Worsening disability and hospitalization risk in sarcopenic obese and dynapenic abdominal obese: A 5.5 years follow-up study in elderly men and women
Open accessAbstract
Background/Objectives: a general lack of studies comparing the effect of both, dynapenic abdominal obesity and sarcopenic obesity on worsening disability and hospitalization risk should be recognized. The aim of the current study was to evaluate with a 5.5-year follow-up, the prognostic value of sarcopenic obesity and dynapenic abdominal obesity definitions on worsening disability and hospitalization risk in a sample of older adults. Subjects/Methods: in 177 women and 97 men, aged 68-78 years, the following outcomes were evaluated at baseline: appendicular skeletal muscle mass (ASMM), percent fat mass (FM%), leg isometric strength, body mass index (BMI), lipid profile, vitamin D3, albumin, fibrinogen, glycemia, physical activity level, income, smoking status and comorbidities. The rate of reported disabilities and hospitalization were also assessed at baseline, 1-yr, 2-yrs, 3-yrs and 5.5-yrs follow-up. The study population was classified into: i) non-sarcopenic/obese (NS/O), sarcopenic/non-obese (S/NO), sarcopenic/obese (S/O), non-sarcopenic/non-obese (NS/NO, reference category) according to relative ASMM/FM% tertiles; ii) non-dynapenic/abdominal obese (ND/AO), dynapenic/non-abdominal obese (D/NAO), dynapenic/abdominal obese (D/AO), non-dynapenic/non-abdominal obese (ND/NAO, reference category) according to muscle strength/waist circumference tertiles. Results: The prevalence of D/AO and S/O was 12.0% and 8.0%, respectively. Only 2 subjects were both D/NAO and S/O (0.8%). D/NAO subjects showed a worsening disability risk of 1.69 times (95% CI:1.11-2.57), ND/AO subjects showed a 2-fold increased risk (95%CI:1.34-2.98), while being D/AO more than trebled the risk, even after adjustment for confounding factors (HR: 3.39, 95%; CI:1.91-6.02). By dividing the study population according to the relative ASMM/FM% tertiles, no groups showed an increased risk of worsening disability. The hospitalization risk, even after adjustment for potential confounders, was 1.84 (95% CI:1.06-3.19) for D/AO. Dividing the study population according to the relative ASMM/FM% tertiles, no groups showed increased risk of hospitalization. Conclusions: our results showed that dynapenic abdominal obesity and sarcopenic obesity seem to indicate two distinct phenotypes associated with different health risk profiles. The distribution of participants in waist circumference and muscle strength tertiles allowed for a more accurate risk stratification for worsening disability and hospitalization.
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Individuals with SO had lower muscle mass, strength, and higher adiposity, as well as higher all-cause mortality and worse surgical prognosis.
“Individuals with SO had lower muscle mass, strength, and higher adiposity, as well as higher all-cause mortality and worse surgical prognosis (17, 32).”
From The role of obesity in sarcopenia and the optimal body composition to prevent against sarcopenia and obesity (2023) · cites this paper as [32]
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- Authors
- Rossi, A. P., Urbani, S., Fantin, F., Nori, N., Brandimarte, P., Martini, A., Zoico, E., Mazzali, G., Babbanini, A., Muollo, V., & Zamboni, M.
- Affiliations
- University of Verona (IT)
- Corresponding author
- Rossi, Andrea P.
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2020-06-30
- Volume
- 11
- Pages
- 314-314
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC7339917
- OpenAlex
- W3034158885
- Cited by
- 42
- References
- 27
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 9 · 2023: 5 · 2022: 9 · 2021: 2
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Iris (University of Trento) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Keywords
- sarcopenic obesity, disability progression, hospitalization risk, older adults, appendicular skeletal muscle mass, fat mass, waist circumference, muscle strength, prognostic factors, comorbidities, physical activity, vitamin D3, fibrinogen, glycemia, albumin, smoking, income, sex differences, body mass index
- MeSH terms
- Activities of Daily Living, Adipose Tissue, Aged, Female, Follow-Up Studies, Persons with Disabilities, Disabled Persons, Hospitalization, Humans, Male, Obesity, Prognosis, Risk Factors, Body Mass Index, Hand Strength, Muscle Strength, Sarcopenia, Obesity, Abdominal
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