New directions for the treatment of adrenal insufficiency
Open accessAbstract
Adrenal disease, whether primary, caused by defects in the hypothalamic-pituitary-adrenal (HPA) axis, or secondary, caused by defects outside the HPA axis, usually results in adrenal insufficiency, which requires lifelong daily replacement of corticosteroids. However, this kind of therapy is far from ideal as physiological demand for steroids varies considerably throughout the day and increases during periods of stress. The development of alternative curative strategies is therefore needed. In this review, we describe the latest technologies aimed at either isolating or generating de novo cells that could be used for novel, regenerative medicine application in the adrenocortical field.
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ESC- and iPSC-derived pancreatic beta cells have been used as an example of cell therapy for potential treatment of type 1 diabetes.
“An example of cell therapy used ESCs-and iPSCs-derived pancreatic beta cells for potential treatment for type 1 diabetes (512).”
From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [512]
The “Stem Cells and Reprograming Strategies” section describes efforts to generate pancreatic beta cells to treat type 1 diabetes and a planned clinical evaluation of stem-cell-derived islet replacement therapy. It does not specify that the pancreatic beta cells were derived from both ESCs and iPSCs; its discussion of cells derived from those sources concerns adrenal cells instead. No page number is available in our copy. (LLM, conf=0.85)
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Acar, Ö. K., Nozhatzadeh, G. D., Kurtoglu, N., & Ayşan, E. (2023) · Springer eBooks · doi:10.1007/978-981-99-0846-2_20-1 · Cited by 1 · see citing works
Ruiz‐Babot, G., Balyura, M., Hadjidemetriou, I., Ajodha, S. J., Taylor, D. R., Ghataore, L., Taylor, N., Schubert, U., Ziegler, C. G., Storr, H. L., et al. (2018) · Yearbook of pediatric endocrinology · doi:10.1530/ey.15.8.14 · Cited by 1 · see citing works
Self-citationNew Horizons: Novel adrenal regenerative therapies
Bornstein, S. R., Malyukov, M., Heller, C., Ziegler, C. G., Ruiz‐Babot, G., Schedl, A., Ludwig, B., & Steenblock, C. (2021) · Yearbook of pediatric endocrinology · doi:10.1530/ey.18.8.11 · Cited by 1 · see citing works
Self-citationHornsby, P. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00010-5 · Cited by 1 · see citing works
Зелінська, Н. Б. (2019) · The Scientific Issues of Ternopil Volodymyr Hnatiuk National Pedagogical University Series pedagogy
The Power of Your Adrenal Glands to Help You Cope With Stress
Ruiz‐Babot, G., & Becerra, M. V. (2022) · Frontiers for Young Minds · doi:10.3389/frym.2022.683150
Self-citationAdrenal gland transplantation in clinical conditions
Rybakov, S. Y. (2022) · Clinical endocrinology and endocrine surgery · doi:10.30978/cees-2022-3-87
Steroids – Good, Bad, and Ugly
Mittal, R., & Kalra, S. (2023) · Bangladesh Journal of Endocrinology and Metabolism · doi:10.4103/bjem.bjem_20_23
Adrenal Multidisipliner Güncel Yaklaşım
Özen, F. Z., Özer, M., Özsoy, Ç., Binnetoğlu, E., Alparslan, A. Ş., Budak, E. S., Kök, E. V., Çetinkaya, G. S., Durmuş, M. E., Köker, G., et al. (2024) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.2992
Acar, Ö. K., Nozhatzadeh, G. D., Kurtoglu, N., & Ayşan, E. (2024) · Springer eBooks · doi:10.1007/978-981-99-7119-0_20
Seeliger, B. (2019) · theses.fr (ABES) · doi:10.70675/4e77927fzf930z4451z9deazf89581812487
- Authors
- Ruiz-Babot, G., Hadjidemetriou, I., King, P. J., & Guasti, L.
- Affiliations
- Queen Mary University of London (GB)
- Corresponding author
- Guasti, Leonardo
- ORCID
- Guasti, Leonardo
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2015-05-06
- Volume
- 6
- Pages
- 70-70
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC4422080
- OpenAlex
- W1533729004
- Cited by
- 37
- References
- 74
- Citations by year
- 2024: 2 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 2
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by)
- Funders
- Rosetrees Trust
- Directorate for Biological Sciences
- Medical Research Council (G0802796, 608765)
- Biotechnology and Biological Sciences Research Council (BB/L00267/1, BB/L002671/1)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- adrenal insufficiency, regenerative medicine, cell therapy, hypothalamic-pituitary-adrenal axis, corticosteroid replacement, stress response, adrenal disorders
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