The DOI matches its Crossref record; 184 of the 189 references it cites were found in a registry or an index.
The Genus Enterococcus: Between Probiotic Potential and Safety Concerns—An Update
Open accessAbstract
A considerable number of strains belonging to different species of Enterococcus are highly competitive due to their resistance to wide range of pH and temperature. Their competitiveness is also owed to their ability to produce bacteriocins recognized for their wide-range effectiveness on pathogenic and spoilage bacteria. Enterococcal bacteriocins have attracted great research interest as natural antimicrobial agents in the food industry, and as a potential drug candidate for replacing antibiotics in order to treat multiple drugs resistance pathogens. However, the prevalence of virulence factors and antibiotic-resistance genes and the ability to cause disease could compromise their application in food, human and animal health. From the current regulatory point of view, the genus Enterococcus is neither recommended for the QPS list nor have GRAS status. Although recent advances in molecular biology and the recommended methods for the safety evaluation of Enterococcus strains allowed the distinction between commensal and clinical clades, development of highly adapted methods and legislations are still required. In the present review, we evaluate some aspects of Enterococcus spp. related to their probiotic properties and safety concerns as well as the current and potential application in food systems and treatment of infections. The regulatory status of commensal Enterococcus candidates for food/feed/probiotic use and recommended methods to assess and ensure their safety are also discussed.
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“This is because, when passing through the digestive tract, Saccharomyces strains have a higher survival capacity compared with the other probiotics. Also, these strains help to maintain the balance of the normal microflora of the intestinal tract and have immunomodulatory effects, acting to fine-tune immunological pathways during pathogenic infections or chronic diseases [32,33,34].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [32]
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Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health
Mazziotta, C., Tognon, M., Martini, F., Torreggiani, E., & Rotondo, J. C. (2023) · Cells · doi:10.3390/cells12010184 · Cited by 889
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The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties
Maftei, N.-M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024) · Microorganisms · doi:10.3390/microorganisms12020234 · Cited by 381
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Metadata
- Authors
- Hanchi, H., Mottawea, W., Sebei, K., & Hammami, R.
- Affiliations
- Tunis University (TN)
- University of Ottawa (CA)
- Corresponding author
- Hammami, Riadh
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2018-08-03
- Volume
- 9
- Pages
- 1791-1791
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC6085487
- OpenAlex
- W2885034377
- Cited by
- 569
- References
- 189
- Citations by year
- 2026: 43 · 2025: 77 · 2024: 99 · 2023: 83 · 2022: 86 · 2021: 91 · 2020: 59 · 2019: 30
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Enterococcus, probiotics, food safety, bacteriocins, antimicrobial peptides, antibiotic resistance, virulence factors, GRAS status, qualified presumption of safety, safety assessment, probiotic regulation, antibiotic alternatives, multidrug resistance
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