Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling
Open accessAbstract
Tissue inflammation is a key component of obesity-induced insulin resistance, with a variety of immune cell types accumulating in adipose tissue. Here, we have demonstrated increased numbers of B2 lymphocytes in obese adipose tissue and have shown that high-fat diet-induced (HFD-induced) insulin resistance is mitigated in B cell-deficient (Bnull) mice. Adoptive transfer of adipose tissue B2 cells (ATB2) from wild-type HFD donor mice into HFD Bnull recipients completely restored the effect of HFD to induce insulin resistance. Recruitment and activation of ATB2 cells was mediated by signaling through the chemokine leukotriene B4 (LTB4) and its receptor LTB4R1. Furthermore, the adverse effects of ATB2 cells on glucose homeostasis were partially dependent upon T cells and macrophages. These results demonstrate the importance of ATB2 cells in obesity-induced insulin resistance and suggest that inhibition of the LTB4/LTB4R1 axis might be a useful approach for developing insulin-sensitizing therapeutics.
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Signaling through leukotriene B4 and its receptor is required for the expansion or infiltration of B cells into obese adipose tissue.
“Although the mechanisms underlying the expansion or infiltration of B cells into obese adipose tissue are poorly defined, signaling through the chemokine, leukotriene B4, and its receptor is required.( 46 )”
From The Emerging Role of B Cells in the Pathogenesis of NAFLD (2021) · cites this paper as [46]
B2 cells accumulate in obese adipose tissue where they contribute to local and systemic insulin resistance through pathogenic IgG antibodies and activation of T cells and macrophages.
“B2 cells accumulate in the obese adipose tissue where they contribute to local and systemic IR through pathogenic IgG antibodies( 45 ) and activation of T cells and macrophages.( 46 )”
From The Emerging Role of B Cells in the Pathogenesis of NAFLD (2021) · cites this paper as [46]
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“172 The nuclear receptor PPAR‐γ collaborates with Foxp3 to regulate the gathering of AT‐Treg cells and maintain their phenotype and functions.173 Furthermore, PPAR‐γ expression by AT‐Treg cells is crucial for the total restoration of insulin sensitivity in obese mice using the thiazolidinedione drug pioglitazone.173 P…”
BackgroundInfluentialFurlong, M., & Klimentidis, Y. C. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109364 · Cited by 95 · see citing works
Chromogranin A and its fragments in cardiovascular, immunometabolic, and cancer regulation
Mahata, S. K., & Corti, A. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14249 · Cited by 91 · see citing works
AlZaim, I., Hammoud, S. H., Al-Koussa, H., Ghazi, A., Eid, A. H., & EL‐Yazbi, A. F. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.602088 · Cited by 75 · see citing works
Adipose Tissue Inflammation Induces B Cell Inflammation and Decreases B Cell Function in Aging
Frasca, D., & Blomberg, B. B. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01003 · Cited by 66 · see citing works
“B2 cells may also be recruited to the AT through leukotriene LTB4/ LTB4R1 signaling (62).”
BackgroundBiology and function of adipose tissue macrophages, dendritic cells and B cells
Ivanov, S., Merlin, J., Lee, M. K. S., Murphy, A. J., & Guinamard, R. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.01.018 · Cited by 62 · see citing works
HIV Persistence in Adipose Tissue Reservoirs
Couturier, J. P., & Lewis, D. E. (2018) · Current HIV/AIDS Reports · doi:10.1007/s11904-018-0378-z · Cited by 61 · see citing works
The Eicosanoids, Redox-Regulated Lipid Mediators in Immunometabolic Disorders
de Araújo, A. C. J., Wheelock, C. E., & Haeggström, J. Z. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7332 · Cited by 57 · see citing works
“Moreover, a report published this year demonstrated that in BLT1 mice or mice treated with a BLT1 antagonist (CP-105696), recruitment of B2 lymphocytes into visceral fat depots is reduced (188).”
Browning Epicardial Adipose Tissue: Friend or Foe?
Doukbi, E., Soghomonian, A., Sengenès, C., Ahmed, S., Ancel, P., Dutour, A., & Gaborit, B. (2022) · Cells · doi:10.3390/cells11060991 · Cited by 56 · see citing works
“LB have also been linked with the accumulation and differentiation of IFN-γ-producing CD4+ and CD8+ T-cells in murine adipose tissue [62].”
BackgroundFerroptosis increases obesity: Crosstalk between adipocytes and the neuroimmune system
Zhang, S., Sun, Z., Jiang, X. Y., Lu, Z., Ding, L., Li, C., Tian, X., & Wang, Q. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1049936 · Cited by 52 · see citing works
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome
Wang, P., Sun, H., Maitiabula, G., Zhang, L., Yang, J., Zhang, Y., Gao, X., Li, J., Xue, B., Li, C., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00744-8 · Cited by 48 · see citing works
Pro-resolving actions of SPM in adipose tissue biology
Clària, J., López‐Vicario, C., Rius, B., & Titos, E. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.03.004 · Cited by 47 · see citing works
Adipose tissue immune cells in obesity, type 2 diabetes mellitus and cardiovascular diseases
Cinkajzlová, A., Mráz, M., & Haluzík, M. (2021) · Journal of Endocrinology · doi:10.1530/joe-21-0159 · Cited by 46 · see citing works
Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models
Sasaki, F., Koga, T., Ohba, M., Saeki, K., Okuno, T., Ishikawa, K., Nakama, T., Nakao, S., Yoshida, S., Ishibashi, T., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.96902 · Cited by 45 · see citing works
Zhang, C., Zhang, J., Liu, Z., & Zhou, Z. (2018) · Obesity Surgery · doi:10.1007/s11695-018-3400-z · Cited by 45 · see citing works
Dual roles of B lymphocytes in mouse models of diet-induced nonalcoholic fatty liver disease
Karl, M., Hasselwander, S., Zhou, Y., Reifenberg, G., Kim, Y. O., Park, K., Ridder, D. A., Wang, X., Seidel, E., Hövelmeyer, N., et al. (2022) · Hepatology · doi:10.1002/hep.32428 · Cited by 44 · see citing works
“[41,42] In our HFD- fed wild- type mice, the number of total liver macrophages was unchanged compared with NCD- fed controls.”
Specialized Proresolving Mediators: Enhancing Nonalcoholic Steatohepatitis and Fibrosis Resolution
Musso, G., Gambino, R., Cassader, M., Paschetta, E., & Sircana, A. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.01.003 · Cited by 44 · see citing works
Obesity-induced changes in lipid mediators persist after weight loss
Hernandez, A. M., Weber, N., Frano, M. R. L., Ying, W., Lantero‐Rodriguez, J., Sears, D. D., Wallenius, V., Börgeson, E., Newman, J. W. I., & Osborn, O. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.266 · Cited by 43 · see citing works
Self-citationAl‐Shaer, A. E., Buddenbaum, N., & Shaikh, S. R. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.158936 · Cited by 44 · see citing works
The Immune System in Obesity: Developing Paradigms Amidst Inconvenient Truths
Agrawal, M., Kern, P. A., & Nikolajczyk, B. S. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0917-9 · Cited by 42 · see citing works
Obesity Accelerates Age Defects in Mouse and Human B Cells
Frasca, D., & Blomberg, B. B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02060 · Cited by 42 · see citing works
“Inhibition of this interaction has been shown to reduce B cell recruitment and activation and to mitigate the contribution of B cells to local inflammation and IR (55).”
BackgroundZiegler, M., Wang, X., Lim, B., Leitner, E., Klingberg, F., Ching, V., Yu, Y., Huang, D., Gao, X., Kiriazis, H., et al. (2017) · Theranostics · doi:10.7150/thno.19698 · Cited by 41 · see citing works
“CD19+CD5- as a combination of markers to identify B2 cells was previously described [54, 55] and used in our gating strategy.”
MethodBerberine Alleviates Insulin Resistance and Inflammation via Inhibiting the LTB4–BLT1 Axis
Gong, M., Duan, H., Wu, F., Ren, Y., Gong, J., Xu, L., Lu, F., & Wang, D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.722360 · Cited by 40 · see citing works
Orchestration of the Adipose Tissue Immune Landscape by Adipocytes
Bradley, D. P., Deng, T., Shantaram, D., & Hsueh, W. A. (2024) · Annual Review of Physiology · doi:10.1146/annurev-physiol-042222-024353 · Cited by 38 · see citing works
FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology
Yu, L., Yang, Y. X., Gong, Z. H., Wan, Q., Du, Y., Zhou, Q., Xiao, Y., Zahr, T., Wang, Z., Yu, Z., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.11.001 · Cited by 38 · see citing works
Hosooka, T., Hosokawa, Y., Matsugi, K., Shinohara, M., Senga, Y., Tamori, Y., Aoki, C., Matsui, S., Sasaki, T., Kitamura, T., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921015117 · Cited by 38 · see citing works
“Moreover, LTB4 was shown to be produced during chronic inflammation associated with diet-induced obesity and to contribute to the recruitment of macrophages and B2 lymphocytes to adipose tissue (12, 27), implicating LTB4 in insulin resistance triggered by such inflammation in adipose tissue.”
BackgroundRelative Adipose Tissue Failure in Alström Syndrome Drives Obesity-Induced Insulin Resistance
Geberhiwot, T., Baig, S., Obringer, C., Girard, D., Dawson, C., Manolopoulos, K. N., Messaddeq, N., Lassen, P. B., Clément, K., Tomlinson, J., et al. (2020) · Diabetes · doi:10.2337/db20-0647 · Cited by 38 · see citing works
“Although AT is not quantitatively important as a site of postprandial glucose disposal compared with skeletal muscle, it does exert major remote effects on insulin sensitivity in muscle, liver, and other tissues (27,28).”
BackgroundMulti-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study
Downie, C. G., Dimos, S. F., Bien, S. A., Hu, Y., Darst, B. F., Polfus, L. M., Wang, Y., Wojcik, G. L., Tao, R., Raffield, L. M., et al. (2021) · Diabetologia · doi:10.1007/s00125-021-05635-9 · Cited by 39 · see citing works
“The pseudogene LRRC37A5P is next to the PTGR1 gene encoding an enzyme involved in the inactivation of chemotactic factor, leukotriene B4, which is associated with insulin resistance and obesity [51, 52].”
BackgroundWu, Z., Xu, J., Tan, J., Song, Y., Liu, L., Zhang, F., Zhang, Y., Li, X., Chi, Y., & Liu, Y. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14232 · Cited by 38 · see citing works
Yang, Z., Chen, F., Zhang, Y., Ou, M., Tan, P., Xu, X., Li, Q., & Zhou, S. (2024) · MedComm · doi:10.1002/mco2.560 · Cited by 35 · see citing works
Carter, S., Miard, S., Caron, A., Sallé-Lefort, S., St‐Pierre, P., Anhê, F. F., Lavoie-Charland, É., Blais‐Lecours, P., Drolet, M., Lefebvre, J. S., et al. (2018) · Diabetes · doi:10.2337/db17-0558 · Cited by 35 · see citing works
“In DIO models, the recruitment of B lymphocytes in WAT precedes the infiltration of inflammatory CD4 and CD8 T cells and macrophages (5,6), leading to Th1 polarization (7,8) and the production of IgG autoantibodies by B2 cells, which are major factors contributing to the development of insulin resistance (9).”
BackgroundResultCarey, A., Nguyen, K., Kandikonda, P., Kruglov, V., Bradley, C., Dahlquist, K. J. V., Cholensky, S. H., Swanson, W. L., Badovinac, V. P., Griffith, T. S., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113967 · Cited by 32 · see citing works
“78 Our data build on this finding, whereby we show that B1 B cells, but not B2 B cells, from vWAT of old female mice exhibit a transcriptional profile composed of inflammatory pathways and genes.”
BackgroundDwaib, H. S., AlZaim, I., Eid, A. H., Obeid, O., & EL‐Yazbi, A. F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.626313 · Cited by 32 · see citing works
Schwartsburd, P. M. (2017) · Future Science OA · doi:10.4155/fsoa-2017-0015 · Cited by 27 · see citing works
Fatty acid binding protein 4/aP2-dependent BLT1R expression and signaling
Hertzel, A. V., Xu, H., Downey, M. C., Kvalheim, N., & Bernlohr, D. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m074542 · Cited by 26 · see citing works
Role of the Gut Microbiome in Beta Cell and Adipose Tissue Crosstalk: A Review
Martínez‐Montoro, J. I., Damas-Fuentes, M., Fernández‐García, J. C., & Tinahones, F. J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.869951 · Cited by 28 · see citing works
“Other adipose tissue-resident immune cells, such as B2 lymphocytes, may promote insulin resistance via the chemokine leukotriene B4 (LTB4) and its receptor, LTB4 receptor-1 (50).”
BackgroundZhao, L., Fan, M., Zhao, L., Yun, H., Yang, Y., Wang, C., & Qin, D. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15872 · Cited by 23 · see citing works
Dai, M., Yang, X., Yu, Y., & Pan, W. X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.827486 · Cited by 22 · see citing works
“Generally, T helper1 (Th1) cells, Th17 cells, CD8 T cells and B2 cells are responsible for the obesity-induced inflammation,while regulatoryT cells (Tregs), regulatory B cells (Bregs), Th2 cells, B1 cells, and eosinophils contribute to the anti-inflammatory response (77, 78).”
BackgroundAdipose tissue lymphocytes and obesity
Gao, F., Litchfield, B., & Wu, H. (2023) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2023.38 · Cited by 21 · see citing works
“Reports on changes in AT B1 cells in obesity were not consistent, with some studies [29,90] showing reductions but another study [24] showing slight increases in AT B1 cells in mice with obesity.”
BackgroundResultInfluentialDissecting the mechanisms of MASLD fibrosis in the era of single-cell and spatial omics
Colella, F., Henderson, N. C., & Ramachandran, P. (2025) · Journal of Clinical Investigation · doi:10.1172/jci186421 · Cited by 22 · see citing works
“However, a detailed study defining the molecular changes in human LSEC during different stages of MASLD is still lacking.”
Virk, R., Buddenbaum, N., Al‐Shaer, A. E., Armstrong, M., Manke, J., Reisdorph, N. A., Sergin, S., Fenton, J. I., Wallace, E. D., Ehrmann, B. M., et al. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100267 · Cited by 18 · see citing works
“One, select B cell subsets are drivers of inflammation and B2 cells infiltrate white adipose tissue and promote inflammation through a leukotriene B4-mediated mechanism (16, 45).”
BackgroundImmunometabolism in type 2 diabetes mellitus: tissue-specific interactions
Pinheiro-Machado, E., Gurgul-Convey, E., & Marzec, M. (2020) · Archives of medical science : AMS · doi:10.5114/aoms.2020.92674 · Cited by 21 · see citing works
“B lymphocytes have been shown to accumulate before T cells in the AT in HFD models [95] and are recruited by the pro-inflammatory chemokines produced by the AT (CXCL10/CCL2/CCL5) [96], and through leukotriene LTB4 signaling [97].”
BackgroundRamalho, T. R. D. O., Pahlavani, M., Kalupahana, N. S., Wijayatunga, N. N., Ramalingam, L., Jancar, S., & Moustaïd‐Moussa, N. (2020) · Biomolecules · doi:10.3390/biom10091292 · Cited by 17 · see citing works
“Regarding the PI3K signaling in B lymphocytes, there is evidence for the role of active B cells in the milieu of inflamed fat [26].”
BackgroundNeuroimmune regulation of white adipose tissues
Qian, X., Meng, X., Zhang, S., & Zeng, W. (2021) · FEBS Journal · doi:10.1111/febs.16213 · Cited by 16 · see citing works
Blood glucose regulation in context of infection
Wensveen, F. M., Šestan, M., Wensveen, T. T., & Polić, B. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2021.06.009 · Cited by 20 · see citing works
Adaptive Immunity and Metabolic Health: Harmony Becomes Dissonant in Obesity and Aging
Bharath, L. P., Ip, B. C., & Nikolajczyk, B. S. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160042 · Cited by 17 · see citing works
Ağagündüz, D., Yeşildemir, Ö., Koçyiğit, E., Koçak, T., Ünaldı, B. Ö., Ayakdaş, G., & Budán, F. (2024) · Nutrients · doi:10.3390/nu16223812 · Cited by 17 · see citing works
Schweitzer, G. R. B., Rios, I. N. M. S., Gonçalves, V. S. S., Magalhães, K. G., & Pizato, N. (2021) · Journal of Nutritional Science · doi:10.1017/jns.2021.46 · Cited by 16 · see citing works
“The extracted information was categorised as follows: (1) Author, Year of publication, and Country; (2) Study design; (3) Study Period; (4) n-3 PUFA source; (5) Study Protocol; (6) Food or supplement adherence protocol; (7) Age; (8) Baseline BMI; (9) Baseline and Post-Intervention serum eicosanoids markers; and (10) M…”
BackgroundMethodFujimori, K., Uno, S., Kuroda, K., Matsumoto, C., & Maehara, T. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.119203 · Cited by 16 · see citing works
Garg, R., Agarwal, A. K., Katekar, R. A., Dadge, S. D., Yadav, S., & Gayen, J. R. (2023) · Amino Acids · doi:10.1007/s00726-023-03252-x · Cited by 16 · see citing works
Daley, A. D., & Bénézech, C. (2024) · Immunological Reviews · doi:10.1111/imr.13339 · Cited by 16 · see citing works
“105 Overall, this body of work demonstrates the pro-inflammatory effect of B2 cell accumulation in adipose tissue and suggests that the mechanisms underlying this could be related to autoreactive IgG secretion or activation and accumulation of other inflammatory immune cells by cytokine production…”
Vertical sleeve gastrectomy induces distinctive transcriptomic responses in liver, fat and muscle
Ahn, C. H., Choi, E. H., Lee, H.-J., Lee, W., Kim, J., & Cho, Y. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-81866-5 · Cited by 16 · see citing works
The role of immunity in insulin resistance in patients with polycystic ovary syndrome
Zhang, Q., Yang, Z., Ou, X., Zhang, M., Qin, X., & Wu, G. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1464561 · Cited by 19 · see citing works
Huang, Q., Liu, J., Dong, H.-B., Wei, Z., Liu, J., Ren, Y., Jiang, X., & Jiang, B. (2023) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2023.11.006 · Cited by 11 · see citing works
Immune activation induced by dysregulated lipid metabolism in the pathogenesis of type 2 diabetes
Yang, H., Yu, W., Mao, Q., & Zhao, L. (2025) · World Journal of Diabetes · doi:10.4239/wjd.v16.i12.114395 · Cited by 11 · see citing works
Wu, X., Sun, A. R., Crawford, R., Xiao, Y., Wang, Y., Prasadam, I., & Mao, X. (2023) · Cartilage · doi:10.1177/19476035231169940 · Cited by 10 · see citing works
“46,47 In this study, we examined the role of the leukotriene pathway in the development of OA.”
BackgroundLipid nutrition: “In silico” studies and undeveloped experiments
Lands, B. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101142 · Cited by 10 · see citing works
Chang, Y., Xing, L., Zhou, W., & Zhang, W. (2021) · Cell Cycle · doi:10.1080/15384101.2021.1878330 · Cited by 10 · see citing works
The Role of LTB4 in Obesity-Induced Insulin Resistance Development: An Overview
Callegari, I. O. M., & Oliveira, A. G. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.848006 · Cited by 9 · see citing works
“However, as adipose tissue also presents eosinophiles, neutrophiles and other immune cells (3, 31), we cannot rule out their participation, besides adipocytes, in LTB4 synthesis during obesity development.”
BackgroundInfluentialRole for BLT1 in regulating inflammation within adipose tissue immune cells of aged mice
Shih, W.-C., Jang, I. H., Kruglov, V., Dickey, D. M., Cholensky, S. H., Bernlohr, D., & Camell, C. D. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00461-0 · Cited by 9 · see citing works
“BLT1 is also reported to be expressed on B2 B cells in the adipose tissue [47].”
BackgroundShades of white: new insights into tissue‐resident leukocyte heterogeneity
Psaila, A. M., Vohralik, E. J., & Quinlan, K. G. R. (2021) · FEBS Journal · doi:10.1111/febs.15737 · Cited by 9 · see citing works
Chen, W., Meng, F., Zeng, X., Cao, X., Bu, G., Du, X., Yu, G., Kong, F., Li, Y., Gan, T., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032308 · Cited by 8 · see citing works
“edu/, accessed on 28 October 2022) [47] was used to measure the relative proportions of the infiltrating immune cells in adipose tissue, based on the gene expression profile, the signature matrix file of the immune cells was built, based on the mouse tissue expression profiles [62].”
MethodLiu, Y., Luo, J., Cai, R., Zhang, J., Xu, Q., Tian, Y., & Zhou, M.-S. (2020) · BioMed Research International · doi:10.1155/2020/5073762 · Cited by 8 · see citing works
Proarrhythmic Lipid Inflammatory Mediators: Mechanisms in Obesity Arrhythmias
Taqanaki, P. B., Aromolaran, K. A., & Aromolaran, A. S. (2025) · Journal of Cellular Physiology · doi:10.1002/jcp.70012 · Cited by 6 · see citing works
Song, M.-Y., Jeon, Y. G., Yang, J. D., Moon, Y. J., Kim, J. B., Bae, E. J., & Park, B. C. (2026) · Nature Communications · doi:10.1038/s41467-025-66040-z · Cited by 4 · see citing works
“The Olefsky group previously identi fi ed LTB 4 as a potent chemokine for immune cells in obese mice 24,25 .”
Microbiota and Glucidic Metabolism: A Link with Multiple Aspects and Perspectives
Ciarambino, T., Crispino, P., Leto, G., Minervini, G., Para, O., & Giordano, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210409 · Cited by 4 · see citing works
“Finally, B2 lymphocytes, adipose-resident immune cells, adipocyte mitochondrial dysfunction, and reactive oxygen species (ROS) can increase insulin resistance [49] and contribute to beta-cell impairment [50].”
BackgroundAdaptive Immunity and Metabolic Health: Harmony Becomes Dissonant in Obesity and Aging
Bharath, L. P., Ip, B. C., & Nikolajczyk, B. S. (2017) · Comprehensive physiology · doi:10.1002/j.2040-4603.2017.tb00780.x · Cited by 4 · see citing works
“tions of the importance of immune cell cross-talk for “diabetogenic” inflammation (51, 108, 262, 279).”
The Role of B Lymphocyte Subsets in Adipose Tissue Development, Metabolism, and Aging
Fernandez, N. C., & Shinoda, K. (2022) · Comprehensive physiology · doi:10.1002/cphy.c220006 · Cited by 4 · see citing works
Ramalho, T. R. D. O., Pereira, N. F., Brandt, S. L., & Serezani, C. H. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-50621-6_4 · Cited by 3 · see citing works
- Authors
- Ying, W., Wollam, J., Ofrecio, J. M., Bandyopadhyay, G., El Ouarrat, D., Lee, Y. S., Oh, D. Y., Li, P., Osborn, O., & Olefsky, J. M.
- Affiliations
- Tongji University (CN)
- University of California San Diego (US)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Olefsky, Jerrold M.
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2017-02-13
- Volume
- 127
- Issue
- 3
- Pages
- 1019-1030
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC5330737
- OpenAlex
- W2587579012
- Cited by
- 128
- References
- 52
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 10 · 2023: 13 · 2022: 10 · 2021: 24 · 2020: 18 · 2019: 7 · 2018: 15 · 2017: 13
- FWCI
- 11.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- American Heart Association (16POST31350039)
- University of California, San Diego (DK063491)
- National Institute of Allergy and Infectious Diseases (P30AI036214)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK063491, DK 074868, DK 033651, R37DK033651, R01DK101395, DK 09062, P01DK074868, F32DK009062, R01DK033651, P30DK063491)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- insulin resistance, obesity, leukotriene B4, high-fat diet, tissue inflammation, chemokine signaling, glucose homeostasis, T cells, macrophages, adoptive transfer, B cell-deficient mice
- MeSH terms
- Adipose Tissue, Animals, Dietary Fats, Insulin Resistance, Leukotriene B4, Macrophages, Obesity, T-Lymphocytes, Signal Transduction, B-Lymphocyte Subsets, Receptors, Leukotriene B4, Mice, Knockout, Mice
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