A Structural View on ESCRT-Mediated Abscission
Open accessAbstract
The endosomal sorting complex required for transport (ESCRT) mediates cellular processes that are related to membrane remodeling, such as multivesicular body (MVB) formation, viral budding and cytokinesis. Abscission is the final stage of cytokinesis that results in the physical separation of the newly formed two daughter cells. Although abscission has been investigated for decades, there are still fundamental open questions related to the ultrastructure and spatio-temporal organization of the molecular machinery involved in this process. Reviewing knowledge obtained from in vitro as well as in vivo experiments, we give a brief overview on the role of ESCRT components in abscission mainly focussing on mammalian cells.
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ESCRT-0, ESCRT-I, and ESCRT-II may regulate cargo sorting, and ESCRT-III is involved in membrane endocytosis and exocytosis.
“Studies have shown that ESCRT-0, ESCRT-I, and ESCRT-II may be regulating cargo sorting, and ESCRT-III is involved in membrane endocytosis and exocytosis.”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [13]
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Banjade, S., Tang, S., Shah, Y. H., & Emr, S. D. (2019) · eLife · doi:10.7554/elife.46207 · Cited by 43 · see citing works
Sep(t)arate or not – how some cells take septin-independent routes through cytokinesis
Menon, M., & Gaestel, M. (2015) · Journal of Cell Science · doi:10.1242/jcs.164830 · Cited by 40 · see citing works
ESCRT Function in Cytokinesis: Location, Dynamics and Regulation by Mitotic Kinases
Bhutta, M. S., McInerny, C., & Gould, G. W. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151221723 · Cited by 39 · see citing works
Resolving new ultrastructural features of cytokinetic abscission with soft-X-ray cryo-tomography
Sherman, S., Kirchenbüechler, D., Nachmias, D., et al. (2016) · Scientific Reports · doi:10.1038/srep27629 · Cited by 35 · see citing works
Callaway, E. (2020) · Nature · doi:10.1038/d41586-020-01658-1 · Cited by 30 · see citing works
Wound-induced contractile ring: a model for cytokinesis
Darenfed, H., & Mandato, C. A. (2005) · Biochemistry and Cell Biology · doi:10.1139/o05-164 · Cited by 27 · see citing works
Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrityPreprint
Gupta, T. K., Klumpe, S., Gries, K., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.11.243204 · Cited by 22 · see citing works
Molecular Simulation of Mechanical Properties and Membrane Activities of the ESCRT-III Complexes
Mandal, T., Lough, W., Spagnolie, S. E., Audhya, A., & Cui, Q. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2020.01.033 · Cited by 17 · see citing works
The Linker Region Plays a Regulatory Role in Assembly and Activity of the Vps4 AAA ATPase
Shestakova, A., Curtiss, M., Davies, B. A., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.497032 · Cited by 12 · see citing works
Malerød, L., & Stenmark, H. (2009) · Cell · doi:10.1016/j.cell.2008.12.029 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System
Li, T., Li, X., Han, G., Liang, M., Yang, Z., Zhang, C., Huang, S., Tai, S., & Yu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010021 · Cited by 110 · see citing works
- Authors
- Horváth, P., & Müller-Reichert, T.
- Affiliations
- Technische Universität Dresden (DE)
- Corresponding author
- Horváth, Péter
- ORCID
- Horváth, Péter
- Venue
- Frontiers in Cell and Developmental Biology
- Publisher
- Frontiers Media SA
- Published
- 2020-11-09
- Volume
- 8
- Pages
- 586880-586880
- ISSN
- 2296-634X (ISSN-L)
- PMC
- PMC7680848
- OpenAlex
- W3105553650
- Cited by
- 16
- References
- 102
- Citations by year
- 2026: 5 · 2023: 2 · 2022: 5 · 2021: 4
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Cell and Developmental Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- ESCRT, abscission, cytokinesis, membrane remodeling, viral budding, membrane ultrastructure, spatiotemporal organization, mammalian cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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