The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Coupling Signals between the Osteoclast and Osteoblast: How are Messages Transmitted between These Temporary Visitors to the Bone Surface?
Open accessAbstract
Skeletal mass is regulated by two key activities: bone removal (resorption) by hematopoietic lineage osteoclasts and bone matrix formation by mesenchymal lineage osteoblasts. During adult life, these activities occur sequentially on the same surface: a process termed as remodeling. Tiny packets of bone are removed by osteoclasts and replaced by new bone matrix produced by osteoblasts. This continual renewal process allows repair of mechanical imperfections and calcium homeostasis.
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“Since TGF-β1 and IGF1 do not remain accessible long enough to affect the complete refilling of the resorption cavity,220 their action might be limited to the early phases of remodeling, when osteoclasts are still actively resorbing the bone matrix.”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [220]
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Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166 · cited 1×
“For example, TGF-β, Semaphorin 4D, Wnt10b, and BMP-2 are released by T-cells (44–46) and macrophages (47, 48), while sphingosine-1-phosphate and PDGF are released by endothelial cells (49, 50).”
BackgroundPresidential Address: Discount Rates
Cochrane, J. H. (2011) · The Journal of Finance · doi:10.1111/j.1540-6261.2011.01671.x · Cited by 2,135
Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin
Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705092200 · Cited by 1,350
TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation
Tang, Y., Wu, X., Lei, W., Pang, L., Wan, C., Shi, Z., Zhao, L., Nagy, T. R., Peng, X., Hu, J., et al. (2009) · Nature Medicine · doi:10.1038/nm.1979 · Cited by 1,165
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis
Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., Nishiwaki, T., Suda, T., & Matsuo, K. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.012 · Cited by 777
Sims, N. A., & Martin, T. J. (2014) · BoneKEy Reports · doi:10.1038/bonekey.2013.215 · Cited by 745
Self-citationOsteoclast-derived activity in the coupling of bone formation to resorption
Martin, T. J., & Sims, N. A. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.12.004 · Cited by 661
Self-citationMatrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells
Xian, L., Wu, X., Pang, L., Lou, M., Rosen, C. J., Qiu, T., Crane, J., Frassica, F., Zhang, L., Rodriguez, J. P., et al. (2012) · Nature Medicine · doi:10.1038/nm.2793 · Cited by 631
Pederson, L., Ruan, M., Westendorf, J. J., Khosla, S., & Oursler, M. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805133106 · Cited by 556
Rickard, D. J., Sullivan, T. A., Shenker, B. J., Leboy, P. S., & Kazhdan, I. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1022 · Cited by 537
Research works printed but not linked: 2
- Sims, Coupling between immune and bone cells
- Hsu, 2014, Finding smart beta in the factor zoo
Cited by
Sorted by citations
Estrogens and androgens in skeletal physiology and pathophysiology
Almeida, M., Laurent, M. R., Dubois, V., Claessens, F., O'Brien, C. A., Bouillon, R., Vanderschueren, D., & Manolagas, S. C. (2017) · Physiological Reviews · doi:10.1152/physrev.00033.2015 · Cited by 860
Osteoclast differentiation by RANKL and OPG signaling pathways
Udagawa, N., Koide, M., Nakamura, M., Nakamichi, Y., Yamashita, T., Uehara, S., Kobayashi, Y., Furuya, Y., Yasuda, H., Fukuda, C., et al. (2020) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-020-01162-6 · Cited by 765
Kenkre, J. E., & Bassett, J. H. D. (2018) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563218759371 · Cited by 775
Agidigbi, T. S., & Kim, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143576 · Cited by 526
Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482
Metadata
- Authors
- Sims, N. A., & Martin, T. J.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Sims, Natalie A.
- ORCID
- Sims, Natalie A.
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2015-03-24
- Volume
- 6
- Pages
- 41-41
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC4371744
- OpenAlex
- W2053586178
- Cited by
- 184
- References
- 63
- Citations by year
- 2026: 14 · 2025: 8 · 2024: 9 · 2023: 11 · 2022: 19 · 2021: 19 · 2020: 19 · 2019: 27 · 2018: 17 · 2017: 19 · 2016: 13 · 2015: 9
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- bone remodeling, osteoclasts, osteoblasts, bone resorption, bone matrix formation, calcium homeostasis, bone turnover
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