Reduced Mass and Diversity of the Colonic Microbiome in Patients with Multiple Sclerosis and Their Improvement with Ketogenic Diet

Alterations of the human gut microbiome in multiple sclerosis

Jangi, S., Gandhi, R., Cox, L. M., Li, N., von Glehn, F., Yan, R., Patel, B., Mazzola, M. A., Liu, S., Glanz, B. L., et al. (2016) · Nature Communications · doi:10.1038/ncomms12015 · Cited by 1,307 · see citing works

Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters

Miyake, S., Kim, S., Suda, W., Oshima, K., Nakamura, M., Matsuoka, T., Chihara, N., Tomita, A., Sato, W., Kim, S.-W., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137429 · Cited by 809 · see citing works

The Gut Microbiome and the Brain

Galland, L. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2014.7000 · Cited by 648 · see citing works

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms

Choi, I. Y., Piccio, L. M., Childress, P., Bollman, B., Ghosh, A., Brandhorst, S., Suarez, J., Michalsen, A., Cross, A. H., Morgan, T. E., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.009 · Cited by 508 · see citing works

probeBase--an online resource for rRNA-targeted oligonucleotide probes: new features 2007

Loy, A., Maixner, F., Wagner, M., & Horn, M. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl856 · Cited by 488 · see citing works

Gut microbiota in early pediatric multiple sclerosis: a case−control study

Tremlett, H. L., Fadrosh, D. W., Faruqi, A. A., Zhu, F., Hart, J., Roalstad, S., Graves, J., Lynch, S. V., & Waubant, E. L. (2016) · European Journal of Neurology · doi:10.1111/ene.13026 · Cited by 347 · see citing works

Inflammation-Mediated Memory Dysfunction and Effects of a Ketogenic Diet in a Murine Model of Multiple Sclerosis

Kim, D. Y., Hao, J., Liu, R.-L., Turner, G., Shi, F.-D., & Rho, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035476 · Cited by 261 · see citing works

Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis

Piccio, L. M., Stark, J. L., & Cross, A. H. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0208133 · Cited by 235 · see citing works

Fusobacterium prausnitzii and Related Species Represent a Dominant Group Within the Human Fecal Flora

Suau, A., Rochet, V., Sghir, A., Gramet, G., Brewaeys, S., Sutren, M., Rigottier‐Gois, L., & Dore, J. M. (2001) · Systematic and Applied Microbiology · doi:10.1078/0723-2020-00015 · Cited by 195 · see citing works

probeBase—an online resource for rRNA-targeted oligonucleotide probes and primers: new features 2016

Greuter, D., Loy, A., Horn, M., & Rattei, T. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1232 · Cited by 184 · see citing works

Microbial view of central nervous system autoimmunity

Berer, K., & Krishnamoorthy, G. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.04.007 · Cited by 150 · see citing works

Enrichment or depletion? The impact of stool pretreatment on metaproteomic characterization of the human gut microbiota

Tanca, A., Palomba, A., Pisanu, S., Addis, M. F., & Uzzau, S. (2015) · PROTEOMICS · doi:10.1002/pmic.201400573 · Cited by 76 · see citing works

Emerging Concepts on the Gut Microbiome and Multiple Sclerosis

Glenn, J. D., & Mowry, E. M. (2016) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2015.0177 · Cited by 30 · see citing works

Functional anatomy of the colonic bioreactor: Impact of antibiotics and Saccharomyces boulardii on bacterial composition in human fecal cylinders

Swidsinski, A. V., Loening-Baucke, V. A., Schulz, S., Manowsky, J., Verstraelen, H., & Swidsinski, S. (2015) · Systematic and Applied Microbiology · doi:10.1016/j.syapm.2015.11.002 · Cited by 30 · see citing works

Functional biostructure of colonic microbiota (central fermenting area, germinal stock area and separating mucus layer) in healthy subjects and patients with diarrhea treated with Saccharomyces boulardii

Swidsinski, A. V., Loening-Baucke, V. A., Kirsch, S., & Döerffel, Y. (2010) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(10)70025-7 · Cited by 26 · see citing works

Standards for bacterial identification by fluorescence in situ hybridization within eukaryotic tissue using ribosomal rRNA-based probes

Swidsinski, A. V. (2006) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200608000-00018 · Cited by 24 · see citing works

Moving microbiota research toward establishing causal associations that represent viable targets for effective public health interventions

Mai, V., Prosperi, M., & Yaghjyan, L. (2016) · Annals of Epidemiology · doi:10.1016/j.annepidem.2016.03.011 · Cited by 13 · see citing works

サッカロミセス・ブラウディによる治療を受けている下痢患者と健康な対象における結腸細菌叢の機能的な生物学的構造(中央発酵部,胚株部,分離粘液層)

Swidsinski, A. V., Loening-Baucke, V. A., Kirsch, S., & Döerffel, Y. (2010) · Gastroentérologie Clinique et Biologique · Cited by 3 · see citing works

The gut microbiota at the intersection of diet and human health

Gentile, C. L., & Weir, T. L. (2018) · Science · doi:10.1126/science.aau5812 · Cited by 1,049 · see citing works

Gut Microbiome: Profound Implications for Diet and Disease

Hills, R. D., Pontefract, B., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2019) · Nutrients · doi:10.3390/nu11071613 · Cited by 1,107 · see citing works

Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation

Romano, S., Savva, G. M., Bedarf, J. R., Charles, I. G., Hildebrand, F., & Narbad, A. (2021) · npj Parkinson's Disease · doi:10.1038/s41531-021-00156-z · Cited by 707 · see citing works

Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations

Zhu, H., Bi, D., Zhang, Y., Kong, C., Du, J., Wu, X., Wei, Q., & Qin, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00831-w · Cited by 412 · see citing works

Exercise, diet and stress as modulators of gut microbiota: Implications for neurodegenerative diseases

Gubert, C., Kong, G., Renoir, T., & Hannan, A. J. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104621 · Cited by 372 · see citing works

Ketogenic Diet and Microbiota: Friends or Enemies?

Paoli, A., Mancin, L., Bianco, A., Thomas, E., Mota, J. F., & Piccini, F. (2019) · Genes · doi:10.3390/genes10070534 · Cited by 265 · see citing works

Butyrate suppresses demyelination and enhances remyelination

Chen, T., Noto, D., Hoshino, Y., Mizuno, M., & Miyake, S. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1552-y · Cited by 229 · see citing works

Leveraging diet to engineer the gut microbiome

Wolter, M., Grant, E. T., Boudaud, M., Steimle, A., Pereira, G. V., Martens, E. C., & Desai, M. S. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00512-7 · Cited by 211 · see citing works

Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity

Montgomery, T. L., Eckstrom, K. M., Lile, K. H., Caldwell, S. K., Heney, E. R., Lahue, K. G., D’Alessandro, A., Wargo, M. J., & Krementsov, D. N. (2022) · Microbiome · doi:10.1186/s40168-022-01408-7 · Cited by 200 · see citing works

The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics

Camara-Lemarroy, C. R., Metz, L. M., Meddings, J. B., Sharkey, K. A., & Yong, V. W. (2018) · Brain · doi:10.1093/brain/awy131 · Cited by 188 · see citing works

Microbiota-gut brain axis involvement in neuropsychiatric disorders

Iannone, L. F., Preda, A., Blottière, H. M., Clarke, G., Albani, D., Belcastro, V., Carotenuto, M., Cattaneo, A., Citraro, R., Ferraris, C., et al. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1638763 · Cited by 177 · see citing works

Diet, nutrients and the microbiome

Dahl, W. J., Rivero‐Mendoza, D., & Lambert, J. M. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.04.006 · Cited by 172 · see citing works

Impact of Different Types of Diet on Gut Microbiota Profiles and Cancer Prevention and Treatment

Klement, R. J., & Pazienza, V. (2019) · Medicina · doi:10.3390/medicina55040084 · Cited by 158 · see citing works

The multiple sclerosis gut microbiota: A systematic review

Mirza, A., Forbes, J. D., Zhu, F., Bernstein, C. N., Domselaar, G. V., Graham, M., Waubant, E. L., & Tremlett, H. L. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.101427 · Cited by 152 · see citing works

Impact of 5 fluorouracil chemotherapy on gut inflammation, functional parameters, and gut microbiota

Sougiannis, A. T., VanderVeen, B. N., Enos, R. T., Velázquez, K. T., Bader, J. E., Carson, M. S., Chatzistamou, I., Walla, M. D., Pena, M. M., Kubinak, J. L., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.02.020 · Cited by 141 · see citing works

Changes in Gut Microbiota and Multiple Sclerosis: A Systematic Review

Ordoñez-Rodriguez, A., Román, P., Rueda‐Ruzafa, L., Campos-Ríos, A., & Cardona, D. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20054624 · Cited by 138 · see citing works

Mining microbes for mental health: determining the role of microbial metabolic pathways in human brain health and disease

Spichak, S., Bastiaanssen, T. F. S., Berding, K., Vlckova, K., Clarke, G., Dinan, T. G., & Cryan, J. F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.044 · Cited by 127 · see citing works

Ketogenic Diets for Adult Neurological Disorders

McDonald, T. J. W., & Cervenka, M. C. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0666-8 · Cited by 127 · see citing works

Neuroprotection by the Ketogenic Diet: Evidence and Controversies

Gough, S. M., Casella, A., Ortega, K. J., & Hackam, A. S. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.782657 · Cited by 119 · see citing works

Molecular Mechanisms of Neuroprotection by Ketone Bodies and Ketogenic Diet in Cerebral Ischemia and Neurodegenerative Diseases

Jang, J., Kim, S. R., Lee, J. E., Lee, S.-Y., Son, H. J., Choe, W., Yoon, K., Kim, S. S., Yeo, E., & Kang, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010124 · Cited by 107 · see citing works

The Impact of Low-FODMAPs, Gluten-Free, and Ketogenic Diets on Gut Microbiota Modulation in Pathological Conditions

Reddel, S., Putignani, L., & Del Chierico, F. (2019) · Nutrients · doi:10.3390/nu11020373 · Cited by 104 · see citing works

Ketogenic diet and fasting diet as Nutritional Approaches in Multiple Sclerosis (NAMS): protocol of a randomized controlled study

Bahr, L. S., Bock, M., Liebscher, D., Bellmann–Strobl, J., Franz, L., Prüß, A., Schumann, D., Piper, S. K., Keßler, C. S., Steckhan, N., et al. (2020) · Trials · doi:10.1186/s13063-019-3928-9 · Cited by 89 · see citing works

The Role of the Gut Microbiome in Energy Balance With a Focus on the Gut-Adipose Tissue Axis

Han, X., & Kang, S. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00297 · Cited by 82 · see citing works

The human gut virome: composition, colonization, interactions, and impacts on human health

Pargin, E., Roach, M. J., Skye, A., Papudeshi, B. N., Inglis, L. K., Mallawaarachchi, V., Grigson, S. R., Harker, C. M., Edwards, R. A., & Giles, S. K. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.963173 · Cited by 82 · see citing works

The Role of Diet and Gut Microbiota in Alzheimer’s Disease

Dissanayaka, D. M. S., Jayasena, V., Rainey‐Smith, S. R., Martins, R. N., & Fernando, W. M. A. D. B. (2024) · Nutrients · doi:10.3390/nu16030412 · Cited by 78 · see citing works

Potential Protective Mechanisms of Ketone Bodies in Migraine Prevention

Gross, E. C., Klement, R. J., Schoenen, J. E., D’Agostino, D. P., & Fischer, D. (2019) · Nutrients · doi:10.3390/nu11040811 · Cited by 76 · see citing works

Gut Microbiome: Profound Implications for Diet and Disease

Hills, R. D., Pontefract, B., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2022) · Kompass Nutrition & Dietetics · doi:10.1159/000523712 · Cited by 79 · see citing works

Focus on the gut-brain axis: Multiple sclerosis, the intestinal barrier and the microbiome

Camara-Lemarroy, C. R., Metz, L. M., & Yong, V. W. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i37.4217 · Cited by 75 · see citing works

Microbiota–gut–brain axis in health and neurological disease: Interactions between gut microbiota and the nervous system

He, Y., Wang, K., Su, N., Yuan, C., Zhang, N., Hu, X., Fu, Y., & Zhao, F. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70099 · Cited by 73 · see citing works

Keto microbiota: A powerful contributor to host disease recovery

Cabrera-Mulero, A., Tinahones, A., Bandera-Merchán, B., Moreno‐Indias, I., Macías‐González, M., & Tinahones, F. J. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09518-8 · Cited by 70 · see citing works

Obesity, Gut Microbiota, and Metabolome: From Pathophysiology to Nutritional Interventions

Puljiz, Z., Kumrić, M., Vrdoljak, J., Martinović, D., Kurir, T. T., Krnic, M. O., Urlić, H., Puljiz, Ž., Žučko, J., Dumanić, P., et al. (2023) · Nutrients · doi:10.3390/nu15102236 · Cited by 72 · see citing works

Ketogenic diets attenuate cyclooxygenase and lipoxygenase gene expression in multiple sclerosis

Bock, M., Karber, M., & Kühn, H. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.08.057 · Cited by 68 · see citing works

Ketogenic Diet for the Treatment and Prevention of Dementia: A Review

Davis, J. J., Fournakis, N. A., & Ellison, J. M. (2020) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988720901785 · Cited by 70 · see citing works

Gut microbes in cerebrovascular diseases: Gut flora imbalance, potential impact mechanisms and promising treatment strategies

Zou, X., Wang, L., Xiao, L., Wang, S., & Zhang, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.975921 · Cited by 70 · see citing works

Ketogenic Diet: An Effective Treatment Approach for Neurodegenerative Diseases

Zhang, H., Tao, Y., & Leng, S. X. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220830102628 · Cited by 71 · see citing works

A serine-conjugated butyrate prodrug with high oral bioavailability suppresses autoimmune arthritis and neuroinflammation in mice

Cao, S., Budina, E., Raczy, M. M., Solanki, A., Nguyen, M., Beckman, T. N., Reda, J. W., Hultgren, K., Ang, P. S., Slezak, A. J., et al. (2024) · Nature Biomedical Engineering · doi:10.1038/s41551-024-01190-x · Cited by 71 · see citing works

An overview of the current state of evidence for the role of specific diets in multiple sclerosis

Evans, E. M., Levasseur, V. A., Cross, A. H., & Piccio, L. M. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.101393 · Cited by 65 · see citing works

A Modified MCT-Based Ketogenic Diet Increases Plasma β-Hydroxybutyrate but Has Less Effect on Fatigue and Quality of Life in People with Multiple Sclerosis Compared to a Modified Paleolithic Diet: A Waitlist-Controlled, Randomized Pilot Study

Lee, J. E., Titcomb, T. J., Bisht, B., Rubenstein, L. M., Louison, R. R., & Wahls, T. L. (2020) · Journal of the American College of Nutrition · doi:10.1080/07315724.2020.1734988 · Cited by 65 · see citing works

Trimethylamine‐N‐oxide is elevated in the acute phase after ischaemic stroke and decreases within the first days

Schneider, C., Okun, J. G., Schwarz, K. V., Hauke, J., Zorn, M., Nürnberg, C., Ungerer, M. N., Ringleb, P. A., & Mundiyanapurath, S. (2020) · European Journal of Neurology · doi:10.1111/ene.14253 · Cited by 64 · see citing works

Impact of the Swank and Wahls elimination dietary interventions on fatigue and quality of life in relapsing-remitting multiple sclerosis: The WAVES randomized parallel-arm clinical trial

Wahls, T. L., Titcomb, T. J., Bisht, B., Eyck, P. T., Rubenstein, L. M., Carr, L. J., Darling, W. G., Hoth, K. F., Kamholz, J. A., & Snetselaar, L. (2021) · Multiple Sclerosis Journal - Experimental Translational and Clinical · doi:10.1177/20552173211035399 · Cited by 62 · see citing works

Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites

Frausto, D. M., Forsyth, C. B., Keshavarzian, A., & Voigt, R. M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.736814 · Cited by 61 · see citing works

A review on preventive role of ketogenic diet (KD) in CNS disorders from the gut microbiota perspective

Rawat, K., Singh, N., Kumari, P., & Saha, L. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0078 · Cited by 58 · see citing works

The impact of keto-adaptation on exercise performance and the role of metabolic-regulating cytokines

Sherrier, M. C., & Li, H. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz145 · Cited by 56 · see citing works

Perturbations of the gut microbiome in anti-CCP positive individuals at risk of developing rheumatoid arthritis

Rooney, C. M., Mankia, K. S., Mitra, S., Moura, I. B., Emery, P., & Wilcox, M. H. (2020) · Rheumatology · doi:10.1093/rheumatology/keaa792 · Cited by 54 · see citing works

A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity

Alexander, M., Upadhyay, V., Rock, R., Ramirez, L., Trepka, K. R., Puchalska, P., Orellana, D. A., Ang, Q. Y., Whitty, C., Turnbaugh, J. A., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114891 · Cited by 48 · see citing works

Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: The guardian angle

Al-Kuraishy, H. M., Jabir, M. S., Albuhadily, A. K., Al-Gareeb, A. I., Jawad, S. F., Swelum, A. A., & Hadi, N. R. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102233 · Cited by 51 · see citing works

Perinatal tissue-derived exosomes ameliorate colitis in mice by regulating the Foxp3 + Treg cells and gut microbiota

Yan, Y., Li, K., Jiang, J., Jiang, L., Ma, X., Ai, F., Qiu, S., & Si, W. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03263-1 · Cited by 51 · see citing works

Dysbiosis of gut microbiota in patients with neuromyelitis optica spectrum disorders: A cross sectional study

Shi, Z., Qiu, Y., Wang, J., Fang, Y., Zhang, Y., Chen, H., Du, Q., Zhao, Z., Yan, C., Yang, M., et al. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.577126 · Cited by 50 · see citing works

Impact of Dietary Intervention on Serum Neurofilament Light Chain in Multiple Sclerosis

Bock, M., Steffen, F., Zipp, F., & Bittner, S. (2021) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000001102 · Cited by 49 · see citing works

One Month of Classic Therapeutic Ketogenic Diet Decreases Short Chain Fatty Acids Production in Epileptic Patients

Ferraris, C., Meroni, E., Casiraghi, M. C., Tagliabue, A., GIORGIS, V. D., & Erba, D. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.613100 · Cited by 47 · see citing works

Feeding the gut microbiome: impact on multiple sclerosis

Bronzini, M., Maglione, A., Rosso, R., Matta, M., Masuzzo, F., Rolla, S., & Clerico, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1176016 · Cited by 46 · see citing works

Changes in Intestinal Microbiota and Predicted Metabolic Pathways During Colonic Fermentation of Mango (Mangifera indica L.)—Based Bar Indigestible Fraction

Gutiérrez-Sarmiento, W., Sáyago‐Ayerdi, S. G., Goñi, I., Gutiérrez-Miceli, F. A., Abud‐Archila, M., Rejón-Orantes, J. D. C., Rincón-Rosales, R., Peña-Ocaña, B. A., & Ruíz-Valdiviezo, V. M. (2020) · Nutrients · doi:10.3390/nu12030683 · Cited by 43 · see citing works

Targeting gut microbiota: new therapeutic opportunities in multiple sclerosis

Kujawa, D., Łaczmański, Ł., Budrewicz, S. P., Pokryszko‐Dragan, A., & Podbielska, M. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2274126 · Cited by 44 · see citing works

The Role of Nutritional Lifestyle and Physical Activity in Multiple Sclerosis Pathogenesis and Management: A Narrative Review

Fanara, S., Aprile, M., Iacono, S., Schirò, G., Bianchi, A., Brighina, F., Dominguez, L. J., Ragonese, P., & Salemi, G. (2021) · Nutrients · doi:10.3390/nu13113774 · Cited by 41 · see citing works

The Relationship of Ketogenic Diet with Neurodegenerative and Psychiatric Diseases: A Scoping Review from Basic Research to Clinical Practice

Mentzelou, M., Dakanalis, A., Vasios, G. K., Gialeli, M., Papadopoulou, S. Κ., & Giaginis, C. (2023) · Nutrients · doi:10.3390/nu15102270 · Cited by 39 · see citing works

The ketogenic diet: its impact on human gut microbiota and potential consequent health outcomes: a systematic literature review.

Rew, L., Harris, M. D., & Goldie, J. H. (2022) · Gastroenterology and hepatology from bed to bench. · doi:10.22037/ghfbb.v15i4.2600 · Cited by 43 · see citing works

Regulation of gut microbiome by ketogenic diet in neurodegenerative diseases: A molecular crosstalk

Kaviyarasan, S., Sia, E. L. C., Retinasamy, T., Arulsamy, A., & Shaikh, M. F. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1015837 · Cited by 39 · see citing works

Twelve Months of Time-Restricted Feeding Improves Cognition and Alters Microbiome Composition Independent of Macronutrient Composition

Hernandez, A. R., Watson, C., Federico, Q. P., Fletcher, R., Brotgandel, A., Buford, T. W., Carter, C. S., & Burke, S. N. (2022) · Nutrients · doi:10.3390/nu14193977 · Cited by 37 · see citing works

Dietary influence on central nervous system myelin production, injury, and regeneration

Langley, M. R., Triplet, E. M., & Scarisbrick, I. A. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165779 · Cited by 35 · see citing works

Modulation of multiple sclerosis risk and pathogenesis by the gut microbiota: Complex interactions between host genetics, bacterial metabolism, and diet

Montgomery, T. L., Peipert, D., & Krementsov, D. N. (2024) · Immunological Reviews · doi:10.1111/imr.13343 · Cited by 37 · see citing works

Meta-analysis identifies common gut microbiota associated with multiple sclerosis

Lin, Q., Dorsett, Y., Mirza, A., Tremlett, H. L., Piccio, L. M., Longbrake, E. E., Choileáin, S. N., Hafler, D. A., Cox, L. M., Weiner, H. L., et al. (2024) · Genome Medicine · doi:10.1186/s13073-024-01364-x · Cited by 36 · see citing works

Gut microbiota modulation by both Lactobacillus fermentum MSK 408 and ketogenic diet in a murine model of pentylenetetrazole-induced acute seizure

Eor, J. Y., Tan, P. L., Son, Y. J., Kwak, M., & Kim, S. H. (2020) · Epilepsy Research · doi:10.1016/j.eplepsyres.2020.106506 · Cited by 33 · see citing works

The second brain: The connection between gut microbiota composition and multiple sclerosis

Farshbafnadi, M., Agah, E., & Rezaei, N. (2021) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2021.577700 · Cited by 31 · see citing works

Systematic evaluation of genome-wide metabolic landscapes in lactic acid bacteria reveals diet- and strain-specific probiotic idiosyncrasies

Koduru, L., Lakshmanan, M., Lee, Y. Q., Ho, P. L., Lim, P. Y., Ler, W. X., Ng, S. K., Kim, D., Park, D., Banu, M., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111735 · Cited by 31 · see citing works

Impact of the Ketogenic Diet on Neurological Diseases: A Review

Rubio, C., López-Landa, A., Parra, H. R., & Rubio‐Osornio, M. (2025) · Life · doi:10.3390/life15010071 · Cited by 30 · see citing works

Generating an In Vitro Gut Model with Physiologically Relevant Biophysical Mucus Properties

McCright, J., Sinha, A., & Maisel, K. (2022) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-022-00740-0 · Cited by 30 · see citing works

Diets, Gut Microbiota and Metabolites

Liu, Y., Zhong, W., Li, X., Shen, F., Ma, X., Yang, Q., Hong, S., & Sun, Y. (2023) · Phenomics · doi:10.1007/s43657-023-00095-0 · Cited by 32 · see citing works

Wash-in and washout effects: mitigating bias in short term dietary and other trials

Ludwig, D. S., Willett, W. C., & Putt, M. E. (2025) · BMJ · doi:10.1136/bmj-2024-082963 · Cited by 30 · see citing works

The Impact of a Very-Low-Calorie Ketogenic Diet in the Gut Microbiota Composition in Obesity

Zambrano, A. K., Cadena-Ullauri, S., Guevara‐Ramírez, P., Frías-Toral, E., Ruiz‐Pozo, V. A., Paz‐Cruz, E., Tamayo‐Trujillo, R., Chapela, S. P., Montalván, M., Sarno, G., et al. (2023) · Nutrients · doi:10.3390/nu15122728 · Cited by 30 · see citing works

Advantages and limitations of experimental autoimmune encephalomyelitis in breaking down the role of the gut microbiome in multiple sclerosis

Melamed, E., Palmer, J. L., & Fonken, C. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1019877 · Cited by 27 · see citing works

Drug resistant epilepsy and ketogenic diet: A narrative review of mechanisms of action

Mishra, P., Singh, S. C., & Ramadass, B. (2024) · World Neurosurgery X · doi:10.1016/j.wnsx.2024.100328 · Cited by 28 · see citing works

Therapeutic potential of the ketogenic diet: A metabolic switch with implications for neurological disorders, the gut-brain axis, and cardiovascular diseases

Shahpasand, S., Khatami, S. H., Ehtiati, S., Alehossein, P., Salmani, F., Toutounchi, A. H., Zarei, T., Shahmohammadi, M. R., Khodarahmi‬, R., Aghamollaii, V., et al. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109693 · Cited by 29 · see citing works

Role of Ketogenic Diets in Multiple Sclerosis and Related Animal Models: An Updated Review

Lin, W., Lin, S.-J., Liao, P.-Y., Suresh, D., Hsu, T., & Wang, P. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac065 · Cited by 30 · see citing works

Effects of the Ketogenic Diet on Microbiota Composition and Short-Chain Fatty Acids in Women with Overweight/Obesity

Akansel, M. G., Baş, M., Gençalp, C., Kahrıman, M., Şahin, E., Öztürk, H., Gür, G., & Gür, C. (2024) · Nutrients · doi:10.3390/nu16244374 · Cited by 26 · see citing works

The Nutrition-Microbiota-Physical Activity Triad: An Inspiring New Concept for Health and Sports Performance

Boisseau, N., Barnich, N., & Koechlin‐Ramonatxo, C. (2022) · Nutrients · doi:10.3390/nu14050924 · Cited by 29 · see citing works

Diet-microbiome-gut-brain nexus in acute and chronic brain injury

Krakovski, M., Arora, N., Jain, S., Glover, J., Dombrowski, K. E., Hernandez, B., Yadav, H., & Sarma, A. K. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1002266 · Cited by 27 · see citing works

Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review

Mazandarani, M., Lashkarbolouk, N., Ejtahed, H., & Qorbani, M. (2023) · Nutrition Journal · doi:10.1186/s12937-023-00893-2 · Cited by 26 · see citing works

The Efficacy of Ketogenic Therapies in the Clinical Management of People with Neurodegenerative Disease: A Systematic Review

Dewsbury, L. S., Lim, C. K., & Steiner, G. Z. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa180 · Cited by 24 · see citing works

Metabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple Sclerosis

Ferret-Sena, V., Capela, C., & Sena, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061639 · Cited by 24 · see citing works

A multiphase dietetic protocol incorporating an improved ketogenic diet enhances weight loss and alters the gut microbiome of obese people

Yuan, W., Lu, W., Wang, H., Wu, W., Zhou, Q., Chen, Y., Lee, Y. K., Zhao, J., Zhang, H., & Chen, W. (2021) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2021.1960957 · Cited by 22 · see citing works

Weight Loss Promotion in Individuals with Obesity through Gut Microbiota Alterations with a Multiphase Modified Ketogenic Diet

Wang, H., Lv, X., Zhao, S., Yuan, W., Zhou, Q., Sadiq, F. A., Zhao, J., Lu, W., & Wu, W. (2023) · Nutrients · doi:10.3390/nu15194163 · Cited by 22 · see citing works

Gut flora in multiple sclerosis: implications for pathogenesis and treatment

Zhang, W., Wang, Y., Zhu, M., Liu, K., & Zhang, H. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.387974 · Cited by 22 · see citing works

Causal relationship between gut microbiota and tuberculosis: a bidirectional two-sample Mendelian randomization analysis

Yuan, Z., Kang, Y., Mo, C., Huang, S., Qin, F., Zhang, J., Wang, F., Jiang, J., Yang, X., Liang, H., et al. (2024) · Respiratory Research · doi:10.1186/s12931-023-02652-7 · Cited by 22 · see citing works

Reframing Nutritional Microbiota Studies To Reflect an Inherent Metabolic Flexibility of the Human Gut: a Narrative Review Focusing on High-Fat Diets

Sholl, J., Mailing, L. J., & Wood, T. R. (2021) · mBio · doi:10.1128/mbio.00579-21 · Cited by 22 · see citing works

Modulating the Gut Microbiome in Multiple Sclerosis Management: A Systematic Review of Current Interventions

Tsogka, A., Kitsos, D. K., Stavrogianni, K., Giannopapas, V., Chasiotis, A. K., Christouli, N., Tsivgoulis, G. K., Tzartos, J. S., & Giannopoulos, S. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12247610 · Cited by 21 · see citing works

Interactions between the gut microbiome and ketogenic diet in refractory epilepsy

Özcan, E., Lum, G. R., & Hsiao, E. Y. (2022) · International review of neurobiology · doi:10.1016/bs.irn.2022.06.002 · Cited by 20 · see citing works

Microbiota-Driven Mechanisms in Multiple Sclerosis: Pathogenesis, Therapeutic Strategies, and Biomarker Potential

Nemati, M. H., Yazdanpanah, E., Kazemi, R., Orooji, N., Dadfar, S., Oksenych, V., & Haghmorad, D. (2025) · Biology · doi:10.3390/biology14040435 · Cited by 21 · see citing works

Ketogenic diet in relapsing multiple sclerosis: Patient perceptions, post-trial diet adherence & outcomes

Wetmore, E. L., Lehner‐Gulotta, D., Florenzo, B., Banwell, B., Bergqvist, A. G. C., Coleman, R., Conaway, M. R., Goldman, M. D., & Brenton, J. N. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.06.029 · Cited by 18 · see citing works

Gut-brain communication in demyelinating disorders

Sauma, S., & Casaccia, P. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.01.005 · Cited by 18 · see citing works

A gut feeling about the ketogenic diet in epilepsy

Pittman, Q. J. (2020) · Epilepsy Research · doi:10.1016/j.eplepsyres.2020.106409 · Cited by 18 · see citing works

Microbiota, IgA and Multiple Sclerosis

Boussamet, L., Rajoka, M. S. R., & Berthelot, L. (2022) · Microorganisms · doi:10.3390/microorganisms10030617 · Cited by 19 · see citing works

Ketogenic Diet: A Dietary Modification as an Anxiolytic Approach?

Włodarczyk, A., Cubała, W. J., & Wielewicka, A. (2020) · Nutrients · doi:10.3390/nu12123822 · Cited by 21 · see citing works

Engineering substrate channeling in biosystems for improved efficiency

Wang, T., Qin, X., Liang, C., & Yuan, H. (2018) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.5731 · Cited by 17 · see citing works

Application of nutrient essentiality criteria to dietary carbohydrates

Tondt, J., Yancy, W. S., & Westman, E. C. (2020) · Nutrition Research Reviews · doi:10.1017/s0954422420000050 · Cited by 17 · see citing works

Perturbations in gut microbiota composition in patients with autoimmune neurological diseases: a systematic review and meta-analysis

Deng, X., Gong, X., Zhou, D., & Hong, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1513599 · Cited by 16 · see citing works

Influence of Aging, Macronutrient Composition and Time-Restricted Feeding on the Fischer344 x Brown Norway Rat Gut Microbiota

Hernandez, A. R., Kemp, K. M., Burke, S. N., Buford, T. W., & Carter, C. S. (2022) · Nutrients · doi:10.3390/nu14091758 · Cited by 15 · see citing works

Impact of dietary carbohydrate, fat or protein restriction on the human gut microbiome: a systematic review

Schoonakker, M. P., van Peet, P. G., van den Burg, E. L., Numans, M. E., Ducarmon, Q. R., Pijl, H., & Wiese, M. (2024) · Nutrition Research Reviews · doi:10.1017/s0954422424000131 · Cited by 16 · see citing works

Potential role of the gut microbiota in neuromyelitis optica spectrum disorder: Implication for intervention

Cui, C., Ruan, Y., & Qiu, W. (2020) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2020.11.011 · Cited by 14 · see citing works

The impact of ketogenic diet on the onset and progression of multiple sclerosis

Brockhoff, J. D., Bereswill, S., & Heimesaat, M. (2023) · European Journal of Microbiology & Immunology · doi:10.1556/1886.2023.00020 · Cited by 14 · see citing works

Multiple sclerosis and the microbiota

Engelenburg, H. J., Lucassen, P. J., Sarafian, J. T., Parker, W., & Laman, J. D. (2022) · Evolution Medicine and Public Health · doi:10.1093/emph/eoac009 · Cited by 13 · see citing works

Functional microbiome shifts are associated with neuroinflammatory outcomes under dietary interventions in multiple sclerosis

Gutmann, F., Bahr, L. S., Brüning, U., Jarquín‐Díaz, V. H., Markó, L., Weygandt, M., Rust, R., Bellmann–Strobl, J., Paul, F., Forslund, S. K., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-73464-0

Functional microbiome reprogramming links dietary interventions to neuroinflammatory outcomes in multiple sclerosisPreprint

Gutmann, F., Bahr, L. S., Brüning, U., Jarquín‐Díaz, V. H., Markó, L., Weygandt, M., Rust, R., Bellmann–Strobl, J., Paul, F., Forslund, S. K., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7434844/v1

Multiple Sclerosis-Associated Gut Microbiome in the Israeli Diverse Populations: Associations with Ethnicity, Gender, Disability Status, Vitamin D Levels, and Mediterranean Diet

Nitzan, Z., Staun-Ram, E., Volkowich, A., & Miller, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241915024 · Cited by 21 · see citing works

Immunotherapy-mediated modulation of the gut microbiota in multiple sclerosis and associations with diet and clinical response—the effect of dimethyl fumarate therapy

Staun-Ram, E., Volkowich, A., & Miller, A. (2025) · Therapeutic Advances in Neurological Disorders · doi:10.1177/17562864241306565 · Cited by 5 · see citing works

Immunological and Clinical Effect of Diet Modulation of the Gut Microbiome in Multiple Sclerosis Patients: A Pilot Study

Saresella, M., Mendozzi, L., Rossi, V., Mazzali, F., Piancone, F., LaRosa, F., Marventano, I., Caputo, D., Felis, G. E., & Clerici, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01391 · Cited by 159 · see citing works