Unique biomarkers for B-cell function predict the serum response to pandemic H1N1 influenza vaccine
Open accessAbstract
In order to develop predictive markers for a beneficial humoral immune response, we evaluated the in vivo and in vitro response to the pandemic (p)H1N1 vaccine in young and elderly individuals. We measured serum antibody response and associated this with the in vitro B-cell response to the vaccine, measured by activation-induced cytidine deaminase (AID). Both responses decrease with age and are significantly correlated. The percentage of switched memory B cells in blood, both before and after vaccination, is decreased with age. The percentage of switched memory B cells at t0 correlates with the hemagglutination inhibition response and therefore, we suggest that this may be used as a predictive marker for B-cell responsiveness. AID induced by CpG before vaccination also predicts the robustness of the vaccine response. Plasmablasts showed a trend to increase after vaccination in young individuals only. This report establishes molecular biomarkers of response, percentage of switched memory B cells and AID response to CpG, useful for identifying individuals at risk of poor response and also for measuring improvements in vaccines and monitoring optimal humoral responses.
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Switched memory B cells are predictors of optimal antibody responses.
“Using these markers, it has been shown that the percentage of switched memory B cells, the predictors of optimal antibody responses [114], decreases with age [115, 116].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [114]
Serum antibody response to seasonal and pandemic influenza vaccines, and in vitro B-cell response after vaccination, both decrease with increasing age and are significantly correlated.
“For example, the serum antibody response to both seasonal and pandemic influenza vaccines, as well as the in vitro B-cell response after vaccination, are both decreased with increasing age and are significantly correlated [114, 124, 125].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [114]
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Self-citation
- Authors
- Frasca, D., Diaz, A., Romero, M., Phillips, M., Mendez, N. V., Landin, A. M., & Blomberg, B. B.
- Affiliations
- University of Miami (US)
- Venue
- International Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-01-25
- Volume
- 24
- Issue
- 3
- Pages
- 175-182
- ISSN
- 0953-8178 (ISSN-L)
- 1460-2377
- PMC
- PMC3621378
- OpenAlex
- W2147320022
- Cited by
- 86
- References
- 38
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 10 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 8 · 2015: 8 · 2014: 4 · 2013: 8 · 2012: 7
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Immunology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Miami
- Sylvester Comprehensive Cancer Center, University of Miami Health Systems
- Leonard M. Miller School of Medicine
- National Institute on Aging (R01AG032576, AG-17618, R01AG017618, AG-28586, R21AG028586)
- National Institute of Allergy and Infectious Diseases (R21AI096446)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- B cell function, predictive biomarkers, humoral immune response, activation-induced cytidine deaminase, switched memory B cells, age-related immune decline, hemagglutination inhibition, CpG, plasmablasts, vaccine response variability
- MeSH terms
- AICDA (Activation-Induced Cytidine Deaminase), Adult, Age Factors, Aged, Aging, Cytidine Deaminase, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Hemagglutination Inhibition Tests, Humans, Influenza, Human, Influenza Vaccines, Male, Middle Aged, Plasma Cells, Biomarkers, Reverse Transcriptase Polymerase Chain Reaction, Influenza A Virus, H1N1 Subtype, Young Adult, Pandemics
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