Insulin sensitivity and pancreatic β-cell function in Ecuadorian women with Turner syndrome
Open accessAbstract
Objective: To assess insulin sensitivity and pancreatic β-cell function in an adult population of Ecuadorian individuals with Turner syndrome (TS). Design and Methods: This was a cross-sectional correlational study conducted in TS subjects (>20 years old; n=38). A standard 2-hour Oral Glucose Tolerance Test (OGTT) was performed in both women with TS and reference group. Glucose, lipids, insulin, and C-peptide concentrations were measured. HOMA-IR, QUICKI, McAuley, Matsuda, and Belfiore indices were calculated to evaluate the degree of insulin resistance (IR). The pancreatic β-cell function was assessed using HOMA-β, basal C-peptide Index (CPI), and CPII at 120´. Results: A higher prevalence of impaired glucose tolerance was found in TS subjects compared with the reference group. Although significant differences were found for glucose concentrations at 60´ and 120´ (but not at 0´), only the baseline insulin concentrations differed significantly between the two groups. The values of the IR indices were statistically different between study and reference groups. A significant number of TS subjects diagnosed with IR were differently classified according to the index applied. The concentrations of C-peptide at 0´ and 120´ of TS subjects were similar to those of the control group. In contrast, the CPI and CPII values in the study group were significantly lower than those in the control group. Conclusion: It is impossible to select the best surrogate method for the assessment of IR in women with TS. CPI and CPII values could be preferable to other indices to assess the pancreatic β-cell function in TS subjects. Our findings suggest that IR and pancreatic β-cell dysfunction could be independent events in women with TS and both conditions seem to be caused by the disease per se. Our results imply that early screening and intervention for TS would be therapeutic for TS women.
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Although the majority of diabetes in adult women with TS is attributed to type 2 diabetes, there is accumulating data for a TS-specific type of diabetes.
“Although the majority of diabetes in adult women is attributed to type 2 diabetes,384 there is accumulating data for a TS-specific type of diabetes.384,707”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [707]
Multiple studies demonstrate impaired beta cell function as well as reduced insulin sensitivity are involved in the development of diabetes in TS, while one study found glucose intolerance despite apparently normal beta cell function.
“Furthermore, multiple studies demonstrate impaired beta cell function as well as reduced insulin sensitivity are involved in the development of diabetes in TS ,227,229,384,705,707,708 while one study found glucose intolerance despite apparently normal beta cell function.709”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [707]
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- Authors
- Álvarez-Nava, F., Bastidas, D., Racines-Orbe, M., & Guarderas, J.
- Affiliations
- Central University of Ecuador (EC)
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2020-08-07
- Volume
- 11
- Pages
- 482-482
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC7427507
- OpenAlex
- W3040377781
- Cited by
- 11
- References
- 36
- Citations by year
- 2026: 4 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 1
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Funders
- Universidad Central del Ecuador
- Directorate for Biological Sciences
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Keywords
- Turner syndrome, insulin resistance, insulin sensitivity, beta-cell function, impaired glucose tolerance, C-peptide, basal insulin secretion, HOMA-IR, QUICKI, insulin resistance index, women, Ecuadorian population
- MeSH terms
- Adult, Cross-Sectional Studies, Ecuador, Female, Humans, Insulin Resistance, Turner Syndrome, Body Mass Index, Glucose Intolerance, Insulin-Secreting Cells
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