The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Macrophages: friend or foe in idiopathic pulmonary fibrosis?
Open accessAbstract
Idiopathic pulmonary fibrosis (IPF) is a prototype of lethal, chronic, progressive interstitial lung disease of unknown etiology. Over the past decade, macrophage has been recognized to play a significant role in IPF pathogenesis. Depending on the local microenvironments, macrophages can be polarized to either classically activated (M1) or alternatively activated (M2) phenotypes. In general, M1 macrophages are responsible for wound healing after alveolar epithelial injury, while M2 macrophages are designated to resolve wound healing processes or terminate inflammatory responses in the lung. IPF is a pathological consequence resulted from altered wound healing in response to persistent lung injury. In this review, we intend to summarize the current state of knowledge regarding the process of macrophage polarization and its mediators in the pathogenesis of pulmonary fibrosis. Our goal is to update the understanding of the mechanisms underlying the initiation and progression of IPF, and by which, we expect to provide help for developing effective therapeutic strategies in clinical settings.
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Cites
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Cited by
Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
Dinh, P.-U. C., Paudel, D., Brochu, H., Popowski, K. D., Gracieux, M. C., Cores, J., Huang, K., Hensley, M. T., Harrell, E., Vandergriff, A. C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14344-7 · Cited by 435
Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries
Bezerra, F. S., Lanzetti, M., Nesi, R. T., Nagato, A. C., Silva, C. P. E., Kennedy-Feitosa, E., Melo, A. C., Cattani-Cavalieri, I., Porto, L. C., & Valenca, S. S. (2023) · Antioxidants · doi:10.3390/antiox12030548 · Cited by 336
Idiopathic Pulmonary Fibrosis and Lung Cancer: Mechanisms and Molecular Targets
Ballester, B., Milara, J., & Cortijo, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030593 · Cited by 308
Roles of Macrophage Polarization and Macrophage-Derived miRNAs in Pulmonary Fibrosis
Kishore, A., & Petrek, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.678457 · Cited by 268
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Self-citation
Metadata
- Authors
- Zhang, L., Wang, Y., Wu, G., Xiong, W., Gu, W., & Wang, C.-Y.
- Venue
- Respiratory Research
- Published
- 2018-09-06
- Volume
- 19
- Issue
- 1
- Pages
- 170-170
- ISSN
- 1465-9921 (ISSN-L)
- 1465-993X
- OpenAlex
- W2891255725
- Cited by
- 375
- References
- 123
- FWCI
- 15.89
- Type
- journal article
- Language
- en
- Open access
- gold
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