PKA Activates AMPK Through LKB1 Signaling in Follicular Thyroid Cancer

Kari, Suresh; Vasko, Vasyl V.; Priya, Shivam; Kirschner, Lawrence S.

doi:10.3389/fendo.2019.00769

Cited by 34Thyroid Cancer Diagnosis and TreatmentMetabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

PKA Activates AMPK Through LKB1 Signaling in Follicular Thyroid Cancer

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Kari, Suresh, Vasko, Vasyl V., Priya, Shivam, Kirschner, Lawrence S.·2019·Frontiers in Endocrinology

DOI 10.3389/fendo.2019.00769PMC PMC6874117

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Abstract

Thyroid cancer affects about one percent of the population, and has seen rising incidence in recent years. Follicular thyroid cancer (FTC) comprises 10-15% of all thyroid cancers. Although FTC is often localized, it can behave aggressively with hematogenous metastasis, leading to an increased risk of cancer death. We previously described a mouse model for FTC caused by tissue-specific ablation of the Protein Kinase A (PKA) regulatory subunit Prkar1a, either by itself or in combination with knockout of Pten. Loss of Prkar1a causes enhanced activity of PKA, whereas ablation of Pten causes activation of Akt signaling. At the molecular level, these genetic manipulations caused activation of mTOR signaling, which was also observed in human FTC cases. To understand the mechanism by which PKA activates mTOR, we began by studying intracellular kinases known to modulate mTOR function. Although AMP-activated kinase (AMPK) has been characterized as a negative regulator of mTOR activity, our tumor model exhibited activation of both AMPK and mTOR. To understand the mechanism by which AMPK was turned on, we next studied kinases known to cause its phosphorylation. In this paper, we report that PKA leads to AMPK activation through the LKB1 kinase. Although LKB1 has traditionally been considered a tumor suppressor, our data indicates that it may have a complex role in the thyroid gland, where its activation appears to be frequently associated with follicular thyroid carcinoma in both mice and humans.

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LKB1 levels increased in the exercise-trained group.
“An increase in the levels of LKB1 (liver kinase B1, STK11)30, an upstream kinase of AMPK31, was observed in the trained group (Fig. 3d,h)”
From Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence (2024) · cites this paper as [30]

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Authors: Kari, S., Vasko, V. V., Priya, S., & Kirschner, L. S.
Affiliations: The Ohio State University (US)
Uniformed Services University of the Health Sciences (US)
Corresponding author: Kirschner, Lawrence S.
ORCID: Kari, Suresh
Vasko, Vasyl V.
Priya, Shivam
Kirschner, Lawrence S.
Venue: Frontiers in Endocrinology
Publisher: Frontiers Media SA
Published: 2019-11-08
Volume: 10
Pages: 769-769
ISSN: 1664-2392 (ISSN-L)
DOI: 10.3389/fendo.2019.00769
PMC: PMC6874117
OpenAlex: W2983332157
Cited by: 34
References: 66
Citations by year: 2026: 3 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 7 · 2020: 2
FWCI: 3.45
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Endocrinology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Cancer Institute
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: follicular thyroid carcinoma, protein kinase A, AMPK, mTOR signaling, PRKAR1A, PTEN, Akt signaling, tumor suppressor kinase, thyroid gland, mouse tumor model

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PKA Activates AMPK Through LKB1 Signaling in Follicular Thyroid Cancer

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