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Cited by 11T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Role of Dendritic Epidermal T Cells in Cutaneous Carcinoma

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Xiang, Jian, Qiu, Minghui, Zhang, Hongyi·2020·Frontiers in Immunology
DOI 10.3389/fimmu.2020.01266PMC PMC7381160
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Abstract

. Eventually, mature DETCs proliferate and maintain a homeostatic population in the epidermis through IL-15 and aryl hydro-carbon receptor signaling. In "stressed" skin, DETCs are activated, exhibiting features such as a round morphology, cytotoxicity, and production of cytokines. In cutaneous carcinoma, DETCs generally inhibit tumor development directly in non-major histocompatibility complex-restricted manner, with the assistance of cytokines. DETCs also recognize and inhibit tumor via TCR, non-TCR receptors (such as 2B4 and NKG2D), or both. This study summarizes the biogenesis and the function of DETCs in cutaneous carcinoma and clarifies the essential surveillance role in the epidermis that DETCs play. As there are no DETCs in human epidermis but only human epidermis γδ T cells, we need to understand the anti-tumor pathways used by DETCs to find analogous immune pathways in human skin, which could be exploited for novel therapeutics.

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  • SKINT1 was shown to couple thymic selections of DETC precursors to their functional programming as IFN-γ producers.

    “Moreover, SKINT1 was shown to couple thymic selections of DETC precursors to their functional programming as IFN-γ producers (31).”

    From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [31]

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Cited by

Sorted by citations

Authors
Xiang, J., Qiu, M., & Zhang, H.
Affiliations
Jinan University (CN)
Corresponding author
Zhang, Hongyi
ORCID
Zhang, Hongyi
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2020-07-14
Volume
11
Pages
1266-1266
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2020.01266
PMC
PMC7381160
OpenAlex
W3043517209
Cited by
11
References
5
Citations by year
2025: 2 · 2024: 3 · 2022: 5 · 2021: 1
FWCI
0.15
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Natural Science Foundation of Guangdong Province
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords
dendritic epidermal T cells, cutaneous carcinoma, IL-15, aryl hydrocarbon receptor, cytotoxic T lymphocytes, NKG2D, 2B4, antitumor immunity, γδ T cells
MeSH terms
Intraepithelial Lymphocytes, Animals, Carcinoma, Cell Transformation, Neoplastic, Disease Susceptibility, Humans, Skin Neoplasms

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