The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Regulatory T-Cells: Potential Regulator of Tissue Repair and Regeneration
Open accessAbstract
The identification of stem cells and growth factors as well as the development of biomaterials hold great promise for regenerative medicine applications. However, the therapeutic efficacy of regenerative therapies can be greatly influenced by the host immune system, which plays a pivotal role during tissue repair and regeneration. Therefore, understanding how the immune system modulates tissue healing is critical to design efficient regenerative strategies. While the innate immune system is well known to be involved in the tissue healing process, the adaptive immune system has recently emerged as a key player. T-cells, in particular, regulatory T-cells (Treg), have been shown to promote repair and regeneration of various organ systems. In this review, we discuss the mechanisms by which Treg participate in the repair and regeneration of skeletal and heart muscle, skin, lung, bone, and the central nervous system.
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Transient Regenerative Potential of the Neonatal Mouse Heart
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The inhibitory cytokine IL-35 contributes to regulatory T-cell function
Collison, L. W., Workman, C. J., Kuo, T. T., Boyd, K., Wang, Y., Vignali, K. M., Cross, R., Sehy, D., Blumberg, R. S., & Vignali, D. A. A. (2007) · Nature · doi:10.1038/nature06306 · Cited by 2,066
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
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Embryonic stem cell trials for macular degeneration: a preliminary report
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Inflammation and metabolism in tissue repair and regeneration
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A Special Population of Regulatory T Cells Potentiates Muscle Repair
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“Overall, studies investigating the role of Treg during tissue regeneration have been largely based on the use of Foxp3DTR mouse model (17, 18, 22, 25, 57, 77, 90).”
BackgroundMethodInfluentialInterleukin-2 and Regulatory T Cells in Graft-versus-Host Disease
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Cited by
Treg Heterogeneity, Function, and Homeostasis
Shevyrev, D., & Tereshchenko, V. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03100 · Cited by 404
Xiong, Y., Mi, B.-B., Lin, Z., Hu, Y.-Q., Yu, L., Zha, K.-K., Panayi, A. C., Yu, T., Chen, L., Liu, Z.-P., et al. (2022) · Military Medical Research · doi:10.1186/s40779-022-00426-8 · Cited by 291
Recent advances in molecular mechanisms of skin wound healing and its treatments
Mamun, A. A., Shao, C., Geng, P., Wang, S., & Xiao, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1395479 · Cited by 284
Organization of the skin immune system and compartmentalized immune responses in infectious diseases
Quaresma, J. A. S. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00034-18 · Cited by 149
Bowles, A. C., Kouroupis, D., Willman, M. A., Perucca Orfei, C., Agarwal, A., & Correa, D. (2020) · Stem Cells · doi:10.1002/stem.3196 · Cited by 120
Metadata
- Authors
- Li, J., Tan, J., Martino, M. M., & Lui, K. O.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2018-03-23
- Volume
- 9
- Pages
- 585-585
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2790194345
- Cited by
- 344
- References
- 110
- FWCI
- 12.82
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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