cell Subsets in Periodontal Diseases

Jiang, Q., Huang, X., Yu, W., Huang, R., Zhao, X., & Chen, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.827461 · Cited by 28 · see citing works

Metabolic Factors Affecting Tumor Immunogenicity: What Is Happening at the Cellular Level?

Sayed, R. E., Haibe, Y., Amhaz, G., Bouferraa, Y., & Shamseddine, A. I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042142 · Cited by 27 · see citing works

Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control

Perdomo-Celis, F., Passaes, C., Monceaux, V., Volant, S., Boufassa, F., de Truchis, P., Marcou, M., Bourdic, K., Weiss, L., Jung, C., et al. (2022) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 27 · see citing works

The mTOR-glycolytic pathway promotes T-cell immunobiology in oral lichen planus

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Melatonin inhibits glycolysis in hepatocellular carcinoma cells by downregulating mitochondrial respiration and mTORC1 activity

Lee, S., Byun, J., Kim, N.-Y., Jin, J., Woo, H., Choi, Y., & Park, K. (2022) · BMB Reports · doi:10.5483/bmbrep.2022.55.9.177 · Cited by 26 · see citing works

Sodium–glucose cotransporter-2 inhibitors for diabetic kidney disease: Targeting Warburg effects in proximal tubular cells

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High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity

Zhu, J., Yang, W., Zhou, X., Zöphel, D., Soriano‐Baguet, L., Dolgener, D., Carlein, C., Hof, C., Zhao, R., Ye, S., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.689337 · Cited by 25 · see citing works

Ferroptosis-related gene SLC1A5 is a novel prognostic biomarker and correlates with immune infiltrates in stomach adenocarcinoma

Zhu, D., Wu, S., Li, Y., Zhang, Y., Chen, J., Ma, J., Cao, L., Lyu, Z., & Hou, T. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02544-8 · Cited by 25 · see citing works

Cross-Talk between the Cytokine IL-37 and Thyroid Hormones in Modulating Chronic Inflammation Associated with Target Organ Damage in Age-Related Metabolic and Vascular Conditions

Majnarić, L. T., Bosnić, Z., Štefanić, M., & Wittlinger, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126456 · Cited by 25 · see citing works

The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses

Meade, N., Toreev, H. K., Chakrabarty, R. P., Hesser, C. R., Park, C., Chandel, N. S., & Walsh, D. (2023) · Nature Communications · doi:10.1038/s41467-023-43635-y · Cited by 25 · see citing works

Fueling influenza and the immune response: Implications for metabolic reprogramming during influenza infection and immunometabolism

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Nutraceuticals as Potential Therapeutic Modulators in Immunometabolism

Álba, G., Dakhaoui, H., Santa‐María, C., Palomares, F., Cejudo‐Guillén, M., Geniz, I., Sobrino, F., la Paz, S. M., & Lopez-Enriquez, S. (2023) · Nutrients · doi:10.3390/nu15020411 · Cited by 26 · see citing works

High fructose consumption aggravates inflammation by promoting effector T cell generation via inducing metabolic reprogramming

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Metformin Modulates T Cell Function and Alleviates Liver Injury Through Bioenergetic Regulation in Viral Hepatitis

Xu, L., Wang, X., Chen, Y., Soong, L., Chen, Y., Cai, J., Liang, Y., & Sun, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.638575 · Cited by 22 · see citing works

Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling

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Transferrin receptor is necessary for proper oligodendrocyte iron homeostasis and development

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Apoptosis, a Metabolic “Head-to-Head” between Tumor and T Cells: Implications for Immunotherapy

Franzese, O., Ancona, P., Bianchi, N., & Aguiari, G. (2024) · Cells · doi:10.3390/cells13110924 · Cited by 24 · see citing works

Directing B7-H3 chimeric antigen receptor T cell homing through IL-8 induces potent antitumor activity against pediatric sarcoma

Lake, J. A., Woods, E., Hoffmeyer, E., Schaller, K., Cruz, J. C., Fernandez, J., Tufa, D. M., Kooiman, B., Hall, S. C., Jones, D., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009221 · Cited by 21 · see citing works

Acidity induces durable enhancement of Treg cell suppressive functions for tumor immune evasion

Mani, N. L., Weinberg, S. E., Chaudhuri, S. M., Montauti, E. I., Tang, A. Y., Iyer, R., & Fang, D. (2024) · Molecular Immunology · doi:10.1016/j.molimm.2024.08.004 · Cited by 20 · see citing works

The role of small molecules in cell and gene therapy

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The RNA regulatory programs that govern lymphocyte development and function

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miR-99a regulates CD4+ T cell differentiation and attenuates experimental autoimmune encephalomyelitis by mTOR-mediated glycolysis

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Metabolic regulation of follicular helper T cell differentiation in a mouse model of lupus

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Blockade of PGK1 and ALDOA enhances bilirubin control of Th17 cells in Crohn’s disease

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S6 ribosomal protein phosphorylation is associated with malignancy of intraductal papillary mucinous neoplasm of the pancreas

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Metabolic and epigenetic orchestration of (CAR) T cell fate and function

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Resveratrol attenuates staphylococcal enterotoxin B-activated immune cell metabolism via upregulation of miR-100 and suppression of mTOR signaling pathway

Alghetaa, H., Mohammed, A. K., Singh, N. P., Wilson, K. M., Cai, G., Putluri, N., Nagarkatti, M., & Nagarkatti, P. S. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1106733 · Cited by 19 · see citing works

Mitochondrial Control for Healthy and Autoimmune T Cells

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Untangling the Knots of Regulatory T Cell Therapy in Solid Organ Transplantation

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Brain energy metabolism is optimized to minimize the cost of enzyme synthesis and transport

Gustafsson, J., Robinson, J. L., Zetterberg, H., & Nielsen, J. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2305035121 · Cited by 18 · see citing works

TREM2-mediated Macrophage Glycolysis Promotes Skin Wound Angiogenesis via the Akt/mTOR/HIF-1α Signaling Axis

Wei, W., Qu, Z.-L., Lei, L., & Zhang, P.-Z. (2024) · Current Medical Science · doi:10.1007/s11596-024-2946-3 · Cited by 16 · see citing works

Reprogramming the neuroblastoma tumor immune microenvironment to enhance GPC2 CAR T cells

Giudice, A. M., Roth, S. L., Matlaga, S., Cresswell-Clay, E., Mishra, P., Schürch, P. M., Boateng-Antwi, K. A. M., Samanta, M., Pascual‐Pasto, G., Zecchino, V. P., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.05.025 · Cited by 17 · see citing works

Metabolic rewiring directs melanoma immunology

Sun, N., Tian, Y., Chen, Y., Guo, W., & Li, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.909580 · Cited by 17 · see citing works

Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter

Iskarpatyoti, J. A., Shi, J., Abraham, M. A., Rathore, A. P. S., Miao, Y., & Abraham, S. N. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111346 · Cited by 17 · see citing works

The role of metabolism on regulatory T cell development and its impact in tumor and transplantation immunity

Сергеевич, Б. А., Khantakova, J. N., Сергеевна, Ш. Н., Shiku, H., & Sennikov, S. V. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1016670 · Cited by 17 · see citing works

Commensal bacterial hybrid nanovesicles improve immune checkpoint therapy in pancreatic cancer through immune and metabolic reprogramming

Liu, G., Huang, W., Chen, L., Tayier, N., You, L., Hamza, M., Tian, X., Wang, H., Nie, G., Zhu, M., et al. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101993 · Cited by 17 · see citing works

A novel role for lipoxin A4 in driving a lymph node–eye axis that controls autoimmunity to the neuroretina

Wei, J., Mattapallil, M. J., Horai, R., Jittayasothorn, Y., Modi, A. P., Sen, H. N., Gronert, K., & Caspi, R. R. (2020) · eLife · doi:10.7554/elife.51102 · Cited by 17 · see citing works

Translational Landscape of mTOR Signaling in Integrating Cues Between Cancer and Tumor Microenvironment

Bazzichetto, C., Conciatori, F., Falcone, I., & Ciuffreda, L. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-35582-1_4 · Cited by 15 · see citing works

mTOR and metabolic pathways in T cell quiescence and functional activation

Yang, K., & Chi, H. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.12.004 · Cited by 115 · see citing works

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

Palmer, C. S., Ostrowski, M., Balderson, B., Christian, N., & Crowe, S. M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00001 · Cited by 992 · see citing works

Metabolism of activated T lymphocytes

Maciolek, J. A., Pasternak, J. A., & Wilson, H. L. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.01.006 · Cited by 224 · see citing works

Metabolic pathways in T cell activation and lineage differentiation

Almeida, L., Lochner, M., Berod, L., & Sparwasser, T. D. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.10.009 · Cited by 475 · see citing works

<scp>mTOR</scp> , metabolism, and the regulation of T‐cell differentiation and function

Waickman, A. T., & Powell, J. D. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01152.x · Cited by 420 · see citing works