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Genetic determinants of inherited susceptibility to hypercholesterolemia—a comprehensive literature review

Paththinige, CS, Sirisena, ND, Dissanayake, VHW·2017·Lipids in Health and Disease
DOI 10.1186/s12944-017-0488-4PMC PMC5457620
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  • Human genome-wide association studies have identified more than 250 loci associated with blood lipid levels.

    “Human genome-wide association studies (GWAS) have also identified >250 loci associated with blood lipid levels[9–11].”

    From Genome-scale CRISPR screening for modifiers of cellular LDL uptake (2021) · cites this paper as [10]

    The section “Other loci associated with plasma lipid levels identified by GWAS” says that many GWAS have identified variants associated with serum lipid traits, supporting the general point. It does not establish the claimed count of more than 250 loci; another section reports over 190 variants in about 60 genes, which is a different measure. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Metadata

Authors
Paththinige, C., Sirisena, N., & Dissanayake, V.
ORCID
Paththinige, CS
Venue
Lipids in Health and Disease
Publisher
Springer Science and Business Media LLC
Published
2017-06-02
Volume
16
Issue
1
ISSN
1476-511X
DOI
10.1186/s12944-017-0488-4
PMC
PMC5457620
Cited by
118
References
18
Language
en

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