Cited by 184Bone Metabolism and DiseasesBone health and osteoporosis researchBone and Dental Protein Studies

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Coupling Signals between the Osteoclast and Osteoblast: How are Messages Transmitted between These Temporary Visitors to the Bone Surface?

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Sims, Natalie A., Martin, T. John·2015·Frontiers in Endocrinology

DOI 10.3389/fendo.2015.00041PMC PMC4371744

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Abstract

Skeletal mass is regulated by two key activities: bone removal (resorption) by hematopoietic lineage osteoclasts and bone matrix formation by mesenchymal lineage osteoblasts. During adult life, these activities occur sequentially on the same surface: a process termed as remodeling. Tiny packets of bone are removed by osteoclasts and replaced by new bone matrix produced by osteoblasts. This continual renewal process allows repair of mechanical imperfections and calcium homeostasis.

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Figure 1 Possible coupling mechanisms that overcome the time delay between bone resorption and formation. (A) Osteoclast-derived factors (either released from the matrix, secreted from the osteoclast, or expressed on the osteoclast cell membrane) initiate differentiation of very early osteoblast progenitors, with the level of osteoblast activity and numbers of differentiated cells being refined by other factors released by a range of cell types within the BMU. Osteoclast-derived factors may act directly on cells that would transmit further signals (dashed lines) to both osteoblast precursors and mature osteoblasts; these transmitting cells could include (B) osteoblast-lineage cells in the remodeling canopy, (C) reversal cells on the bone surface, and (D) osteocytes. Finally, (E) physical changes brought about by the osteoclast, including the resorptive pit itself, and mechanical strain detected by the osteocyte network, would provide signals required for initiation and completion of the correct level of matrix production by mature osteoblasts on the bone surface. Periods of time required for each step are based on adult human iliac crest biopsies.CC BY · PubMed Central

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Authors: Sims, N. A., & Martin, T. J.
Affiliations: The University of Melbourne (AU)
Corresponding author: Sims, Natalie A.
ORCID: Sims, Natalie A.
Venue: Frontiers in Endocrinology
Publisher: Frontiers Media SA
Published: 2015-03-24
Volume: 6
Pages: 41-41
ISSN: 1664-2392 (ISSN-L)
DOI: 10.3389/fendo.2015.00041
PMC: PMC4371744
OpenAlex: W2053586178
Cited by: 184
References: 63
Citations by year: 2026: 14 · 2025: 8 · 2024: 9 · 2023: 11 · 2022: 19 · 2021: 19 · 2020: 19 · 2019: 27 · 2018: 17 · 2017: 19 · 2016: 13 · 2015: 9
FWCI: 1.87
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Endocrinology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Minerva Access (University of Melbourne) (submittedVersion, cc-by)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
Keywords: bone remodeling, osteoclasts, osteoblasts, bone resorption, bone matrix formation, calcium homeostasis, bone turnover

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Coupling Signals between the Osteoclast and Osteoblast: How are Messages Transmitted between These Temporary Visitors to the Bone Surface?

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