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The Genus Enterococcus: Between Probiotic Potential and Safety Concerns—An Update
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A considerable number of strains belonging to different species of Enterococcus are highly competitive due to their resistance to wide range of pH and temperature. Their competitiveness is also owed to their ability to produce bacteriocins recognized for their wide-range effectiveness on pathogenic and spoilage bacteria. Enterococcal bacteriocins have attracted great research interest as natural antimicrobial agents in the food industry, and as a potential drug candidate for replacing antibiotics in order to treat multiple drugs resistance pathogens. However, the prevalence of virulence factors and antibiotic-resistance genes and the ability to cause disease could compromise their application in food, human and animal health. From the current regulatory point of view, the genus Enterococcus is neither recommended for the QPS list nor have GRAS status. Although recent advances in molecular biology and the recommended methods for the safety evaluation of Enterococcus strains allowed the distinction between commensal and clinical clades, development of highly adapted methods and legislations are still required. In the present review, we evaluate some aspects of Enterococcus spp. related to their probiotic properties and safety concerns as well as the current and potential application in food systems and treatment of infections. The regulatory status of commensal Enterococcus candidates for food/feed/probiotic use and recommended methods to assess and ensure their safety are also discussed.
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“This is because, when passing through the digestive tract, Saccharomyces strains have a higher survival capacity compared with the other probiotics. Also, these strains help to maintain the balance of the normal microflora of the intestinal tract and have immunomodulatory effects, acting to fine-tune immunological pathways during pathogenic infections or chronic diseases [32,33,34].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [32]
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Metadata
- Authors
- Hanchi, H., Mottawea, W., Sebei, K., & Hammami, R.
- Affiliations
- Tunis University (TN)
- University of Ottawa (CA)
- Corresponding author
- Hammami, Riadh
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2018-08-03
- Volume
- 9
- Pages
- 1791-1791
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC6085487
- OpenAlex
- W2885034377
- Cited by
- 569
- References
- 189
- Citations by year
- 2026: 43 · 2025: 77 · 2024: 99 · 2023: 83 · 2022: 86 · 2021: 91 · 2020: 59 · 2019: 30
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Enterococcus, probiotics, food safety, bacteriocins, antimicrobial peptides, antibiotic resistance, virulence factors, GRAS status, qualified presumption of safety, safety assessment, probiotic regulation, antibiotic alternatives, multidrug resistance
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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