Zinc and copper toxicity in host defense against pathogens: Mycobacterium tuberculosis as a model example of an emerging paradigm
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M. tuberculosis expresses mycobacterial copper transport protein B (MctB) and ATPase CtpV, which play an important role for pathogen proliferation by avoiding copper intoxication within the phagolysosome and maintaining low copper levels.
“On the other hand, M. tuberculosis expresses the mycobacterial copper transport protein B (MctB) and the ATPase CtpV, which play an important role for pathogen proliferation by avoiding copper intoxication within the phagolysome and maintaining low copper levels in this environment (160, 237–239).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [239]
M. tuberculosis expresses p-type ATPase to promote zinc efflux and resist metal intoxication.
“As with copper, M. tuberculosis express p-type ATPase to promote zinc efflux and to resist metal intoxication (239, 242).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [239]
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- Authors
- Neyrolles, O., Mintz, E., & Catty, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Neyrolles, Olivier
- ORCID
- Neyrolles, Olivier
- Venue
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 3
- Issue
- 89
- Pages
- 89-89
- ISSN
- 2235-2988 (ISSN-L)
- PMC
- PMC3841717
- OpenAlex
- W2036103234
- Cited by
- 56
- References
- 29
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 7 · 2019: 3 · 2018: 2 · 2017: 7 · 2016: 3 · 2015: 8 · 2014: 2
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- European Commission
- Agence Nationale de la Recherche
- Fondation pour la Recherche Médicale
- Centre National de la Recherche Scientifique
- Fondation Mérieux
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- zinc toxicity, copper toxicity, host defense, Mycobacterium tuberculosis, metal homeostasis, host-pathogen interaction, innate immunity
- MeSH terms
- Anti-Bacterial Agents, Copper, Immunity, Innate, Metabolism, Mycobacterium tuberculosis, Zinc
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