Cited by 56Tuberculosis Research and EpidemiologyTrace Elements in HealthImmune Response and Inflammation

Zinc and copper toxicity in host defense against pathogens: Mycobacterium tuberculosis as a model example of an emerging paradigm

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Neyrolles, Olivier, Mintz, Elisabeth, Catty, Patrice·2013·Frontiers in Cellular and Infection Microbiology

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Crossref · 10.3389/fcimb.2013.00089

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  • M. tuberculosis expresses mycobacterial copper transport protein B (MctB) and ATPase CtpV, which play an important role for pathogen proliferation by avoiding copper intoxication within the phagolysosome and maintaining low copper levels.

    “On the other hand, M. tuberculosis expresses the mycobacterial copper transport protein B (MctB) and the ATPase CtpV, which play an important role for pathogen proliferation by avoiding copper intoxication within the phagolysome and maintaining low copper levels in this environment (160, 237–239).”

    From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [239]

  • M. tuberculosis expresses p-type ATPase to promote zinc efflux and resist metal intoxication.

    “As with copper, M. tuberculosis express p-type ATPase to promote zinc efflux and to resist metal intoxication (239, 242).”

    From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [239]

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Authors
Neyrolles, O., Mintz, E., & Catty, P.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Neyrolles, Olivier
Venue
Frontiers in Cellular and Infection Microbiology
Published
2013
Volume
3
Issue
89
Pages
89-89
ISSN
2235-2988 (ISSN-L)
OpenAlex
W2036103234
Cited by
56
References
29
Citations by year
2026: 2 · 2025: 6 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 7 · 2019: 3 · 2018: 2 · 2017: 7 · 2016: 3 · 2015: 8 · 2014: 2
FWCI
3.16
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • European Commission
  • Agence Nationale de la Recherche
  • Fondation pour la Recherche Médicale
  • Centre National de la Recherche Scientifique
  • Fondation Mérieux
Topics
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
zinc toxicity, copper toxicity, host defense, Mycobacterium tuberculosis, metal homeostasis, host-pathogen interaction, innate immunity
MeSH terms
Anti-Bacterial Agents, Copper, Immunity, Innate, Metabolism, Mycobacterium tuberculosis, Zinc

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