Taxonomic profiling and populational patterns of bacterial bile salt hydrolase (BSH) genes based on worldwide human gut microbiome
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Abstract
BACKGROUND: Bile salt hydrolase plays an important role in bile acid-mediated signaling pathways, which regulate lipid absorption, glucose metabolism, and energy homeostasis. Several reports suggest that changes in the composition of bile acids are found in many diseases caused by dysbacteriosis. RESULTS: Here, we present the taxonomic identification of bile salt hydrolase (BSH) in human microbiota and elucidate the abundance and activity differences of various bacterial BSH among 11 different populations from six continents. For the first time, we revealed that bile salt hydrolase protein sequences (BSHs) are distributed in 591 intestinal bacterial strains within 117 genera in human microbiota, and 27.52% of these bacterial strains containing BSH paralogs. Significant variations are observed in BSH distribution patterns among different populations. Based on phylogenetic analysis, we reclassified these BSHs into eight phylotypes and investigated the abundance patterns of these phylotypes among different populations. From the inspection of enzyme activity among different BSH phylotypes, BSH-T3 showed the highest enzyme activity and is only found in Lactobaclillus. The phylotypes of BSH-T5 and BSH-T6 mainly from Bacteroides with high percentage of paralogs exhibit different enzyme activity and deconjugation activity. Furthermore, we found that there were significant differences between healthy individuals and patients with atherosclerosis and diabetes in some phylotypes of BSHs though the correlations were pleiotropic. CONCLUSION: This study revealed the taxonomic and abundance profiling of BSH in human gut microbiome and provided a phylogenetic-based system to assess BSHs activity by classifying the target sequence into specific phylotype. Furthermore, the present work disclosed the variation patterns of BSHs among different populations of geographical regions and health/disease cohorts, which is essential to understand the role of BSH in the development and progression of related diseases.
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BSH activity is widely distributed among gastrointestinal microbes, including various Lactobacillaceae species.
“BSH activity is widely distributed among gastrointestinal microbes, including various Lactobacillaceae species [5–8], where the presence of multiple bsh orthologs reflects strain-specific adaptations into the intestinal environment [5, 8–10].”
From Bile Salt Hydrolase Activity in the Food-Derived Strain Levilactobacillus brevis M3R3: Genomic and Functional Characterization (2026) · cites this paper as [7]
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Cites
BLAST+: architecture and applications
Camacho, C., Coulouris, G., Avagyan, V., Ma, N., Papadopoulos, J., Bealer, K., & Madden, T. L. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-421 · Cited by 22,074 · see citing works
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726 · see citing works
The Phyre2 web portal for protein modeling, prediction and analysis
Kelley, L. A., Mezulis, S., Yates, C. M., Wass, M. N., & Sternberg, M. J. E. (2015) · Nature Protocols · doi:10.1038/nprot.2015.053 · Cited by 9,652 · see citing works
<tt>BLAT</tt> —The <tt>BLAST</tt> -Like Alignment Tool
Kent, W. J. (2002) · Genome Research · doi:10.1101/gr.229202 · Cited by 8,480 · see citing works
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762 · see citing works
Self-citationDe Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579 · see citing works
SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler
Luo, R., Liu, B., Xie, Y., Li, Z., Huang, W., Yuan, J., He, G., Chen, Y., Pan, Q., Liu, Y., et al. (2012) · GigaScience · doi:10.1186/2047-217x-1-18 · Cited by 5,270 · see citing works
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662 · see citing works
Self-citationThe Human Intestinal Microbiome in Health and Disease
Lynch, S. V., & Pedersen, O. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1600266 · Cited by 3,637 · see citing works
Gut metagenome in European women with normal, impaired and diabetic glucose control
Karlsson, F. H., Tremaroli, V., Nookaew, I., Bergström, G., Behre, C. J., Fagerberg, B., Nielsen, J., & Bäckhed, F. (2013) · Nature · doi:10.1038/nature12198 · Cited by 3,115 · see citing works
Identification of a nuclear receptor for bile acids
Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science · doi:10.1126/science.284.5418.1362 · Cited by 2,714 · see citing works
Alterations of the human gut microbiome in liver cirrhosis
Qin, N., Yang, F., Li, A., Prifti, E., Chen, Y., Shao, L., Guo, J., Le Chatelier, E., Yao, J., Wu, L., et al. (2014) · Nature · doi:10.1038/nature13568 · Cited by 2,177 · see citing works
An integrated catalog of reference genes in the human gut microbiome
MetaHIT Consortium, Li, J., Jia, H., Cai, X., Zhong, H., Feng, Q., Sunagawa, S., Arumugam, M., Kultima, J. R., Prifti, E., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.2942 · Cited by 2,164 · see citing works
Self-citationAb initio gene identification in metagenomic sequences
Zhu, W., Lomsadze, A., & Borodovsky, M. Y. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq275 · Cited by 1,793 · see citing works
The gut microbiome in atherosclerotic cardiovascular disease
Jie, Z., Xia, H., Zhong, S.-L., Feng, Q., Li, S., Liang, S., Zhong, H., Liu, Z., Gao, Y., Zhao, H., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00900-1 · Cited by 1,638 · see citing works
Self-citationGut microbiome development along the colorectal adenoma-carcinoma sequence
Feng, Q., Liang, S., Jia, H., Stadlmayr, A., Tang, L., Lan, Z., Zhang, D., Xia, H., Xu, X., Jie, Z., et al. (2015) · Nature Communications · doi:10.1038/ncomms7528 · Cited by 1,506 · see citing works
Self-citationPotential of fecal microbiota for early-stage detection of colorectal cancer
Zeller, G., Tap, J., Voigt, A. Y., Sunagawa, S., Kultima, J. R., Costea, P. I., Amiot, A., Böhm, J., Brunetti, F., Habermann, N., et al. (2014) · Molecular Systems Biology · doi:10.15252/msb.20145645 · Cited by 1,375 · see citing works
Gut microbiome of the Hadza hunter-gatherers
Schnorr, S. L., Candela, M., Rampelli, S., Centanni, M., Consolandi, C., Basaglia, G., Turroni, S., Biagi, E., Peano, C., Severgnini, M., et al. (2014) · Nature Communications · doi:10.1038/ncomms4654 · Cited by 1,317 · see citing works
Jones, B. V., Begley, M., Hill, C., Gahan, C. G. M., & Marchesi, J. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804437105 · Cited by 1,098 · see citing works
Bile acid signaling in metabolic disease and drug therapy
Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935 · see citing works
Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut
Joyce, S. A., MacSharry, J., Casey, P. G., Kinsella, M., Murphy, E. F., Shanahan, F., Hill, C., & Gahan, C. G. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323599111 · Cited by 604 · see citing works
Subsistence strategies in traditional societies distinguish gut microbiomes
Obregon-Tito, A. J., Tito, R. Y., Metcalf, J., Sankaranarayanan, K., Clemente, J. C., Ursell, L. K., Zech Xu, Z., Van Treuren, W., Knight, R., Gaffney, P. M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7505 · Cited by 587 · see citing works
Martínez, I., Stegen, J. C., Maldonado-Gómez, M. X., Eren, A. M., Siba, P. M., Greenhill, A. R., & Walter, J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.049 · Cited by 576 · see citing works
Metabolic Footprint of Diabetes: A Multiplatform Metabolomics Study in an Epidemiological Setting
Suhre, K., Meisinger, C., Döring, A., Altmaier, E., Belcredi, P., Gieger, C., Chang, D., Milburn, M. V., Gall, W. E., Weinberger, K. M., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013953 · Cited by 557 · see citing works
Sun, Z., Harris, H. M. B., McCann, A., Guo, C., Argimón, S., Zhang, W., Yang, X., Jeffery, I. B., Cooney, J. C., Kagawa, T. F., et al. (2015) · Nature Communications · doi:10.1038/ncomms9322 · Cited by 543 · see citing works
Self-citationThe gut microbiome of healthy Japanese and its microbial and functional uniqueness
Nishijima, S., Suda, W., Oshima, K., Kim, S.-W., Hirose, Y., Morita, H., & Hattori, M. (2016) · DNA Research · doi:10.1093/dnares/dsw002 · Cited by 498 · see citing works
Human Insulin Resistance Is Associated With Increased Plasma Levels of 12α-Hydroxylated Bile Acids
Haeusler, R. A., Astiarraga, B., Camastra, S., Accili, D., & Ferrannini, E. (2013) · Diabetes · doi:10.2337/db13-0639 · Cited by 444 · see citing works
Metagenome Sequencing of the Hadza Hunter-Gatherer Gut Microbiota
Rampelli, S., Schnorr, S. L., Consolandi, C., Turroni, S., Severgnini, M., Peano, C., Brigidi, P., Crittenden, A. N., Henry, A. G., & Candela, M. (2015) · Current Biology · doi:10.1016/j.cub.2015.04.055 · Cited by 399 · see citing works
Mizuno, S., Masaoka, T., Naganuma, M., Kishimoto, T., Kitazawa, M., Kurokawa, S., Nakashima, M., Takeshita, K., Suda, W., Mimura, M., et al. (2017) · Digestion · doi:10.1159/000471919 · Cited by 395 · see citing works
Cipriani, S., Mencarelli, A., Chini, M. G., Distrutti, E., Renga, B., Bifulco, G., Baldelli, F., Donini, A., & Fiorucci, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025637 · Cited by 382 · see citing works
Dussurget, O., Cabanes, D., Dehoux, P., Lecuit, M., Buchrieser, C., Glaser, P., & Cossart, P. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03080.x · Cited by 356 · see citing works
Degirolamo, C., Rainaldi, S., Bovenga, F., Murzilli, S., & Moschetta, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.032 · Cited by 356 · see citing works
Conjugated Bile Acids Activate the Sphingosine–1–Phosphate Receptor 2 in Primary Rodent Hepatocytes
Studer, E. J., Zhou, X., Zhao, R., Wang, Y., Takabe, K., Nagahashi, M., Pandak, W. M., Dent, P., Spiegel, S., Shi, R., et al. (2011) · Hepatology · doi:10.1002/hep.24681 · Cited by 319 · see citing works
Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease
Porez, G., Prawitt, J., Gross, B. S., & Staels, B. (2012) · Journal of Lipid Research · doi:10.1194/jlr.r024794 · Cited by 287 · see citing works
Bile Salt Hydrolase of Bifidobacterium longum —Biochemical and Genetic Characterization
Tanaka, H., Hashiba, H., Kok, J., & Mierau, I. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.6.2502-2512.2000 · Cited by 285 · see citing works
A selective gut bacterial bile salt hydrolase alters host metabolism
Yao, L., Seaton, S. C., Ndousse-Fetter, S., Adhikari, A. A., DiBenedetto, N., Mina, A. I., Banks, A. S., Bry, L., & Devlin, A. S. (2018) · eLife · doi:10.7554/elife.37182 · Cited by 274 · see citing works
Begley, M., Sleator, R. D., Gahan, C. G. M., & Hill, C. (2005) · Infection and Immunity · doi:10.1128/iai.73.2.894-904.2005 · Cited by 264 · see citing works
Structural comparison of Ntn‐hydrolases
Oinonen, C., & Rouvinen, J. (2000) · Protein Science · doi:10.1110/ps.9.12.2329 · Cited by 261 · see citing works
Comprehensive Metabolomic Characterization of Coronary Artery Diseases
Fan, Y., Li, Y., Chen, Y., Zhao, Y., Liu, L., Li, J., Wang, S.-L., Alolga, R. N., Yin, Y., Wang, X., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.06.044 · Cited by 248 · see citing works
Self-citationMolecular mechanisms underlying bile acid‐stimulated glucagon‐like peptide‐1 secretion
Parker, H. E., Wallis, K., le Roux, C. W., Wong, K. Y., Reimann, F. M., & Gribble, F. M. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01561.x · Cited by 227 · see citing works
Lambert, J. M., Bongers, R. S., de Vos, W. M., & Kleerebezem, M. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.00137-08 · Cited by 212 · see citing works
Bile Salt Hydrolase Activity of Three Strains of Lactobacillus acidophilus
Corzo, G. A., & Gilliland, S. E. (1999) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(99)75256-2 · Cited by 190 · see citing works
Bile???Acid???Sequestrants???and???the???Treatment of Type??2??Diabetes??Mellitus
Staels, B., & Kuipers, F. (2007) · Drugs · doi:10.2165/00003495-200767100-00001 · Cited by 174 · see citing works
Meta‐analysis of the human gut microbiome from urbanized and pre‐agricultural populations
Mancabelli, L., Milani, C., Lugli, G. A., Turroni, F., Ferrario, C., van Sinderen, D., & Ventura, M. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13692 · Cited by 172 · see citing works
Increased Secondary/Primary Bile Acid Ratio in Chronic Heart Failure
Mayerhofer, C. C. K., Ueland, T., Broch, K., Vincent, R. P., Cross, G. F., Dahl, C. P., Aukrust, P., Gullestad, L. L., Hov, J. R., & Trøseid, M. (2017) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2017.06.007 · Cited by 169 · see citing works
Bile Acids and the Membrane Bile Acid Receptor TGR5—Connecting Nutrition and Metabolism
Thomas, C., Auwerx, J. H., & Schoonjans, K. (2008) · Thyroid · doi:10.1089/thy.2007.0255 · Cited by 154 · see citing works
Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis
Stellwag, E. J., & Hylemon, P. B. (1976) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(76)90068-1 · Cited by 145 · see citing works
Labbé, A., Ganopolsky, J. G., Martoni, C., Prakash, S., & Jones, M. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115175 · Cited by 144 · see citing works
Lim, M. Y., Rho, M., Song, Y., Lee, K., Sung, J., & Ko, G. (2014) · Scientific Reports · doi:10.1038/srep07348 · Cited by 144 · see citing works
Kumar, R. S., Brannigan, J. A., Prabhune, A. A., Pundle, A. V., Dodson, G. G., Dodson, E. J., & Suresh, C. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604172200 · Cited by 143 · see citing works
Cloning and characterization of a conjugated bile acid hydrolase gene from Clostridium perfringens
Coleman, J. P., & Hudson, L. L. (1995) · Applied and Environmental Microbiology · doi:10.1128/aem.61.7.2514-2520.1995 · Cited by 140 · see citing works
Barrasa, J. I., Olmo, N., Pérez-Ramos, P., Santiago-Gómez, A., Lecona, E., Turnay, J., & Lizarbe, M. A. (2011) · APOPTOSIS · doi:10.1007/s10495-011-0633-x · Cited by 139 · see citing works
Rossocha, M., Schultz‐Heienbrok, R., von Moeller, H., Coleman, J. P., & Saenger, W. (2005) · Biochemistry · doi:10.1021/bi0473206 · Cited by 138 · see citing works
Steiner, C., Othman, A., Saely, C. H., Rein, P., Drexel, H., von Eckardstein, A., & Rentsch, K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025006 · Cited by 132 · see citing works
Liu, H., Hu, C., Zhang, X., & Jia, W. (2017) · Journal of Diabetes Investigation · doi:10.1111/jdi.12687 · Cited by 125 · see citing works
Unique Features of Ethnic Mongolian Gut Microbiome revealed by metagenomic analysis
Liu, W., Zhang, J., Wu, C., Cai, S., Huang, W., Chen, J., Xi, X., Liang, Z., Hou, Q., Zhou, B., et al. (2016) · Scientific Reports · doi:10.1038/srep34826 · Cited by 119 · see citing works
Franz, C. M. A. P., Specht, I., Haberer, P., & Holzapfel, W. H. (2001) · Journal of Food Protection · doi:10.4315/0362-028x-64.5.725 · Cited by 118 · see citing works
Cariou, B., Chétiveaux, M., Zaïr, Y., Pouteau, E. B., Disse, E., Guyomarch, B., Laville, M., & Krempf, M. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-48 · Cited by 116 · see citing works
Kim, G., Miyamoto, C. M., Meighen, E. A., & Lee, B. H. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.9.5603-5612.2004 · Cited by 105 · see citing works
Wang, Z., Zeng, X., Mo, Y., Smith, K., Guo, Y., & Lin, J. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.02519-12 · Cited by 99 · see citing works
Molecular features of bile salt hydrolases and relevance in human health
Chand, D., Avinash, V. S., Yadav, Y., Pundle, A. V., Suresh, C. G., & Ramasamy, S. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.09.024 · Cited by 95 · see citing works
Fang, F., Li, Y., Bumann, M., Raftis, E. J., Casey, P. G., Cooney, J. C., Walsh, M. A., & O’Toole, P. W. (2009) · Journal of Bacteriology · doi:10.1128/jb.00506-09 · Cited by 94 · see citing works
Molecular pathophysiology and physical chemistry of cholesterol gallstones
Helen, H. W. (2007) · Frontiers in bioscience · doi:10.2741/2688 · Cited by 93 · see citing works
Higher circulating bile acid concentrations in obese patients with type 2 diabetes
Vincent, R. P., Omar, S., Ghozlan, S., Taylor, D. R., Cross, G. F., Sherwood, R. A., Fändriks, L., Olbers, T., Werling, M., Alaghband‐Zadeh, J., et al. (2013) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563212473450 · Cited by 84 · see citing works
Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice
Pierre, J. F., Martinez, K., Ye, H., Nadimpalli, A., Morton, T. C., Yang, J., Wang, Q., Patno, N., Chang, E. B., & Yin, D. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00202.2016 · Cited by 82 · see citing works
Corzo, G., & Gilliland, S. E. (1999) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(99)75255-0 · Cited by 76 · see citing works
Chae, J. P., Valeriano, V. D., Kim, G., & Kang, D. K. (2012) · Journal of Applied Microbiology · doi:10.1111/jam.12027 · Cited by 73 · see citing works
The association of bile acid excretion and atherosclerotic coronary artery disease
Charach, G., Grosskopf, I., Rabinovich, A., Shochat, M. K., Weintraub, M. S., & Rabinovich, P. (2010) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x10388682 · Cited by 69 · see citing works
Charach, G., Argov, O., Geiger, K. R., Charach, L., Rogowski, O., & Grosskopf, I. (2017) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x17743420 · Cited by 69 · see citing works
Chand, D., Panigrahi, P., Varshney, N. K., Ramasamy, S., & Suresh, C. G. (2018) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2018.01.003 · Cited by 64 · see citing works
Wijaya, A., Hermann, A., Abriouel, H., Specht, I., Yousif, N. M. K., Holzapfel, W. H., & Franz, C. M. A. P. (2004) · Journal of Food Protection · doi:10.4315/0362-028x-67.12.2772 · Cited by 60 · see citing works
Bacterial bile salt hydrolase: an intestinal microbiome target for enhanced animal health
Geng, W., & Lin, J. (2016) · Animal Health Research Reviews · doi:10.1017/s1466252316000153 · Cited by 60 · see citing works
Bile Salt Hydrolase Activities: A Novel Target to Screen Anti-Giardia Lactobacilli?
Allain, T., Chaouch, S., Thomas, M., Travers, M., Valle, I., Langella, P., Grellier, P., Polack, B., Florent, I., & Bermúdez‐Humarán, L. G. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00089 · Cited by 53 · see citing works
Bile acids, FGF15/19 and liver regeneration: From mechanisms to clinical applications
Álvarez‐Sola, G., Uriarte, I., Latasa, M. U., Jiménez, M., Bárcena‐Varela, M., Santamaría, E., Urtasun, R., Rodríguez‐Ortigosa, C. M., Prìeto, J., Berraondo, P., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.06.025 · Cited by 50 · see citing works
The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease
Gylling, H., Hallikainen, M., Rajaratnam, R., Simonen, P. P., Pihlajamäki, J., Laakso, M., & Miettinen, T. A. (2009) · Metabolism · doi:10.1016/j.metabol.2008.10.015 · Cited by 39 · see citing works
Cloning and characterization of a bile salt hydrolase (bsh) from Bifidobacterium adolescentis
Kim, G., Brochet, M., & Lee, B. H. (2005) · Biotechnology Letters · doi:10.1007/s10529-005-6717-3 · Cited by 39 · see citing works
New therapeutical indications of ursodeoxycholic acid.
Copaci, I., Micu, L., Iliescu, L. E., & Voiculescu, M. (2005) · PubMed · Cited by 38 · see citing works
Liang, L., Yi, Y., Lv, Y., Qian, J., Lei, X., & Zhang, G. (2018) · Molecules · doi:10.3390/molecules23051157 · Cited by 38 · see citing works
Decreased fecal bile acid output in patients with coronary atherosclerosis.
Charach, G., Rabinovich, P., Konikoff, F. M., Grosskopf, I., Weintraub, M. S., & Gilat, T. (1998) · PubMed · Cited by 36 · see citing works
New insight into the catalytic properties of bile salt hydrolase
Bi, J., Fang, F., Lu, S., Du, G., & Chen, J. (2013) · Journal of Molecular Catalysis B Enzymatic · doi:10.1016/j.molcatb.2013.06.010 · Cited by 24 · see citing works
Dong, Z., Zhang, J., Li, H., Du, G., Chen, J., & Lee, B. (2015) · Protein and Peptide Letters · doi:10.2174/0929866522666150610094829 · Cited by 18 · see citing works
Kumar, R., Brannigan, J. A., Pundle, A. V., Prabhune, A. A., Dodson, G. G., & Suresh, C. G. (2004) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444904017561 · Cited by 9 · see citing works
Periplasmic Export of Bile Salt Hydrolase in Escherichia coli by the Twin-Arginine Signal Peptides
Dong, Z., Zhang, J., Du, G., Chen, J., Li, H., & Lee, B. (2015) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-015-1755-3 · Cited by 4 · see citing works
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- [24]National Center for Biotechnology Information, U.S. https://www.ncbi.nlm.nih.gov. Accessed 17 Oct 2018.
- [53]Haeusler RA Astiarraga B Camastra S Accili D Ferrannini E Human insulin resistance is associated with increased plasma levels of 12a-hydroxylated bile acids Diabetes 2013 62 4184 4191 10.2337/db13-0639 23884887 PMC3837033 · DOI · Paper page
Cited by
Sorted by citations
Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis
Cai, J., Sun, L., & Gonzalez, F. J. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.02.004 · Cited by 855 · see citing works
Review: microbial transformations of human bile acids
Guzior, D. V., & Quinn, R. A. (2021) · Microbiome · doi:10.1186/s40168-021-01101-1 · Cited by 762 · see citing works
Mukherjee, A., Lordan, C., Ross, R. P., & Cotter, P. D. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1802866 · Cited by 703 · see citing works
Gut-Microbiota-Derived Metabolites Maintain Gut and Systemic Immune Homeostasis
Wang, J., Zhu, N., Su, L., Gao, Y., & Yang, R. (2023) · Cells · doi:10.3390/cells12050793 · Cited by 621 · see citing works
Profiling the human intestinal environment under physiological conditions
Shalon, D., Culver, R. N., Grembi, J. A., Folz, J., Treit, P. V., Shi, H., Rosenberger, F. A., Dethlefsen, L., Meng, X., Yaffe, E., et al. (2023) · Nature · doi:10.1038/s41586-023-05989-7 · Cited by 484 · see citing works
Gut Microbiota Metabolites in NAFLD Pathogenesis and Therapeutic Implications
Chen, J., & Vitetta, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155214 · Cited by 352 · see citing works
Gut microbiota Turicibacter strains differentially modify bile acids and host lipids
Lynch, J. B., Gonzalez, E. L., Choy, K., Faull, K. F., Jewell, T., Arellano, A., Liang, J., Yu, K. B., Paramo, J., & Hsiao, E. Y. (2023) · Nature Communications · doi:10.1038/s41467-023-39403-7 · Cited by 352 · see citing works
Streidl, T., Karkossa, I., Muñoz, R. R. S., Eberl, C., Zaufel, A., Plagge, J., Schmaltz, R. J., Schubert, K. A., Basic, M., Schneider, K. M., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1854008 · Cited by 313 · see citing works
Bile acid metabolism and signalling in liver disease
Fuchs, C. D., Simbrunner, B., Baumgartner, M., Campbell, C., Reiberger, T., & Trauner, M. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.09.032 · Cited by 246 · see citing works
A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity
Wylensek, D., Hitch, T. C. A., Riedel, T., Afrizal, A., Kumar, N., Wortmann, E., Liu, T., Devendran, S., Lesker, T. R., Hernández, S. B., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19929-w · Cited by 232 · see citing works
Bustos, A. Y., Font de Valdez, G., Fadda, S., & Taranto, M. P. (2018) · Food Research International · doi:10.1016/j.foodres.2018.06.035 · Cited by 232 · see citing works
The changing metabolic landscape of bile acids – keys to metabolism and immune regulation
Mohanty, I., Allaband, C., Mannochio-Russo, H., Abiead, Y. E., Hagey, L. R., Knight, R. D., & Dorrestein, P. C. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00914-3 · Cited by 225 · see citing works
Bile Acid–Gut Microbiota Axis in Inflammatory Bowel Disease: From Bench to Bedside
Yang, M., Gu, Y., Li, L., Liu, T., Song, X., Sun, Y., Cao, X., Wang, B., Jiang, K., & Cao, H. (2021) · Nutrients · doi:10.3390/nu13093143 · Cited by 216 · see citing works
The underappreciated diversity of bile acid modifications
Mohanty, I., Mannochio-Russo, H., Schweer, J. V., Abiead, Y. E., Bittremieux, W., Xing, S., Schmid, R., Zuffa, S., Vasquez, F. J. D. A., Muti, V. B., et al. (2024) · Cell · doi:10.1016/j.cell.2024.02.019 · Cited by 202 · see citing works
Guan, B., Tong, J., Hao, H., Yang, Z., Chen, K., Xu, H., & Wang, A. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.12.011 · Cited by 208 · see citing works
Foley, M. H., O’Flaherty, S., Allen, G., Rivera, A. J., Stewart, A. K., Barrangou, R., & Theriot, C. M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017709118 · Cited by 205 · see citing works
Wu, Q., Liang, X., Wang, K., Lin, J., Wang, X., Wang, P., Zhang, Y., Nie, Q., Liu, H., Zhang, Z., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.007 · Cited by 201 · see citing works
Self-citationWang, S., Martins, R., Sullivan, M. C., Friedman, E. S., Misic, A. M., El‐Fahmawi, A., Martinis, E. C. P. D., O’Brien, K. M., Chen, Y., Bradley, C. W., et al. (2019) · Microbiome · doi:10.1186/s40168-019-0740-4 · Cited by 200 · see citing works
Molecular mechanisms of probiotic prevention of antibiotic-associated diarrhea
Mekonnen, S. A., Merenstein, D. J., Fraser, C. M., & Marco, M. L. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.01.005 · Cited by 198 · see citing works
Another renaissance for bile acid gastrointestinal microbiology
Ridlon, J. M., & Gaskins, H. R. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00896-2 · Cited by 193 · see citing works
Foley, M. H., Walker, M. E., Stewart, A. K., O’Flaherty, S., Gentry, E. C., Patel, S., Beaty, V. V., Allen, G., Pan, M., Simpson, J. B., et al. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01337-7 · Cited by 181 · see citing works
Ma, J., Hong, Y., Zheng, N., Xie, G., Lyu, Y., Gu, Y., Xi, C., Chen, L., Wu, G., Li, Y., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1763770 · Cited by 171 · see citing works
A Comprehensive Analysis of the Global Human Gut Archaeome from a Thousand Genome Catalogue
Chibani, C. M., Mahnert, A., Borrel, G., Almeida, A., Werner, A., Brugère, J., Gribaldo, S., Finn, R. D., Schmitz, R. A., & Moissl‐Eichinger, C. (2020) · Nature Microbiology · doi:10.1038/s41564-021-01020-9 · Cited by 183 · see citing works
Gut microbiota: A new target for T2DM prevention and treatment
Liu, L., Zhang, J., Cheng, Y., Zhu, M., Xiao, Z., Ruan, G., & Wei, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.958218 · Cited by 182 · see citing works
Interpersonal Gut Microbiome Variation Drives Susceptibility and Resistance to Cholera Infection
Alavi, S., Mitchell, J., Cho, J. Y., Liu, R., Macbeth, J. C., & Hsiao, A. (2020) · Cell · doi:10.1016/j.cell.2020.05.036 · Cited by 174 · see citing works
Gut microbiota exaggerates triclosan-induced liver injury via gut-liver axis
Zhang, P., Zheng, L., Duan, Y., Gao, Y., Gao, H., Mao, D., & Luo, Y. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.126707 · Cited by 174 · see citing works
Gut microbiota derived bile acid metabolites maintain the homeostasis of gut and systemic immunity
Su, L., Gao, Y., & Yang, R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1127743 · Cited by 167 · see citing works
Jiang, Z., Zhuo, L., He, Y., Fu, Y., Shen, L., Xu, F., Gou, W., Miao, Z., Shuai, M., Liang, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30712-x · Cited by 156 · see citing works
Gut microbiome and bile acids in obesity-related diseases
Li, R., Andreu‐Sánchez, S., Kuipers, F., & Fu, J. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101493 · Cited by 150 · see citing works
Chen, B., Bai, Y., Tong, F., Yan, J., Zhang, R., Zhong, Y., Tan, H., & Ma, X. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2192155 · Cited by 143 · see citing works
Bile Salt Hydrolases: At the Crossroads of Microbiota and Human Health
Bourgin, M., Kriaa, A., Mkaouar, H., Mariaule, V., Jablaoui, A., Maguin, E., & Rhimi, M. (2021) · Microorganisms · doi:10.3390/microorganisms9061122 · Cited by 141 · see citing works
Jia, B., Park, D., Hahn, Y., & Jeon, C. O. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1748261 · Cited by 135 · see citing works
Quraishi, M. N., Acharjee, A., Beggs, A. D., Horniblow, R. D., Tselepis, C., Gkoutos, G. V., Ghosh, S. K., Rossiter, A. E., Loman, N. J., van Schaik, W., et al. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa021 · Cited by 130 · see citing works
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer
Sun, L., Zhang, Y., Cai, J., Rimal, B., Rocha, E. R., Coleman, J. P., Zhang, C., Nichols, R. G., Luo, Y., Kim, B., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36089-9 · Cited by 121 · see citing works
Wu, R., Xiong, R., Li, Y., Chen, J., & Yan, R. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103062 · Cited by 121 · see citing works
Development of a covalent inhibitor of gut bacterial bile salt hydrolases
Adhikari, A. A., Seegar, T. C. M., Ficarro, S. B., McCurry, M. D., Ramachandran, D., Yao, L., Chaudhari, S. N., Ndousse-Fetter, S., Banks, A. S., Marto, J. A., et al. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0467-3 · Cited by 115 · see citing works
Yang, H., Guo, R., Li, S., Liang, F., Cheng, T., Zhao, X., Long, Y., Liu, F., Jiang, M., Zhang, Y., et al. (2020) · npj Biofilms and Microbiomes · doi:10.1038/s41522-020-00142-y · Cited by 116 · see citing works
Intestinal flora imbalance affects bile acid metabolism and is associated with gallstone formation
Wang, Q., Hao, C., Yao, W., Zhu, D., Lu, H., Li, L., Ma, B., Sun, B., Xue, D., & Zhang, W. (2020) · BMC Gastroenterology · doi:10.1186/s12876-020-01195-1 · Cited by 113 · see citing works
Depletion of gut microbiota induces skeletal muscle atrophy by FXR-FGF15/19 signalling
Qiu, Y., Yu, J., Li, Y., Yang, F., Yu, H., Xue, M., Zhang, F., Jiang, X., Ji, X., & Bao, Z. (2021) · Annals of Medicine · doi:10.1080/07853890.2021.1900593 · Cited by 105 · see citing works
Zhuge, A., Li, S., Lou, P., Wu, W., Wang, K., Yuan, Y., Xia, J., Li, B., & Li, L. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.00047-22 · Cited by 100 · see citing works
Huang, Y., Chen, H., Zhang, K., Lu, Y., Wu, Q., Chen, J., Li, Y., Wu, Q.-X., & Chen, Y. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.06.049 · Cited by 101 · see citing works
Regulation of bile acids and their receptor FXR in metabolic diseases
Li, Y., Wang, L., Qing, Y., Luo, L., & Xiong, Y. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1447878 · Cited by 107 · see citing works
Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption
Li, X., Yang, J., Zhou, X., Dai, C., Kong, M., Xie, L., Liu, C., Liu, Y., Li, D., Ma, X., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01072-1 · Cited by 94 · see citing works
Self-citationLin, L., Lai, Z., Huisheng, Y., Zhang, J., Qi, W., Xie, F., & Mao, S. (2022) · The ISME Journal · doi:10.1038/s41396-022-01333-5 · Cited by 93 · see citing works
Wise, J. L., & Cummings, B. P. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1093420 · Cited by 94 · see citing works
Mining Lactobacillus and Bifidobacterium for organisms with long-term gut colonization potential
Xiao, Y., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.05.014 · Cited by 91 · see citing works
Wang, D., Doestzada, M., Chen, L., Andreu‐Sánchez, S., van den Munckhof, I., Augustijn, H. E., Koehorst, M., Ruiz-Moreno, A. J., Bloks, V. W., Riksen, N. P., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.11.003 · Cited by 94 · see citing works
Jia, W., Rajani, C., Kaddurah‐Daouk, R., & Li, H. (2020) · Medicinal Research Reviews · doi:10.1002/med.21653 · Cited by 88 · see citing works
Agolino, G., Pino, A., Vaccalluzzo, A., Cristofolini, M., Solieri, L., Caggia, C., & Randazzo, C. L. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106357 · Cited by 87 · see citing works
Correlation of fecal metabolomics and gut microbiota in mice with endometriosis
Ni, Z., Sun, S., Bi, Y., Ding, J., Cheng, W., Yu, J., Zhou, L., Li, M., & Yu, C. (2020) · American Journal of Reproductive Immunology · doi:10.1111/aji.13307 · Cited by 85 · see citing works
Xu, M., Lan, R., Qiao, L., Lin, X., Hu, D., Zhang, S., Yang, H. J., Zhou, J., Ren, Z., Li, X., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.02517-22 · Cited by 85 · see citing works
Self-citationImmunology of bile acids regulated receptors
Fiorucci, S., Marchianò, S., Urbani, G., Giorgio, C. D., Distrutti, E., Zampella, A., & Biagioli, M. (2024) · Progress in Lipid Research · doi:10.1016/j.plipres.2024.101291 · Cited by 84 · see citing works
The bridge of the gut–joint axis: Gut microbial metabolites in rheumatoid arthritis
Xu, X., Wang, M., Wang, Z., Chen, Q., Chen, X., Xu, Y., Dai, M., Wu, B., & Li, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1007610 · Cited by 85 · see citing works
Hua, Y., Jia, Y., Zhang, X., Yuan, Z., Ji, P., Hu, J., & Wei, Y. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111320 · Cited by 81 · see citing works
Schirmer, M., Stražar, M., Ávila-Pacheco, J., Rojas‐Tapias, D. F., Brown, E., Temple, E. R., Deik, A., Bullock, K. H., Jeanfavre, S., Pierce, K. A., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2023.12.013 · Cited by 82 · see citing works
Bile acids in immunity: Bidirectional mediators between the host and the microbiota
Godlewska, U., Bulanda, E., & Wypych, T. P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.949033 · Cited by 77 · see citing works
Surve, S., Shinde, D. B., & Kulkarni, R. (2022) · Scientific Reports · doi:10.1038/s41598-022-05850-3 · Cited by 74 · see citing works
Applying probiotics and prebiotics in new delivery formats – is the clinical evidence transferable?
Cunningham, M., Vinderola, G., Charalampopoulos, D., Lebeer, S., Sanders, M. E., & Grimaldi, R. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.04.009 · Cited by 78 · see citing works
Novel approaches in IBD therapy: targeting the gut microbiota-bile acid axis
Pan, Y., Zhang, H., Li, M., He, T., Guo, S., Zhu, L., Tan, J., & Wang, B. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2356284 · Cited by 77 · see citing works
Imidacloprid disturbed the gut barrier function and interfered with bile acids metabolism in mice
Yang, G., Yuan, X., Jin, C., Wang, D., Wang, Y., Miao, W., & Jin, Y. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115290 · Cited by 71 · see citing works
The role of fecal sulfur metabolome in inflammatory bowel diseases
Walker, A., & Schmitt‐Kopplin, P. (2021) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2021.151513 · Cited by 70 · see citing works
Shu, Y., Huang, Y., Dong, W., Fan, X., Sun, Y., Chen, G., Zeng, X., & Ye, H. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125662 · Cited by 70 · see citing works
Ranaivo, H., Thirion, F., Béra‐Maillet, C., Guilly, S., Simon, C., Sothier, M., Berghe, L. V. D., Feugier, N., Lambert-Porcheron, S., Dussous, I., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2044722 · Cited by 69 · see citing works
Role of Hydrogen Sulfide in Inflammatory Bowel Disease
Stummer, N., Feichtinger, R. G., Weghuber, D., Kofler, B., & Schneider, A.-M. (2023) · Antioxidants · doi:10.3390/antiox12081570 · Cited by 71 · see citing works
Chen, Z.-H., Chen, H., Huang, W., Guo, X., Yu, L., Shan, J., Deng, X., Liu, J., Li, W., Shen, W., et al. (2024) · Gut microbes · doi:10.1080/19490976.2024.2379566 · Cited by 70 · see citing works
The small intestine: dining table of host–microbiota meetings
Delbaere, K., Roegiers, I. H., Bron, A., Durif, C., de Wiele, T. V., Blanquet‐Diot, S., & Marinelli, L. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad022 · Cited by 68 · see citing works
Hsiao, A., & Zhu, J. (2020) · Virulence · doi:10.1080/21505594.2020.1845039 · Cited by 65 · see citing works
Bile Salt Hydrolase-Competent Probiotics in the Management of IBD: Unlocking the “Bile Acid Code”
Gadaleta, R. M., Cariello, M., Crudele, L., & Moschetta, A. (2022) · Nutrients · doi:10.3390/nu14153212 · Cited by 65 · see citing works
Teng, Y., Wang, Y., Tian, Y., Chen, Y.-Y., Guan, W., Piao, C., & Wang, Y. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103665 · Cited by 63 · see citing works
Pan, Z., Hu, Y., Huang, Z., Han, N., Li, Y., Zhuang, X., Yin, J., Peng, H., Gao, Q., Zhang, W., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-021-2056-1 · Cited by 63 · see citing works
Self-citationEffect of Gut Microbiota on Blood Cholesterol: A Review on Mechanisms
Deng, C., Pan, J., Zhu, H., & Chen, Z. (2023) · Foods · doi:10.3390/foods12234308 · Cited by 62 · see citing works
Balance between bile acid conjugation and hydrolysis activity can alter outcomes of gut inflammation
Fu, Y., Guzior, D. V., Okros, M., Bridges, C., Rosset, S. L., Gonzalez, C. T., Christian Martin, H., Karunarathne, H., Watson, V. E., & Quinn, R. A. (2025) · Nature Communications · doi:10.1038/s41467-025-58649-x · Cited by 61 · see citing works
Jiang, M., Li, F., Liu, Y., Gu, Z., Zhang, L., Lee, J., He, L., Vatsalya, V., Zhang, H., Deng, Z., et al. (2022) · Hepatology · doi:10.1002/hep.32608 · Cited by 60 · see citing works
Zhong, X., Liu, Y., Gao, X., Krausz, K. W., Niu, B., Gonzalez, F. J., & Xie, C. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00921-7 · Cited by 59 · see citing works
The contribution of bile acid metabolism to the pathogenesis of Clostridioides difficile infection
Mullish, B. H., & Allegretti, J. R. (2021) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848211017725 · Cited by 58 · see citing works
Bile Acid and Gut Microbiota in Irritable Bowel Syndrome
Min, Y. W., Rezaie, A. R., & Pimentel, M. (2022) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm22129 · Cited by 58 · see citing works
The Interface of Vibrio cholerae and the Gut Microbiome
Cho, J. Y., Liu, R., Macbeth, J. C., & Hsiao, A. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1937015 · Cited by 58 · see citing works
Li, D. K., Chaudhari, S. N., Sojoodi, M., Lee, Y., Adhikari, A. A., Zukerberg, L. R., Shroff, S. G., Barrett, S. C., Tanabe, K. K., Chung, R. T., et al. (2022) · Science Advances · doi:10.1126/sciadv.abo2794 · Cited by 57 · see citing works
Zhang, Y., Feng, H., Liang, X., He, S., Lan, J., & Li, L. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.01.010 · Cited by 57 · see citing works
Yang, Y., & Wu, C. (2022) · Food & Function · doi:10.1039/d2fo01252a · Cited by 57 · see citing works
Ke, J., Li, Y., Han, C., He, R., Lin, R., Qian, W., & Hou, X. (2020) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa007 · Cited by 57 · see citing works
Song, Z., Feng, S., Zhou, X., Song, Z.-X., Li, J., & Li, P. (2023) · iMeta · doi:10.1002/imt2.128 · Cited by 60 · see citing works
Self-citationZhai, Y., Zhou, W., Yan, X., Qiao, Y., Guan, L., Zhang, Z., Liu, H., Jiang, J., Liu, J., & Peng, L. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154444 · Cited by 55 · see citing works
Qu, T., Yang, L., Wang, Y., Jiang, B., Shen, M., & Ren, D. (2020) · Food & Function · doi:10.1039/c9fo02478f · Cited by 58 · see citing works
A Gut-Restricted Lithocholic Acid Analog as an Inhibitor of Gut Bacterial Bile Salt Hydrolases
Adhikari, A. A., Ramachandran, D., Chaudhari, S. N., Powell, C. E., Li, W., McCurry, M. D., Banks, A. S., & Devlin, A. S. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.1c00192 · Cited by 55 · see citing works
Qu, Y., Su, C., Zhao, Q., Shi, A., Zhao, F., Tang, L., Xu, D., Xiang, Z., Wang, Y., Wang, Y., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.837543 · Cited by 54 · see citing works
Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes
Lamichhane, S., Sen, P., Dickens, A. M., Alves, M. A., Härkönen, T., Honkanen, J. K., Vatanen, T., Xavier, R. J., Hyötyläinen, T., Knip, M., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100762 · Cited by 54 · see citing works
The Role of the Gut Microbiome and Trimethylamine Oxide in Atherosclerosis and Age-Related Disease
Hage, R. E., Al-Arawe, N., & Hinterseher, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032399 · Cited by 55 · see citing works
Ileal FXR-FGF15/19 signaling activation improves skeletal muscle loss in aged mice
Qiu, Y., Yu, J., Ji, X., Yu, H., Xue, M., Zhang, F., Li, Y., & Bao, Z. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111630 · Cited by 53 · see citing works
Yntema, T., Koonen, D. P. Y., & Kuipers, F. (2023) · Nutrients · doi:10.3390/nu15081850 · Cited by 55 · see citing works
Mao, Z., Hui, H., Zhao, X., Xu, L., Qi, Y., Yin, L., Qu, L., Han, L., & Peng, J. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.06.007 · Cited by 50 · see citing works
Xiao, Y., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2021) · Microbial Genomics · doi:10.1099/mgen.0.000581 · Cited by 54 · see citing works
Regulation of gut microbiota-bile acids axis by probiotics in inflammatory bowel disease
Li, L., Liu, T., Gu, Y., Wang, X., Xie, R., Sun, Y., Wang, B., & Cao, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.974305 · Cited by 51 · see citing works
Self-citationSex, puberty, and the gut microbiome
Sisk-Hackworth, L., Kelley, S. T., & Thackray, V. G. (2022) · Reproduction · doi:10.1530/rep-22-0303 · Cited by 51 · see citing works
Therdtatha, P., Song, Y., Tanaka, M., Mariyatun, M., Almunifah, M., Manurung, N. E. P., Indriarsih, S., Lu, Y., Nagata, K., Fukami, K., et al. (2021) · Microorganisms · doi:10.3390/microorganisms9050897 · Cited by 49 · see citing works
Zhuge, A., Li, S., Yuan, Y., Han, S., Xia, J., Wang, Q., Wang, S., Lou, P., Li, B., & Li, L. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102582 · Cited by 48 · see citing works
Cai, H., Zhang, J., Liu, C., Le, T. N., Lu, Y., Feng, F., & Zhao, M. (2024) · Foods · doi:10.3390/foods13050699 · Cited by 48 · see citing works
Biagioli, M., Giorgio, C. D., Massa, C., Marchianò, S., Bellini, R., Bordoni, M., Urbani, G., Roselli, R., Lachi, G., Morretta, E., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117731 · Cited by 50 · see citing works
Gut Microbiota and Microbial Metabolism in Early Risk of Cardiometabolic Disease
Gabriel, C. L., & Ferguson, J. F. (2023) · Circulation Research · doi:10.1161/circresaha.123.322055 · Cited by 46 · see citing works
Meng, Y., Zheng, X., Fan, J., Cheng, W., Yan, T., Lai, Y., Zhang, N., Lu, Y., Qi, J., Huo, Z., et al. (2024) · Advanced Science · doi:10.1002/advs.202307981 · Cited by 47 · see citing works
Self-citation
- Authors
- Song, Z., Cai, Y., Lao, X., Wang, X., Lin, X., Cui, Y., Kalavagunta, P. K., Liao, J., Jin, L., Shang, J., & Li, J.
- Affiliations
- China Pharmaceutical University (CN)
- Corresponding author
- Jin, Liang
- Shang, Jing
- Li, Jing
- ORCID
- Venue
- Microbiome
- Published
- 2019-01-23
- Volume
- 7
- Issue
- 1
- Pages
- 9-9
- ISSN
- 2049-2618 (ISSN-L)
- PMC
- PMC6345003
- OpenAlex
- W2952656298
- Cited by
- 505
- References
- 85
- Citations by year
- 2026: 56 · 2025: 88 · 2024: 109 · 2023: 78 · 2022: 77 · 2021: 58 · 2020: 32 · 2019: 6 · 2018: 1
- FWCI
- 14.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Microbiome (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (31670495)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Keywords
- bile salt hydrolase, human gut microbiome, bile acid deconjugation, Lactobacillus, Bacteroides, population variation, atherosclerosis, diabetes mellitus, dysbiosis, bile acid signaling
- MeSH terms
- Gastrointestinal Microbiome, Amidohydrolases, Amino Acid Sequence, Bacteria, Bile Acids and Salts, Humans, Phylogeny, Protein Structure, Secondary, Enzyme Assays, Molecular Docking Simulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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