The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Mesenchymal Stem Cell-Derived Extracellular Vesicles: Challenges in Clinical Applications
Open accessAbstract
Stem cell therapy has garnered much attention and application in the past decades for the treatment of diseases and injuries. Mesenchymal stem cells (MSCs) are studied most extensively for their therapeutic roles, which appear to be derived from their paracrine activity. Recent studies suggest a critical therapeutic role for extracellular vesicles (EV) secreted by MSCs. EV are nano-sized membrane-bound vesicles that shuttle important biomolecules between cells to maintain physiological homeostasis. Studies show that EV from MSCs (MSC-EV) have regenerative and anti-inflammatory properties. The use of MSC-EV, as an alternative to MSCs, confers several advantages, such as higher safety profile, lower immunogenicity, and the ability to cross biological barriers, and avoids complications that arise from stem cell-induced ectopic tumor formation, entrapment in lung microvasculature, and immune rejection. These advantages and the growing body of evidence suggesting that MSC-EV display therapeutic roles contribute to the strong rationale for developing EV as an alternative therapeutic option. Despite the success in preclinical studies, use of MSC-EV in clinical settings will require careful consideration; specifically, several critical issues such as (i) production methods, (ii) quantification and characterization, (iii) pharmacokinetics, targeting and transfer to the target sites, and (iv) safety profile assessments need to be resolved. Keeping these issues in mind, the aim of this mini-review is to shed light on the challenges faced in MSC-EV research in translating successful preclinical studies to clinical platforms.
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Cited by
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Biomimetic immunomodulation strategies for effective tissue repair and restoration
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Torres Crigna, A., Uhlig, S., Elvers-Hornung, S., Klüter, H., & Bieback, K. (2020) · Cells · doi:10.3390/cells9112419 · Cited by 46
Mesenchymal Stromal Cells for Aging Cartilage Regeneration: A Review
Wu, K.-C., Chang, Y.-H., Ding, D.-C., & Lin, S.-Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312911 · Cited by 33
Haller, O. J., Semendric, I., George, R. P., Collins-Praino, L. E., & Whittaker, A. L. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105120 · Cited by 13
Metadata
- Authors
- Gowen, A., Shahjin, F., Chand, S., Odegaard, K. E., & Yelamanchili, S. V.
- Venue
- Frontiers in Cell and Developmental Biology
- Publisher
- Frontiers Media SA
- Published
- 2020-03-12
- Volume
- 8
- Pages
- 149-149
- ISSN
- 2296-634X (ISSN-L)
- OpenAlex
- W3011116178
- Cited by
- 334
- References
- 98
- FWCI
- 13.55
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gowen, A., Shahjin, F., Chand, S., Odegaard, K. E., & Yelamanchili, S. V. (2020). Mesenchymal Stem Cell-Derived Extracellular Vesicles: Challenges in Clinical Applications. Frontiers in Cell and Developmental Biology. https://doi.org/10.3389/fcell.2020.00149
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
