Cited by 569Probiotics and Fermented FoodsAgricultural safety and regulationsBacterial Genetics and Biotechnology

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The Genus Enterococcus: Between Probiotic Potential and Safety Concerns—An Update

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Hanchi, Hasna, Mottawea, Walid, Sebei, Khaled, Hammami, Riadh·2018·Frontiers in Microbiology

DOI 10.3389/fmicb.2018.01791PMC PMC6085487

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Abstract

A considerable number of strains belonging to different species of Enterococcus are highly competitive due to their resistance to wide range of pH and temperature. Their competitiveness is also owed to their ability to produce bacteriocins recognized for their wide-range effectiveness on pathogenic and spoilage bacteria. Enterococcal bacteriocins have attracted great research interest as natural antimicrobial agents in the food industry, and as a potential drug candidate for replacing antibiotics in order to treat multiple drugs resistance pathogens. However, the prevalence of virulence factors and antibiotic-resistance genes and the ability to cause disease could compromise their application in food, human and animal health. From the current regulatory point of view, the genus Enterococcus is neither recommended for the QPS list nor have GRAS status. Although recent advances in molecular biology and the recommended methods for the safety evaluation of Enterococcus strains allowed the distinction between commensal and clinical clades, development of highly adapted methods and legislations are still required. In the present review, we evaluate some aspects of Enterococcus spp. related to their probiotic properties and safety concerns as well as the current and potential application in food systems and treatment of infections. The regulatory status of commensal Enterococcus candidates for food/feed/probiotic use and recommended methods to assess and ensure their safety are also discussed.

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Authors: Hanchi, H., Mottawea, W., Sebei, K., & Hammami, R.
Affiliations: Tunis University (TN)
University of Ottawa (CA)
Corresponding author: Hammami, Riadh
ORCID: Mottawea, Walid
Sebei, Khaled
Hammami, Riadh
Venue: Frontiers in Microbiology
Publisher: Frontiers Media SA
Published: 2018-08-03
Volume: 9
Pages: 1791-1791
ISSN: 1664-302X (ISSN-L)
DOI: 10.3389/fmicb.2018.01791
PMC: PMC6085487
OpenAlex: W2885034377
Cited by: 569
References: 189
Citations by year: 2026: 43 · 2025: 77 · 2024: 99 · 2023: 83 · 2022: 86 · 2021: 91 · 2020: 59 · 2019: 30
FWCI: 4.59
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Frontiers in Microbiology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Greater South Information System
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: Enterococcus, probiotics, food safety, bacteriocins, antimicrobial peptides, antibiotic resistance, virulence factors, GRAS status, qualified presumption of safety, safety assessment, probiotic regulation, antibiotic alternatives, multidrug resistance

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The Genus Enterococcus: Between Probiotic Potential and Safety Concerns—An Update

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