Minireview: steroidogenic factor 1: its roles in differentiation, development, and disease

Schimmer, Bernard P.; White, Perrin C.

doi:10.1210/me.2009-0519

Cited by 269Adrenal Hormones and DisordersSexual Differentiation and DisordersEstrogen and related hormone effects

Minireview: steroidogenic factor 1: its roles in differentiation, development, and disease

Open access

Schimmer, Bernard P., White, Perrin C.·2010·Molecular Endocrinology

DOI 10.1210/me.2009-0519PMC PMC5417463

Open this paper in CoChat — free account Open PDF

Abstract

The orphan nuclear receptor steroidogenic factor 1 (SF-1, also called Ad4BP, encoded by the NR5A1 gene) is an essential regulator of endocrine development and function. Initially identified as a tissue-specific transcriptional regulator of cytochrome P450 steroid hydroxylases, studies of both global and tissue-specific knockout mice have demonstrated that SF-1 is required for the development of the adrenal glands, gonads, and ventromedial hypothalamus and for the proper functioning of pituitary gonadotropes. Many genes are transcriptionally regulated by SF-1, and many proteins, in turn, interact with SF-1 and modulate its activity. Whereas mice with heterozygous mutations that disrupt SF-1 function have only subtle abnormalities, humans with heterozygous SF-1 mutations can present with XY sex reversal (i.e. testicular failure), ovarian failure, and occasionally adrenal insufficiency; dysregulation of SF-1 has been linked to diseases such as endometriosis and adrenocortical carcinoma. The current state of knowledge of this important transcription factor will be reviewed with a particular emphasis on the pioneering work on SF-1 by the late Keith Parker.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/me.2009-0519

Cites

177 of 177 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

When the gene conversion extends to the P30L missense mutation, it becomes a simple virilizing (Group B) allele.
“When the gene conversion extends to the P30L missense mutation (which is usually a Group C, i.e. nonclassic allele; see section III.D), it becomes a simple virilizing (Group B) allele (180).”
From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [180]
The “Mutations of SF-1” section discusses mutations in NR5A1 and their adrenal and gonadal effects, but does not address a P30L gene conversion or Group B and Group C alleles. Searches for P30L, gene conversion, and simple virilizing alleles found no passage supporting the attributed claim. (LLM, conf=0.76)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Orphan Nuclear Receptor Nur77 Induces Zinc Finger Protein GIOT-1 Gene Expression, and GIOT-1 Acts as a Novel Corepressor of Orphan Nuclear Receptor SF-1 via Recruitment of HDAC2
Song, K., Park, Y., Kee, H. J., Hong, C. Y., Lee, Y., Ahn, S.-W., Kim, H.-J., Lee, K., Kook, H., Lee, I., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m505937200 · Cited by 22 · see citing works
Retracted
A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation
Luo, X., Ikeda, Y., & Parker, K. L. (1994) · Cell · doi:10.1016/0092-8674(94)90211-9 · Cited by 1,631 · see citing works
Proximal events in Wnt signal transduction
Angers, S., & Moon, R. T. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2717 · Cited by 1,106 · see citing works
Steroidogenic factor 1: a key determinant of endocrine development and function
Parker, K. L., & Schimmer, B. P. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0301 · Cited by 764 · see citing works
A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans
Achermann, J. C., Ito, M., Ito, M., Hindmarsh, P. C., & Jameson, J. L. (1999) · Nature Genetics · doi:10.1038/9629 · Cited by 709 · see citing works
Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I
Lala, D. S. (1992) · Molecular Endocrinology · doi:10.1210/me.6.8.1249 · Cited by 678 · see citing works
Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases
Ikeda, Y., Shen, W. H., Ingraham, H. A., & Parker, K. L. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.5.8058073 · Cited by 628 · see citing works
Direct Interaction of SRY-Related Protein SOX9 and Steroidogenic Factor 1 Regulates Transcription of the Human Anti-Müllerian Hormone Gene
Barbara, P. D. S., Bonneaud, N., Boizet‐Bonhoure, B., Desclozeaux, M., Moniot, B., Südbeck, P., Scherer, G., Poulat, F., & Berta, P. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6653 · Cited by 605 · see citing works
Wilms’ tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression.
Nachtigal, M. W., Hirokawa, Y., Enyeart-VanHouten, D. L., Flanagan, J. N., Hammer, G. D., & Ingraham, H. A. (1998) · Cell · doi:10.1016/s0092-8674(00)81172-1 · Cited by 591 · see citing works
The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis.Preprint
Ingraham, H. A., Lala, D. S., Ikeda, Y., Luo, X., Shen, W. H., Nachtigal, M. W., Abbud-Antaki, R., Nilson, J. H., & Parker, K. L. (1994) · Genes & Development · doi:10.1101/gad.8.19.2302 · Cited by 588 · see citing works
Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesisPreprint
Yao, H. H., Whoriskey, W. J., & Capel, B. (2002) · Genes & Development · doi:10.1101/gad.981202 · Cited by 541 · see citing works
Foxl2 Up-Regulates Aromatase Gene Transcription in a Female-Specific Manner by Binding to the Promoter as Well as Interacting with Ad4 Binding Protein/Steroidogenic Factor 1
Wang, D.-S., Kobayashi, T., Zhou, L.-Y., Paul‐Prasanth, B., Ijiri, S., Sakai, F., Okubo, K., Morohashi, K.-I., & Nagahama, Y. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0248 · Cited by 507 · see citing works
The medial hypothalamic defensive system: Hodological organization and functional implications
Canteras, N. S. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00685-2 · Cited by 463 · see citing works
Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids.
Sadovsky, Y., Crawford, P. A., Woodson, K. G., Polish, J. A., Clements, M. A., Tourtellotte, L. M., Simburger, K. S., & Milbrandt, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.10939 · Cited by 460 · see citing works
DAX-1 Inhibits SF-1-Mediated Transactivation via a Carboxy-Terminal Domain That Is Deleted in Adrenal Hypoplasia Congenita
Ito, M., Yu, R. N., & Jameson, J. L. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1476 · Cited by 452 · see citing works
Targeted Mutagenesis of the Endogenous Mouse Mis Gene Promoter
Arango, N. A., Lovell-Badge, R. H., & Behringer, R. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81527-5 · Cited by 449 · see citing works
The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus
Ikeda, Y., Luo, X., Abbud-Antaki, R., Nilson, J. H., & Parker, K. L. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.4.7659091 · Cited by 429 · see citing works
The hedgehog signaling network
Cohen, M. M. (2003) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.20495 · Cited by 418 · see citing works
Structural Analyses Reveal Phosphatidyl Inositols as Ligands for the NR5 Orphan Receptors SF-1 and LRH-1
Krylova, I. N., Sablin, E. P., Moore, J. M. R., Xu, R. X., Waitt, G. M., MacKay, J. A., JUZUMIENE, D. I., Bynum, J. M., Madauss, K. P., Montana, V. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.01.024 · Cited by 405 · see citing works
Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily.
Honda, S., Morohashi, K.-I., Nomura, M., Takeya, H., Kitajima, M., & Omura, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53202-6 · Cited by 403 · see citing works
Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression
Ikeda, Y., Lala, D. S., Luo, X., Kim, E., Moisan, M., & Parker, K. L. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.7.8413309 · Cited by 400 · see citing works
The Orphan Receptors NGFI-B and Steroidogenic Factor 1 Establish Monomer Binding as a Third Paradigm of Nuclear Receptor-DNA Interaction
Wilson, T. E., Fahrner, T. J., & Milbrandt, J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5794 · Cited by 399 · see citing works
Mutations in NR5A1 Associated with Ovarian Insufficiency
Lourenço, D., Brauner, R., Lin, L., Perdigo, A. D., Weryha, G., Mureşan, M., Boudjenah, R., Guerra‐Júnior, G., Maciel‐Guerra, A. T., Achermann, J. C., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0806228 · Cited by 394 · see citing works
Phosphorylation of the Nuclear Receptor SF-1 Modulates Cofactor Recruitment
Hammer, G. D., Krylova, I., Zhang, Y., Darimont, B. D., Simpson, K., Weigel, N. L., & Ingraham, H. A. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80480-3 · Cited by 375 · see citing works
Developmental defects of the ventromedial hypothalamic nucleus and pituitary gonadotroph in the Ftz‐F1 disrupted mice
Shinoda, K., Lei, H., Yoshii, H., Nomura, M., Nagano, M., Shiba, H., Sasaki, H., Osawa, Y., Ninomiya, Y., Niwa, O., et al. (1995) · Developmental Dynamics · doi:10.1002/aja.1002040104 · Cited by 357 · see citing works
Nuclear Receptor DAX-1 Recruits Nuclear Receptor Corepressor N-CoR to Steroidogenic Factor 1
Crawford, P. A., Dorn, C., Sadovsky, Y., & Milbrandt, J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2949 · Cited by 332 · see citing works
Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development
Ikeda, Y., Swain, A., Weber, T. J., Hentges, K. E., Zanaria, E., Lalli, E., Tamai, T. K., Sassone‐Corsi, P., Lovell-Badge, R. H., Camerino, G., et al. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.10.9121493 · Cited by 318 · see citing works
Gonadal determination and adrenal development are regulated by the orphan nuclear receptor steroidogenic factor-1, in a dose-dependent manner
Achermann, J. C., Ozisik, G., Ito, M., Orun, U. A., Harmanci, K., Gurakan, B., & Jameson, J. L. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8376 · Cited by 305 · see citing works
Genetics and epigenetics: stability and plasticity during cellular differentiation
Mohn, F., & Schübeler, D. (2009) · Trends in Genetics · doi:10.1016/j.tig.2008.12.005 · Cited by 299 · see citing works
Ovaries and Female Phenotype in a Girl with 46,XY Karyotype and Mutations in the CBX2 Gene
Biason‐Lauber, A., Konrad, D., Meyer‐Böni, M., de Beaufort, C. E., & Schoenle, E. J. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.03.016 · Cited by 296 · see citing works
The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1Preprint
Wilhelm, D., & Englert, C. (2002) · Genes & Development · doi:10.1101/gad.220102 · Cited by 280 · see citing works
Cell-Specific Knockout of Steroidogenic Factor 1 Reveals Its Essential Roles in Gonadal Function
Jeyasuria, P., Ikeda, Y., Jamin, S. P., Zhao, L., de Rooij, D. G., Themmen, A. P. N., Behringer, R. R., & Parker, K. L. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0404 · Cited by 276 · see citing works
Egr-1 Is a Downstream Effector of GnRH and Synergizes by Direct Interaction with Ptx1 and SF-1 To Enhance Luteinizing Hormone β Gene Transcription
Tremblay, J. J., & Drouin, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2567 · Cited by 272 · see citing works
The orphan nuclear receptor, steroidogenic factor-1, regulates the glycoprotein hormone alpha-subunit gene in pituitary gonadotropes.
Barnhart, K. M., & Mellon, P. L. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.7.7527122 · Cited by 241 · see citing works
GATA Factors Differentially Activate Multiple Gonadal Promoters through Conserved GATA Regulatory Elements
Tremblay, J., & Viger, R. S. (2001) · Endocrinology · doi:10.1210/endo.142.3.7995 · Cited by 240 · see citing works
Apparently normal ovarian differentiation in a prepubertal girl with transcriptionally inactive steroidogenic factor 1 (NR5A1/SF-1) and adrenocortical insufficiency
Biason-Lauber, A., & Schoenle, E. J. (2000) · The American Journal of Human Genetics · doi:10.1086/316893 · Cited by 240 · see citing works
Transcription Factor GATA-4 Enhances Mullerian Inhibiting Substance Gene Transcription through a Direct Interaction with the Nuclear Receptor SF-1
Tremblay, J., & Viger, R. S. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.8.0330 · Cited by 239 · see citing works
Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function
Zhao, L., Bakke, M., Krimkevich, Y., Cushman, L. J., Parlow, A. F., Camper, S. A., & Parker, K. L. (2001) · Development · doi:10.1242/dev.128.2.147 · Cited by 230 · see citing works
Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5′ CpG island in endometriosis
Xue, Q., Lin, Z., Yin, P., Milad, M. P., Cheng, Y.-H., Confino, E., Reierstad, S., & Bulun, S. E. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0494 · Cited by 219 · see citing works
Crystallographic Identification and Functional Characterization of Phospholipids as Ligands for the Orphan Nuclear Receptor Steroidogenic Factor-1
Li, Y., Choi, M., Cavey, G. S., Daugherty, J., Suino, K., Kovach, A., Bingham, N. C., Kliewer, S. A., & Xu, H. E. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.002 · Cited by 205 · see citing works
Targeted disruption of β-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex
Kim, A. C., Reuter, A. L., Zubair, M., Else, T., Serecky, K., Bingham, N. C., Lavery, G. G., Parker, K. L., & Hammer, G. D. (2008) · Development · doi:10.1242/dev.021493 · Cited by 202 · see citing works
The nuclear receptor SF-1 mediates sexually dimorphic expression of Müllerian Inhibiting Substance, in vivo
Giuili, G., Shen, W.-H., & Ingraham, H. A. (1997) · Development · doi:10.1242/dev.124.9.1799 · Cited by 198 · see citing works
Expression profiles of SF-1, DAX1, and CYP17 in the human fetal adrenal gland: potential interactions in gene regulation.
Hanley, N. A., Rainey, W. E., Wilson, D. I., Ball, S. G., & Parker, K. L. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.1.0585 · Cited by 193 · see citing works
Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/β-catenin synergy
Jordan, B. K., Shen, J. H.-C., Olaso, R., Ingraham, H. A., & Vilain, E. J. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834480100 · Cited by 192 · see citing works
Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols
Lala, D. S., Syka, P. M., Lazarchik, S. B., Mangelsdorf, D. J., Parker, K. L., & Heyman, R. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.4895 · Cited by 189 · see citing works
Steroidogenic Factor 1: A Key Determinant of Endocrine Development and Function
Parker, K. L. (1997) · Endocrine Reviews · doi:10.1210/er.18.3.361 · Cited by 185 · see citing works
Follicle-stimulating hormone/cAMP regulation of aromatase gene expression requires β-catenin
Boyle, T. P., Hernandez, J. A., Grammer, J. C., Weck, J., Hunzicker-Dunn, M. E., Zeleznik, A. J., & Nilson, J. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603006103 · Cited by 184 · see citing works
SUMO association with repressor complexes, emerging routes for transcriptional control.
García-Domínguez, M., & Reyes, J. (2009) · Biochimica et Biophysica Acta · doi:10.1016/j.bbagrm.2009.07.001 · Cited by 180 · see citing works
Expression of steroidogenic factor 1 and Wilms' tumour 1 during early human gonadal development and sex determination
Hanley, N. A., Ball, S. G., Clement-Jones, M., Hagan, D., Strachan, T., Lindsay, S., Robson, S. C., D, H. O. M., Parker, K. L., & Wilson, D. I. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00123-9 · Cited by 178 · see citing works
Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response
Bland, M. L., Jamieson, C., Akana, S. F., Bornstein, S. R., Eisenhofer, G., Dallman, M. F., & Ingraham, H. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.26.14488 · Cited by 177 · see citing works
The orphan nuclear receptor steroidogenic factor-1 regulates the cyclic adenosine 3',5'-monophosphate-mediated transcriptional activation of rat cytochrome P450c17 (17 alpha-hydroxylase/c17-20 lyase).
Zhang, P., & Mellon, S. H. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.2.8825555 · Cited by 176 · see citing works
Stimulation of Luteinizing Hormone β Gene Promoter Activity by the Orphan Nuclear Receptor, Steroidogenic Factor-1
Halvorson, L. M., Kaiser, U. B., & Chin, W. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.12.6645 · Cited by 171 · see citing works
SOX8 Is Expressed during Testis Differentiation in Mice and Synergizes with SF1 to Activate the Amh Promoter in Vitro
Schepers, G., Wilson, M. J., Wilhelm, D., & Koopman, P. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304067200 · Cited by 169 · see citing works
Functional difference between Ad4BP and ELP, and their distributions in steroidogenic tissues
Morohashi, K.-I., Iida, H., Nomura, M., Hatano, O., Honda, S., Tsukiyama, T., Niwa, O., Hara, T., Takakusu, A., & Shibata, Y. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.5.8058072 · Cited by 168 · see citing works
Five novel mutations in steroidogenic factor 1 (SF1,NR5A1) in 46,XY patients with severe underandrogenization but without adrenal insufficiency
Köhler, B., Lin, L., Ferraz‐de‐Souza, B., Wieacker, P. F., Heidemann, P. H., Schröder, V., Biebermann, H., Schnabel, D., Grüters, A., & Achermann, J. C. (2007) · Human Mutation · doi:10.1002/humu.20588 · Cited by 160 · see citing works
Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation
Lin, B. C., Suzawa, M., Blind, R. D., Tobias, S. C., Bulun, S. E., Scanlan, T. S., & Ingraham, H. A. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-1622 · Cited by 157 · see citing works
Steroidogenic Factor 1 (SF-1) and SP1 Are Required for Regulation of Bovine CYP11A Gene Expression in Bovine Luteal Cells and Adrenal Y1 Cells
Liu, Z., & Simpson, E. R. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.2.9890 · Cited by 156 · see citing works
The Neonatal Ventromedial Hypothalamus Transcriptome Reveals Novel Markers with Spatially Distinct Patterning
Kurrasch, D. M., Cheung, C. C., Lee, F. Y., Tran, P. V., Hata, K., & Ingraham, H. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2858-07.2007 · Cited by 154 · see citing works
A Steroidogenic Factor-1 Binding Site Is Required for Activity of the Luteinizing Hormone β Subunit Promoter in Gonadotropes of Transgenic Mice
Keri, R. A., & Nilson, J. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10782 · Cited by 153 · see citing works
LXXLL-Related Motifs in Dax-1 Have Target Specificity for the Orphan Nuclear Receptors Ad4BP/SF-1 and LRH-1
Suzuki, T., Kasahara, M., Yoshioka, H., Morohashi, K.-I., & Umesono, K. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.238-249.2003 · Cited by 153 · see citing works
Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function
Hinshelwood, M. M., Repa, J. J., Shelton, J. M., Richardson, J. A., Mangelsdorf, D. J., & Mendelson, C. R. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(03)00257-0 · Cited by 148 · see citing works
Regulation of the human P450scc gene by steroidogenic factor 1 is mediated by CBP/p300
Monté, D., DeWitte, F., & Hum, D. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.8.4585 · Cited by 147 · see citing works
Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1
Bassett, M., Zhang, Y., Clyne, C., White, P., & Rainey, W. (2002) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0280125 · Cited by 146 · see citing works
The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1
Wang, W., Zhang, C., Marimuthu, A., Krupka, H. I., Tabrizizad, M., Shellooe, R., Mehra, U., Eng, K., Nguyen, H. T., Settachatgul, C., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409482102 · Cited by 145 · see citing works
Minireview: Transcriptional Regulation of Adrenocortical Development
Hammer, G. D., Parker, K. L., & Schimmer, B. P. (2004) · Endocrinology · doi:10.1210/en.2004-1385 · Cited by 143 · see citing works
Dax-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1) Gene Transcription Is Regulated by Wnt4 in the Female Developing Gonad
Mizusaki, H., Kawabe, K., Mukai, T., Ariyoshi, E., Kasahara, M., Yoshioka, H., Swain, A., & Morohashi, K.-I. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0362 · Cited by 140 · see citing works
Steroidogenic Factor-1 Contains a Carboxy-Terminal Transcriptional Activation Domain That Interacts with Steroid Receptor Coactivator-1
Ito, M., Yu, R. N., & Jameson, J. L. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.2.0059 · Cited by 137 · see citing works
Amplification of the Steroidogenic Factor 1 Gene in Childhood Adrenocortical Tumors
de Figueiredo, B. C., Cavalli, L. R., Pianovski, M. A. D., Lalli, E., Sandrini, R., Ribeiro, R. C., Zambetti, G. P., DeLacerda, L., Rodrigues, G. A., & Haddad, B. R. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0942 · Cited by 135 · see citing works
Ptx1 regulates SF‐1 activity by an interaction that mimics the role of the ligand‐binding domain
Tremblay, J., Marcil, A., Gauthier, Y., & Drouin, J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.12.3431 · Cited by 135 · see citing works
Two-Step Regulation of Ad4BP/SF-1 Gene Transcription during Fetal Adrenal Development: Initiation by a Hox-Pbx1-Prep1 Complex and Maintenance via Autoregulation by Ad4BP/SF-1
Zubair, M., Ishihara, S., Oka, S., Okumura, K., & Morohashi, K.-I. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00222-06 · Cited by 135 · see citing works
Nuclear receptor steroidogenic factor 1 directs embryonic stem cells toward the steroidogenic lineage
Crawford, P. A., Sadovsky, Y., & Milbrandt, J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.7.3997 · Cited by 134 · see citing works
Steroidogenic factor‐1 expression in marmoset and rat hippocampus: co‐localization with StAR and aromatase
Wehrenberg, U., Prange‐Kiel, J., & Rune, G. M. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00207.x · Cited by 128 · see citing works
Transcriptional Activation of Human CYP17 in H295R Adrenocortical Cells Depends on Complex Formation among p54<sup>nrb</sup>/NonO, Protein-Associated Splicing Factor, and SF-1, a Complex That Also Participates in Repression of Transcription
Sewer, M. B., Nguyen, V. Q., Huang, C.-J., Tucker, P. W., Kagawa, N., & Waterman, M. R. (2002) · Endocrinology · doi:10.1210/endo.143.4.8748 · Cited by 123 · see citing works
An E Box Element Is Required for the Expression of the ad4bp Gene, a Mammalian Homologue of ftz-f1 Gene, Which Is Essential for Adrenal and Gonadal Development
Nomura, M., Bärtsch, S., Nawata, H., Omura, T., & Morohashi, K.-I. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7453 · Cited by 119 · see citing works
Impaired Follicle Development and Infertility in Female Mice Lacking Steroidogenic Factor 1 in Ovarian Granulosa Cells1
Pelusi, C., Ikeda, Y., Zubair, M., & Parker, K. L. (2008) · Biology of Reproduction · doi:10.1095/biolreprod.108.069435 · Cited by 119 · see citing works
Synergistic Activation of the Inhibin α-Promoter by Steroidogenic Factor-1 and Cyclic Adenosine 3′,5′-Monophosphate
Ito, M., Park, Y., Weck, J., Mayo, K. E., & Jameson, J. L. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.1.0410 · Cited by 119 · see citing works
The DEAD-Box Protein DP103 (Ddx20 or Gemin-3) Represses Orphan Nuclear Receptor Activity via SUMO Modification
Lee, M. B. H., Lebedeva, L. A., Suzawa, M., Wadekar, S. A., Desclozeaux, M., & Ingraham, H. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1879-1890.2005 · Cited by 118 · see citing works
Activation of the Hedgehog pathway in the mouse fetal ovary leads to ectopic appearance of fetal Leydig cells and female pseudohermaphroditism
Barsoum, I. B., Bingham, N. C., Parker, K. L., Jorgensen, J. S., & Yao, H. H. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.02.025 · Cited by 117 · see citing works
Dax-1 and Steroid Receptor RNA Activator (SRA) Function as Transcriptional Coactivators for Steroidogenic Factor 1 in Steroidogenesis
Xu, B., Yang, W., Gerin, I., Hu, C., Hammer, G. D., & Koenig, R. J. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01010-08 · Cited by 117 · see citing works
Reciprocal Regulation of a Glucocorticoid Receptor-Steroidogenic Factor-1 Transcription Complex on the Dax-1 Promoter by Glucocorticoids and Adrenocorticotropic Hormone in the Adrenal Cortex
Gummow, B. M., Scheys, J. O., Cancelli, V. R., & Hammer, G. D. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0461 · Cited by 114 · see citing works
Developmental Links between the Fetal and Adult Zones of the Adrenal Cortex Revealed by Lineage Tracing
Zubair, M., Parker, K. L., & Morohashi, K.-I. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00900-08 · Cited by 113 · see citing works
Small Ubiquitin-Like Modifier 1 (SUMO-1) Modification of the Synergy Control Motif of Ad4 Binding Protein/Steroidogenic Factor 1 (Ad4BP/SF-1) Regulates Synergistic Transcription between Ad4BP/SF-1 and Sox9
Komatsu, T., Mizusaki, H., Mukai, T., Ogawa, H., Baba, D., Shirakawa, M., Hatakeyama, S., Nakayama, K. I., Yamamoto, H., Kikuchi, A., et al. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0173 · Cited by 111 · see citing works
Steroidogenic Factor 1 Messenger Ribonucleic Acid Expression in Steroidogenic and Nonsteroidogenic Human Tissues: Northern Blot and in Situ Hybridization Studies
Ramayya, M. S., Zhou, J., Kino, T., Segars, J. H., Bondy, C. A., & Chrousos, G. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.3967 · Cited by 110 · see citing works
Phosphorylation and Intramolecular Stabilization of the Ligand Binding Domain in the Nuclear Receptor Steroidogenic Factor 1
Desclozeaux, M., Krylova, I. N., Horn, F., Fletterick, R. J., & Ingraham, H. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.20.7193-7203.2002 · Cited by 109 · see citing works
SUMO modification of repression domains modulates function of nuclear receptor 5A1 (steroidogenic factor-1)
Chen, W.-Y., Lee, W.-C., Hsu, N.-C., Huang, F., & Chung, B.-C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405006200 · Cited by 104 · see citing works
A Binding Site for Steroidogenic Factor-1 is Part of a Complex Enhancer that Mediates Expression of the Murine Gonadotropin-Releasing Hormone Receptor Gene1
Duval, D. L., Nelson, S. E., & Clay, C. M. (1997) · Biology of Reproduction · doi:10.1095/biolreprod56.1.160 · Cited by 102 · see citing works
SF-1 overexpression in childhood adrenocortical tumours
Pianovski, M. A. D., Cavalli, L. R., de Figueiredo, B. C., Santos, S. C. L., Doghman, M., Ribeiro, R. C., Oliveira, A. G., Michalkiewicz, E., Rodrigues, G. A., Zambetti, G. P., et al. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.01.022 · Cited by 101 · see citing works
The Activation Function-2 Hexamer of Steroidogenic Factor-1 Is Required, but Not Sufficient for Potentiation by SRC-1
Crawford, P. A., Polish, J. A., Ganpule, G., & Sadovsky, Y. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.11.9970 · Cited by 99 · see citing works
The Role of Human MBF1 as a Transcriptional Coactivator
Kabe, Y., Goto, M., Shima, D., Imai, T., Wada, T., Morohashi, K.-I., Shirakawa, M., Hirose, S., & Handa, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.34196 · Cited by 97 · see citing works
Convergence of Wnt Signaling and Steroidogenic Factor-1 (SF-1) on Transcription of the Rat Inhibin α Gene
Gummow, B. M., Winnay, J. N., & Hammer, G. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212677200 · Cited by 96 · see citing works
Mouse Polycomb M33 is required for splenic vascular and adrenal gland formation through regulating Ad4BP/SF1 expression
Fukui, Y., Owaki, A., Toyama, Y., Kusaka, M., Shinohara, Y., Maekawa, M., Toshimori, K., & Morohashi, K.-I. (2005) · Blood · doi:10.1182/blood-2004-08-3367 · Cited by 94 · see citing works
Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1
Urs, A. N., Dammer, E., & Sewer, M. B. (2006) · Endocrinology · doi:10.1210/en.2006-0355 · Cited by 94 · see citing works
Transcription of the Leydig Insulin-Like Gene Is Mediated by Steroidogenic Factor-1
Zimmermann, S., Schwärzler, A., Buth, S., Engel, W., & Adham, I. M. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.5.0107 · Cited by 94 · see citing works
Identification of Small Molecule Agonists of the Orphan Nuclear Receptors Liver Receptor Homolog-1 and Steroidogenic Factor-1
Whitby, R. J., Dixon, S., Maloney, P., Delerive, P., Goodwin, B. J., Parks, D. J., & Willson, T. M. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060990k · Cited by 92 · see citing works
Regulation of the Orphan Nuclear Receptor Steroidogenic Factor 1 by Sox Proteins
Shen, J. H.-C., & Ingraham, H. A. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.3.0782 · Cited by 92 · see citing works
Structural and functional abnormalities in the spleen of an mFtz-F1 gene-disrupted mouse.
Morohashi, K. I., Tsuboi-Asai, H., Matsushita, S., Suda, M., Nakashima, M., Sasano, H., Hataba, Y., Li, C. L., Fukata, J., Irie, J., et al. (1999) · PubMed · doi:10.1182/blood.v93.5.1586 · Cited by 91 · see citing works
Steroidogenic Factor-1 Interacts with a Gonadotrope-Specific Element within the First Exon of the Human Gonadotropin-Releasing Hormone Receptor Gene to Mediate Gonadotrope-Specific Expression
Ngan, E., Cheng, P. K. W., Leung, P. C. K., & Chow, B. (1999) · Endocrinology · doi:10.1210/endo.140.6.6759 · Cited by 91 · see citing works
Hormonal Regulation of Messenger Ribonucleic Acid Expression for Steroidogenic Factor-1, Steroidogenic Acute Regulatory Protein, and Cytochrome P450 Side-Chain Cleavage in Bovine Luteal Cells
Mamluk, R., Greber, Y., & Meidan, R. (1999) · Biology of Reproduction · doi:10.1095/biolreprod60.3.628 · Cited by 91 · see citing works
Acetylation of Steroidogenic Factor 1 Protein Regulates Its Transcriptional Activity and Recruits the Coactivator GCN5
Jacob, A. L. J., Lund, J., Martı́nez, P., & Hedin, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104427200 · Cited by 90 · see citing works
Function of Steroidogenic Factor 1 Domains in Nuclear Localization, Transactivation, and Interaction with Transcription Factor TFIIB and c-Jun
Li, L., Chiang, E. F.-L., Chen, J., Hsu, N.-C., Chen, Y.-J., & Chung, B. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.9.0349 · Cited by 86 · see citing works
Structure of SF-1 Bound by Different Phospholipids: Evidence for Regulatory Ligands
Sablin, E. P., Blind, R. D., Krylova, I. N., Ingraham, J. G., Cai, F., Williams, J. D., Fletterick, R. J., & Ingraham, H. A. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0508 · Cited by 86 · see citing works
The Role of the Orphan Nuclear Receptor, Liver Receptor Homologue-1, in the Regulation of Human Corpus Luteum 3β-Hydroxysteroid Dehydrogenase Type II
Peng, N., Kim, J. W., Rainey, W. E., Carr, B. R., & Attia, G. R. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030880 · Cited by 85 · see citing works
Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF‐1 gene dosage
Tran, P. V., Akana, S. F., Malkovska, I., Dallman, M. F., Parada, L. F., & Ingraham, H. A. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21070 · Cited by 81 · see citing works
Central Nervous System-Specific Knockout of Steroidogenic Factor 1 Results in Increased Anxiety-Like Behavior
Zhao, L., Kim, K. W., Ikeda, Y., Anderson, K. K., Beck, L., Chase, S., Tobet, S. A., & Parker, K. L. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0034 · Cited by 80 · see citing works
Steroidogenic factor-1 and endometriosis
Bulun, S. E., Utsunomiya, H., Lin, Z., Yin, P., Cheng, Y.-H., Pavone, M. E., Tokunaga, H., Trukhacheva, E., Attar, E., Gurates, B., et al. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.12.012 · Cited by 80 · see citing works
Developmental and Hormonal Regulation of Murine Scavenger Receptor, Class B, Type 1
Cao, G., Zhao, L., Stangl, H., Hasegawa, T., Richardson, J. A., Parker, K. L., & Hobbs, H. H. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.9.0346 · Cited by 80 · see citing works
The DEAD Box Protein DP103 Is a Regulator of Steroidogenic Factor-1
Ou, Q., Mouillet, J., Yan, X., Dorn, C., Crawford, P. A., & Sadovsky, Y. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.1.0580 · Cited by 78 · see citing works
PNRC: A Proline-Rich Nuclear Receptor Coregulatory Protein That Modulates Transcriptional Activation of Multiple Nuclear Receptors Including Orphan Receptors SF1 (Steroidogenic Factor 1) and ERR 1 (Estrogen Related Receptor -1)
Zhou, D., Quach, K. M., Yang, C., Lee, S. Y., Pohajdak, B., & Chen, S. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.7.0480 · Cited by 78 · see citing works
SF-1 (Nuclear Receptor 5A1) Activity Is Activated by Cyclic AMP via p300-Mediated Recruitment to Active Foci, Acetylation, and Increased DNA Binding
Chen, W., Juan, L., & Chung, B. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.23.10442-10453.2005 · Cited by 78 · see citing works
Gonadal and extragonadal functions of Ad4BP/SF-1: developmental aspects
Morohashi, K.-I. (1999) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(98)00142-8 · Cited by 77 · see citing works
Expression of murine 21-hydroxylase in mouse adrenal glands and in transfected Y1 adrenocortical tumor cells
Parker, K. L., Chaplin, D. D., Wong, M., Seidman, J. G., Smith, J. A., & Schimmer, B. P. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.23.7860 · Cited by 76 · see citing works
Adipose Tissue-Derived and Bone Marrow-Derived Mesenchymal Cells Develop into Different Lineage of Steroidogenic Cells by Forced Expression of Steroidogenic Factor 1
Gondo, S., Okabe, T., Tanaka, T., Morinaga, H., Nomura, M., Takayanagi, R., Nawata, H., & Yanase, T. (2008) · Endocrinology · doi:10.1210/en.2007-1808 · Cited by 75 · see citing works
Adrenocorticotropic Hormone-Mediated Signaling Cascades Coordinate a Cyclic Pattern of Steroidogenic Factor 1-Dependent Transcriptional Activation
Winnay, J. N., & Hammer, G. D. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0215 · Cited by 74 · see citing works
AR Suppresses Transcription of the LH Subunit by Interacting with Steroidogenic Factor-1
Jorgensen, J. S., & Nilson, J. H. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.9.0691 · Cited by 74 · see citing works
Oxysterol Regulation of Steroidogenic Acute Regulatory Protein Gene Expression
Christenson, L. K., McAllister, J. M., MARTIN, K. O., Javitt, N. B., Osborne, T. F., & Strauss, J. F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30729 · Cited by 74 · see citing works
25-Hydroxycholesterol Is Not a Ligand for the Orphan Nuclear Receptor Steroidogenic Factor-1 (SF-1)
Mellon, S. H., & Bair, S. R. (1998) · Endocrinology · doi:10.1210/endo.139.6.6129 · Cited by 74 · see citing works
Characterization of the Promoter of SF-1, an Orphan Nuclear Receptor Required for Adrenal and Gonadal Development
Woodson, K. G., Crawford, P. A., Sadovsky, Y., & Milbrandt, J. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.2.9881 · Cited by 73 · see citing works
Molecular mechanism for cooperation between Sp1 and steroidogenic factor-1 (SF-1) to regulate bovine CYP11A gene expression
Liu, Z., & R. Simpson, E. (1999) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(99)00036-2 · Cited by 71 · see citing works
Expression of MIS in the Testis Is Downregulated by Tumor Necrosis Factor Alpha through the Negative Regulation of SF-1 Transactivation by NF-κB
Hong, C. Y., Park, J. H., Seo, K. H., Kim, J., Im, S., Lee, J. W., Choi, H., & Lee, K. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.17.6000-6012.2003 · Cited by 70 · see citing works
Sequence-Specific Deoxyribonucleic Acid (DNA) Recognition by Steroidogenic Factor 1: A Helix at the Carboxy Terminus of the DNA Binding Domain Is Necessary for Complex Stability
Little, T. H., Zhang, Y., Matulis, C. K., Weck, J., Zhang, Z., Ramachandran, A., Mayo, K. E., & Radhakrishnan, I. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0384 · Cited by 68 · see citing works
Adrenocorticotropin-Dependent Changes in SF-1/DAX-1 Ratio Influence Steroidogenic Genes Expression in a Novel Model of Glucocorticoid-Producing Adrenocortical Cell Lines Derived from Targeted Tumorigenesis
Ragazzon, B., Lefrançois-Martinez, A.-M., Val, P., Sahut-Barnola, I., Tournaire, C., Chambon, C., Gachancard-Bouya, J.-L., Begue, R.-J., Veyssière, G., & Martinez, A. (2006) · Endocrinology · doi:10.1210/en.2005-1279 · Cited by 67 · see citing works
Development of a Transgenic Green Fluorescent Protein Lineage Marker for Steroidogenic Factor 1
Stallings, N. R., Hanley, N. A., Majdič, G., Zhao, L., Bakke, M., & Parker, K. L. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0003 · Cited by 67 · see citing works
Role of Steroidogenic-Factor 1 in Basal and 3′,5′-Cyclic Adenosine Monophosphate-Mediated Regulation of Cytochrome P450 Side-Chain Cleavage Enzyme in the Mouse1
Chau, Y. M., Crawford, P. A., Woodson, K. G., Polish, J. A., OLSON, L. M., & Sadovsky, Y. (1997) · Biology of Reproduction · doi:10.1095/biolreprod57.4.765 · Cited by 67 · see citing works
The Orphan Receptors NGFI-B and Steroidogenic Factor 1 Establish Monomer Binding as a Third Paradigm of Nuclear Receptor-DNA Interaction
Wilson, T. E., Fahrner, T. J., & Milbrandt, J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5794-5804.1993 · Cited by 66 · see citing works
SF‐1/Ad4BP transforms primary long‐term cultured bone marrow cells into ACTH‐responsive steroidogenic cells
Gondo, S., Yanase, T., Okabe, T., Tanaka, T., Morinaga, H., Nomura, M., Goto, K., & Nawata, H. (2004) · Genes to Cells · doi:10.1111/j.1365-2443.2004.00801.x · Cited by 64 · see citing works
Synergistic Cooperation between the β-Catenin Signaling Pathway and Steroidogenic Factor 1 in the Activation of the Mullerian Inhibiting Substance Type II Receptor
Hossain, A., & Saunders, G. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300804200 · Cited by 64 · see citing works
Transgenic Expression ofAd4BP/SF-1in Fetal Adrenal Progenitor Cells Leads to Ectopic Adrenal Formation
Zubair, M., Oka, S., Parker, K. L., & Morohashi, K.-I. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0055 · Cited by 64 · see citing works
The Basic Helix-Loop-Helix, Leucine Zipper Transcription Factor, USF (Upstream Stimulatory Factor), Is a Key Regulator of SF-1 (Steroidogenic Factor-1) Gene Expression in Pituitary Gonadotrope and Steroidogenic Cells
Harris, A. N., & Mellon, P. L. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.5.0100 · Cited by 64 · see citing works
Genes essential for early events in gonadal development
Parker, K. L., Schimmer, B. P., & Schedl, A. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050337 · Cited by 64 · see citing works
Nuclear Factor Y and Steroidogenic Factor 1 Physically and Functionally Interact to Contribute to Cell-Specific Expression of the Mouse Follicle-Stimulating Hormone-β Gene
Jacobs, S. B. R., Coss, D., McGillivray, S. M., & Mellon, P. L. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0286 · Cited by 63 · see citing works
Steroidogenic Factor-1 Mediates Cyclic 3',5'-Adenosine Monophosphate Regulation of the High Density Lipoprotein Receptor
Lopez, D., Sandhoff, T. W., & McLean, M. P. (1999) · Endocrinology · doi:10.1210/endo.140.7.6846 · Cited by 63 · see citing works
SUMOylation Inhibits SF-1 Activity by Reducing CDK7-Mediated Serine 203 Phosphorylation
Yang, W., Heaton, J. H., Brevig, H., Mukherjee, S., Iñiguez-Lluhı́, J. A., & Hammer, G. D. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00295-08 · Cited by 63 · see citing works
An enhancer element and a functional cyclic AMP-dependent protein kinase are required for expression of adrenocortical 21-hydroxylase.
Handler, J. D., Schimmer, B. P., Flynn, T., Moshe Szyf, A., Seidman, J. G., & Parker, K. L. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37672-5 · Cited by 62 · see citing works
Pod-1/Capsulin shows a sex- and stage-dependent expression pattern in the mouse gonad development and represses expression of Ad4BP/SF-1
Tamura, M., Kanno, Y., Chuma, S., Saito, T., & Nakatsuji, N. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00298-2 · Cited by 62 · see citing works
The Nuclear Receptor Coactivators p300/CBP/Cointegrator-Associated Protein (p/CIP) and Transcription Intermediary Factor 2 (TIF2) Differentially Regulate PKA-Stimulated Transcriptional Activity of Steroidogenic Factor 1
Børud, B., Hoang, T., Bakke, M., Jacob, A. L. J., Lund, J., & Mellgren, G. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.4.0799 · Cited by 62 · see citing works
Expression of Steroidogenic Factor 1 in the Testis Requires an E Box and CCAAT Box in its Promoter Proximal Region1
Daggett, M. A. F., Rice, D. A., & Heckert, L. L. (2000) · Biology of Reproduction · doi:10.1095/biolreprod62.3.670 · Cited by 62 · see citing works
Steroidogenic factor 1/adrenal 4 binding protein transforms human bone marrow mesenchymal cells into steroidogenic cells
Tanaka, T., Gondo, S., Okabe, T., Ohe, K., Shirohzu, H., Morinaga, H., Nomura, M., Tani, K., Takayanagi, R., Nawata, H., et al. (2007) · Journal of Molecular Endocrinology · doi:10.1677/jme-07-0076 · Cited by 60 · see citing works
Decreased Recognition of SUMO-Sensitive Target Genes following Modification of SF-1 (NR5A1)
Campbell, L. A., Faivre, E. J., Show, M. D., Ingraham, J. G., Flinders, J., Gross, J. D., & Ingraham, H. A. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00103-08 · Cited by 59 · see citing works
The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells
Gizard, F., Lavallée, B., DeWitte, F., Teissier, E., Staels, B., & Hum, D. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205786200 · Cited by 58 · see citing works
Protein Kinase A Potentiates Adrenal 4 Binding Protein/Steroidogenic Factor 1 Transactivation by Reintegrating the Subcellular Dynamic Interactions of the Nuclear Receptor with Its Cofactors, General Control Nonderepressed-5/Transformation/ Transcription Domain-Associated Protein, and Suppressor, Dosage-Sensitive Sex Reversal-1: a Laser Confocal Imaging Study in Living KGN Cells
Fan, W., Yanase, T., Wu, Y., Kawate, H., Saitoh, M., Oba, K., Nomura, M., Okabe, T., Goto, K., Yanagisawa, J., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0110 · Cited by 58 · see citing works
Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase θ Facilitates Induction of CYP17
Li, D., Urs, A. N., Allegood, J., Leon, A., Merrill, A. H., & Sewer, M. B. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00355-07 · Cited by 58 · see citing works
Activation of cAMP-Dependent Protein Kinase Increases the Protein Level of Steroidogenic Factor-1
Aesöy, R., Mellgren, G., Morohashi, K.-I., & Lund, J. (2002) · Endocrinology · doi:10.1210/endo.143.1.8599 · Cited by 56 · see citing works
Sexually dimorphic expression of Dax‐1 in the adrenal cortex
Mukai, T., Kusaka, M., Kawabe, K., Goto, K., Nawata, H., Fujieda, K., & Morohashi, K. (2002) · Genes to Cells · doi:10.1046/j.1365-2443.2002.00556.x · Cited by 56 · see citing works
Transcriptional Regulation of Adrenocortical Steroidogenic Gene Expression
Sewer, M. B., Dammer, E. B., & Jagarlapudi, S. (2007) · Drug Metabolism Reviews · doi:10.1080/03602530701498828 · Cited by 55 · see citing works
SF-1 (Steroidogenic Factor-1), C/EBP (CCAAT/Enhancer Binding Protein), and Ubiquitous Transcription Factors NF1 (Nuclear Factor 1) and Sp1 (Selective Promoter Factor 1) Are Required for Regulation of the Mouse Aldose Reductase-Like Gene (AKR1B7) Expression in Adrenocortical Cells
Aigueperse, C., Val, P., Pacot, C., Darné, C., Lalli, E., Sassone‐Corsi, P., VEYSSIERE, G., Jean, C., & Martinez, A. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.1.0577 · Cited by 53 · see citing works
Coregulator Exchange and Sphingosine-Sensitive Cooperativity of Steroidogenic Factor-1, General Control Nonderepressed 5, p54, and p160 Coactivators Regulate Cyclic Adenosine 3′,5′-Monophosphate-Dependent Cytochrome P450c17 Transcription Rate
Dammer, E. B., Leon, A., & Sewer, M. B. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0361 · Cited by 53 · see citing works
RIP 140 Modulates Transcription of the Steroidogenic Acute Regulatory Protein Gene through Interactions with Both SF-1 and DAX-1
Sugawara, T., Abe, S., Sakuragi, N., Fujimoto, Y., Nomura, E., Fujieda, K., Saito, M., & Fujimoto, S. (2001) · Endocrinology · doi:10.1210/endo.142.8.8309 · Cited by 49 · see citing works
Characterization of a regulatory region of the steroid 21-hydroxylase gene.
Parker, K. L., Schimmer, B. P., Chaplin, D., & Seidman, J. G. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66715-8 · Cited by 48 · see citing works
Function and distribution of a steroidogenic cell-specific transcription factor, Ad4BP
Morohashi, K.-I., Hatano, O., Nomura, M., Takayama, K., Hara, M., Yoshii, H., Takakusu, A., & Omura, T. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00041-w · Cited by 48 · see citing works
Phosphorylation of Steroidogenic Factor 1 Is Mediated by Cyclin-Dependent Kinase 7
Lewis, A. E., Rusten, M., Høivik, E. A., Vikse, E. L., Hansson, M. L., Wallberg, A. E., & Bakke, M. (2007) · Molecular Endocrinology · doi:10.1210/me.2006-0478 · Cited by 44 · see citing works
Central nervous system-specific knockout of steroidogenic factor 1
Kim, K. W., Zhao, L., & Parker, K. L. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.09.026 · Cited by 42 · see citing works
Adrenocortical and Gonadal Expression of the Mammalian Ftz-F1 Gene Encoding Ad4BP/SF-1 Is Independent of Pituitary Control
Nomura, M., Kawabe, K., Matsushita, S., Oka, S., Hatano, O., Harada, N., Nawata, H., & Morohashi, K. (1998) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022083 · Cited by 42 · see citing works
Ventromedial Hypothalamic Nucleus-Specific Enhancer of Ad4BP/SF-1 Gene
Shima, Y., Zubair, M., Ishihara, S., Shinohara, Y., Oka, S., Kimura, S., Okamoto, S., Minokoshi, Y., Suita, S., & Morohashi, K.-I. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0431 · Cited by 42 · see citing works
Pituitary Homeobox 2 Regulates Adrenal4 Binding Protein/Steroidogenic Factor-1 Gene Transcription in the Pituitary Gonadotrope through Interaction with the Intronic Enhancer
Shima, Y., Zubair, M., Komatsu, T., Oka, S., Yokoyama, C., Tachibana, T., Hjalt, T. Å. H., Drouin, J., & Morohashi, K.-I. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0444 · Cited by 41 · see citing works
Hedgehog Signaling: Is Smo a G Protein-Coupled Receptor?
Philipp, M., & Caron, M. G. (2009) · Current Biology · doi:10.1016/j.cub.2008.12.010 · Cited by 41 · see citing works
Identification of the First Synthetic Steroidogenic Factor 1 Inverse Agonists: Pharmacological Modulation of Steroidogenic Enzymes
Tredici, A. L. D., Andersen, C., Currier, E. A., Ohrmund, S. R., Fairbain, L. C., Lund, B. W., Nash, N. R., Olsson, R., & Piu, F. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.040089 · Cited by 40 · see citing works
Small Nuclear RING Finger Protein Stimulates the Rat Luteinizing Hormone-β Promoter by Interacting with Sp1 and Steroidogenic Factor-1 and Protects from Androgen Suppression
Curtin, D., Ferris, H. A., Häkli, M., Gibson, M. A., Jänne, O. A., Palvimo, J. J., & Shupnik, M. A. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0221 · Cited by 39 · see citing works
Genes essential for early events in gonadal development
Parker, K. L., & Schimmer, B. P. (2002) · Annals of Medicine · doi:10.1080/ann.34.3.171.178 · Cited by 38 · see citing works
Deoxyribonucleic Acid Methylation Controls Cell Type-Specific Expression of Steroidogenic Factor 1
Høivik, E. A., Aumo, L., Aesöy, R., Lillefosse, H. H., Lewis, A. E., Perrett, R. M., Stallings, N. R., Hanley, N. A., & Bakke, M. (2008) · Endocrinology · doi:10.1210/en.2008-0104 · Cited by 37 · see citing works
Inhibition of steroidogenesis in Leydig cells by Müllerian-inhibiting substance
Fynn-Thompson, E., Cheng, H. S., & Teixeira, J. M. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.09.015 · Cited by 36 · see citing works
Mutations in NR5A1 Associated With Ovarian Insufficiency
Lourenço, D., Brauner, R., Lin, L., Perdigo, A. D., Weryha, G., Mureşan, M., Boudjenah, R., Guerra‐Júnior, G., Maciel‐Guerra, A. T., Achermann, J. C., et al. (2009) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000359268.91477.36 · Cited by 34 · see citing works
Expression of Steroidogenic Factor 1 in the Testis Requires an Interactive Array of Elements Within Its Proximal Promoter1
Scherrer, S., Rice, D. A., & Heckert, L. L. (2002) · Biology of Reproduction · doi:10.1095/biolreprod.102.006932 · Cited by 33 · see citing works
Steroidogenic Factor-1 and The Gonadotrope-Specific Element Enhance Basal and Pituitary Adenylate Cyclase-Activating Polypeptide-Stimulated Transcription of the Human Glycoprotein Hormone α-Subunit Gene in Gonadotropes
Fowkes, R. C., Desclozeaux, M., Patel, M. V., Aylwin, S. J. B., King, P., Ingraham, H. A., & Burrin, J. M. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0393 · Cited by 32 · see citing works
Phosphorylation of CtBP1 by cAMP-dependent Protein Kinase Modulates Induction of CYP17 by Stimulating Partnering of CtBP1 and 2
Dammer, E. B., & Sewer, M. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708432200 · Cited by 31 · see citing works
Impaired Steroidogenic Factor 1 (NR5A1) Activity in Mutant Y1 Mouse Adrenocortical Tumor Cells
Frigeri, C., Tsao, J., Czerwinski, W., & Schimmer, B. P. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.4.0440 · Cited by 29 · see citing works
Characterization of the transcription start site of the ACTH receptor gene: presence of an intronic sequence in the 5'-flanking region
Naville, D., Barjhoux, L., Jaillard, C., Lebrethon, M. C., Saez, J. M., & Bégeot, M. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90194-5 · Cited by 28 · see citing works
A Ftz-F1-Containing Yeast Artificial Chromosome Recapitulates Expression of Steroidogenic Factor 1 in Vivo
Karpova, T., Presley, J., Manimaran, R. R., Scherrer, S., Tejada, L. V., Peterson, K. R., & Heckert, L. L. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0386 · Cited by 27 · see citing works
Characterization of receptor-interacting protein RIP140 in the regulation of SF-1 responsive target genes
Mellgren, G., Børud, B., Hoang, T., Yri, O. E., Fladeby, C., Lien, E. A., & Lund, J. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(03)00097-2 · Cited by 25 · see citing works
Contributions of Specificity Protein-1 and Steroidogenic Factor 1 to Adcy4 Expression in Y1 Mouse Adrenal Cells
Rui, X., Tsao, J., Scheys, J. O., Hammer, G. D., & Schimmer, B. P. (2008) · Endocrinology · doi:10.1210/en.2008-0203 · Cited by 23 · see citing works
Role of Nuclear Receptors in INSL3 Gene Transcription in Leydig Cells
Tremblay, J., & Robert, N. M. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1336.020 · Cited by 20 · see citing works
Nuclear Receptors, Testosterone, and Posttranslational Modifications in Human INSL3 Promoter Activity in Testicular Leydig Cells
Tremblay, J., Robert, N. M., & Laguë, É. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03807.x · Cited by 20 · see citing works
A boundary for histone acetylation allows distinct expression patterns of the Ad4BP/SF-1 and GCNF loci in adrenal cortex cells
Ishihara, S., & Morohashi, K.-I. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.011 · Cited by 20 · see citing works
Effects of Mutating Different Steroidogenic Factor-1 Protein Regions on Gene Regulation
Lopez, D., Nackley, A. C., Shea-Eaton, W. K., Xue, J., Schimmer, B. P., & McLean, M. P. (2001) · Endocrine · doi:10.1385/endo:14:3:353 · Cited by 19 · see citing works
Cloning and Characterization of a Novel Zinc Finger Protein that Modulates the Transcriptional Activity of Nuclear Receptors
Børud, B., Mellgren, G., Lund, J., & Bakke, M. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0158 · Cited by 15 · see citing works
EID-1 Interacts with Orphan Nuclear Receptor SF-1 and Represses Its Transactivation
Park, Y., Park, K. C., Shong, M., Lee, S.-J., Lee, Y., & Choi, H. (2007) · Molecules and Cells · doi:10.1016/s1016-8478(23)07353-3 · Cited by 13 · see citing works
Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies
Sakai, N., Terami, H., Suzuki, S., Haga, M., Nomoto, K., Tsuchida, N., Morohashi, K.-I., Saito, N., Asada, M., Hashimoto, M., et al. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0027 · Cited by 11 · see citing works
Development of a Transgenic Green Fluorescent Protein Lineage Marker for Steroidogenic Factor 1
Stallings, N. R. (2002) · Molecular Endocrinology · doi:10.1210/me.2001-0003 · Cited by 4 · see citing works

Flagged first, then by citations

Sorted by citations

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458 · see citing works
Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management
Claahsen - van der Grinten, H. L., Speiser, P. W., Ahmed, S. F., Arlt, W., Auchus, R. J., Falhammar, H., Flück, C. E., Guasti, L., Huebner, A., Kortmann, B. B. M., et al. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab016 · Cited by 556 · see citing works
Steroid hormone synthesis in mitochondria
Miller, W. L. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.04.014 · Cited by 479 · see citing works
Adrenocortical carcinoma: a clinician’s update
Fassnacht, M., Libé, R., Kroiss, M., & Allolio, B. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.235 · Cited by 396 · see citing works
Steroidogenic factor-1 (SF-1, NR5A1) and human disease
Ferraz‐de‐Souza, B., Lin, L., & Achermann, J. C. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.006 · Cited by 191 · see citing works
The Orphan Nuclear Receptors Steroidogenic Factor-1 and Liver Receptor Homolog-1: Structure, Regulation, and Essential Roles in Mammalian Reproduction
Meinsohn, M.-C., Smith, O. E., Bertolin, K., & Murphy, B. D. (2019) · Physiological Reviews · doi:10.1152/physrev.00019.2018 · Cited by 146 · see citing works
The Wnt/beta-catenin pathway in adrenocortical development and cancer
El Wakil, A., & Lalli, E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.014 · Cited by 134 · see citing works
Human sex-determination and disorders of sex-development (DSD)
Bashamboo, A., & McElreavey, K. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.10.030 · Cited by 104 · see citing works
The orphan nuclear receptors at their 25-year reunion
Mullican, S. E., DiSpirito, J. R., & Lazar, M. A. (2013) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0212 · Cited by 102 · see citing works
60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH
Gallo-Payet, N. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0257 · Cited by 98 · see citing works
The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis
Han, S. J., & O’Malley, B. W. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu002 · Cited by 98 · see citing works
The Concise Guide to PHARMACOLOGY 2013/14: Nuclear Hormone Receptors
Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Spedding, M., Peters, J. A., Harmar, A. J., & Collaborators, C. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12448 · Cited by 92 · see citing works
Gonadal transactivation of STARD1, CYP11A1 and HSD3B
Steven, R. K. (2011) · Frontiers in bioscience · doi:10.2741/3959 · Cited by 85 · see citing works
Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation
Milbank, E., Dragano, N. R. V., González‐García, I., García, M. R., Rivas-Limeres, V., Perdomo, L., Hilairet, G., Ruíz-Pino, F., Mallegol, P., Morgan, D. A., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00467-8 · Cited by 84 · see citing works
Wnt Signaling in Ovarian Development Inhibits Sf1 Activation of Sox9 via the Tesco Enhancer
Bernard, P., Ryan, J., Sim, H., Czech, D., Sinclair, A. H., Koopman, P. A., & Harley, V. R. (2011) · Endocrinology · doi:10.1210/en.2011-1347 · Cited by 82 · see citing works
Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2)
Whitby, R. J., Stec, J., Blind, R. D., Dixon, S., Leesnitzer, L. M., Orband‐Miller, L. A., Williams, S. P., Willson, T. M., Xu, R. X., Zuercher, W. J., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm1014296 · Cited by 79 · see citing works
MAPK pathway activation in the embryonic pituitary results in stem cell compartment expansion, differentiation defects and provides insights into the pathogenesis of papillary craniopharyngioma
Haston, S., Pozzi, S., Carreno, G., Manshaei, S., Panousopoulos, L., González-Meljem, J. M., Apps, J. R., Virasami, A. K., Thavaraj, S., Gutteridge, A., et al. (2017) · Development · doi:10.1242/dev.150490 · Cited by 78 · see citing works
Cholesterol and male fertility: What about orphans and adopted?
Maqdasy, S., Baptissart, M., Vega, A., Baron, S., Lobaccaro, J. A., & Volle, D. H. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.06.011 · Cited by 72 · see citing works
Steroidogenic Factor-1 and Human Disease
El‐Khairi, R., & Achermann, J. C. (2012) · Seminars in Reproductive Medicine · doi:10.1055/s-0032-1324720 · Cited by 74 · see citing works
Mutational screening of NR5A1 gene encoding steroidogenic factor 1 in cryptorchidism and male factor infertility and functional analysis of seven undescribed mutations
Ferlin, A., Rocca, M. S., Vinanzi, C., Ghezzi, M., Nisio, A. D., & Foresta, C. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.04.017 · Cited by 70 · see citing works
Specific genes are selectively expressed between cumulus and granulosa cells from individual human pre-ovulatory follicles
Grøndahl, M. L., Andersen, C. Y., Bogstad, J. W., Borgbo, T., Boujida, V. H., & Borup, R. (2012) · Molecular Human Reproduction · doi:10.1093/molehr/gas035 · Cited by 67 · see citing works
Hedgehog Signaling and Steroidogenesis
Finco, I., LaPensee, C. R., Krill, K. T., & Hammer, G. D. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-061214-111754 · Cited by 67 · see citing works
Extra-Adrenal Glucocorticoid Synthesis in the Intestinal Mucosa: Between Immune Homeostasis and Immune Escape
Ahmed, A. S., Schmidt, C., & Brunner, T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01438 · Cited by 66 · see citing works
Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells
Ruiz-Babot, G., Balyura, M., Hadjidemetriou, I., Ajodha, S. J., Taylor, D. R., Ghataore, L., Taylor, N. F., Schubert, U., Ziegler, C. G., Storr, H. L., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.003 · Cited by 65 · see citing works
Arsenic exposure diminishes ovarian follicular reserve and induces abnormal steroidogenesis by DNA methylation
Chen, Y., Sun, Y., Zhao, A., Cai, X.-F., Yu, A., Xu, Q., Wang, P., Yao, J., Wang, Q., & Wang, W. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113816 · Cited by 65 · see citing works
Broad phenotypes in heterozygous NR5A1 46,XY patients with a disorder of sex development: an oligogenic origin?
Camats, N., Fernández‐Cancio, M., Audı́, L., Schaller, A., & Flück, C. E. (2018) · European Journal of Human Genetics · doi:10.1038/s41431-018-0202-7 · Cited by 65 · see citing works
Pediatric Adrenocortical Tumors: What They Can Tell Us on Adrenal Development and Comparison with Adult Adrenal Tumors
Lalli, E., & de Figueiredo, B. C. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00023 · Cited by 64 · see citing works
Transcription of CYP19A1 is directly regulated by SF-1 in the theca cells of ovary follicles in chicken
Wang, J., & Gong, Y. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.03.013 · Cited by 62 · see citing works
Steroid Hormones and the Development of Reproductive Organs
Morohashi, K.-I., Baba, T., & Tanaka, M. (2012) · Sexual Development · doi:10.1159/000342272 · Cited by 60 · see citing works
Directing differentiation of human induced pluripotent stem cells toward androgen-producing Leydig cells rather than adrenal cells
Li, L., Li, Y., Sottas, C. M., Culty, M., Fan, J., Hu, Y., Cheung, G., Chemes, H., & Papadopoulos, V. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908207116 · Cited by 61 · see citing works
From Sex Determination to Initial Folliculogenesis in Mammalian Ovaries: Morphogenetic Waves along the Anteroposterior and Dorsoventral Axes
Suzuki, H., Kanai‐Azuma, M., & Kanai, Y. (2015) · Sexual Development · doi:10.1159/000440689 · Cited by 59 · see citing works
Pituitary Physiology and Diagnostic Evaluation
Melmed, S. K., Kleinberg, D. L., & Ho, K. K. Y. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00008-0 · Cited by 58 · see citing works
Steroidogenic Factor 1 Differentially Regulates Fetal and Adult Leydig Cell Development in Male Mice1
Karpova, T., Ravichandiran, K., Insisienmay, L., Rice, D. A., Agbor, V. A., & Heckert, L. L. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.115.131193 · Cited by 57 · see citing works
Treating canine Cushing’s syndrome: Current options and future prospects
Sanders, K., Kooistra, H. S., & Galac, S. (2018) · The Veterinary Journal · doi:10.1016/j.tvjl.2018.09.014 · Cited by 56 · see citing works
The ERK1/2 pathway regulates testosterone synthesis by coordinately regulating the expression of steroidogenic genes in Leydig cells
Matzkin, M. E., Yamashita, S., & Ascoli, M. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.02.017 · Cited by 55 · see citing works
Sterol O-Acyltransferase 1 (SOAT1, ACAT) Is a Novel Target of Steroidogenic Factor-1 (SF-1, NR5A1, Ad4BP) in the Human Adrenal
Ferraz‐de‐Souza, B., Hudson‐Davies, R. E., Lin, L., Parnaik, R., Hubank, M. J. F., Dattani, M., & Achermann, J. C. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2021 · Cited by 53 · see citing works
Adrenal disorders in pregnancy
Monticone, S., Auchus, R. J., & Rainey, W. E. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.155 · Cited by 53 · see citing works
Oligogenic Origin of Differences of Sex Development in Humans
Camats, N., Flück, C. E., & Audı́, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051809 · Cited by 53 · see citing works
Differentiation of mesenchymal stem cells and embryonic stem cells into steroidogenic cells using steroidogenic factor-1 and liver receptor homolog-1
Yazawa, T., Kawabe, S., Inaoka, Y., Okada, R., Mizutani, T., Imamichi, Y., Ju, Y., Yamazaki, Y., Usami, Y., Kuribayashi, M., et al. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.025 · Cited by 53 · see citing works
Adrenal cortex tissue homeostasis and zonation: A WNT perspective
Drelon, C., Berthon, A. S., Mathieu, M., Martinez, A., & Val, P. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.12.014 · Cited by 52 · see citing works
Molecular heterogeneity of XY sex reversal in horses
Raudsepp, T., Durkin, K., Lear, T. L., Das, P. J., Avila, F. F. D., Kachroo, P., & Chowdhary, B. P. (2010) · Animal Genetics · doi:10.1111/j.1365-2052.2010.02101.x · Cited by 51 · see citing works
Gonadotropes and Gonadotropin-Releasing Hormone Signaling
McArdle, C. A., & Roberson, M. S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00010-7 · Cited by 50 · see citing works
Intestinal steroidogenesis
Bouguen, G., Dubuquoy, L., Desreumaux, P., Brunner, T., & Bertin, B. (2015) · Steroids · doi:10.1016/j.steroids.2014.12.022 · Cited by 49 · see citing works
Role of DAX-1 (NR0B1) and Steroidogenic Factor-1 (NR5A1) in Human Adrenal Function
El‐Khairi, R., Martínez‐Aguayo, A., Ferraz‐de‐Souza, B., Lin, L., & Achermann, J. C. (2010) · Endocrine development · doi:10.1159/000321213 · Cited by 48 · see citing works
Aetiological coding sequence variants in non-syndromic premature ovarian failure: From genetic linkage analysis to next generation sequencing
Laissue, P. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.05.005 · Cited by 49 · see citing works
Phospholipid – Driven gene regulation
Musille, P. M., Kohn, J. A., & Ortlund, E. A. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.01.004 · Cited by 47 · see citing works
Evaluation of carvacrol on pituitary and sexual hormones and their receptors in the testicle of male diabetic rats
Shoorei, H., Khaki, A., Shokoohi, M., Khaki, A., Alihemmati, A., Moghimian, M., & Abtahi-Eivary, S.-H. (2020) · Human & Experimental Toxicology · doi:10.1177/0960327120909525 · Cited by 46 · see citing works
Human NR5A1/SF-1 Mutations Show Decreased Activity on BDNF (Brain-Derived Neurotrophic Factor), an Important Regulator of Energy Balance: Testing Impact of Novel SF-1 Mutations Beyond Steroidogenesis
Malíková, J., Camats, N., Fernández‐Cancio, M., Heath, K. E., González, I., Caimari, M., Campo, M. D., Albisu, M., Koloušková, S., Audı́, L., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104838 · Cited by 45 · see citing works
Gene Mutations Associated with Anomalies of Human Gonad Formation
Bashamboo, A., & McElreavey, K. (2012) · Sexual Development · doi:10.1159/000342188 · Cited by 45 · see citing works
NR5A Nuclear Receptor Hr39 Controls Three-Cell Secretory Unit Formation in Drosophila Female Reproductive Glands
Sun, J., & Spradling, A. C. (2012) · Current Biology · doi:10.1016/j.cub.2012.03.059 · Cited by 45 · see citing works
Current and Emerging Therapies for Advanced Adrenocortical Carcinoma
Tacon, L. J., Prichard, R. S., Soon, P. S. H., Robinson, B. G., Clifton-Bligh, R. J., & Sidhu, S. B. (2011) · The Oncologist · doi:10.1634/theoncologist.2010-0270 · Cited by 42 · see citing works
Transcription Factors in the Regulation of Leydig Cell Gene Expression and Function
de Mattos, K., Viger, R. S., & Tremblay, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.881309 · Cited by 43 · see citing works
Clinical and genetic characteristics of a large international cohort of individuals with rare NR5A1/SF-1 variants of sex development
Kouri, C., Sommer, G., de la Piscina, I. M., Elzenaty, R. N., Tack, L. J. W., Cools, M., Ahmed, S. F., Flück, C. E., Abalı, S., Abalı, Z. Y., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2023.104941 · Cited by 43 · see citing works
Oxysterol-related-binding-protein related Protein-2 (ORP2) regulates cortisol biosynthesis and cholesterol homeostasis
Escajadillo, T., Wang, H., LI, L. C., Li, D., & Sewer, M. B. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.03.006 · Cited by 43 · see citing works
Adrenocortical Carcinoma: Current Therapeutic State-of-the-Art
Lebastchi, A. H., Kunstman, J. W., & Carling, T. (2012) · Journal of Oncology · doi:10.1155/2012/234726 · Cited by 39 · see citing works
FOXL2 Is an Essential Activator of SF-1-Induced Transcriptional Regulation of Anti-Müllerian Hormone in Human Granulosa Cells
Jin, H., Won, M., Park, S. E., Lee, S., Park, M., & Bae, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159112 · Cited by 41 · see citing works
Steroidogenic Factor-1 (SF-1)-Driven Differentiation of Murine Embryonic Stem (ES) Cells into a Gonadal Lineage
Jadhav, U., & Jameson, J. L. (2011) · Endocrinology · doi:10.1210/en.2011-0219 · Cited by 41 · see citing works
Diagnosis and Treatment of Disorders of Sexual Development
Rey, R. A., & Josso, N. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00119-0 · Cited by 40 · see citing works
The Essential Role of GATA6 in the Activation of Estrogen Synthesis in Endometriosis
Bernardi, L. A., Dyson, M. T., Tokunaga, H., Sison, C., Oral, M., Robins, J. C., & Bulun, S. E. (2019) · Reproductive Sciences · doi:10.1177/1933719118756751 · Cited by 40 · see citing works
Stem/progenitor cells in pituitary organ homeostasis and tumourigenesis
Haston, S., Manshaei, S., & Martı́nez-Barberá, J. P. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0258 · Cited by 39 · see citing works
Pituitary Physiology and Diagnostic Evaluation
Kaiser, U. B., & Ho, K. K. Y. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00008-3 · Cited by 38 · see citing works
Binding domain-driven intracellular trafficking of sterols for synthesis of steroid hormones, bile acids and oxysterols
Midzak, A., & Papadopoulos, V. (2014) · Traffic · doi:10.1111/tra.12177 · Cited by 38 · see citing works
Folate deficiency impairs decidualization and alters methylation patterns of the genome in mice
Geng, Y., Gao, R., Chen, X., Liu, X., Liao, X., Li, Y., Liu, S., Ding, Y., Wang, Y., & Junlin, H. (2015) · Molecular Human Reproduction · doi:10.1093/molehr/gav045 · Cited by 38 · see citing works
Increased circulating miR-370-3p regulates steroidogenic factor 1 in endometriosis
Hu, Z., Mamillapalli, R., & Taylor, H. S. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00244.2018 · Cited by 38 · see citing works
Transcriptional Regulation of Ovarian Steroidogenic Genes: Recent Findings Obtained from Stem Cell-Derived Steroidogenic Cells
Yazawa, T., Imamichi, Y., Sekiguchi, T., Miyamoto, K., Uwada, J., Khan, M. R. I., Suzuki, N., Umezawa, A., & Taniguchi, T. (2019) · BioMed Research International · doi:10.1155/2019/8973076 · Cited by 38 · see citing works
New directions for the treatment of adrenal insufficiency
Ruiz-Babot, G., Hadjidemetriou, I., King, P. J., & Guasti, L. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00070 · Cited by 37 · see citing works
Disorders of sex development
Barbaro, M., Wedell, A., & Nordenström, A. (2011) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2011.01.001 · Cited by 37 · see citing works
Beyond steroidogenesis: Novel target genes for SF-1 discovered by genomics
Lalli, E., Doghman, M., de Laté, P. L., Wakil, A. E., & Mus‐Veteau, I. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.11.005 · Cited by 37 · see citing works
Notch signaling represses GATA4-induced expression of genes involved in steroid biosynthesis
George, R. M., Hahn, K. L., Rawls, A., Viger, R. S., & Wilson‐Rawls, J. (2015) · Reproduction · doi:10.1530/rep-15-0226 · Cited by 36 · see citing works
Lipid-sensors, enigmatic-orphan and orphan nuclear receptors as therapeutic targets in breast-cancer
Garattini, E., Bolis, M., Gianni’, M., Paroni, G., Fratelli, M., & Terao, M. (2016) · Oncotarget · doi:10.18632/oncotarget.7410 · Cited by 36 · see citing works
NR5A1 is required for functional maturation of Sertoli cells during postnatal development
Kato, T., Esaki, M., Matsuzawa, A., & Ikeda, Y. (2012) · Reproduction · doi:10.1530/rep-11-0365 · Cited by 35 · see citing works
Advances in stem cell research for the treatment of primary hypogonadism
Li, L., & Papadopoulos, V. (2021) · Nature Reviews Urology · doi:10.1038/s41585-021-00480-2 · Cited by 35 · see citing works
Ventromedial hypothalamic OGT drives adipose tissue lipolysis and curbs obesity
Wang, Q., Zhang, B., Stutz, B., Liu, Z. W., Horváth, T. L., & Yang, X. (2022) · Science Advances · doi:10.1126/sciadv.abn8092 · Cited by 35 · see citing works
Heterogeneity of Ovarian Theca and Interstitial Gland Cells in Mice
Miyabayashi, K., Tokunaga, K., Otake, H., Baba, T., Shima, Y., & Morohashi, K.-I. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128352 · Cited by 35 · see citing works
Nuclear Receptor 5A (NR5A) Family Regulates 5-Aminolevulinic Acid Synthase 1 (ALAS1) Gene Expression in Steroidogenic Cells
Ju, Y., Mizutani, T., Imamichi, Y., Yazawa, T., Matsumura, T., Kawabe, S., Kanno, M., Umezawa, A., Kangawa, K., & Miyamoto, K. (2012) · Endocrinology · doi:10.1210/en.2012-1334 · Cited by 35 · see citing works
The Synthesis and Metabolism of Steroid Hormones
Strauss, J. F. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4907-4.00004-8 · Cited by 35 · see citing works
Sumoylated NHR-25/NR5A Regulates Cell Fate during C. elegans Vulval Development
Ward, J. D., Bojanala, N., Bernal, T. U., Ashrafi, K., Asahina, M., & Yamamoto, K. R. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003992 · Cited by 34 · see citing works
The role of nuclear receptors in controlling the fine balance between proliferation and differentiation of neural stem cells
Στεργιόπουλος, Α., & Politis, P. K. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.09.009 · Cited by 34 · see citing works
p54nrb/NONO Regulates Cyclic AMP-Dependent Glucocorticoid Production by Modulating Phosphodiesterase mRNA Splicing and Degradation
Lu, J., & Sewer, M. B. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00993-14 · Cited by 34 · see citing works
Transcriptional regulation of genes related to progesterone production [Review]
Mizutani, T., Ishikane, S., Kawabe, S., Umezawa, A., & Miyamoto, K. (2015) · Endocrine Journal · doi:10.1507/endocrj.ej15-0260 · Cited by 34 · see citing works
Regulation of Steroidogenesis, Development, and Cell Differentiation by Steroidogenic Factor-1 and Liver Receptor Homolog-1
Yazawa, T., Imamichi, Y., & Miyamoto, K. (2015) · ZOOLOGICAL SCIENCE · doi:10.2108/zs140237 · Cited by 34 · see citing works
Disorders of Sex Development
Achermann, J. C., & Hughes, I. A. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00023-7 · Cited by 34 · see citing works
Sertoli cell‐derived exosome‐mediated transfer of miR‐145‐5p inhibits Leydig cell steroidogenesis by targeting steroidogenic factor 1
Liang, J., Li, H., Mei, J., Cao, Z., Tang, Y., Huang, R., Xia, H., Zhang, Q., Xiang, Q., Yang, Y., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002589rrrr · Cited by 33 · see citing works
ChIP-on-chip analysis reveals angiopoietin 2 (Ang2, ANGPT2) as a novel target of steroidogenic factor-1 (SF-1, NR5A1) in the human adrenal gland
Ferraz-de-Souza, B., Lin, L., Shah, S. H., Jina, N., Hubank, M., Dattani, M., & Achermann, J. (2011) · The FASEB Journal · doi:10.1096/fj.10-170522 · Cited by 31 · see citing works
Oncogenic Activation of the Wnt/β-Catenin Signaling Pathway in Signet Ring Stromal Cell Tumor of the Ovary
Kopczyński, J., Kowalik, A., Chłopek, M., Wang, Z.-F., Góźdź, S. S., Lasota, J. P., & Miettinen, M. (2015) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0000000000000271 · Cited by 30 · see citing works
Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland
Witt, A., Mateska, I., Palladini, A., Sinha, A. N., Wölk, M., Harauma, A., Bechmann, N., Pamporaki, C., Dahl, A., Rothe, M., et al. (2023) · Science Advances · doi:10.1126/sciadv.adf6710 · Cited by 30 · see citing works
Screening and familial characterization of copy‐number variations in NR5A1 in 46,XY disorders of sex development and premature ovarian failure
Harrison, S. M., Campbell, I. M., Keays, M. A., Granberg, C. F., Villanueva, C., Tannin, G. M., Zinn, A. R., Castrillón, D. H., Shaw, C. A., Stankiewicz, P., et al. (2013) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36084 · Cited by 30 · see citing works
Knockdown of SF-1 and RNF31 Affects Components of Steroidogenesis, TGFβ, and Wnt/β-catenin Signaling in Adrenocortical Carcinoma Cells
Ehrlund, A., Jonsson, P., Vedin, L., Williams, C., Gustafsson, J.-Å., & Treuter, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032080 · Cited by 30 · see citing works
Leydig cell dysfunction is associated with post-transcriptional deregulation of CYP17A1 in men with Sertoli cell-only syndrome
Lardone, M. C., Argandoña, F., Lorca, M., Piottante, A., Flórez, M., Palma, C., Ebensperger, M., & Andrea Castro, G. (2018) · Molecular Human Reproduction · doi:10.1093/molehr/gay006 · Cited by 29 · see citing works
Phenotype and Molecular Characterizations of 30 Children From China With NR5A1 Mutations
Song, Y., Fan, L., & Gong, C. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01224 · Cited by 28 · see citing works
Steroidogenic Factor 1 Promotes Aggressive Growth of Castration-Resistant Prostate Cancer Cells by Stimulating Steroid Synthesis and Cell Proliferation
Lewis, S. R., Hedman, C. J., Ziegler, T. E., Ricke, W. A., & Jorgensen, J. S. (2013) · Endocrinology · doi:10.1210/en.2013-1583 · Cited by 28 · see citing works
Progesterone: Synthesis, Metabolism, Mechanism of Action, and Effects in the Nervous System
Schumacher, M., Zhu, X., & Guennoun, R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00054-7 · Cited by 28 · see citing works
Role of NR5A1 Gene Mutations in Disorders of Sex Development: Molecular and Clinical Features
Luppino, G., Wasniewska, M. G., Coco, R., Pepe, G., Morabito, L. A., Pomi, A. L., Corica, D., & Aversa, T. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46050274 · Cited by 29 · see citing works
The next generation of therapies for adrenocortical cancers
Kirschner, L. S. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.04.001 · Cited by 27 · see citing works
Transactivation of miR-202-5p by Steroidogenic Factor 1 (SF1) Induces Apoptosis in Goat Granulosa Cells by Targeting TGFβR2
Ding, Q., Jin, M., Wang, Y., Liu, J., Kalds, P., Wang, Y., Yang, Y., Wang, X., & Chen, Y. (2020) · Cells · doi:10.3390/cells9020445 · Cited by 27 · see citing works
Embryological and molecular development of the adrenal glands
Ross, I. L., & Louw, G. (2014) · Clinical Anatomy · doi:10.1002/ca.22422 · Cited by 27 · see citing works
The Anti-Epileptic Drug Valproic Acid (VPA) Inhibits Steroidogenesis in Bovine Theca and Granulosa Cells In Vitro
Glister, C., Satchell, L., Michael, A. E., Bicknell, A. B., & Knight, P. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049553 · Cited by 27 · see citing works
SF-1 expression during adrenal development and tumourigenesis
Gardiner, J. R., Shima, Y., Morohashi, K.-I., & Swain, A. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.10.007 · Cited by 27 · see citing works
Idiopathic Hypogonadotropic Hypogonadism Caused by Inactivating Mutations in SRA1
Kotan, L. D., Cooper, C., Darcan, Ş., Carr, I., Özen, S., Yan, Y., Hamedani, M. K., Gürbüz, F., Mengen, E., Turan, İ., et al. (2016) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.3248 · Cited by 26 · see citing works
Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis
Vasquez, Y. M., Wu, S., Anderson, M. L., Hawkins, S. M., Creighton, C. J., Ray, M., Tsai, S. Y., Tsai, M., Lydon, J. P., & DeMayo, F. J. (2016) · Molecular Endocrinology · doi:10.1210/me.2015-1215 · Cited by 26 · see citing works

Steroidogenic factor 1: an essential mediator of endocrine development. Recent Prog. Horm. Res
Parker, K. L., Rice, D. A., Lala, D. S., Ikeda, Y., Luo, X., Wong, M., Bakke, M., Zhao, L., Hanley, N. A., Stallings, N. R., et al. (2002)
Steroidogenic Factor 1: an Essential Mediator of Endocrine Development
Parker, K. L. (2002) · Recent Progress in Hormone Research · doi:10.1210/rp.57.1.19 · Cited by 346 · see citing works
The roles of the nuclear receptor steroidogenic factor 1 in endocrine differentiation and development
Parker, K. L., & Schimmer, B. P. (1996) · Trends in Endocrinology and Metabolism · doi:10.1016/1043-2760(96)00105-1 · Cited by 35 · see citing works
Steroidogenic factor 1 plays multiple roles in endocrine development and function.
Wong, M., Ikeda, Y., Luo, X., Caron, K. M., Weber, T. J., Swain, A., Schimmer, B. P., & Parker, K. L. (1997) · PubMed · Cited by 37 · see citing works
Steroidogenic Factor 1 Plays Key Roles in Adrenal and Gonadal Development and in Endocrine Function
Caron, K. M., Ikeda, Y., Luo, X., & Parker, K. L. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-693-5_4 · Cited by 1 · see citing works

Authors: Schimmer, B. P., & White, P. C.
Affiliations: University of Toronto (CA)
ORCID: White, Perrin C.
Venue: Molecular Endocrinology
Publisher: The Endocrine Society
Published: 2010-07
Volume: 24
Issue: 7
Pages: 1322-1337
ISSN: 0888-8809 (ISSN-L)
1944-9917
DOI: 10.1210/me.2009-0519
PMC: PMC5417463
OpenAlex: W2039590485
Cited by: 268
References: 176
Citations by year: 2026: 13 · 2025: 14 · 2024: 15 · 2023: 15 · 2022: 12 · 2021: 14 · 2020: 9 · 2019: 14 · 2018: 15 · 2017: 12 · 2016: 14 · 2015: 29 · 2014: 18 · 2013: 17 · 2012: 27
FWCI: 3.31
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Molecular Endocrinology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research (MOP-64325)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords: steroidogenic factor 1, orphan nuclear receptor, transcriptional regulation, adrenal development, gonad development, ventromedial hypothalamus, gonadotrophs, XY sex reversal, ovarian failure, adrenal insufficiency, endometriosis, adrenocortical carcinoma, heterozygous mutation
MeSH terms: Animals, Disease, Humans, Hypothalamus, Mutation, Pituitary Gland, Protein Binding, Mice, Knockout, Mice, Steroidogenic Factor 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Minireview: steroidogenic factor 1: its roles in differentiation, development, and disease

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks