The Role of Bile Acids in Glucose Metabolism and Their Relation with Diabetes
Open accessAbstract
Bile acids (BAs), the end products of cholesterol catabolism, are essential for the absorption of lipids and fat-soluble vitamins; but they have also emerged as novel signaling molecules that act as metabolic regulators. It has been well described that the enterohe-patic circulation, a nuclear (FXR) and a cytoplasmic (TGR5/M-BAR) receptor aid in controlling hepatic bile acid synthesis. Modulating bile acid synthesis greatly impacts in metabolism, because these receptors also are implicated in glucose, lipid, and energy expenditure. Recent studies had revealed the way these receptors participate in regulating gluconeogenesis, peripheral insulin sensitivity, glycogen synthesis, glucagon like peptide 1 (GLP-1) and insulin secretion. Nowadays, it is demonstrated that enhancing bile acid signaling in the intestine contributes to the metabolic benefits of bile acid sequestrants and bariatric surgery on glucose homeos-tasis. This paper discusses the role of bile acid as regulators of glucose metabolism and their potential as therapeutic targets for diabetes.
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The GM influences BA metabolism, and BAs affect the GM's composition.
“The GM influences BA metabolism, and BAs affect the GM’s composition (296).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [296]
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“C C Changes in gut micro fl ora also alter the expression level of BSH, thus a ff ecting the composition of the host BA pool and BA signaling [10, 25] (more details are shown in Figure 1).”
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- Authors
- Alberto González-Regueiro, J., Moreno-Castañeda, L., Uribe, M., & Carlos Chávez-Tapia, N.
- Affiliations
- Hospital Médica Sur (MX)
- ORCID
- Uribe, Misael
- Venue
- Annals of Hepatology
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 16
- Issue
- Suppl. 1: s3-105.
- Pages
- S15-S20
- ISSN
- 1665-2681 (ISSN-L)
- OpenAlex
- W3194266802
- Cited by
- 247
- References
- 49
- Citations by year
- 2026: 25 · 2025: 26 · 2024: 43 · 2023: 34 · 2022: 34 · 2021: 38 · 2020: 20 · 2019: 12 · 2018: 15
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Annals of Hepatology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Australian Government
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- bile acids, glucose metabolism, diabetes mellitus, enterohepatic circulation, farnesoid X receptor, TGR5, bile acid synthesis, gluconeogenesis, insulin sensitivity, glycogen synthesis, glucagon-like peptide-1, insulin secretion, bile acid sequestrants, bariatric surgery, glucose homeostasis, therapeutic target
- MeSH terms
- Gastrointestinal Microbiome, Animals, Bacteria, Bile Acids and Salts, Energy Metabolism, Humans, Intestines, Obesity, Signal Transduction, Host-Pathogen Interactions, Dysbiosis
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