Cited by 71Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismNutrition and Health in Aging

Adipokines and Aging: Findings From Centenarians and the Very Old

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Arai, Yasumichi, Kamide, Kei, Hirose, Nobuyoshi·2019·Frontiers in Endocrinology

Abstract

Adipose tissue, which was once considered as a simple energy storage depot, is now recognized as an active endocrine organ that regulates the whole-body energy homeostasis by secreting hundreds of bioactive substances termed adipokines. Dysregulation of adipokines is a key feature of insulin resistance and a metabolic syndrome associated with obesity. Adipokine dysregulation and insulin resistance are also associated with energy-deprivation conditions, such as frailty in old age. Previous studies have demonstrated that preserved insulin sensitivity and low prevalence of diabetes are the metabolic peculiarities of centenarians, suggesting the possible role of adipokine homeostasis in healthy longevity. Among the numerous adipokines, adiponectin is regarded as unique and salutary, showing negative correlations with several age- and obesity-related metabolic disturbances and a positive correlation with longevity and insulin sensitivity among centenarians. However, large-scale epidemiological studies have implied the opposite aspect of this adipokine as a prognostic factor for all-cause and cardiovascular mortality in patients with heart failure or kidney disease. In this review, the clinical significance of adiponectin was comparatively addressed in centenarians and the very old, in terms of frailty, cardiovascular risk, and mortality.

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  1. [19]Louhija J Finnish centenarians: a clinical epidemiological study (Thesis/Dissertation). Helsinki University Press, Finland (1994).

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Authors
Arai, Y., Kamide, K., & Hirose, N.
Affiliations
  • Keio University (JP)
  • The University of Osaka (JP)
Corresponding author
Arai, Yasumichi
Venue
Frontiers in Endocrinology
Published
2019-03-14
Volume
10
Pages
142-142
ISSN
1664-2392 (ISSN-L)
OpenAlex
W2921600589
Cited by
71
References
70
Citations by year
2026: 7 · 2025: 7 · 2024: 10 · 2023: 6 · 2022: 15 · 2021: 8 · 2020: 14 · 2019: 4
FWCI
1.50
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Endocrinology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Keio University
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
adipokines, aging, centenarians, oldest old, adiponectin, insulin resistance, frailty, cardiovascular risk, mortality, heart failure, kidney disease, adipose tissue endocrine function, healthy longevity

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