Cited by 140Chronic Kidney Disease and DiabetesDiabetes, Cardiovascular Risks, and LipoproteinsRenal Diseases and Glomerulopathies

The DOI matches its Crossref record; 161 of the 162 references it cites were found in a registry or an index.

Metabolic Syndrome-Related Kidney Injury: A Review and Update

Open access
Lin, Lirong, Tan, Wei, Pan, Xianfeng, Tian, En, Wu, Zhifeng, Yang, Jurong·2022·Frontiers in Endocrinology

Abstract

Metabolic syndrome (MetS) includes visceral obesity, hyperglycemia, dyslipidemia, and hypertension. The prevalence of MetS is 20-25%, which is an important risk factor for chronic kidney disease (CKD). MetS causes effects on renal pathophysiology, including glomerular hyperfiltration, RAAS, microalbuminuria, profibrotic factors and podocyte injury. This review compares several criteria of MetS and analyzes their differences. MetS and the pathogenesis of CKD includes insulin resistance, obesity, dyslipidemia, inflammation, oxidative stress, and endothelial dysfunction. The intervention of MetS-related renal damage is the focus of this article and includes controlling body weight, hypertension, hyperglycemia, and hyperlipidemia, requiring all components to meet the criteria. In addition, interventions such as endoplasmic reticulum stress, oxidative stress, gut microbiota, body metabolism, appetite inhibition, podocyte apoptosis, and mesenchymal stem cells are reviewed.

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Crossref · 10.3389/fendo.2022.904001

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Figures

Figure 1 The pathogenesis of MetS-related kidney injury.
Figure 1 The pathogenesis of MetS-related kidney injury.CC BY · PubMed Central
Figure 2 Kidney pathological characteristics for patients with MetS. Tubular atrophy (arrows) and interstitial fibrosis (arrowheads), PASM. This picture is from Mariam P et al., 2009 (98).
Figure 2 Kidney pathological characteristics for patients with MetS. Tubular atrophy (arrows) and interstitial fibrosis (arrowheads), PASM. This picture is from Mariam P et al., 2009 (98).CC BY · PubMed Central

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Research works printed but not linked: 1

  1. Alexander, 2009, Singh AK.Kidney Pathological Changes in Metabolic Syndrome: A Cross-Sectional Study, Am J Kidney Dis, 5, 10.1053/j.ajkd.2009.01.255 · DOI

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Metadata

Authors
Lin, L., Tan, W., Pan, X., Tian, E., Wu, Z., & Yang, J.
Affiliations
  • Chongqing Medical University (CN)
  • People's Hospital of Kaizhou District (CN)
Corresponding author
Yang, Jurong
Venue
Frontiers in Endocrinology
Published
2022-06-23
Volume
13
Pages
904001-904001
ISSN
1664-2392 (ISSN-L)
OpenAlex
W4283317650
Cited by
139
References
162
Citations by year
2026: 27 · 2025: 51 · 2024: 37 · 2023: 22 · 2022: 2
FWCI
4.21
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Endocrinology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China
Topics
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
Keywords
metabolic syndrome, chronic kidney disease, kidney injury, visceral obesity, hyperglycemia, dyslipidemia, hypertension, glomerular hyperfiltration, renin-angiotensin-aldosterone system, microalbuminuria, podocyte injury, renal fibrosis, insulin resistance, oxidative stress, endothelial dysfunction, endoplasmic reticulum stress, gut microbiota, mesenchymal stem cells, podocyte apoptosis
MeSH terms
Humans, Hyperglycemia, Hypertension, Kidney, Metabolic Syndrome, Renal Insufficiency, Chronic

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