The DOI matches its Crossref record; 355 of the 355 references it cites were found in a registry or an index.
The Therapeutic Potential of Metformin in Neurodegenerative Diseases
Open accessAbstract
The search for treatments for neurodegenerative diseases is a major concern in light of today’s aging population and an increasing burden on individuals, families and society. Although great advances have been made in the last decades to understand the underlying genetic and biological cause of these diseases, only some symptomatic treatments are available. Metformin has long since been used to treat Type 2 Diabetes and has been shown to be beneficial in several other conditions. Metformin is well-tested in vitro and an approved compound that targets diverse pathways including mitochondrial energy production and insulin signaling. There is growing evidence for the benefits of metformin to counteract age-related diseases such as cancer, cardiovascular disease and neurodegenerative diseases. We will discuss evidence showing that certain neurodegenerative diseases and diabetes are explicitly linked and that metformin along with other diabetes drugs can reduce neurological symptoms in some patients and reduce disease phenotypes in animal and cell models. An interesting therapeutic factor might be how metformin is able to balance survival and death signaling in cells through pathways that are commonly associated with neurodegenerative diseases. In healthy neurons, these overarching signals keep energy metabolism, oxidative stress and proteostasis in check, avoiding the dysfunction and neuronal death that defines neurodegenerative disease. We will discuss the biological mechanisms involved and the relevance of neuronal vulnerability and potential difficulties for future trials and development of therapies.
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Cited by
Ageing as a risk factor for neurodegenerative disease
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Impaired dopamine metabolism in Parkinson’s disease pathogenesis
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Metadata
- Authors
- Rotermund, C., Machetanz, G., & Fitzgerald, J. C.
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2018-07-19
- Volume
- 9
- Pages
- 400-400
- ISSN
- 1664-2392 (ISSN-L)
- OpenAlex
- W2884134082
- Cited by
- 304
- References
- 355
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- gold
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