The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Roles of Macrophage Polarization and Macrophage-Derived miRNAs in Pulmonary Fibrosis
Open accessAbstract
This mini-review summarizes the current evidence for the role of macrophage activation and polarization in inflammation and immune response pertinent to interstitial lung disease, specifically pulmonary fibrosis. In the fibrosing lung, the production and function of inflammatory and fibrogenic mediators involved in the disease development have been reported to be regulated by the effects of polarized M1/M2 macrophage populations. The M1 and M2 macrophage phenotypes were suggested to correspond with the pro-inflammatory and pro-fibrogenic signatures, respectively. These responses towards tissue injury followed by the development and progression of lung fibrosis are further regulated by macrophage-derived microRNAs (miRNAs). Besides cellular miRNAs, extracellular exosomal-miRNAs derived from M2 macrophages have also been proposed to promote the progression of pulmonary fibrosis. In a future perspective, harnessing the noncoding miRNAs with a key role in the macrophage polarization is, therefore, suggested as a promising therapeutic strategy for this debilitating disease.
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Murray, P. J. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034339 · Cited by 2,981
Martinez, F. J., Collard, H. R., Pardo, A., Raghu, G., Richeldi, L., Selman, M., Swigris, J. J., Taniguchi, H., & Wells, A. U. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.74 · Cited by 1,388
M2b macrophage polarization and its roles in diseases
Wang, L.-X., Zhang, S.-X., Wu, H.-J., Rong, X.-L., & Guo, J. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ru1018-378rr · Cited by 884
Macrophage activation switching: an asset for the resolution of inflammation
Porcheray, F., Viaud, S., Rimaniol, A.-C., Léone, C., Samah, B., Dereuddre-Bosquet, N., Dormont, D., & Gras, G. (2005) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2005.02934.x · Cited by 840
Macrophages: Their role, activation and polarization in pulmonary diseases
Arora, S., Dev, K., Agarwal, B., Das, P., & Syed, M. A. (2018) · Immunobiology · doi:10.1016/j.imbio.2017.11.001 · Cited by 639
Essandoh, K., Li, Y., Huo, J., & Fan, G.-C. (2016) · Shock · doi:10.1097/shk.0000000000000604 · Cited by 606
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Pulmonary macrophages: key players in the innate defence of the airways
Byrne, A. J., Mathie, S. A., Gregory, L. G., & Lloyd, C. M. (2015) · Thorax · doi:10.1136/thoraxjnl-2015-207020 · Cited by 484
Macrophages: friend or foe in idiopathic pulmonary fibrosis?
Zhang, L., Wang, Y., Wu, G., Xiong, W., Gu, W., & Wang, C.-Y. (2018) · Respiratory Research · doi:10.1186/s12931-018-0864-2 · Cited by 375
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Hu, Z., Chen, G., Yan, C., Li, Z., Wu, T., Li, L., & Zhang, S. (2023) · Environmental Toxicology · doi:10.1002/tox.23795 · Cited by 18
Astrab, L. R., Skelton, M. L., & Caliari, S. R. (2024) · doi:10.1101/2024.10.13.618034 · Cited by 2
Metadata
- Authors
- Kishore, A., & Petrek, M.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2021-08-13
- Volume
- 12
- Pages
- 678457-678457
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W3195196860
- Cited by
- 268
- References
- 83
- FWCI
- 22.69
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kishore, A., & Petrek, M. (2021). Roles of Macrophage Polarization and Macrophage-Derived miRNAs in Pulmonary Fibrosis. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2021.678457
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
