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Cited by 22Sepsis Diagnosis and TreatmentAcute Kidney Injury ResearchGut microbiota and health

Contribution of gut microbiota toward renal function in sepsis

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Xu, Yaya, Kong, Xiangmei, Zhu, Yueniu, Xu, Jiayue, Mao, Haoyun, Li, Jiru, Zhang, Jianhua, Zhu, Xiaodong·2022·Frontiers in Microbiology
DOI 10.3389/fmicb.2022.985283PMC PMC9486003
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Abstract

Sepsis most often involves the kidney and is one of the most common causes of acute kidney injury. The prevalence of septic acute kidney injury has increased significantly in recent years. The gut microbiota plays an important role in sepsis. It interacts with the kidney in a complex and multifactorial process, which is not fully understood. Sepsis may lead to gut microbiota alteration, orchestrate gut mucosal injury, and cause gut barrier failure, which further alters the host immunological and metabolic homeostasis. The pattern of gut microbiota alteration also varies with sepsis progression. Changes in intestinal microecology have double-edged effects on renal function, which also affects intestinal homeostasis. This review aimed to clarify the interaction between gut microbiota and renal function during the onset and progression of sepsis. The mechanism of gut–kidney crosstalk may provide potential insights for the development of novel therapeutic strategies for sepsis.

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Cited by

Sorted by citations

Authors
Xu, Y., Kong, X., Zhu, Y., Xu, J., Mao, H., Li, J., Zhang, J., & Zhu, X.
Affiliations
Shanghai Jiao Tong University (CN)
Corresponding author
  • Zhang, Jianhua
  • Zhu, Xiaodong
ORCID
Venue
Frontiers in Microbiology
Publisher
Frontiers Media SA
Published
2022-09-06
Volume
13
Pages
985283-985283
ISSN
1664-302X (ISSN-L)
DOI
10.3389/fmicb.2022.985283
PMC
PMC9486003
OpenAlex
W4294718905
Cited by
22
References
5
Citations by year
2026: 5 · 2025: 3 · 2024: 5 · 2023: 9
FWCI
0.68
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Microbiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
gut microbiota, sepsis, acute kidney injury, renal function, intestinal mucosal injury, intestinal homeostasis, metabolic homeostasis

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