Adipokines and Aging: Findings From Centenarians and the Very Old
Open accessAbstract
Adipose tissue, which was once considered as a simple energy storage depot, is now recognized as an active endocrine organ that regulates the whole-body energy homeostasis by secreting hundreds of bioactive substances termed adipokines. Dysregulation of adipokines is a key feature of insulin resistance and a metabolic syndrome associated with obesity. Adipokine dysregulation and insulin resistance are also associated with energy-deprivation conditions, such as frailty in old age. Previous studies have demonstrated that preserved insulin sensitivity and low prevalence of diabetes are the metabolic peculiarities of centenarians, suggesting the possible role of adipokine homeostasis in healthy longevity. Among the numerous adipokines, adiponectin is regarded as unique and salutary, showing negative correlations with several age- and obesity-related metabolic disturbances and a positive correlation with longevity and insulin sensitivity among centenarians. However, large-scale epidemiological studies have implied the opposite aspect of this adipokine as a prognostic factor for all-cause and cardiovascular mortality in patients with heart failure or kidney disease. In this review, the clinical significance of adiponectin was comparatively addressed in centenarians and the very old, in terms of frailty, cardiovascular risk, and mortality.
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Plasma ApN levels are higher among centenarians compared to elderly individuals.
“Most studies demonstrate that plasma ApN levels are higher among centenarians compared to elderly individuals.”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [116]
ApN has beneficial metabolic effects for enhancing longevity.
“thereby signifying the beneficial metabolic effects of ApN for enhancing longevity [116].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [116]
ApN levels in centenarians were correlated with a preferable metabolic phenotype including good lipid profile and insulin sensitivity.
“Those levels were correlated with a preferable metabolic phenotype, including good lipid profile and insulin sensitivity”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [116]
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Additional file 1 of Transforming L1000 profiles to RNA-seq-like profiles with deep learning
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- Authors
- Arai, Y., Kamide, K., & Hirose, N.
- Affiliations
- Keio University (JP)
- The University of Osaka (JP)
- Corresponding author
- Arai, Yasumichi
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2019-03-14
- Volume
- 10
- Pages
- 142-142
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC6426744
- OpenAlex
- W2921600589
- Cited by
- 71
- References
- 70
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 10 · 2023: 6 · 2022: 15 · 2021: 8 · 2020: 14 · 2019: 4
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Keio University
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- adipokines, aging, centenarians, oldest old, adiponectin, insulin resistance, frailty, cardiovascular risk, mortality, heart failure, kidney disease, adipose tissue endocrine function, healthy longevity
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