Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine
Open accessAbstract
Cytomegalovirus (CMV)-seropositivity has been shown to have a negative effect on influenza vaccine-specific antibody responses. In this paper, we confirm and extend these results showing for the first time, a negative association between CMV-seropositivity and B cell predictive biomarkers of optimal vaccine responses. These biomarkers are switched memory B cells and AID in CpG-stimulated B cell cultures measured before vaccination which positively correlate with the serum response to the influenza vaccine. We also found that CMV-seropositivity is associated with increased levels of B cell-intrinsic inflammation and these both correlate with lower B cell function. Finally, CMV-seropositivity is associated with decreased percentages of individuals responding to the vaccine in both young and elderly individuals.
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These intrinsic B-cell defects include decreases in expression and function of the transcription factor E47.
“and include decreases in expression and function of the key transcription factor E47 (see below), along with a reduction in activation-induced cytidine deaminase (AID), the enzyme of class switch recombination and somatic hypermutation.”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [122]
These intrinsic B-cell defects include a reduction in activation-induced cytidine deaminase (AID).
“and include decreases in expression and function of the key transcription factor E47 (see below), along with a reduction in activation-induced cytidine deaminase (AID), the enzyme of class switch recombination and somatic hypermutation.”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [122]
Age-related intrinsic B-cell defects responsible for sub-optimal antibody responses in elderly to infections and vaccines have been identified.
“Age-related intrinsic B-cell defects, responsible for sub-optimal antibody responses in elderly individuals to infections and vaccines have been identified [95, 121–123]”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [122]
Immune changes associated with HCMV may have significant impact during co-infection and vaccination, as well as on general and immunological fitness.
“Immune changes associated with HCMV may have significant impact during co-infection and vaccination, as well as on general and immunological fitness.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [54]
The correlation between HCMV positivity and impaired responses is controversial because this relationship is observed in some but not all studies.
“However, the correlation between HCMV positivity and impaired responses is controversial because this relationship is observed in some but not all studies (54–56).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [54]
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- Authors
- Frasca, D., Diaz, A., Romero, M., Landin, A. M., & Blomberg, B. B.
- Affiliations
- University of Miami (US)
- Corresponding author
- Frasca, Daniela
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 33
- Issue
- 12
- Pages
- 1433-1439
- ISSN
- 0264-410X (ISSN-L)
- PMC
- PMC4352374
- OpenAlex
- W2091998440
- Cited by
- 116
- References
- 37
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 4 · 2023: 6 · 2022: 14 · 2021: 9 · 2020: 14 · 2019: 8 · 2018: 9 · 2017: 16 · 2016: 19 · 2015: 4
- FWCI
- 12.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Miami
- Sylvester Comprehensive Cancer Center, University of Miami Health Systems
- National Institutes of Health
- Leonard M. Miller School of Medicine
- National Institute on Aging (R01AG032576, AG32576, R56AG032576, R21AG042826)
- National Institute of Allergy and Infectious Diseases (R21AI096446)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- cytomegalovirus seropositivity, influenza vaccination, B cell response, vaccine antibody response, switched memory B cells, activation-induced cytidine deaminase, older adults, young adults
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Antibodies, Viral, B-Lymphocytes, Cytomegalovirus Infections, Cytomegalovirus, Female, Humans, Immunologic Memory, Influenza Vaccines, Male, Middle Aged, Serologic Tests, Vaccination, Biomarkers, Young Adult
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